Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CAP-Gly domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4HYB1_LEIIN

TriTrypDb:

LINF_190014600

Length:

666

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0035371	microtubule plus-end	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990752	microtubule end	2	1

Expansion

Sequence features

A4HYB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYB1

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0006996	organelle organization	4	1
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0031122	cytoplasmic microtubule organization	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097435	supramolecular fiber organization	4	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0051010	microtubule plus-end binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	624	628	PF00656	0.494
CLV_C14_Caspase3-7	646	650	PF00656	0.502
CLV_NRD_NRD_1	117	119	PF00675	0.487
CLV_NRD_NRD_1	304	306	PF00675	0.465
CLV_NRD_NRD_1	33	35	PF00675	0.346
CLV_NRD_NRD_1	499	501	PF00675	0.424
CLV_NRD_NRD_1	548	550	PF00675	0.545
CLV_PCSK_KEX2_1	117	119	PF00082	0.487
CLV_PCSK_KEX2_1	209	211	PF00082	0.536
CLV_PCSK_KEX2_1	318	320	PF00082	0.448
CLV_PCSK_KEX2_1	32	34	PF00082	0.345
CLV_PCSK_KEX2_1	499	501	PF00082	0.588
CLV_PCSK_KEX2_1	548	550	PF00082	0.509
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.533
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.409
CLV_PCSK_SKI1_1	191	195	PF00082	0.456
CLV_PCSK_SKI1_1	275	279	PF00082	0.474
CLV_PCSK_SKI1_1	34	38	PF00082	0.388
CLV_PCSK_SKI1_1	358	362	PF00082	0.490
CLV_PCSK_SKI1_1	656	660	PF00082	0.595
CLV_PCSK_SKI1_1	67	71	PF00082	0.460
DEG_SCF_FBW7_1	658	665	PF00400	0.626
DOC_CKS1_1	659	664	PF01111	0.634
DOC_CYCLIN_RxL_1	480	490	PF00134	0.551
DOC_CYCLIN_RxL_1	636	649	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	86	92	PF00134	0.459
DOC_MAPK_gen_1	279	288	PF00069	0.570
DOC_MAPK_gen_1	32	39	PF00069	0.312
DOC_MAPK_gen_1	594	603	PF00069	0.510
DOC_MAPK_gen_1	623	632	PF00069	0.637
DOC_MAPK_MEF2A_6	165	172	PF00069	0.434
DOC_MAPK_MEF2A_6	463	470	PF00069	0.523
DOC_MAPK_MEF2A_6	626	634	PF00069	0.584
DOC_MAPK_RevD_3	21	34	PF00069	0.495
DOC_PP1_RVXF_1	174	180	PF00149	0.441
DOC_PP1_RVXF_1	639	646	PF00149	0.503
DOC_PP1_SILK_1	34	39	PF00149	0.388
DOC_PP2B_LxvP_1	86	89	PF13499	0.472
DOC_PP4_FxxP_1	579	582	PF00568	0.494
DOC_PP4_FxxP_1	659	662	PF00568	0.625
DOC_PP4_FxxP_1	81	84	PF00568	0.319
DOC_USP7_MATH_1	16	20	PF00917	0.494
DOC_USP7_MATH_1	193	197	PF00917	0.508
DOC_USP7_MATH_1	257	261	PF00917	0.633
DOC_USP7_MATH_1	265	269	PF00917	0.483
DOC_USP7_MATH_1	293	297	PF00917	0.500
DOC_USP7_MATH_1	339	343	PF00917	0.550
DOC_USP7_MATH_1	413	417	PF00917	0.530
DOC_USP7_MATH_1	515	519	PF00917	0.548
DOC_USP7_MATH_1	6	10	PF00917	0.724
DOC_USP7_UBL2_3	154	158	PF12436	0.593
DOC_WW_Pin1_4	578	583	PF00397	0.689
DOC_WW_Pin1_4	658	663	PF00397	0.658
LIG_14-3-3_CanoR_1	523	527	PF00244	0.572
LIG_14-3-3_CanoR_1	594	599	PF00244	0.604
LIG_14-3-3_CanoR_1	609	618	PF00244	0.447
LIG_14-3-3_CanoR_1	8	16	PF00244	0.598
LIG_Actin_WH2_2	130	147	PF00022	0.515
LIG_BIR_II_1	1	5	PF00653	0.599
LIG_DLG_GKlike_1	594	601	PF00625	0.534
LIG_FHA_1	391	397	PF00498	0.536
LIG_FHA_1	505	511	PF00498	0.603
LIG_FHA_2	157	163	PF00498	0.565
LIG_FHA_2	228	234	PF00498	0.474
