LeishMANIAdb
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Guanine nucleotide-binding protein subunit beta-like protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Guanine nucleotide-binding protein subunit beta-like protein
Gene product:
WD domain - G-beta repeat - putative
Species:
Leishmania infantum
UniProt:
A4HYB8_LEIIN
TriTrypDb:
LINF_190015400
Length:
811

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005840 ribosome 5 6
GO:0031931 TORC1 complex 4 8
GO:0031932 TORC2 complex 4 8
GO:0032991 protein-containing complex 1 8
GO:0038201 TOR complex 3 8
GO:0043226 organelle 2 6
GO:0043228 non-membrane-bounded organelle 3 6
GO:0043229 intracellular organelle 3 6
GO:0043232 intracellular non-membrane-bounded organelle 4 6
GO:0110165 cellular anatomical entity 1 6
GO:0140535 intracellular protein-containing complex 2 8
GO:1990904 ribonucleoprotein complex 2 6
GO:0005737 cytoplasm 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HYB8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYB8

Function

Biological processes
Term Name Level Count
GO:0007165 signal transduction 2 8
GO:0009987 cellular process 1 8
GO:0031929 TOR signaling 4 8
GO:0035556 intracellular signal transduction 3 8
GO:0050789 regulation of biological process 2 8
GO:0050794 regulation of cellular process 3 8
GO:0065007 biological regulation 1 8
GO:0032956 regulation of actin cytoskeleton organization 5 1
GO:0032970 regulation of actin filament-based process 4 1
GO:0033043 regulation of organelle organization 5 1
GO:0051128 regulation of cellular component organization 4 1
GO:0051493 regulation of cytoskeleton organization 6 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 632 636 PF00656 0.511
CLV_C14_Caspase3-7 678 682 PF00656 0.675
CLV_NRD_NRD_1 214 216 PF00675 0.432
CLV_NRD_NRD_1 806 808 PF00675 0.518
CLV_PCSK_KEX2_1 214 216 PF00082 0.496
CLV_PCSK_KEX2_1 805 807 PF00082 0.421
CLV_PCSK_PC1ET2_1 805 807 PF00082 0.482
CLV_PCSK_SKI1_1 133 137 PF00082 0.577
CLV_PCSK_SKI1_1 194 198 PF00082 0.383
CLV_PCSK_SKI1_1 215 219 PF00082 0.363
CLV_PCSK_SKI1_1 24 28 PF00082 0.371
CLV_PCSK_SKI1_1 347 351 PF00082 0.663
CLV_PCSK_SKI1_1 354 358 PF00082 0.616
CLV_PCSK_SKI1_1 442 446 PF00082 0.485
CLV_PCSK_SKI1_1 549 553 PF00082 0.289
CLV_PCSK_SKI1_1 743 747 PF00082 0.191
DEG_APCC_DBOX_1 295 303 PF00400 0.410
DOC_CKS1_1 371 376 PF01111 0.532
DOC_MAPK_MEF2A_6 188 195 PF00069 0.291
DOC_MAPK_MEF2A_6 549 556 PF00069 0.281
DOC_MAPK_MEF2A_6 794 801 PF00069 0.322
DOC_PP1_RVXF_1 329 335 PF00149 0.261
DOC_PP4_FxxP_1 40 43 PF00568 0.416
DOC_PP4_FxxP_1 575 578 PF00568 0.288
DOC_SPAK_OSR1_1 574 578 PF12202 0.284
DOC_USP7_MATH_1 251 255 PF00917 0.480
DOC_USP7_MATH_1 282 286 PF00917 0.505
DOC_USP7_MATH_1 310 314 PF00917 0.315
