Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HYB0_LEIIN

TriTrypDb:

LINF_190014500

Length:

908

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HYB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYB0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.462
CLV_C14_Caspase3-7	311	315	PF00656	0.564
CLV_C14_Caspase3-7	551	555	PF00656	0.632
CLV_C14_Caspase3-7	666	670	PF00656	0.592
CLV_C14_Caspase3-7	820	824	PF00656	0.579
CLV_MEL_PAP_1	362	368	PF00089	0.583
CLV_NRD_NRD_1	128	130	PF00675	0.663
CLV_NRD_NRD_1	180	182	PF00675	0.511
CLV_NRD_NRD_1	27	29	PF00675	0.623
CLV_NRD_NRD_1	426	428	PF00675	0.649
CLV_NRD_NRD_1	457	459	PF00675	0.466
CLV_NRD_NRD_1	700	702	PF00675	0.497
CLV_NRD_NRD_1	704	706	PF00675	0.465
CLV_NRD_NRD_1	801	803	PF00675	0.648
CLV_PCSK_FUR_1	126	130	PF00082	0.655
CLV_PCSK_FUR_1	25	29	PF00082	0.621
CLV_PCSK_FUR_1	424	428	PF00082	0.647
CLV_PCSK_FUR_1	701	705	PF00082	0.558
CLV_PCSK_FUR_1	799	803	PF00082	0.533
CLV_PCSK_KEX2_1	128	130	PF00082	0.663
CLV_PCSK_KEX2_1	27	29	PF00082	0.623
CLV_PCSK_KEX2_1	426	428	PF00082	0.674
CLV_PCSK_KEX2_1	432	434	PF00082	0.633
CLV_PCSK_KEX2_1	457	459	PF00082	0.505
CLV_PCSK_KEX2_1	700	702	PF00082	0.492
CLV_PCSK_KEX2_1	703	705	PF00082	0.481
CLV_PCSK_KEX2_1	801	803	PF00082	0.648
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.691
CLV_PCSK_PC7_1	700	706	PF00082	0.471
CLV_PCSK_SKI1_1	148	152	PF00082	0.408
CLV_PCSK_SKI1_1	182	186	PF00082	0.496
CLV_PCSK_SKI1_1	460	464	PF00082	0.472
CLV_PCSK_SKI1_1	56	60	PF00082	0.462
CLV_PCSK_SKI1_1	832	836	PF00082	0.451
CLV_PCSK_SKI1_1	839	843	PF00082	0.473
DEG_APCC_DBOX_1	520	528	PF00400	0.549
DEG_APCC_DBOX_1	537	545	PF00400	0.633
DEG_COP1_1	803	811	PF00400	0.548
DEG_Nend_UBRbox_2	1	3	PF02207	0.572
DEG_SCF_FBW7_1	744	750	PF00400	0.628
DEG_SCF_FBW7_1	893	898	PF00400	0.601
DEG_SPOP_SBC_1	581	585	PF00917	0.720
DEG_SPOP_SBC_1	747	751	PF00917	0.579
DOC_ANK_TNKS_1	127	134	PF00023	0.601
DOC_CDC14_PxL_1	845	853	PF14671	0.560
DOC_CKS1_1	744	749	PF01111	0.629
DOC_CYCLIN_yCln2_LP_2	31	37	PF00134	0.615
DOC_MAPK_gen_1	181	187	PF00069	0.495
DOC_MAPK_gen_1	25	33	PF00069	0.541
DOC_MAPK_gen_1	303	310	PF00069	0.473
DOC_MAPK_gen_1	457	464	PF00069	0.529
DOC_MAPK_gen_1	518	526	PF00069	0.550
DOC_MAPK_MEF2A_6	303	310	PF00069	0.496
DOC_MAPK_MEF2A_6	774	783	PF00069	0.557
DOC_MIT_MIM_1	784	793	PF04212	0.475
DOC_PP2B_LxvP_1	31	34	PF13499	0.640
DOC_PP4_FxxP_1	206	209	PF00568	0.491
DOC_USP7_MATH_1	102	106	PF00917	0.641