LIG_FHA_2	329	335	PF00498	0.476
LIG_FHA_2	354	360	PF00498	0.492
LIG_FHA_2	622	628	PF00498	0.494
LIG_LIR_Apic_2	612	618	PF02991	0.659
LIG_LIR_Gen_1	18	28	PF02991	0.432
LIG_LIR_Nem_3	18	23	PF02991	0.409
LIG_LIR_Nem_3	47	53	PF02991	0.321
LIG_NRBOX	373	379	PF00104	0.457
LIG_NRBOX	597	603	PF00104	0.536
LIG_RPA_C_Fungi	213	225	PF08784	0.554
LIG_SH2_SRC	90	93	PF00017	0.520
LIG_SH2_STAP1	591	595	PF00017	0.487
LIG_SH2_STAT5	71	74	PF00017	0.352
LIG_SH3_2	89	94	PF14604	0.439
LIG_SH3_3	10	16	PF00018	0.598
LIG_SH3_3	22	28	PF00018	0.353
LIG_SH3_3	86	92	PF00018	0.545
LIG_SUMO_SIM_anti_2	18	25	PF11976	0.398
LIG_TRAF2_1	108	111	PF00917	0.460
LIG_TRAF2_1	417	420	PF00917	0.458
LIG_WRC_WIRS_1	17	22	PF05994	0.404
MOD_CK1_1	133	139	PF00069	0.587
MOD_CK1_1	353	359	PF00069	0.484
MOD_CK1_1	453	459	PF00069	0.742
MOD_CK2_1	16	22	PF00069	0.410
MOD_CK2_1	193	199	PF00069	0.509
MOD_CK2_1	328	334	PF00069	0.410
MOD_CK2_1	353	359	PF00069	0.490
MOD_Cter_Amidation	546	549	PF01082	0.404
MOD_GlcNHglycan	102	105	PF01048	0.644
MOD_GlcNHglycan	195	198	PF01048	0.592
MOD_GlcNHglycan	215	218	PF01048	0.561
MOD_GlcNHglycan	266	270	PF01048	0.456
MOD_GlcNHglycan	415	418	PF01048	0.547
MOD_GlcNHglycan	566	570	PF01048	0.573
MOD_GlcNHglycan	611	614	PF01048	0.612
MOD_GlcNHglycan	653	656	PF01048	0.474
MOD_GlcNHglycan	9	12	PF01048	0.700
MOD_GSK3_1	126	133	PF00069	0.551
MOD_GSK3_1	386	393	PF00069	0.550
MOD_GSK3_1	447	454	PF00069	0.707
MOD_GSK3_1	565	572	PF00069	0.649
MOD_GSK3_1	605	612	PF00069	0.488
MOD_GSK3_1	617	624	PF00069	0.601
MOD_GSK3_1	658	665	PF00069	0.615
MOD_N-GLC_1	258	263	PF02516	0.648
MOD_NEK2_1	130	135	PF00069	0.492
MOD_NEK2_1	328	333	PF00069	0.478
MOD_NEK2_1	487	492	PF00069	0.470
MOD_NEK2_1	504	509	PF00069	0.546
MOD_NEK2_1	643	648	PF00069	0.493
MOD_PIKK_1	248	254	PF00454	0.601
MOD_PIKK_1	487	493	PF00454	0.446
MOD_PIKK_1	617	623	PF00454	0.533
MOD_PKA_2	451	457	PF00069	0.644
MOD_PKA_2	522	528	PF00069	0.558
MOD_PKA_2	608	614	PF00069	0.604
MOD_PKA_2	625	631	PF00069	0.507
MOD_PKA_2	7	13	PF00069	0.648
MOD_Plk_1	130	136	PF00069	0.451
MOD_Plk_1	237	243	PF00069	0.574
MOD_Plk_1	504	510	PF00069	0.422
MOD_Plk_1	605	611	PF00069	0.447
MOD_Plk_2-3	156	162	PF00069	0.593
MOD_Plk_2-3	462	468	PF00069	0.566
MOD_Plk_4	16	22	PF00069	0.431
MOD_ProDKin_1	578	584	PF00069	0.682
MOD_ProDKin_1	658	664	PF00069	0.664
MOD_SUMO_for_1	104	107	PF00179	0.456
MOD_SUMO_for_1	157	160	PF00179	0.600
MOD_SUMO_for_1	354	357	PF00179	0.511
MOD_SUMO_rev_2	160	167	PF00179	0.468
MOD_SUMO_rev_2	184	193	PF00179	0.496
MOD_SUMO_rev_2	300	307	PF00179	0.485
MOD_SUMO_rev_2	379	387	PF00179	0.457
TRG_DiLeu_BaEn_1	373	378	PF01217	0.456
TRG_DiLeu_BaEn_1	420	425	PF01217	0.501
TRG_DiLeu_BaEn_4	369	375	PF01217	0.529
TRG_DiLeu_BaLyEn_6	638	643	PF01217	0.592
TRG_DiLeu_LyEn_5	420	425	PF01217	0.440
TRG_ER_diArg_1	116	118	PF00400	0.437
TRG_ER_diArg_1	32	34	PF00400	0.350
TRG_ER_diArg_1	421	424	PF00400	0.476
TRG_ER_diArg_1	481	484	PF00400	0.559
TRG_Pf-PMV_PEXEL_1	423	427	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	596	600	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSH8	Leptomonas seymouri	37%	93%
A0A3Q8IEJ2	Leishmania donovani	100%	100%
A4HA45	Leishmania braziliensis	69%	95%
E9AS44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	98%
Q4QDC2	Leishmania major	89%	98%