LeishMANIAdb
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Vps53_N domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Vps53_N domain-containing protein
Gene product:
vps53-like domain protein
Species:
Leishmania infantum
UniProt:
A4HYA1_LEIIN
TriTrypDb:
LINF_190013000
Length:
869

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0000938 GARP complex 3 12
GO:0005829 cytosol 2 12
GO:0010008 endosome membrane 5 12
GO:0012506 vesicle membrane 4 12
GO:0016020 membrane 2 12
GO:0030659 cytoplasmic vesicle membrane 5 12
GO:0031090 organelle membrane 3 12
GO:0032991 protein-containing complex 1 12
GO:0098588 bounding membrane of organelle 4 12
GO:0099023 vesicle tethering complex 2 12
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

A4HYA1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYA1

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 12
GO:0009987 cellular process 1 12
GO:0016192 vesicle-mediated transport 4 12
GO:0016197 endosomal transport 4 12
GO:0016482 cytosolic transport 4 12
GO:0042147 retrograde transport, endosome to Golgi 5 12
GO:0046907 intracellular transport 3 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0051641 cellular localization 2 12
GO:0051649 establishment of localization in cell 3 12
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 21 25 PF00656 0.567
CLV_MEL_PAP_1 93 99 PF00089 0.292
CLV_NRD_NRD_1 155 157 PF00675 0.296
CLV_NRD_NRD_1 267 269 PF00675 0.276
CLV_NRD_NRD_1 352 354 PF00675 0.219
CLV_NRD_NRD_1 449 451 PF00675 0.329
CLV_NRD_NRD_1 474 476 PF00675 0.369
CLV_NRD_NRD_1 58 60 PF00675 0.412
CLV_NRD_NRD_1 617 619 PF00675 0.418
CLV_NRD_NRD_1 662 664 PF00675 0.368
CLV_NRD_NRD_1 713 715 PF00675 0.395
CLV_PCSK_FUR_1 252 256 PF00082 0.312
CLV_PCSK_FUR_1 615 619 PF00082 0.386
CLV_PCSK_KEX2_1 154 156 PF00082 0.312
CLV_PCSK_KEX2_1 254 256 PF00082 0.286
CLV_PCSK_KEX2_1 267 269 PF00082 0.254
CLV_PCSK_KEX2_1 352 354 PF00082 0.394
CLV_PCSK_KEX2_1 430 432 PF00082 0.343
CLV_PCSK_KEX2_1 449 451 PF00082 0.325
CLV_PCSK_KEX2_1 473 475 PF00082 0.375
CLV_PCSK_KEX2_1 617 619 PF00082 0.418
CLV_PCSK_KEX2_1 713 715 PF00082 0.393
CLV_PCSK_KEX2_1 726 728 PF00082 0.411
CLV_PCSK_KEX2_1 734 736 PF00082 0.385
CLV_PCSK_KEX2_1 863 865 PF00082 0.671
CLV_PCSK_PC1ET2_1 154 156 PF00082 0.412
CLV_PCSK_PC1ET2_1 254 256 PF00082 0.292
CLV_PCSK_PC1ET2_1 352 354 PF00082 0.394
CLV_PCSK_PC1ET2_1 430 432 PF00082 0.343
CLV_PCSK_PC1ET2_1 726 728 PF00082 0.436
CLV_PCSK_PC1ET2_1 734 736 PF00082 0.385
CLV_PCSK_PC1ET2_1 863 865 PF00082 0.671