DOC_USP7_MATH_1 349 353 PF00917 0.457
DOC_USP7_MATH_1 402 406 PF00917 0.639
DOC_USP7_MATH_1 429 433 PF00917 0.564
DOC_USP7_MATH_1 524 528 PF00917 0.667
DOC_USP7_MATH_1 706 710 PF00917 0.508
DOC_USP7_UBL2_3 395 399 PF12436 0.556
DOC_WW_Pin1_4 208 213 PF00397 0.307
DOC_WW_Pin1_4 257 262 PF00397 0.527
DOC_WW_Pin1_4 370 375 PF00397 0.548
DOC_WW_Pin1_4 389 394 PF00397 0.735
DOC_WW_Pin1_4 472 477 PF00397 0.554
DOC_WW_Pin1_4 554 559 PF00397 0.288
DOC_WW_Pin1_4 681 686 PF00397 0.620
DOC_WW_Pin1_4 718 723 PF00397 0.537
DOC_WW_Pin1_4 729 734 PF00397 0.553
LIG_14-3-3_CanoR_1 188 194 PF00244 0.421
LIG_14-3-3_CanoR_1 24 30 PF00244 0.315
LIG_14-3-3_CanoR_1 354 359 PF00244 0.512
LIG_14-3-3_CanoR_1 413 417 PF00244 0.483
LIG_14-3-3_CanoR_1 502 508 PF00244 0.534
LIG_14-3-3_CanoR_1 783 788 PF00244 0.378
LIG_Actin_WH2_2 569 584 PF00022 0.342
LIG_APCC_ABBAyCdc20_2 27 33 PF00400 0.371
LIG_BIR_II_1 1 5 PF00653 0.352
LIG_BRCT_BRCA1_1 103 107 PF00533 0.386
LIG_BRCT_BRCA1_1 27 31 PF00533 0.351
LIG_BRCT_BRCA1_1 785 789 PF00533 0.399
LIG_eIF4E_1 550 556 PF01652 0.334
LIG_FHA_1 155 161 PF00498 0.469
LIG_FHA_1 355 361 PF00498 0.567
LIG_FHA_1 404 410 PF00498 0.740
LIG_FHA_1 43 49 PF00498 0.366
LIG_FHA_1 642 648 PF00498 0.704
LIG_FHA_1 791 797 PF00498 0.317
LIG_FHA_2 141 147 PF00498 0.436
LIG_FHA_2 174 180 PF00498 0.276
LIG_FHA_2 364 370 PF00498 0.631
LIG_IRF3_LxIS_1 577 584 PF10401 0.313
LIG_LIR_Apic_2 227 232 PF02991 0.281
LIG_LIR_Apic_2 38 43 PF02991 0.398
LIG_LIR_Apic_2 392 397 PF02991 0.548
LIG_LIR_Apic_2 432 436 PF02991 0.597
LIG_LIR_Gen_1 104 115 PF02991 0.363
LIG_LIR_Gen_1 168 175 PF02991 0.375
LIG_LIR_Gen_1 307 316 PF02991 0.315
LIG_LIR_Gen_1 44 55 PF02991 0.289
LIG_LIR_Gen_1 539 548 PF02991 0.372
LIG_LIR_Gen_1 738 745 PF02991 0.175
LIG_LIR_LC3C_4 443 447 PF02991 0.490
LIG_LIR_Nem_3 104 110 PF02991 0.359
LIG_LIR_Nem_3 168 174 PF02991 0.382
LIG_LIR_Nem_3 307 311 PF02991 0.382
LIG_LIR_Nem_3 44 50 PF02991 0.297
LIG_LIR_Nem_3 539 544 PF02991 0.376
LIG_LIR_Nem_3 715 719 PF02991 0.552
LIG_LIR_Nem_3 738 742 PF02991 0.287
LIG_Pex14_1 753 757 PF04695 0.397
LIG_REV1ctd_RIR_1 182 192 PF16727 0.266
LIG_SH2_CRK 308 312 PF00017 0.350
LIG_SH2_CRK 394 398 PF00017 0.718
LIG_SH2_CRK 433 437 PF00017 0.586
LIG_SH2_CRK 548 552 PF00017 0.330
LIG_SH2_STAP1 11 15 PF00017 0.287
LIG_SH2_STAT3 11 14 PF00017 0.293
LIG_SH2_STAT5 216 219 PF00017 0.399
LIG_SH2_STAT5 47 50 PF00017 0.262
LIG_SH2_STAT5 550 553 PF00017 0.314
LIG_SH3_3 368 374 PF00018 0.705
LIG_SH3_3 607 613 PF00018 0.564
LIG_SUMO_SIM_anti_2 3 8 PF11976 0.337
LIG_SUMO_SIM_par_1 3 8 PF11976 0.337
LIG_TRAF2_1 285 288 PF00917 0.489
LIG_TYR_ITSM 43 50 PF00017 0.359
LIG_WRC_WIRS_1 26 31 PF05994 0.359
LIG_WRC_WIRS_1 61 66 PF05994 0.397
LIG_WRC_WIRS_1 713 718 PF05994 0.509
LIG_WRC_WIRS_1 96 101 PF05994 0.391
