FYVE-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FYVE zinc finger containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HYB5_LEIIN

TriTrypDb:

LINF_190015000

Length:

763

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYB5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.625
CLV_NRD_NRD_1	145	147	PF00675	0.639
CLV_NRD_NRD_1	213	215	PF00675	0.597
CLV_NRD_NRD_1	24	26	PF00675	0.438
CLV_NRD_NRD_1	353	355	PF00675	0.480
CLV_NRD_NRD_1	357	359	PF00675	0.439
CLV_NRD_NRD_1	365	367	PF00675	0.374
CLV_NRD_NRD_1	393	395	PF00675	0.304
CLV_NRD_NRD_1	400	402	PF00675	0.304
CLV_NRD_NRD_1	408	410	PF00675	0.304
CLV_NRD_NRD_1	413	415	PF00675	0.183
CLV_NRD_NRD_1	483	485	PF00675	0.304
CLV_NRD_NRD_1	55	57	PF00675	0.634
CLV_NRD_NRD_1	555	557	PF00675	0.438
CLV_PCSK_FUR_1	398	402	PF00082	0.304
CLV_PCSK_FUR_1	553	557	PF00082	0.425
CLV_PCSK_KEX2_1	145	147	PF00082	0.639
CLV_PCSK_KEX2_1	213	215	PF00082	0.597
CLV_PCSK_KEX2_1	23	25	PF00082	0.444
CLV_PCSK_KEX2_1	353	355	PF00082	0.500
CLV_PCSK_KEX2_1	357	359	PF00082	0.452
CLV_PCSK_KEX2_1	365	367	PF00082	0.368
CLV_PCSK_KEX2_1	393	395	PF00082	0.304
CLV_PCSK_KEX2_1	400	402	PF00082	0.304
CLV_PCSK_KEX2_1	408	410	PF00082	0.304
CLV_PCSK_KEX2_1	413	415	PF00082	0.183
CLV_PCSK_KEX2_1	483	485	PF00082	0.304
CLV_PCSK_KEX2_1	55	57	PF00082	0.634
CLV_PCSK_KEX2_1	555	557	PF00082	0.438
CLV_PCSK_PC7_1	20	26	PF00082	0.475
CLV_PCSK_PC7_1	353	359	PF00082	0.442
CLV_PCSK_PC7_1	409	415	PF00082	0.304
CLV_PCSK_SKI1_1	331	335	PF00082	0.592
CLV_PCSK_SKI1_1	366	370	PF00082	0.406
CLV_PCSK_SKI1_1	400	404	PF00082	0.304
CLV_PCSK_SKI1_1	670	674	PF00082	0.570
DEG_SPOP_SBC_1	255	259	PF00917	0.607
DOC_CKS1_1	174	179	PF01111	0.630
DOC_CKS1_1	230	235	PF01111	0.622
DOC_CKS1_1	634	639	PF01111	0.497
DOC_CYCLIN_RxL_1	394	407	PF00134	0.304
DOC_MAPK_gen_1	23	31	PF00069	0.463
DOC_MAPK_gen_1	534	543	PF00069	0.304
DOC_MAPK_RevD_3	11	25	PF00069	0.483
DOC_MAPK_RevD_3	541	556	PF00069	0.304
DOC_PP2B_LxvP_1	183	186	PF13499	0.611
DOC_PP2B_LxvP_1	252	255	PF13499	0.626
DOC_USP7_MATH_1	212	216	PF00917	0.663
DOC_USP7_MATH_1	256	260	PF00917	0.769
DOC_USP7_MATH_1	285	289	PF00917	0.644
DOC_USP7_MATH_1	421	425	PF00917	0.304
DOC_USP7_MATH_1	65	69	PF00917	0.649
DOC_USP7_MATH_1	650	654	PF00917	0.497
DOC_USP7_MATH_1	90	94	PF00917	0.644
DOC_WW_Pin1_4	129	134	PF00397	0.668
DOC_WW_Pin1_4	173	178	PF00397	0.628
DOC_WW_Pin1_4	222	227	PF00397	0.681
