Peptidylprolyl isomerase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-prolyl cis-trans isomerase - macrophage infectivity potentiator precursor - putative

Species:

Leishmania infantum

UniProt:

A4HYB4_LEIIN

TriTrypDb:

LINF_190014900

Length:

201

Annotations

Annotations by Jardim et al.

Chaperone/Protein Folding, Peptidyl-prolyl cis-trans isomerase

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 7
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HYB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYB4

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	2
GO:0006457	protein folding	2	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018208	peptidyl-proline modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0061077	chaperone-mediated protein folding	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	16
GO:0003824	catalytic activity	1	16
GO:0016853	isomerase activity	2	16
GO:0016859	cis-trans isomerase activity	3	16
GO:0140096	catalytic activity, acting on a protein	2	16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.280
CLV_NRD_NRD_1	69	71	PF00675	0.366
CLV_PCSK_KEX2_1	108	110	PF00082	0.280
CLV_PCSK_KEX2_1	69	71	PF00082	0.367
CLV_PCSK_SKI1_1	183	187	PF00082	0.422
CLV_PCSK_SKI1_1	49	53	PF00082	0.403
DOC_CYCLIN_yCln2_LP_2	133	139	PF00134	0.202
DOC_PP2B_LxvP_1	133	136	PF13499	0.243
DOC_USP7_MATH_1	54	58	PF00917	0.358
DOC_USP7_UBL2_3	143	147	PF12436	0.174
DOC_WW_Pin1_4	107	112	PF00397	0.298
LIG_14-3-3_CanoR_1	3	8	PF00244	0.458
LIG_14-3-3_CanoR_1	37	42	PF00244	0.391
LIG_Clathr_ClatBox_1	64	68	PF01394	0.247
LIG_FHA_1	14	20	PF00498	0.371
LIG_FHA_2	171	177	PF00498	0.272
LIG_LIR_Apic_2	88	94	PF02991	0.160
LIG_LIR_Gen_1	129	139	PF02991	0.228
LIG_LIR_Gen_1	197	201	PF02991	0.568
LIG_LIR_Gen_1	2	12	PF02991	0.250
LIG_LIR_Gen_1	40	47	PF02991	0.276
LIG_LIR_Nem_3	129	135	PF02991	0.228
LIG_LIR_Nem_3	197	201	PF02991	0.568
LIG_LIR_Nem_3	2	7	PF02991	0.346
LIG_LIR_Nem_3	40	44	PF02991	0.280
LIG_OCRL_FandH_1	3	15	PF00620	0.286
LIG_PAM2_1	22	34	PF00658	0.227
LIG_PDZ_Class_1	196	201	PF00595	0.341
LIG_SH2_CRK	41	45	PF00017	0.254
LIG_SH2_CRK	91	95	PF00017	0.160
LIG_SH2_NCK_1	41	45	PF00017	0.254
LIG_SH2_SRC	132	135	PF00017	0.262
LIG_SH2_STAP1	87	91	PF00017	0.160
LIG_SH2_STAT5	132	135	PF00017	0.273
LIG_SH2_STAT5	180	183	PF00017	0.392
LIG_SH2_STAT5	198	201	PF00017	0.476
LIG_SH2_STAT5	46	49	PF00017	0.262
LIG_SH2_STAT5	87	90	PF00017	0.187
LIG_SUMO_SIM_par_1	15	20	PF11976	0.320
LIG_SUMO_SIM_par_1	22	27	PF11976	0.277
LIG_TYR_ITIM	196	201	PF00017	0.379
MOD_CK1_1	170	176	PF00069	0.287
MOD_CK1_1	29	35	PF00069	0.416
MOD_CK1_1	6	12	PF00069	0.380
MOD_CK2_1	170	176	PF00069	0.282
MOD_GlcNHglycan	167	170	PF01048	0.527
MOD_GlcNHglycan	173	176	PF01048	0.299
MOD_GlcNHglycan	56	59	PF01048	0.311
MOD_GlcNHglycan	60	63	PF01048	0.339
MOD_GSK3_1	13	20	PF00069	0.303
MOD_GSK3_1	167	174	PF00069	0.367
MOD_GSK3_1	2	9	PF00069	0.362
MOD_GSK3_1	22	29	PF00069	0.301
MOD_GSK3_1	54	61	PF00069	0.360
MOD_N-GLC_1	54	59	PF02516	0.363
MOD_NEK2_1	17	22	PF00069	0.317
MOD_NEK2_1	85	90	PF00069	0.207
MOD_PIKK_1	109	115	PF00454	0.340
MOD_PKA_2	2	8	PF00069	0.473
MOD_Plk_1	26	32	PF00069	0.523
MOD_Plk_1	54	60	PF00069	0.369
MOD_Plk_4	13	19	PF00069	0.327
MOD_Plk_4	26	32	PF00069	0.202
MOD_Plk_4	6	12	PF00069	0.391
MOD_ProDKin_1	107	113	PF00069	0.298
MOD_SUMO_rev_2	144	152	PF00179	0.188
TRG_DiLeu_BaEn_1	120	125	PF01217	0.187
TRG_ENDOCYTIC_2	132	135	PF00928	0.174
TRG_ENDOCYTIC_2	198	201	PF00928	0.527
TRG_ENDOCYTIC_2	41	44	PF00928	0.283
TRG_ER_diArg_1	107	109	PF00400	0.254
TRG_NES_CRM1_1	113	127	PF08389	0.303

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTT4	Leptomonas seymouri	30%	100%
A0A0N1II12	Leptomonas seymouri	66%	100%
A0A1X0P7N1	Trypanosomatidae	39%	95%
A0A3Q8IB31	Leishmania donovani	29%	100%
A0A3S5H764	Leishmania donovani	100%	100%
A0A3S5IR72	Trypanosoma rangeli	40%	100%
A4H677	Leishmania braziliensis	30%	100%
A4HA48	Leishmania braziliensis	76%	100%
A4HUK1	Leishmania infantum	29%	100%
D0A0P0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AN99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AS47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q09734	Trypanosoma cruzi	38%	100%
Q4QDB9	Leishmania major	96%	100%
Q4QHC5	Leishmania major	29%	100%
Q9JYI8	Neisseria meningitidis serogroup B (strain MC58)	28%	74%