LIG_WW_1 93 96 PF00397 0.423
MOD_CDC14_SPxK_1 211 214 PF00782 0.328
MOD_CDC14_SPxK_1 392 395 PF00782 0.591
MOD_CDC14_SPxK_1 396 399 PF00782 0.599
MOD_CDK_SPK_2 681 686 PF00069 0.510
MOD_CDK_SPxK_1 208 214 PF00069 0.306
MOD_CDK_SPxK_1 389 395 PF00069 0.589
MOD_CDK_SPxxK_3 208 215 PF00069 0.369
MOD_CK1_1 126 132 PF00069 0.591
MOD_CK1_1 138 144 PF00069 0.483
MOD_CK1_1 189 195 PF00069 0.420
MOD_CK1_1 208 214 PF00069 0.299
MOD_CK1_1 22 28 PF00069 0.313
MOD_CK1_1 254 260 PF00069 0.537
MOD_CK1_1 352 358 PF00069 0.534
MOD_CK1_1 403 409 PF00069 0.661
MOD_CK1_1 419 425 PF00069 0.495
MOD_CK1_1 458 464 PF00069 0.623
MOD_CK1_1 474 480 PF00069 0.530
MOD_CK1_1 500 506 PF00069 0.642
MOD_CK1_1 527 533 PF00069 0.511
MOD_CK1_1 584 590 PF00069 0.615
MOD_CK1_1 599 605 PF00069 0.458
MOD_CK1_1 729 735 PF00069 0.570
MOD_CK1_1 758 764 PF00069 0.429
MOD_CK1_1 769 775 PF00069 0.438
MOD_CK1_1 82 88 PF00069 0.694
MOD_CK1_1 98 104 PF00069 0.290
MOD_CK2_1 282 288 PF00069 0.537
MOD_CK2_1 398 404 PF00069 0.599
MOD_CK2_1 419 425 PF00069 0.571
MOD_CK2_1 681 687 PF00069 0.618
MOD_CK2_1 94 100 PF00069 0.353
MOD_GlcNHglycan 128 131 PF01048 0.603
MOD_GlcNHglycan 162 165 PF01048 0.484
MOD_GlcNHglycan 188 191 PF01048 0.432
MOD_GlcNHglycan 207 210 PF01048 0.279
MOD_GlcNHglycan 21 24 PF01048 0.372
MOD_GlcNHglycan 264 267 PF01048 0.500
MOD_GlcNHglycan 284 287 PF01048 0.498
MOD_GlcNHglycan 307 311 PF01048 0.389
MOD_GlcNHglycan 354 357 PF01048 0.580
MOD_GlcNHglycan 385 388 PF01048 0.736
MOD_GlcNHglycan 400 403 PF01048 0.558
MOD_GlcNHglycan 406 409 PF01048 0.526
MOD_GlcNHglycan 418 421 PF01048 0.445
MOD_GlcNHglycan 442 445 PF01048 0.418
MOD_GlcNHglycan 459 463 PF01048 0.695
MOD_GlcNHglycan 476 479 PF01048 0.649
MOD_GlcNHglycan 512 515 PF01048 0.668
MOD_GlcNHglycan 526 529 PF01048 0.522
MOD_GlcNHglycan 566 569 PF01048 0.330
MOD_GlcNHglycan 589 592 PF01048 0.686
MOD_GlcNHglycan 601 604 PF01048 0.487
MOD_GlcNHglycan 618 621 PF01048 0.502
MOD_GlcNHglycan 656 659 PF01048 0.615
MOD_GlcNHglycan 66 69 PF01048 0.503
MOD_GlcNHglycan 7 10 PF01048 0.260
MOD_GlcNHglycan 708 711 PF01048 0.659
MOD_GlcNHglycan 74 77 PF01048 0.503
MOD_GSK3_1 122 129 PF00069 0.576
MOD_GSK3_1 133 140 PF00069 0.530
MOD_GSK3_1 18 25 PF00069 0.358
MOD_GSK3_1 230 237 PF00069 0.399
MOD_GSK3_1 306 313 PF00069 0.338
MOD_GSK3_1 31 38 PF00069 0.254
MOD_GSK3_1 339 346 PF00069 0.472
MOD_GSK3_1 350 357 PF00069 0.571
MOD_GSK3_1 381 388 PF00069 0.708
MOD_GSK3_1 389 396 PF00069 0.602
MOD_GSK3_1 398 405 PF00069 0.708
MOD_GSK3_1 412 419 PF00069 0.562
MOD_GSK3_1 474 481 PF00069 0.586
MOD_GSK3_1 564 571 PF00069 0.335
MOD_GSK3_1 583 590 PF00069 0.407
MOD_GSK3_1 592 599 PF00069 0.519
MOD_GSK3_1 60 67 PF00069 0.400
MOD_GSK3_1 608 615 PF00069 0.513
MOD_GSK3_1 648 655 PF00069 0.620
MOD_GSK3_1 673 680 PF00069 0.583
MOD_GSK3_1 681 688 PF00069 0.589
MOD_GSK3_1 72 79 PF00069 0.469
MOD_GSK3_1 765 772 PF00069 0.438
MOD_GSK3_1 80 87 PF00069 0.586
MOD_GSK3_1 94 101 PF00069 0.277
MOD_N-GLC_1 105 110 PF02516 0.299
MOD_N-GLC_1 429 434 PF02516 0.560
MOD_N-GLC_1 500 505 PF02516 0.602
MOD_NEK2_1 105 110 PF00069 0.289
MOD_NEK2_1 128 133 PF00069 0.600
MOD_NEK2_1 135 140 PF00069 0.611
MOD_NEK2_1 148 153 PF00069 0.421
MOD_NEK2_1 154 159 PF00069 0.345
MOD_NEK2_1 160 165 PF00069 0.442
MOD_NEK2_1 184 189 PF00069 0.450
MOD_NEK2_1 31 36 PF00069 0.378
MOD_NEK2_1 383 388 PF00069 0.576
MOD_NEK2_1 412 417 PF00069 0.572
MOD_NEK2_1 469 474 PF00069 0.583
MOD_NEK2_1 562 567 PF00069 0.268
MOD_NEK2_1 581 586 PF00069 0.608
MOD_NEK2_1 64 69 PF00069 0.467
MOD_NEK2_1 763 768 PF00069 0.401
MOD_PIKK_1 31 37 PF00454 0.313
MOD_PIKK_1 354 360 PF00454 0.552
MOD_PIKK_1 608 614 PF00454 0.554
MOD_PIKK_1 641 647 PF00454 0.732
MOD_PIKK_1 98 104 PF00454 0.370
MOD_PK_1 339 345 PF00069 0.461
MOD_PK_1 783 789 PF00069 0.393
MOD_PKA_2 343 349 PF00069 0.483
MOD_PKA_2 412 418 PF00069 0.485
MOD_PKA_2 455 461 PF00069 0.519
MOD_PKA_2 503 509 PF00069 0.496
MOD_PKA_2 581 587 PF00069 0.455
MOD_PKA_2 616 622 PF00069 0.609
MOD_Plk_1 105 111 PF00069 0.298
MOD_Plk_1 306 312 PF00069 0.353
MOD_Plk_1 339 345 PF00069 0.461
MOD_Plk_1 429 435 PF00069 0.574
MOD_Plk_1 568 574 PF00069 0.314
MOD_Plk_1 769 775 PF00069 0.441
MOD_Plk_2-3 726 732 PF00069 0.544
MOD_Plk_4 224 230 PF00069 0.364
MOD_Plk_4 25 31 PF00069 0.405
MOD_Plk_4 35 41 PF00069 0.246
MOD_Plk_4 412 418 PF00069 0.608
MOD_Plk_4 60 66 PF00069 0.379
MOD_Plk_4 785 791 PF00069 0.375
MOD_ProDKin_1 208 214 PF00069 0.308
MOD_ProDKin_1 257 263 PF00069 0.530
MOD_ProDKin_1 370 376 PF00069 0.548
MOD_ProDKin_1 389 395 PF00069 0.736
MOD_ProDKin_1 472 478 PF00069 0.555
MOD_ProDKin_1 554 560 PF00069 0.287
MOD_ProDKin_1 681 687 PF00069 0.621
MOD_ProDKin_1 718 724 PF00069 0.541
MOD_ProDKin_1 729 735 PF00069 0.546
MOD_SUMO_for_1 518 521 PF00179 0.494
MOD_SUMO_rev_2 237 245 PF00179 0.458
TRG_DiLeu_BaEn_1 168 173 PF01217 0.387
TRG_DiLeu_BaLyEn_6 356 361 PF01217 0.512
TRG_DiLeu_BaLyEn_6 708 713 PF01217 0.535
TRG_ENDOCYTIC_2 308 311 PF00928 0.357
TRG_ENDOCYTIC_2 47 50 PF00928 0.262
TRG_ENDOCYTIC_2 548 551 PF00928 0.339
TRG_ENDOCYTIC_2 96 99 PF00928 0.388
TRG_ER_diArg_1 214 216 PF00400 0.490
TRG_ER_diArg_1 806 808 PF00400 0.525
TRG_Pf-PMV_PEXEL_1 133 137 PF00026 0.577
TRG_Pf-PMV_PEXEL_1 194 198 PF00026 0.379

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7T2 Leptomonas seymouri 55% 100%
A0A1X0P678 Trypanosomatidae 35% 100%
A0A3S7WVI8 Leishmania donovani 100% 100%
A4HA53 Leishmania braziliensis 71% 98%
E9AS52 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
Q4QDB4 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS