Putative folate/biopterin transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pteridine transporter (truncated) - putative

Species:

Leishmania infantum

UniProt:

A4HYA9_LEIIN

TriTrypDb:

LINF_190014400

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 70
NetGPI	no	yes: 0, no: 70

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	71
GO:0110165	cellular anatomical entity	1	71
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4HYA9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYA9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	662	666	PF00656	0.737
CLV_NRD_NRD_1	195	197	PF00675	0.228
CLV_NRD_NRD_1	41	43	PF00675	0.376
CLV_PCSK_KEX2_1	136	138	PF00082	0.296
CLV_PCSK_KEX2_1	194	196	PF00082	0.247
CLV_PCSK_KEX2_1	41	43	PF00082	0.418
CLV_PCSK_KEX2_1	524	526	PF00082	0.517
CLV_PCSK_KEX2_1	652	654	PF00082	0.307
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.292
CLV_PCSK_PC1ET2_1	524	526	PF00082	0.517
CLV_PCSK_PC1ET2_1	652	654	PF00082	0.302
CLV_PCSK_PC7_1	191	197	PF00082	0.211
CLV_PCSK_SKI1_1	119	123	PF00082	0.350
CLV_PCSK_SKI1_1	372	376	PF00082	0.258
CLV_PCSK_SKI1_1	653	657	PF00082	0.421
DEG_ODPH_VHL_1	623	635	PF01847	0.351
DEG_SPOP_SBC_1	300	304	PF00917	0.394
DEG_SPOP_SBC_1	506	510	PF00917	0.191
DOC_CDC14_PxL_1	610	618	PF14671	0.327
DOC_CKS1_1	603	608	PF01111	0.194
DOC_CYCLIN_yCln2_LP_2	627	633	PF00134	0.393
DOC_CYCLIN_yCln2_LP_2	634	640	PF00134	0.276
DOC_MAPK_gen_1	260	270	PF00069	0.545
DOC_MAPK_gen_1	288	295	PF00069	0.570
DOC_MAPK_gen_1	41	49	PF00069	0.465
DOC_MAPK_gen_1	524	532	PF00069	0.318
DOC_MAPK_HePTP_8	495	507	PF00069	0.394
DOC_MAPK_MEF2A_6	498	507	PF00069	0.473
DOC_MAPK_MEF2A_6	524	532	PF00069	0.353
DOC_PP2B_LxvP_1	445	448	PF13499	0.383
DOC_PP2B_LxvP_1	627	630	PF13499	0.406
DOC_PP2B_LxvP_1	633	636	PF13499	0.178
DOC_USP7_MATH_1	159	163	PF00917	0.267
DOC_USP7_MATH_1	202	206	PF00917	0.315
DOC_USP7_MATH_1	450	454	PF00917	0.340
DOC_USP7_MATH_1	566	570	PF00917	0.480
DOC_USP7_MATH_1	59	63	PF00917	0.558
DOC_USP7_UBL2_3	652	656	PF12436	0.454
DOC_WW_Pin1_4	296	301	PF00397	0.576
DOC_WW_Pin1_4	602	607	PF00397	0.345
LIG_14-3-3_CanoR_1	107	114	PF00244	0.493
LIG_14-3-3_CanoR_1	502	506	PF00244	0.486
LIG_APCC_ABBA_1	251	256	PF00400	0.399
LIG_APCC_ABBA_1	53	58	PF00400	0.631
LIG_BRCT_BRCA1_1	468	472	PF00533	0.305
LIG_CSL_BTD_1	553	556	PF09270	0.391
LIG_eIF4E_1	88	94	PF01652	0.394
LIG_EVH1_2	606	610	PF00568	0.356
LIG_FHA_1	120	126	PF00498	0.566
LIG_FHA_1	19	25	PF00498	0.658
LIG_FHA_1	256	262	PF00498	0.467
LIG_FHA_1	387	393	PF00498	0.349
LIG_FHA_1	402	408	PF00498	0.255
LIG_FHA_1	502	508	PF00498	0.493
LIG_FHA_2	301	307	PF00498	0.535
LIG_HP1_1	556	560	PF01393	0.392
LIG_LIR_Apic_2	32	38	PF02991	0.591
LIG_LIR_Apic_2	422	427	PF02991	0.409
LIG_LIR_Gen_1	127	134	PF02991	0.515
LIG_LIR_Gen_1	186	197	PF02991	0.524
LIG_LIR_Gen_1	471	480	PF02991	0.325
LIG_LIR_Gen_1	490	496	PF02991	0.387
LIG_LIR_Gen_1	516	523	PF02991	0.313
LIG_LIR_Gen_1	571	581	PF02991	0.511
LIG_LIR_Gen_1	609	618	PF02991	0.265
LIG_LIR_LC3C_4	504	507	PF02991	0.201
LIG_LIR_Nem_3	127	132	PF02991	0.490
LIG_LIR_Nem_3	135	141	PF02991	0.488
LIG_LIR_Nem_3	186	192	PF02991	0.541
LIG_LIR_Nem_3	205	211	PF02991	0.288
LIG_LIR_Nem_3	362	368	PF02991	0.531
LIG_LIR_Nem_3	422	426	PF02991	0.378
LIG_LIR_Nem_3	469	473	PF02991	0.298
LIG_LIR_Nem_3	490	495	PF02991	0.335
LIG_LIR_Nem_3	516	521	PF02991	0.313
LIG_LIR_Nem_3	553	557	PF02991	0.289
LIG_LIR_Nem_3	597	603	PF02991	0.291
LIG_LIR_Nem_3	609	613	PF02991	0.257
LIG_Pex14_1	206	210	PF04695	0.364
LIG_Pex14_2	172	176	PF04695	0.358
LIG_Pex14_2	375	379	PF04695	0.485
LIG_Pex14_2	468	472	PF04695	0.306
LIG_Pex14_2	492	496	PF04695	0.364
LIG_PTB_Apo_2	490	497	PF02174	0.434
LIG_SH2_CRK	105	109	PF00017	0.508
LIG_SH2_CRK	189	193	PF00017	0.510
LIG_SH2_CRK	384	388	PF00017	0.338
LIG_SH2_CRK	44	48	PF00017	0.682
LIG_SH2_CRK	473	477	PF00017	0.298
LIG_SH2_NCK_1	473	477	PF00017	0.296
LIG_SH2_PTP2	35	38	PF00017	0.588
LIG_SH2_SRC	35	38	PF00017	0.595
LIG_SH2_STAP1	134	138	PF00017	0.496
LIG_SH2_STAP1	189	193	PF00017	0.485
LIG_SH2_STAP1	31	35	PF00017	0.493
LIG_SH2_STAP1	384	388	PF00017	0.387
LIG_SH2_STAP1	574	578	PF00017	0.332
LIG_SH2_STAT3	88	91	PF00017	0.413
LIG_SH2_STAT5	134	137	PF00017	0.500
LIG_SH2_STAT5	35	38	PF00017	0.586
LIG_SH2_STAT5	438	441	PF00017	0.356
LIG_SH2_STAT5	444	447	PF00017	0.347
LIG_SH2_STAT5	455	458	PF00017	0.326
LIG_SH2_STAT5	470	473	PF00017	0.297
LIG_SH2_STAT5	494	497	PF00017	0.447
LIG_SH2_STAT5	538	541	PF00017	0.316
LIG_SH2_STAT5	551	554	PF00017	0.375
LIG_SH2_STAT5	658	661	PF00017	0.574
LIG_SH2_STAT5	75	78	PF00017	0.518
LIG_SH3_3	354	360	PF00018	0.597
LIG_SH3_3	460	466	PF00018	0.273
LIG_SH3_3	600	606	PF00018	0.346
LIG_SUMO_SIM_par_1	503	510	PF11976	0.300
LIG_SUMO_SIM_par_1	556	562	PF11976	0.322
LIG_TRAF2_1	457	460	PF00917	0.194
LIG_TYR_ITIM	103	108	PF00017	0.293
LIG_TYR_ITIM	442	447	PF00017	0.326
LIG_TYR_ITSM	469	476	PF00017	0.397
LIG_UBA3_1	152	160	PF00899	0.343
LIG_Vh1_VBS_1	382	400	PF01044	0.401
LIG_Vh1_VBS_1	472	490	PF01044	0.380
LIG_WRC_WIRS_1	451	456	PF05994	0.335
MOD_CK1_1	109	115	PF00069	0.365
MOD_CK1_1	163	169	PF00069	0.249
MOD_CK1_1	226	232	PF00069	0.283
MOD_CK1_1	299	305	PF00069	0.266
MOD_CK1_1	497	503	PF00069	0.344
MOD_CK1_1	590	596	PF00069	0.329
MOD_CK1_1	664	670	PF00069	0.597
MOD_CK2_1	2	8	PF00069	0.458
MOD_CK2_1	300	306	PF00069	0.391
MOD_CMANNOS	206	209	PF00535	0.247
MOD_GlcNHglycan	100	103	PF01048	0.284
MOD_GlcNHglycan	161	165	PF01048	0.358
MOD_GlcNHglycan	326	330	PF01048	0.435
MOD_GlcNHglycan	476	479	PF01048	0.383
MOD_GlcNHglycan	667	670	PF01048	0.694
MOD_GSK3_1	106	113	PF00069	0.401
MOD_GSK3_1	159	166	PF00069	0.269
MOD_GSK3_1	296	303	PF00069	0.385
MOD_GSK3_1	382	389	PF00069	0.367
MOD_GSK3_1	468	475	PF00069	0.372
MOD_GSK3_1	497	504	PF00069	0.358
MOD_GSK3_1	54	61	PF00069	0.375
MOD_GSK3_1	583	590	PF00069	0.371
MOD_GSK3_1	657	664	PF00069	0.600
MOD_NEK2_1	114	119	PF00069	0.369
MOD_NEK2_1	132	137	PF00069	0.288
MOD_NEK2_1	140	145	PF00069	0.339
MOD_NEK2_1	225	230	PF00069	0.373
MOD_NEK2_1	325	330	PF00069	0.357
MOD_NEK2_1	382	387	PF00069	0.365
MOD_NEK2_1	401	406	PF00069	0.307
MOD_NEK2_1	468	473	PF00069	0.354
MOD_NEK2_1	505	510	PF00069	0.360
MOD_NEK2_1	583	588	PF00069	0.357
MOD_NEK2_2	450	455	PF00069	0.360
MOD_NEK2_2	487	492	PF00069	0.191
MOD_OFUCOSY	390	397	PF10250	0.391
MOD_PIKK_1	18	24	PF00454	0.614
MOD_PK_1	107	113	PF00069	0.447
MOD_PKA_2	106	112	PF00069	0.379
MOD_PKA_2	501	507	PF00069	0.342
MOD_PKA_2	566	572	PF00069	0.328
MOD_Plk_1	226	232	PF00069	0.270
MOD_Plk_2-3	345	351	PF00069	0.318
MOD_Plk_4	202	208	PF00069	0.341
MOD_Plk_4	226	232	PF00069	0.351
MOD_Plk_4	382	388	PF00069	0.349
MOD_Plk_4	412	418	PF00069	0.417
MOD_Plk_4	419	425	PF00069	0.388
MOD_Plk_4	450	456	PF00069	0.326
MOD_Plk_4	468	474	PF00069	0.391
MOD_Plk_4	501	507	PF00069	0.338
MOD_Plk_4	513	519	PF00069	0.324
MOD_Plk_4	550	556	PF00069	0.312
MOD_Plk_4	568	574	PF00069	0.374
MOD_Plk_4	590	596	PF00069	0.330
MOD_Plk_4	629	635	PF00069	0.374
MOD_Plk_4	81	87	PF00069	0.311
MOD_ProDKin_1	296	302	PF00069	0.456
MOD_ProDKin_1	602	608	PF00069	0.412
MOD_SUMO_for_1	651	654	PF00179	0.371
TRG_ENDOCYTIC_2	105	108	PF00928	0.318
TRG_ENDOCYTIC_2	189	192	PF00928	0.347
TRG_ENDOCYTIC_2	384	387	PF00928	0.339
TRG_ENDOCYTIC_2	438	441	PF00928	0.351
TRG_ENDOCYTIC_2	44	47	PF00928	0.486
TRG_ENDOCYTIC_2	444	447	PF00928	0.353
TRG_ENDOCYTIC_2	473	476	PF00928	0.349
TRG_ENDOCYTIC_2	574	577	PF00928	0.341
TRG_ER_diArg_1	193	196	PF00400	0.257
TRG_ER_diArg_1	354	357	PF00400	0.402
TRG_ER_diArg_1	41	43	PF00400	0.574
TRG_NES_CRM1_1	359	373	PF08389	0.224
TRG_NES_CRM1_1	446	460	PF08389	0.295
TRG_NES_CRM1_1	585	597	PF08389	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	51%	96%
A0A0N1HY49	Leptomonas seymouri	54%	100%
A0A0N1HZ06	Leptomonas seymouri	43%	100%
A0A0N1IHL1	Leptomonas seymouri	46%	94%
A0A0N1PAY4	Leptomonas seymouri	50%	76%
A0A0N1PB77	Leptomonas seymouri	42%	100%
A0A0N1PBZ2	Leptomonas seymouri	54%	100%
A0A0N1PCC1	Leptomonas seymouri	48%	100%
A0A381MBI0	Leishmania infantum	47%	100%
A0A3Q8I8X7	Leishmania donovani	47%	100%
A0A3Q8IAZ0	Leishmania donovani	53%	96%
A0A3Q8IH50	Leishmania donovani	60%	93%
A0A3Q8IVN0	Leishmania donovani	42%	100%
A0A3R7M4J1	Trypanosoma rangeli	41%	100%
A0A3S5H5P4	Leishmania donovani	50%	99%
A0A3S5H5V2	Leishmania donovani	46%	100%
A0A3S5H6F6	Leishmania donovani	52%	96%
A0A3S5H763	Leishmania donovani	99%	100%
A0A3S7WR10	Leishmania donovani	48%	90%
A0A3S7WR14	Leishmania donovani	55%	98%
A0A3S7WR15	Leishmania donovani	52%	79%
A0A3S7WR24	Leishmania donovani	52%	96%
A4H4T8	Leishmania braziliensis	45%	100%
A4H5Y4	Leishmania braziliensis	48%	100%
A4H617	Leishmania braziliensis	53%	100%
A4H618	Leishmania braziliensis	52%	100%
A4H619	Leishmania braziliensis	53%	100%
A4H620	Leishmania braziliensis	63%	100%
A4H6C3	Leishmania braziliensis	48%	100%
A4HNH7	Leishmania braziliensis	41%	100%
A4HSS2	Leishmania infantum	49%	100%
A4HUE4	Leishmania infantum	48%	100%
A4HUE5	Leishmania infantum	53%	100%
A4HUE6	Leishmania infantum	55%	100%
A4HUE7	Leishmania infantum	52%	100%
A4HUE8	Leishmania infantum	51%	100%
A4HUF4	Leishmania infantum	51%	100%
A4HUF5	Leishmania infantum	63%	100%
A4IC33	Leishmania infantum	42%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AG72	Leishmania infantum	46%	100%
E9AI40	Leishmania braziliensis	52%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
Q4QDC4	Leishmania major	96%	100%
Q4QH81	Leishmania major	47%	100%
Q4QHH7	Leishmania major	62%	100%
Q4QHH8	Leishmania major	51%	100%
Q4QHH9	Leishmania major	51%	100%
Q4QHI0	Leishmania major	52%	100%
Q4QHI1	Leishmania major	56%	100%
Q4QHI2	Leishmania major	53%	100%
Q4QIU9	Leishmania major	44%	100%
Q4QJ48	Leishmania major	49%	100%
Q7KIP2	Leishmania major	41%	100%