DOC_USP7_MATH_1	107	111	PF00917	0.580
DOC_USP7_MATH_1	135	139	PF00917	0.522
DOC_USP7_MATH_1	16	20	PF00917	0.640
DOC_USP7_MATH_1	319	323	PF00917	0.578
DOC_USP7_MATH_1	325	329	PF00917	0.595
DOC_USP7_MATH_1	35	39	PF00917	0.605
DOC_USP7_MATH_1	364	368	PF00917	0.490
DOC_USP7_MATH_1	471	475	PF00917	0.517
DOC_USP7_MATH_1	519	523	PF00917	0.658
DOC_USP7_MATH_1	581	585	PF00917	0.657
DOC_USP7_MATH_1	596	600	PF00917	0.623
DOC_USP7_MATH_1	628	632	PF00917	0.797
DOC_USP7_MATH_1	642	646	PF00917	0.538
DOC_USP7_MATH_1	647	651	PF00917	0.653
DOC_USP7_MATH_1	81	85	PF00917	0.573
DOC_USP7_MATH_1	895	899	PF00917	0.600
DOC_WW_Pin1_4	100	105	PF00397	0.601
DOC_WW_Pin1_4	159	164	PF00397	0.530
DOC_WW_Pin1_4	204	209	PF00397	0.525
DOC_WW_Pin1_4	280	285	PF00397	0.595
DOC_WW_Pin1_4	323	328	PF00397	0.604
DOC_WW_Pin1_4	356	361	PF00397	0.633
DOC_WW_Pin1_4	587	592	PF00397	0.678
DOC_WW_Pin1_4	605	610	PF00397	0.585
DOC_WW_Pin1_4	673	678	PF00397	0.549
DOC_WW_Pin1_4	743	748	PF00397	0.641
DOC_WW_Pin1_4	891	896	PF00397	0.629
DOC_WW_Pin1_4	93	98	PF00397	0.643
LIG_14-3-3_CanoR_1	25	34	PF00244	0.593
LIG_14-3-3_CanoR_1	265	271	PF00244	0.700
LIG_14-3-3_CanoR_1	350	355	PF00244	0.469
LIG_14-3-3_CanoR_1	365	373	PF00244	0.528
LIG_14-3-3_CanoR_1	401	407	PF00244	0.465
LIG_14-3-3_CanoR_1	441	447	PF00244	0.561
LIG_14-3-3_CanoR_1	502	507	PF00244	0.627
LIG_14-3-3_CanoR_1	518	527	PF00244	0.457
LIG_14-3-3_CanoR_1	559	567	PF00244	0.615
LIG_14-3-3_CanoR_1	67	71	PF00244	0.485
LIG_14-3-3_CanoR_1	689	695	PF00244	0.513
LIG_14-3-3_CanoR_1	717	723	PF00244	0.593
LIG_Actin_WH2_2	136	153	PF00022	0.387
LIG_Actin_WH2_2	444	459	PF00022	0.573
LIG_BRCT_BRCA1_1	42	46	PF00533	0.567
LIG_BRCT_BRCA1_1	879	883	PF00533	0.564
LIG_CaM_IQ_9	444	460	PF13499	0.527
LIG_CaM_NSCaTE_8	309	316	PF13499	0.558
LIG_CaM_NSCaTE_8	506	513	PF13499	0.595
LIG_Clathr_ClatBox_1	840	844	PF01394	0.488
LIG_CSL_BTD_1	252	255	PF09270	0.547
LIG_EH_1	880	884	PF12763	0.586
LIG_eIF4E_1	370	376	PF01652	0.481
LIG_eIF4E_1	846	852	PF01652	0.559
LIG_FHA_1	137	143	PF00498	0.523
LIG_FHA_1	160	166	PF00498	0.518
LIG_FHA_1	273	279	PF00498	0.618
LIG_FHA_1	346	352	PF00498	0.517
LIG_FHA_1	357	363	PF00498	0.520
LIG_FHA_1	370	376	PF00498	0.283
LIG_FHA_1	614	620	PF00498	0.591
LIG_FHA_1	639	645	PF00498	0.795
LIG_FHA_1	785	791	PF00498	0.501
LIG_FHA_1	793	799	PF00498	0.549
LIG_FHA_2	178	184	PF00498	0.462
LIG_FHA_2	726	732	PF00498	0.637
LIG_FHA_2	748	754	PF00498	0.535
LIG_LIR_Apic_2	844	849	PF02991	0.486
LIG_LIR_Gen_1	110	120	PF02991	0.397
LIG_LIR_Gen_1	409	417	PF02991	0.474
LIG_LIR_Gen_1	459	468	PF02991	0.483
LIG_LIR_Gen_1	503	512	PF02991	0.692
LIG_LIR_Nem_3	110	115	PF02991	0.418
LIG_LIR_Nem_3	367	373	PF02991	0.585
LIG_LIR_Nem_3	409	413	PF02991	0.472
LIG_LIR_Nem_3	459	464	PF02991	0.481
LIG_LIR_Nem_3	503	507	PF02991	0.526
LIG_NRBOX	189	195	PF00104	0.430
LIG_PDZ_Class_2	903	908	PF00595	0.598
LIG_Pex14_2	491	495	PF04695	0.449
LIG_PTAP_UEV_1	320	325	PF05743	0.657
LIG_SH2_CRK	691	695	PF00017	0.561
LIG_SH2_GRB2like	354	357	PF00017	0.563
LIG_SH2_NCK_1	709	713	PF00017	0.609
LIG_SH2_PTP2	846	849	PF00017	0.488
LIG_SH2_SRC	222	225	PF00017	0.584
LIG_SH2_STAP1	691	695	PF00017	0.489
LIG_SH2_STAP1	836	840	PF00017	0.457
LIG_SH2_STAT3	825	828	PF00017	0.570
LIG_SH2_STAT5	186	189	PF00017	0.450
LIG_SH2_STAT5	354	357	PF00017	0.608
LIG_SH2_STAT5	370	373	PF00017	0.482
LIG_SH2_STAT5	825	828	PF00017	0.570
LIG_SH2_STAT5	846	849	PF00017	0.488
LIG_SH3_3	101	107	PF00018	0.598
LIG_SH3_3	205	211	PF00018	0.641
LIG_SH3_3	258	264	PF00018	0.504
LIG_SH3_3	281	287	PF00018	0.602
LIG_SH3_3	31	37	PF00018	0.627
LIG_SH3_3	318	324	PF00018	0.668
LIG_SH3_3	371	377	PF00018	0.508
LIG_SH3_3	588	594	PF00018	0.818
LIG_SH3_3	599	605	PF00018	0.693
LIG_SH3_3	643	649	PF00018	0.624
LIG_SH3_3	671	677	PF00018	0.600
LIG_SH3_3	94	100	PF00018	0.655
LIG_SH3_CIN85_PxpxPR_1	592	597	PF14604	0.723
LIG_SH3_CIN85_PxpxPR_1	605	610	PF14604	0.583
LIG_SUMO_SIM_anti_2	196	202	PF11976	0.536
LIG_SUMO_SIM_anti_2	216	221	PF11976	0.509
LIG_SUMO_SIM_anti_2	290	297	PF11976	0.483
LIG_SUMO_SIM_anti_2	372	378	PF11976	0.420
LIG_SUMO_SIM_par_1	210	216	PF11976	0.655
LIG_SUMO_SIM_par_1	372	378	PF11976	0.492
LIG_TRAF2_1	543	546	PF00917	0.612
LIG_TRAF2_1	728	731	PF00917	0.630
LIG_ULM_U2AF65_1	457	462	PF00076	0.468
LIG_WRC_WIRS_1	501	506	PF05994	0.558
MOD_CDK_SPK_2	592	597	PF00069	0.651
MOD_CDK_SPK_2	605	610	PF00069	0.640
MOD_CDK_SPxK_1	891	897	PF00069	0.606
MOD_CK1_1	103	109	PF00069	0.543
MOD_CK1_1	111	117	PF00069	0.383
MOD_CK1_1	17	23	PF00069	0.646
MOD_CK1_1	207	213	PF00069	0.557
MOD_CK1_1	288	294	PF00069	0.590
MOD_CK1_1	315	321	PF00069	0.579
MOD_CK1_1	326	332	PF00069	0.533
MOD_CK1_1	358	364	PF00069	0.621
MOD_CK1_1	42	48	PF00069	0.625
MOD_CK1_1	583	589	PF00069	0.658
MOD_CK1_1	891	897	PF00069	0.597
MOD_CK1_1	93	99	PF00069	0.619
MOD_CK2_1	280	286	PF00069	0.680
MOD_CK2_1	51	57	PF00069	0.693
MOD_CK2_1	540	546	PF00069	0.654
MOD_CK2_1	690	696	PF00069	0.493
MOD_CK2_1	725	731	PF00069	0.603
MOD_Cter_Amidation	126	129	PF01082	0.664
MOD_DYRK1A_RPxSP_1	204	208	PF00069	0.563
MOD_DYRK1A_RPxSP_1	280	284	PF00069	0.615
MOD_GlcNHglycan	115	118	PF01048	0.502
MOD_GlcNHglycan	16	19	PF01048	0.622
MOD_GlcNHglycan	239	242	PF01048	0.641
MOD_GlcNHglycan	280	283	PF01048	0.622
MOD_GlcNHglycan	286	290	PF01048	0.539
MOD_GlcNHglycan	314	317	PF01048	0.602
MOD_GlcNHglycan	321	324	PF01048	0.598
MOD_GlcNHglycan	366	369	PF01048	0.587
MOD_GlcNHglycan	37	40	PF01048	0.734
MOD_GlcNHglycan	402	405	PF01048	0.667
MOD_GlcNHglycan	413	416	PF01048	0.490
MOD_GlcNHglycan	550	553	PF01048	0.647
MOD_GlcNHglycan	585	588	PF01048	0.668
MOD_GlcNHglycan	598	601	PF01048	0.626
MOD_GlcNHglycan	621	624	PF01048	0.669
MOD_GlcNHglycan	666	669	PF01048	0.657
MOD_GlcNHglycan	736	739	PF01048	0.633
MOD_GlcNHglycan	802	805	PF01048	0.553
MOD_GlcNHglycan	92	95	PF01048	0.659
MOD_GSK3_1	103	110	PF00069	0.606
MOD_GSK3_1	116	123	PF00069	0.387
MOD_GSK3_1	173	180	PF00069	0.455
MOD_GSK3_1	23	30	PF00069	0.593
MOD_GSK3_1	237	244	PF00069	0.742
MOD_GSK3_1	266	273	PF00069	0.649
MOD_GSK3_1	274	281	PF00069	0.656
MOD_GSK3_1	315	322	PF00069	0.548
MOD_GSK3_1	35	42	PF00069	0.570
MOD_GSK3_1	350	357	PF00069	0.541
MOD_GSK3_1	396	403	PF00069	0.647
MOD_GSK3_1	456	463	PF00069	0.608
MOD_GSK3_1	47	54	PF00069	0.471
MOD_GSK3_1	471	478	PF00069	0.577
MOD_GSK3_1	496	503	PF00069	0.471
MOD_GSK3_1	581	588	PF00069	0.658
MOD_GSK3_1	592	599	PF00069	0.633
MOD_GSK3_1	614	621	PF00069	0.698
MOD_GSK3_1	624	631	PF00069	0.609
MOD_GSK3_1	638	645	PF00069	0.617
MOD_GSK3_1	742	749	PF00069	0.617
MOD_GSK3_1	754	761	PF00069	0.475
MOD_GSK3_1	873	880	PF00069	0.608
MOD_GSK3_1	891	898	PF00069	0.488
MOD_N-GLC_1	136	141	PF02516	0.477
MOD_N-GLC_1	355	360	PF02516	0.578
MOD_N-GLC_1	39	44	PF02516	0.598
MOD_N-GLC_1	497	502	PF02516	0.546
MOD_N-GLC_1	619	624	PF02516	0.729
MOD_N-GLC_1	81	86	PF02516	0.561
MOD_N-GLC_2	792	794	PF02516	0.460
MOD_NEK2_1	173	178	PF00069	0.479
MOD_NEK2_1	185	190	PF00069	0.448
MOD_NEK2_1	194	199	PF00069	0.440
MOD_NEK2_1	270	275	PF00069	0.607
MOD_NEK2_1	416	421	PF00069	0.560
MOD_NEK2_1	456	461	PF00069	0.564
MOD_NEK2_1	475	480	PF00069	0.609
MOD_NEK2_1	496	501	PF00069	0.535
MOD_NEK2_1	51	56	PF00069	0.650
MOD_NEK2_1	59	64	PF00069	0.566
MOD_NEK2_1	684	689	PF00069	0.506
MOD_NEK2_2	396	401	PF00069	0.528
MOD_PIKK_1	241	247	PF00454	0.738
MOD_PIKK_1	530	536	PF00454	0.605
MOD_PIKK_1	784	790	PF00454	0.438
MOD_PKA_1	27	33	PF00069	0.623
MOD_PKA_2	26	32	PF00069	0.616
MOD_PKA_2	266	272	PF00069	0.590
MOD_PKA_2	364	370	PF00069	0.471
MOD_PKA_2	400	406	PF00069	0.480
MOD_PKA_2	440	446	PF00069	0.681
MOD_PKA_2	456	462	PF00069	0.378
MOD_PKA_2	478	484	PF00069	0.769
MOD_PKA_2	517	523	PF00069	0.546
MOD_PKA_2	596	602	PF00069	0.650
MOD_PKA_2	66	72	PF00069	0.479
MOD_PKA_2	716	722	PF00069	0.663
MOD_PKA_2	800	806	PF00069	0.532
MOD_PKA_2	871	877	PF00069	0.597
MOD_PKB_1	25	33	PF00069	0.622
MOD_PKB_1	350	358	PF00069	0.513
MOD_PKB_1	458	466	PF00069	0.464
MOD_Plk_1	136	142	PF00069	0.470
MOD_Plk_1	215	221	PF00069	0.582
MOD_Plk_1	291	297	PF00069	0.559
MOD_Plk_1	497	503	PF00069	0.542
MOD_Plk_4	108	114	PF00069	0.470
MOD_Plk_4	167	173	PF00069	0.468
MOD_Plk_4	194	200	PF00069	0.609
MOD_Plk_4	215	221	PF00069	0.602
MOD_Plk_4	291	297	PF00069	0.490
MOD_Plk_4	460	466	PF00069	0.410
MOD_Plk_4	47	53	PF00069	0.522
MOD_Plk_4	471	477	PF00069	0.478
MOD_Plk_4	690	696	PF00069	0.564
MOD_Plk_4	847	853	PF00069	0.562
MOD_ProDKin_1	100	106	PF00069	0.599
MOD_ProDKin_1	159	165	PF00069	0.524
MOD_ProDKin_1	204	210	PF00069	0.523
MOD_ProDKin_1	280	286	PF00069	0.595
MOD_ProDKin_1	323	329	PF00069	0.601
MOD_ProDKin_1	356	362	PF00069	0.638
MOD_ProDKin_1	587	593	PF00069	0.678
MOD_ProDKin_1	605	611	PF00069	0.586
MOD_ProDKin_1	673	679	PF00069	0.545
MOD_ProDKin_1	743	749	PF00069	0.641
MOD_ProDKin_1	891	897	PF00069	0.629
MOD_ProDKin_1	93	99	PF00069	0.643
MOD_SUMO_for_1	577	580	PF00179	0.646
TRG_DiLeu_BaEn_4	697	703	PF01217	0.552
TRG_DiLeu_BaLyEn_6	189	194	PF01217	0.430
TRG_DiLeu_BaLyEn_6	737	742	PF01217	0.555
TRG_ENDOCYTIC_2	370	373	PF00928	0.572
TRG_ENDOCYTIC_2	691	694	PF00928	0.569
TRG_ER_diArg_1	125	128	PF00400	0.645
TRG_ER_diArg_1	25	28	PF00400	0.622
TRG_ER_diArg_1	264	267	PF00400	0.605
TRG_ER_diArg_1	302	305	PF00400	0.516
TRG_ER_diArg_1	349	352	PF00400	0.527
TRG_ER_diArg_1	424	427	PF00400	0.648
TRG_ER_diArg_1	456	458	PF00400	0.477
TRG_ER_diArg_1	476	479	PF00400	0.488
TRG_ER_diArg_1	699	701	PF00400	0.493
TRG_ER_diArg_1	702	705	PF00400	0.471
TRG_ER_diArg_1	798	801	PF00400	0.558
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.385
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	418	422	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P316	Leptomonas seymouri	34%	100%
A0A3S7WVF4	Leishmania donovani	99%	100%
A4HA44	Leishmania braziliensis	66%	98%
E9AS43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QDC3	Leishmania major	89%	100%