CLV_PCSK_SKI1_1 161 165 PF00082 0.271
CLV_PCSK_SKI1_1 20 24 PF00082 0.583
CLV_PCSK_SKI1_1 268 272 PF00082 0.296
CLV_PCSK_SKI1_1 273 277 PF00082 0.256
CLV_PCSK_SKI1_1 284 288 PF00082 0.220
CLV_PCSK_SKI1_1 337 341 PF00082 0.276
CLV_PCSK_SKI1_1 384 388 PF00082 0.377
CLV_PCSK_SKI1_1 430 434 PF00082 0.414
CLV_PCSK_SKI1_1 514 518 PF00082 0.464
CLV_PCSK_SKI1_1 572 576 PF00082 0.443
CLV_PCSK_SKI1_1 595 599 PF00082 0.323
CLV_PCSK_SKI1_1 636 640 PF00082 0.366
CLV_PCSK_SKI1_1 671 675 PF00082 0.348
CLV_PCSK_SKI1_1 84 88 PF00082 0.331
DEG_APCC_DBOX_1 448 456 PF00400 0.450
DEG_APCC_DBOX_1 594 602 PF00400 0.319
DEG_SPOP_SBC_1 147 151 PF00917 0.312
DOC_CDC14_PxL_1 534 542 PF14671 0.403
DOC_CYCLIN_RxL_1 267 280 PF00134 0.276
DOC_CYCLIN_RxL_1 592 599 PF00134 0.317
DOC_MAPK_gen_1 264 272 PF00069 0.276
DOC_MAPK_gen_1 449 455 PF00069 0.319
DOC_MAPK_gen_1 473 480 PF00069 0.339
DOC_MAPK_MEF2A_6 369 376 PF00069 0.276
DOC_MAPK_NFAT4_5 369 377 PF00069 0.276
DOC_MAPK_RevD_3 461 475 PF00069 0.476
DOC_PP1_RVXF_1 504 511 PF00149 0.453
DOC_PP2B_LxvP_1 639 642 PF13499 0.376
DOC_PP2B_LxvP_1 780 783 PF13499 0.617
DOC_USP7_MATH_1 104 108 PF00917 0.312
DOC_USP7_MATH_1 565 569 PF00917 0.510
DOC_USP7_MATH_1 776 780 PF00917 0.680
DOC_USP7_MATH_1 786 790 PF00917 0.673
DOC_USP7_MATH_1 817 821 PF00917 0.722
DOC_USP7_UBL2_3 178 182 PF12436 0.310
DOC_USP7_UBL2_3 426 430 PF12436 0.344
DOC_WW_Pin1_4 466 471 PF00397 0.416
LIG_14-3-3_CanoR_1 101 111 PF00244 0.266
LIG_14-3-3_CanoR_1 155 164 PF00244 0.299
LIG_14-3-3_CanoR_1 202 206 PF00244 0.336
LIG_14-3-3_CanoR_1 57 66 PF00244 0.269
LIG_14-3-3_CanoR_1 649 659 PF00244 0.467
LIG_14-3-3_CanoR_1 850 859 PF00244 0.520
LIG_Actin_WH2_2 414 432 PF00022 0.326
LIG_Actin_WH2_2 44 61 PF00022 0.328
LIG_APCC_ABBA_1 686 691 PF00400 0.344
LIG_APCC_ABBAyCdc20_2 202 208 PF00400 0.312
LIG_BRCT_BRCA1_1 148 152 PF00533 0.276
LIG_BRCT_BRCA1_1 170 174 PF00533 0.308
LIG_BRCT_BRCA1_1 249 253 PF00533 0.312
LIG_BRCT_BRCA1_1 764 768 PF00533 0.447
LIG_BRCT_BRCA1_1 854 858 PF00533 0.540
LIG_BRCT_BRCA1_2 148 154 PF00533 0.412
LIG_BRCT_BRCA1_2 170 176 PF00533 0.380
LIG_DLG_GKlike_1 739 747 PF00625 0.497
LIG_FHA_1 127 133 PF00498 0.276
LIG_FHA_1 298 304 PF00498 0.276
LIG_FHA_1 324 330 PF00498 0.276
LIG_FHA_1 480 486 PF00498 0.323
LIG_FHA_1 520 526 PF00498 0.490
LIG_FHA_1 573 579 PF00498 0.423
LIG_FHA_1 654 660 PF00498 0.449
LIG_FHA_2 303 309 PF00498 0.276
LIG_FHA_2 342 348 PF00498 0.394
LIG_FHA_2 487 493 PF00498 0.439
LIG_FHA_2 575 581 PF00498 0.468
LIG_FHA_2 731 737 PF00498 0.397
LIG_FHA_2 75 81 PF00498 0.365
LIG_FHA_2 828 834 PF00498 0.607
LIG_Integrin_RGD_1 864 866 PF01839 0.487
LIG_LIR_Gen_1 167 177 PF02991 0.295
LIG_LIR_Gen_1 266 276 PF02991 0.276
LIG_LIR_Gen_1 277 287 PF02991 0.276
LIG_LIR_Gen_1 419 429 PF02991 0.303
LIG_LIR_Gen_1 507 517 PF02991 0.377
LIG_LIR_Gen_1 635 644 PF02991 0.343
LIG_LIR_Gen_1 656 666 PF02991 0.355
LIG_LIR_Gen_1 682 693 PF02991 0.376
LIG_LIR_Gen_1 765 776 PF02991 0.420
LIG_LIR_Gen_1 843 853 PF02991 0.645
LIG_LIR_Nem_3 204 209 PF02991 0.340
LIG_LIR_Nem_3 266 272 PF02991 0.276
LIG_LIR_Nem_3 27 31 PF02991 0.252
LIG_LIR_Nem_3 277 282 PF02991 0.276
LIG_LIR_Nem_3 411 417 PF02991 0.374
LIG_LIR_Nem_3 419 425 PF02991 0.271
LIG_LIR_Nem_3 507 513 PF02991 0.390
LIG_LIR_Nem_3 515 520 PF02991 0.330
LIG_LIR_Nem_3 635 641 PF02991 0.340
LIG_LIR_Nem_3 656 661 PF02991 0.364
LIG_LIR_Nem_3 665 669 PF02991 0.308
LIG_LIR_Nem_3 682 688 PF02991 0.420
LIG_LIR_Nem_3 765 771 PF02991 0.537
LIG_NRBOX 271 277 PF00104 0.397
LIG_NRBOX 593 599 PF00104 0.316
LIG_PCNA_yPIPBox_3 697 710 PF02747 0.446
LIG_Pex14_1 345 349 PF04695 0.276
LIG_Pex14_2 283 287 PF04695 0.271
LIG_Pex14_2 768 772 PF04695 0.531
LIG_PTB_Apo_2 200 207 PF02174 0.412
LIG_PTB_Apo_2 32 39 PF02174 0.276
LIG_PTB_Apo_2 542 549 PF02174 0.378
LIG_PTB_Apo_2 608 615 PF02174 0.459
LIG_PTB_Phospho_1 608 614 PF10480 0.454
LIG_SH2_CRK 279 283 PF00017 0.412
LIG_SH2_GRB2like 33 36 PF00017 0.292
LIG_SH2_NCK_1 279 283 PF00017 0.315
LIG_SH2_NCK_1 644 648 PF00017 0.417
LIG_SH2_PTP2 269 272 PF00017 0.254
LIG_SH2_PTP2 658 661 PF00017 0.392
LIG_SH2_PTP2 94 97 PF00017 0.394
LIG_SH2_SRC 33 36 PF00017 0.336
LIG_SH2_SRC 414 417 PF00017 0.445
LIG_SH2_STAP1 170 174 PF00017 0.292
LIG_SH2_STAP1 249 253 PF00017 0.292
LIG_SH2_STAP1 279 283 PF00017 0.394
LIG_SH2_STAP1 5 9 PF00017 0.580
LIG_SH2_STAP1 521 525 PF00017 0.332
LIG_SH2_STAP1 690 694 PF00017 0.366
LIG_SH2_STAT3 327 330 PF00017 0.276
LIG_SH2_STAT5 200 203 PF00017 0.277
LIG_SH2_STAT5 269 272 PF00017 0.292
LIG_SH2_STAT5 327 330 PF00017 0.321
LIG_SH2_STAT5 33 36 PF00017 0.292
LIG_SH2_STAT5 414 417 PF00017 0.445
LIG_SH2_STAT5 521 524 PF00017 0.450
LIG_SH2_STAT5 658 661 PF00017 0.459
LIG_SH2_STAT5 94 97 PF00017 0.394
LIG_SH3_3 13 19 PF00018 0.510
LIG_SH3_3 585 591 PF00018 0.364
LIG_SH3_3 689 695 PF00018 0.457
LIG_SH3_3 780 786 PF00018 0.717
LIG_Sin3_3 222 229 PF02671 0.394
LIG_SUMO_SIM_anti_2 321 326 PF11976 0.279
LIG_SUMO_SIM_par_1 224 233 PF11976 0.463
LIG_SUMO_SIM_par_1 321 326 PF11976 0.284
LIG_SUMO_SIM_par_1 331 336 PF11976 0.263
LIG_TRAF2_1 163 166 PF00917 0.412
LIG_TRAF2_1 305 308 PF00917 0.412
LIG_TRAF2_1 835 838 PF00917 0.602
LIG_TYR_ITIM 688 693 PF00017 0.473
LIG_UBA3_1 173 182 PF00899 0.312
LIG_UBA3_1 421 430 PF00899 0.319
LIG_WW_3 17 21 PF00397 0.519
LIG_WW_3 503 507 PF00397 0.562
LIG_WW_3 781 785 PF00397 0.626
MOD_CDK_SPxxK_3 466 473 PF00069 0.480
MOD_CK1_1 131 137 PF00069 0.296
MOD_CK1_1 394 400 PF00069 0.478
MOD_CK1_1 524 530 PF00069 0.470
MOD_CK1_1 653 659 PF00069 0.420
MOD_CK1_1 74 80 PF00069 0.393
MOD_CK1_1 759 765 PF00069 0.665
MOD_CK1_1 843 849 PF00069 0.534
MOD_CK1_1 851 857 PF00069 0.541
MOD_CK2_1 102 108 PF00069 0.329
MOD_CK2_1 147 153 PF00069 0.292
MOD_CK2_1 302 308 PF00069 0.292
MOD_CK2_1 401 407 PF00069 0.546
MOD_CK2_1 466 472 PF00069 0.486
MOD_CK2_1 74 80 PF00069 0.393
MOD_GlcNHglycan 170 173 PF01048 0.359
MOD_GlcNHglycan 365 368 PF01048 0.368
MOD_GlcNHglycan 393 396 PF01048 0.531
MOD_GlcNHglycan 410 413 PF01048 0.480
MOD_GlcNHglycan 459 462 PF01048 0.499
MOD_GlcNHglycan 652 655 PF01048 0.512
MOD_GlcNHglycan 750 753 PF01048 0.601
MOD_GlcNHglycan 761 764 PF01048 0.504
MOD_GlcNHglycan 77 80 PF01048 0.348
MOD_GlcNHglycan 775 779 PF01048 0.561
MOD_GlcNHglycan 789 792 PF01048 0.551
MOD_GSK3_1 123 130 PF00069 0.368
MOD_GSK3_1 164 171 PF00069 0.251
MOD_GSK3_1 337 344 PF00069 0.394
MOD_GSK3_1 406 413 PF00069 0.519
MOD_GSK3_1 515 522 PF00069 0.358
MOD_GSK3_1 71 78 PF00069 0.318
MOD_GSK3_1 739 746 PF00069 0.495
MOD_GSK3_1 770 777 PF00069 0.533
MOD_GSK3_1 800 807 PF00069 0.647
MOD_GSK3_1 840 847 PF00069 0.597
MOD_GSK3_1 848 855 PF00069 0.583
MOD_GSK3_1 95 102 PF00069 0.443
MOD_N-GLC_1 126 131 PF02516 0.276
MOD_N-GLC_1 696 701 PF02516 0.457
MOD_N-GLC_1 74 79 PF02516 0.412
MOD_N-GLC_1 786 791 PF02516 0.635
MOD_NEK2_1 128 133 PF00069 0.281
MOD_NEK2_1 164 169 PF00069 0.330
MOD_NEK2_1 214 219 PF00069 0.299
MOD_NEK2_1 297 302 PF00069 0.301
MOD_NEK2_1 363 368 PF00069 0.292
MOD_NEK2_1 485 490 PF00069 0.330
MOD_NEK2_1 601 606 PF00069 0.394
MOD_NEK2_1 634 639 PF00069 0.371
MOD_NEK2_1 743 748 PF00069 0.635
MOD_NEK2_1 800 805 PF00069 0.644
MOD_NEK2_1 848 853 PF00069 0.561
MOD_NEK2_2 516 521 PF00069 0.355
MOD_NEK2_2 609 614 PF00069 0.453
MOD_PIKK_1 155 161 PF00454 0.299
MOD_PIKK_1 188 194 PF00454 0.412
MOD_PIKK_1 337 343 PF00454 0.395
MOD_PIKK_1 487 493 PF00454 0.407
MOD_PIKK_1 99 105 PF00454 0.394
MOD_PK_1 278 284 PF00069 0.330
MOD_PK_1 840 846 PF00069 0.611
MOD_PKA_1 155 161 PF00069 0.299
MOD_PKA_1 254 260 PF00069 0.292
MOD_PKA_1 551 557 PF00069 0.655
MOD_PKA_2 155 161 PF00069 0.299