DOC_WW_Pin1_4	229	234	PF00397	0.662
DOC_WW_Pin1_4	288	293	PF00397	0.626
DOC_WW_Pin1_4	300	305	PF00397	0.549
DOC_WW_Pin1_4	314	319	PF00397	0.539
DOC_WW_Pin1_4	47	52	PF00397	0.587
DOC_WW_Pin1_4	489	494	PF00397	0.313
DOC_WW_Pin1_4	55	60	PF00397	0.604
DOC_WW_Pin1_4	61	66	PF00397	0.591
DOC_WW_Pin1_4	633	638	PF00397	0.508
LIG_14-3-3_CanoR_1	14	22	PF00244	0.477
LIG_14-3-3_CanoR_1	140	147	PF00244	0.685
LIG_14-3-3_CanoR_1	169	177	PF00244	0.689
LIG_14-3-3_CanoR_1	201	205	PF00244	0.685
LIG_14-3-3_CanoR_1	213	222	PF00244	0.556
LIG_14-3-3_CanoR_1	263	267	PF00244	0.680
LIG_14-3-3_CanoR_1	331	341	PF00244	0.586
LIG_14-3-3_CanoR_1	400	406	PF00244	0.369
LIG_14-3-3_CanoR_1	444	448	PF00244	0.459
LIG_14-3-3_CanoR_1	588	596	PF00244	0.551
LIG_14-3-3_CanoR_1	655	662	PF00244	0.503
LIG_BIR_III_4	105	109	PF00653	0.619
LIG_BRCT_BRCA1_1	186	190	PF00533	0.686
LIG_Clathr_ClatBox_1	711	715	PF01394	0.679
LIG_CtBP_PxDLS_1	310	315	PF00389	0.561
LIG_deltaCOP1_diTrp_1	156	165	PF00928	0.602
LIG_eIF4E_1	363	369	PF01652	0.432
LIG_eIF4E_1	397	403	PF01652	0.304
LIG_FHA_1	14	20	PF00498	0.451
LIG_FHA_1	174	180	PF00498	0.629
LIG_FHA_1	256	262	PF00498	0.621
LIG_FHA_1	288	294	PF00498	0.632
LIG_FHA_1	431	437	PF00498	0.304
LIG_FHA_1	458	464	PF00498	0.504
LIG_FHA_1	466	472	PF00498	0.373
LIG_FHA_1	504	510	PF00498	0.308
LIG_FHA_1	581	587	PF00498	0.484
LIG_FHA_1	634	640	PF00498	0.493
LIG_FHA_1	99	105	PF00498	0.629
LIG_FHA_2	107	113	PF00498	0.568
LIG_FHA_2	318	324	PF00498	0.615
LIG_FHA_2	343	349	PF00498	0.515
LIG_FHA_2	462	468	PF00498	0.284
LIG_FHA_2	580	586	PF00498	0.403
LIG_FHA_2	655	661	PF00498	0.504
LIG_FHA_2	742	748	PF00498	0.646
LIG_FHA_2	93	99	PF00498	0.654
LIG_HCF-1_HBM_1	478	481	PF13415	0.304
LIG_LIR_Nem_3	572	578	PF02991	0.380
LIG_MYND_1	177	181	PF01753	0.629
LIG_MYND_1	300	304	PF01753	0.586
LIG_MYND_1	493	497	PF01753	0.314
LIG_SH2_CRK	239	243	PF00017	0.561
LIG_SH2_GRB2like	548	551	PF00017	0.304
LIG_SH2_NCK_1	239	243	PF00017	0.561
LIG_SH2_STAP1	216	220	PF00017	0.686
LIG_SH2_STAP1	459	463	PF00017	0.304
LIG_SH2_STAT3	147	150	PF00017	0.672
LIG_SH2_STAT5	147	150	PF00017	0.650
LIG_SH2_STAT5	216	219	PF00017	0.597
LIG_SH2_STAT5	405	408	PF00017	0.369
LIG_SH2_STAT5	426	429	PF00017	0.304
LIG_SH2_STAT5	435	438	PF00017	0.304
LIG_SH2_STAT5	459	462	PF00017	0.304
LIG_SH2_STAT5	617	620	PF00017	0.601
LIG_SH2_STAT5	661	664	PF00017	0.532
LIG_SH2_STAT5	665	668	PF00017	0.574
LIG_SH3_2	51	56	PF14604	0.629
LIG_SH3_3	178	184	PF00018	0.686
LIG_SH3_3	301	307	PF00018	0.616
LIG_SH3_3	433	439	PF00018	0.369
LIG_SH3_3	45	51	PF00018	0.628
LIG_SH3_3	540	546	PF00018	0.369
LIG_SUMO_SIM_anti_2	505	513	PF11976	0.303
LIG_SUMO_SIM_anti_2	707	713	PF11976	0.640
LIG_SUMO_SIM_par_1	340	348	PF11976	0.480
LIG_SUMO_SIM_par_1	505	513	PF11976	0.303
LIG_SUMO_SIM_par_1	755	763	PF11976	0.689
LIG_TRAF2_1	345	348	PF00917	0.480
LIG_TRAF2_1	582	585	PF00917	0.486
MOD_CDK_SPK_2	129	134	PF00069	0.580
MOD_CK1_1	167	173	PF00069	0.618
MOD_CK1_1	175	181	PF00069	0.624
MOD_CK1_1	203	209	PF00069	0.601
MOD_CK1_1	228	234	PF00069	0.686
MOD_CK1_1	288	294	PF00069	0.590
MOD_CK1_1	309	315	PF00069	0.789
MOD_CK1_1	404	410	PF00069	0.304
MOD_CK1_1	457	463	PF00069	0.304
MOD_CK1_1	625	631	PF00069	0.518
MOD_CK1_1	707	713	PF00069	0.632
MOD_CK1_1	79	85	PF00069	0.667
MOD_CK2_1	288	294	PF00069	0.590
MOD_CK2_1	342	348	PF00069	0.465
MOD_CK2_1	579	585	PF00069	0.399
MOD_CK2_1	92	98	PF00069	0.607
MOD_Cter_Amidation	427	430	PF01082	0.304
MOD_GlcNHglycan	109	112	PF01048	0.660
MOD_GlcNHglycan	142	145	PF01048	0.811
MOD_GlcNHglycan	239	242	PF01048	0.566
MOD_GlcNHglycan	258	261	PF01048	0.583
MOD_GlcNHglycan	274	277	PF01048	0.485
MOD_GlcNHglycan	279	282	PF01048	0.576
MOD_GlcNHglycan	287	290	PF01048	0.577
MOD_GlcNHglycan	294	298	PF01048	0.495
MOD_GlcNHglycan	308	311	PF01048	0.580
MOD_GlcNHglycan	334	337	PF01048	0.597
MOD_GlcNHglycan	38	41	PF01048	0.539
MOD_GlcNHglycan	564	567	PF01048	0.524
MOD_GlcNHglycan	612	616	PF01048	0.562
MOD_GlcNHglycan	624	627	PF01048	0.495
MOD_GlcNHglycan	646	649	PF01048	0.471
MOD_GlcNHglycan	652	655	PF01048	0.519
MOD_GlcNHglycan	67	70	PF01048	0.639
MOD_GlcNHglycan	687	690	PF01048	0.691
MOD_GSK3_1	113	120	PF00069	0.640
MOD_GSK3_1	136	143	PF00069	0.619
MOD_GSK3_1	161	168	PF00069	0.603
MOD_GSK3_1	169	176	PF00069	0.623
MOD_GSK3_1	221	228	PF00069	0.650
MOD_GSK3_1	250	257	PF00069	0.763
MOD_GSK3_1	277	284	PF00069	0.628
MOD_GSK3_1	439	446	PF00069	0.482
MOD_GSK3_1	457	464	PF00069	0.222
MOD_GSK3_1	517	524	PF00069	0.369
MOD_GSK3_1	55	62	PF00069	0.647
MOD_GSK3_1	650	657	PF00069	0.496
MOD_GSK3_1	76	83	PF00069	0.653
MOD_N-GLC_1	154	159	PF02516	0.670
MOD_N-GLC_1	79	84	PF02516	0.657
MOD_N-GLC_2	567	569	PF02516	0.425
MOD_NEK2_1	165	170	PF00069	0.614
MOD_NEK2_1	205	210	PF00069	0.687
MOD_NEK2_1	272	277	PF00069	0.581
MOD_NEK2_1	293	298	PF00069	0.619
MOD_NEK2_1	311	316	PF00069	0.552
MOD_NEK2_1	666	671	PF00069	0.576
MOD_NEK2_2	81	86	PF00069	0.546
MOD_PIKK_1	113	119	PF00454	0.564
MOD_PIKK_1	13	19	PF00454	0.578
MOD_PIKK_1	145	151	PF00454	0.653
MOD_PIKK_1	322	328	PF00454	0.557
MOD_PKA_1	145	151	PF00069	0.609
MOD_PKA_1	353	359	PF00069	0.486
MOD_PKA_2	117	123	PF00069	0.642
MOD_PKA_2	13	19	PF00069	0.474
MOD_PKA_2	145	151	PF00069	0.624
MOD_PKA_2	165	171	PF00069	0.555
MOD_PKA_2	200	206	PF00069	0.604
MOD_PKA_2	212	218	PF00069	0.602
MOD_PKA_2	262	268	PF00069	0.677
MOD_PKA_2	353	359	PF00069	0.489
MOD_PKA_2	36	42	PF00069	0.538
MOD_PKA_2	443	449	PF00069	0.464
MOD_PKA_2	587	593	PF00069	0.532
MOD_PKA_2	654	660	PF00069	0.498
MOD_PKA_2	73	79	PF00069	0.624
MOD_PKB_1	219	227	PF00069	0.627
MOD_Plk_1	421	427	PF00069	0.318
MOD_Plk_1	431	437	PF00069	0.369
MOD_Plk_1	477	483	PF00069	0.369
MOD_Plk_1	707	713	PF00069	0.619
MOD_Plk_2-3	741	747	PF00069	0.671
MOD_Plk_4	200	206	PF00069	0.669
MOD_Plk_4	317	323	PF00069	0.618
MOD_Plk_4	431	437	PF00069	0.304
MOD_Plk_4	503	509	PF00069	0.322
MOD_Plk_4	707	713	PF00069	0.684
MOD_ProDKin_1	129	135	PF00069	0.668
MOD_ProDKin_1	173	179	PF00069	0.629
MOD_ProDKin_1	222	228	PF00069	0.681
MOD_ProDKin_1	229	235	PF00069	0.662
MOD_ProDKin_1	288	294	PF00069	0.627
MOD_ProDKin_1	300	306	PF00069	0.549
MOD_ProDKin_1	314	320	PF00069	0.534
MOD_ProDKin_1	47	53	PF00069	0.590
MOD_ProDKin_1	489	495	PF00069	0.313
MOD_ProDKin_1	55	61	PF00069	0.604
MOD_ProDKin_1	633	639	PF00069	0.501
MOD_SUMO_for_1	455	458	PF00179	0.304
MOD_SUMO_rev_2	346	352	PF00179	0.497
TRG_DiLeu_BaEn_4	347	353	PF01217	0.419
TRG_DiLeu_BaEn_4	584	590	PF01217	0.513
TRG_DiLeu_BaLyEn_6	372	377	PF01217	0.490
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.660
TRG_ENDOCYTIC_2	577	580	PF00928	0.359
TRG_ER_diArg_1	145	147	PF00400	0.639
TRG_ER_diArg_1	22	25	PF00400	0.431
TRG_ER_diArg_1	35	38	PF00400	0.511
TRG_ER_diArg_1	352	354	PF00400	0.489
TRG_ER_diArg_1	357	359	PF00400	0.433
TRG_ER_diArg_1	397	400	PF00400	0.304
TRG_ER_diArg_1	482	484	PF00400	0.304
TRG_ER_diArg_1	54	56	PF00400	0.646
TRG_ER_diArg_1	552	555	PF00400	0.395
TRG_Pf-PMV_PEXEL_1	366	371	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0R7	Leptomonas seymouri	53%	91%
A0A3S7WVE0	Leishmania donovani	100%	92%
A4HA51	Leishmania braziliensis	81%	100%
E9AS48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QDB8	Leishmania major	94%	100%