MOD_PKA_2 201 207 PF00069 0.312
MOD_PKA_2 254 260 PF00069 0.273
MOD_PKA_2 58 64 PF00069 0.293
MOD_PKA_2 849 855 PF00069 0.546
MOD_PKA_2 95 101 PF00069 0.292
MOD_Plk_1 214 220 PF00069 0.291
MOD_Plk_1 337 343 PF00069 0.276
MOD_Plk_1 40 46 PF00069 0.294
MOD_Plk_1 634 640 PF00069 0.380
MOD_Plk_1 696 702 PF00069 0.387
MOD_Plk_1 739 745 PF00069 0.474
MOD_Plk_4 201 207 PF00069 0.312
MOD_Plk_4 278 284 PF00069 0.326
MOD_Plk_4 323 329 PF00069 0.276
MOD_Plk_4 410 416 PF00069 0.450
MOD_Plk_4 516 522 PF00069 0.331
MOD_Plk_4 524 530 PF00069 0.313
MOD_Plk_4 601 607 PF00069 0.383
MOD_Plk_4 609 615 PF00069 0.358
MOD_Plk_4 634 640 PF00069 0.432
MOD_Plk_4 840 846 PF00069 0.703
MOD_ProDKin_1 466 472 PF00069 0.415
MOD_SUMO_for_1 260 263 PF00179 0.312
MOD_SUMO_rev_2 258 262 PF00179 0.296
MOD_SUMO_rev_2 566 571 PF00179 0.529
MOD_SUMO_rev_2 78 86 PF00179 0.383
TRG_DiLeu_BaLyEn_6 387 392 PF01217 0.516
TRG_ENDOCYTIC_2 170 173 PF00928 0.292
TRG_ENDOCYTIC_2 269 272 PF00928 0.276
TRG_ENDOCYTIC_2 279 282 PF00928 0.276
TRG_ENDOCYTIC_2 360 363 PF00928 0.276
TRG_ENDOCYTIC_2 414 417 PF00928 0.445
TRG_ENDOCYTIC_2 658 661 PF00928 0.338
TRG_ENDOCYTIC_2 689 692 PF00928 0.353
TRG_ENDOCYTIC_2 94 97 PF00928 0.292
TRG_ER_diArg_1 155 157 PF00400 0.412
TRG_ER_diArg_1 267 269 PF00400 0.276
TRG_ER_diArg_1 448 450 PF00400 0.461
TRG_ER_diArg_1 473 475 PF00400 0.371
TRG_ER_diArg_1 614 617 PF00400 0.376
TRG_ER_diArg_1 712 714 PF00400 0.407
TRG_NES_CRM1_1 667 679 PF08389 0.372
TRG_NLS_MonoExtC_3 233 238 PF00514 0.412
TRG_NLS_MonoExtC_3 351 356 PF00514 0.219
TRG_Pf-PMV_PEXEL_1 273 277 PF00026 0.276
TRG_Pf-PMV_PEXEL_1 337 341 PF00026 0.412
TRG_Pf-PMV_PEXEL_1 450 454 PF00026 0.456
TRG_Pf-PMV_PEXEL_1 595 599 PF00026 0.323
TRG_Pf-PMV_PEXEL_1 617 621 PF00026 0.425

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HSX2 Leptomonas seymouri 79% 98%
A0A0S4J071 Bodo saltans 52% 100%
A0A1X0P670 Trypanosomatidae 59% 95%
A0A3R7KBJ1 Trypanosoma rangeli 58% 98%
A0A3S7WVF6 Leishmania donovani 100% 100%
A4HA38 Leishmania braziliensis 88% 100%
D0A0N7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
E9AS33 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
P34561 Caenorhabditis elegans 23% 100%
P87129 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 21% 100%
Q0WQF4 Arabidopsis thaliana 26% 100%
Q4QDE0 Leishmania major 96% 100%
Q5R5J4 Pongo abelii 23% 100%
Q5VIR6 Homo sapiens 23% 100%
Q5ZLD7 Gallus gallus 23% 100%
Q8CCB4 Mus musculus 23% 100%
V5AZ39 Trypanosoma cruzi 59% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS