LeishMANIAdb
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ATP-binding cassette protein subfamily F, member 2

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ATP-binding cassette protein subfamily F, member 2
Gene product:
ABC transport system ATP-binding protein - putative
Species:
Leishmania infantum
UniProt:
A4HYA0_LEIIN
TriTrypDb:
LINF_190012900
Length:
612

Annotations

Annotations by Jardim et al.

Transporters, ATP-binding cassette F, member 2 ABCF2

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HYA0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HYA0

Function

Biological processes
Term Name Level Count
GO:0044087 regulation of cellular component biogenesis 4 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
GO:0090069 regulation of ribosome biogenesis 5 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 11
GO:0005488 binding 1 11
GO:0005524 ATP binding 5 11
GO:0017076 purine nucleotide binding 4 11
GO:0030554 adenyl nucleotide binding 5 11
GO:0032553 ribonucleotide binding 3 11
GO:0032555 purine ribonucleotide binding 4 11
GO:0032559 adenyl ribonucleotide binding 5 11
GO:0035639 purine ribonucleoside triphosphate binding 4 11
GO:0036094 small molecule binding 2 11
GO:0043167 ion binding 2 11
GO:0043168 anion binding 3 11
GO:0097159 organic cyclic compound binding 2 11
GO:0097367 carbohydrate derivative binding 2 11
GO:1901265 nucleoside phosphate binding 3 11
GO:1901363 heterocyclic compound binding 2 11
GO:0003824 catalytic activity 1 1
GO:0016787 hydrolase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 146 150 PF00656 0.236
CLV_C14_Caspase3-7 190 194 PF00656 0.224
CLV_C14_Caspase3-7 25 29 PF00656 0.624
CLV_C14_Caspase3-7 508 512 PF00656 0.196
CLV_C14_Caspase3-7 542 546 PF00656 0.283
CLV_NRD_NRD_1 216 218 PF00675 0.349
CLV_PCSK_KEX2_1 187 189 PF00082 0.216
CLV_PCSK_KEX2_1 216 218 PF00082 0.349
CLV_PCSK_KEX2_1 525 527 PF00082 0.373
CLV_PCSK_KEX2_1 584 586 PF00082 0.463
CLV_PCSK_PC1ET2_1 187 189 PF00082 0.216
CLV_PCSK_PC1ET2_1 525 527 PF00082 0.368
CLV_PCSK_PC1ET2_1 584 586 PF00082 0.452
CLV_PCSK_SKI1_1 203 207 PF00082 0.216
CLV_PCSK_SKI1_1 269 273 PF00082 0.246
CLV_PCSK_SKI1_1 329 333 PF00082 0.182
CLV_PCSK_SKI1_1 489 493 PF00082 0.216
CLV_PCSK_SKI1_1 5 9 PF00082 0.475
CLV_PCSK_SKI1_1 516 520 PF00082 0.264
DEG_MDM2_SWIB_1 222 230 PF02201 0.216
DEG_SCF_FBW7_1 503 508 PF00400 0.202
DOC_CKS1_1 502 507 PF01111 0.216
DOC_CYCLIN_RxL_1 266 275 PF00134 0.260
DOC_MAPK_FxFP_2 376 379 PF00069 0.287
DOC_MAPK_FxFP_2 396 399 PF00069 0.313
DOC_MAPK_gen_1 200 210 PF00069 0.210
DOC_MAPK_gen_1 525 532 PF00069 0.364
DOC_PP1_RVXF_1 201 207 PF00149 0.216
DOC_PP1_RVXF_1 371 377 PF00149 0.336
DOC_PP1_RVXF_1 390 397 PF00149 0.300
DOC_PP1_RVXF_1 514 520 PF00149 0.216
DOC_PP2B_LxvP_1 384 387 PF13499 0.323
DOC_PP4_FxxP_1 237 240 PF00568 0.216
DOC_PP4_FxxP_1 376 379 PF00568 0.287
DOC_PP4_FxxP_1 396 399 PF00568 0.313
DOC_PP4_FxxP_1 63 66 PF00568 0.343
DOC_SPAK_OSR1_1 494 498 PF12202 0.216
DOC_USP7_MATH_1 126 130 PF00917 0.349
DOC_USP7_MATH_1 15 19 PF00917 0.626
DOC_USP7_MATH_1 54 58 PF00917 0.388
DOC_USP7_MATH_1 550 554 PF00917 0.329
DOC_USP7_MATH_1 59 63 PF00917 0.335
DOC_USP7_MATH_2 471 477 PF00917 0.237
DOC_USP7_UBL2_3 156 160 PF12436 0.237
DOC_USP7_UBL2_3 354 358 PF12436 0.477
DOC_USP7_UBL2_3 5 9 PF12436 0.486
DOC_USP7_UBL2_3 580 584 PF12436 0.415
DOC_WW_Pin1_4 33 38 PF00397 0.573
DOC_WW_Pin1_4 467 472 PF00397 0.216
DOC_WW_Pin1_4 501 506 PF00397 0.216
LIG_14-3-3_CanoR_1 227 233 PF00244 0.259
LIG_14-3-3_CanoR_1 361 369 PF00244 0.520
LIG_14-3-3_CanoR_1 603 609 PF00244 0.428
LIG_BRCT_BRCA1_1 276 280 PF00533 0.275
LIG_FHA_1 239 245 PF00498 0.223
LIG_FHA_1 247 253 PF00498 0.207
LIG_FHA_1 363 369 PF00498 0.354
LIG_FHA_1 534 540 PF00498 0.275
LIG_FHA_1 92 98 PF00498 0.216
LIG_FHA_2 307 313 PF00498 0.388
LIG_FHA_2 404 410 PF00498 0.319
LIG_FHA_2 468 474 PF00498 0.226
LIG_FHA_2 506 512 PF00498 0.196
LIG_IRF3_LxIS_1 76 83 PF10401 0.317
LIG_LIR_Apic_2 393 399 PF02991 0.309
LIG_LIR_Apic_2 62 66 PF02991 0.422
LIG_LIR_Gen_1 403 412 PF02991 0.262
LIG_LIR_Nem_3 183 189 PF02991 0.216
LIG_LIR_Nem_3 300 306 PF02991 0.395
LIG_LIR_Nem_3 403 408 PF02991 0.328
LIG_LIR_Nem_3 476 482 PF02991 0.223
LIG_LYPXL_yS_3 479 482 PF13949 0.235
LIG_MAD2 118 126 PF02301 0.216
LIG_PCNA_yPIPBox_3 594 605 PF02747 0.381
LIG_Pex14_1 259 263 PF04695 0.256
LIG_Pex14_2 206 210 PF04695 0.216
LIG_Pex14_2 222 226 PF04695 0.216
LIG_Pex14_2 457 461 PF04695 0.216
LIG_PTB_Apo_2 62 69 PF02174 0.332
LIG_PTB_Phospho_1 62 68 PF10480 0.461
LIG_Rb_LxCxE_1 115 137 PF01857 0.295
LIG_Rb_LxCxE_1 429 442 PF01857 0.216
LIG_SH2_CRK 103 107 PF00017 0.336
LIG_SH2_CRK 524 528 PF00017 0.281
LIG_SH2_STAP1 608 612 PF00017 0.465
LIG_SH2_STAT3 135 138 PF00017 0.281
LIG_SH2_STAT5 135 138 PF00017 0.260
LIG_SH2_STAT5 263 266 PF00017 0.315
LIG_SH2_STAT5 306 309 PF00017 0.399
LIG_SH2_STAT5 334 337 PF00017 0.382
LIG_SH2_STAT5 445 448 PF00017 0.216
LIG_SH2_STAT5 6 9 PF00017 0.432
LIG_SH3_3 380 386 PF00018 0.341
LIG_SH3_3 396 402 PF00018 0.323
LIG_SH3_3 479 485 PF00018 0.235
LIG_SUMO_SIM_anti_2 241 247 PF11976 0.216
LIG_SUMO_SIM_par_1 149 155 PF11976 0.216
LIG_SUMO_SIM_par_1 240 247 PF11976 0.217
LIG_SUMO_SIM_par_1 557 562 PF11976 0.237
LIG_TRAF2_1 309 312 PF00917 0.477
LIG_TRAF2_1 50 53 PF00917 0.506
LIG_UBA3_1 204 212 PF00899 0.349
LIG_WRC_WIRS_1 551 556 PF05994 0.325
LIG_WRC_WIRS_1 60 65 PF05994 0.429
MOD_CDK_SPxK_1 501 507 PF00069 0.349
MOD_CK1_1 143 149 PF00069 0.196
MOD_CK1_1 36 42 PF00069 0.682
MOD_CK1_1 403 409 PF00069 0.371
MOD_CK2_1 160 166 PF00069 0.237
MOD_CK2_1 306 312 PF00069 0.381
MOD_CK2_1 467 473 PF00069 0.216
MOD_Cter_Amidation 43 46 PF01082 0.492
MOD_GlcNHglycan 144 148 PF01048 0.283
MOD_GlcNHglycan 222 225 PF01048 0.216
MOD_GlcNHglycan 341 344 PF01048 0.186
MOD_GlcNHglycan 489 492 PF01048 0.216
MOD_GlcNHglycan 497 500 PF01048 0.216
MOD_GlcNHglycan 56 59 PF01048 0.358
MOD_GlcNHglycan 98 101 PF01048 0.349
MOD_GSK3_1 216 223 PF00069 0.258
MOD_GSK3_1 29 36 PF00069 0.690
MOD_GSK3_1 348 355 PF00069 0.382
MOD_GSK3_1 501 508 PF00069 0.259
MOD_GSK3_1 604 611 PF00069 0.332
MOD_N-GLC_1 33 38 PF02516 0.726
MOD_N-GLC_1 91 96 PF02516 0.216
MOD_N-GLC_2 109 111 PF02516 0.216
MOD_N-GLC_2 283 285 PF02516 0.281
MOD_NEK2_1 228 233 PF00069 0.232
MOD_NEK2_1 267 272 PF00069 0.363
MOD_NEK2_1 495 500 PF00069 0.225
MOD_NEK2_1 604 609 PF00069 0.325
MOD_NEK2_1 80 85 PF00069 0.365
MOD_PIKK_1 134 140 PF00454 0.281
MOD_PIKK_1 274 280 PF00454 0.264
MOD_PIKK_1 473 479 PF00454 0.266
MOD_PIKK_1 480 486 PF00454 0.231
MOD_PKA_1 216 222 PF00069 0.349
MOD_PKA_2 216 222 PF00069 0.216
MOD_PKA_2 228 234 PF00069 0.216
MOD_PKA_2 400 406 PF00069 0.422
MOD_Plk_1 143 149 PF00069 0.196
MOD_Plk_1 352 358 PF00069 0.382
MOD_Plk_1 392 398 PF00069 0.329
MOD_Plk_1 599 605 PF00069 0.261
MOD_Plk_1 80 86 PF00069 0.319
MOD_Plk_1 91 97 PF00069 0.225
MOD_Plk_2-3 540 546 PF00069 0.281
MOD_Plk_4 112 118 PF00069 0.238
MOD_Plk_4 238 244 PF00069 0.216
MOD_Plk_4 267 273 PF00069 0.353
MOD_Plk_4 400 406 PF00069 0.408
MOD_ProDKin_1 33 39 PF00069 0.573
MOD_ProDKin_1 467 473 PF00069 0.216
MOD_ProDKin_1 501 507 PF00069 0.216
MOD_SUMO_for_1 50 53 PF00179 0.496
MOD_SUMO_rev_2 579 586 PF00179 0.381
TRG_DiLeu_BaLyEn_6 563 568 PF01217 0.259
TRG_ENDOCYTIC_2 103 106 PF00928 0.336
TRG_ENDOCYTIC_2 186 189 PF00928 0.216
TRG_ENDOCYTIC_2 479 482 PF00928 0.228
TRG_ER_diArg_1 216 218 PF00400 0.259
TRG_ER_diArg_1 226 229 PF00400 0.175
TRG_NES_CRM1_1 144 157 PF08389 0.254
TRG_NES_CRM1_1 159 174 PF08389 0.131
TRG_NES_CRM1_1 549 564 PF08389 0.394
TRG_NLS_MonoExtN_4 5 12 PF00514 0.508
TRG_Pf-PMV_PEXEL_1 187 191 PF00026 0.216
TRG_Pf-PMV_PEXEL_1 566 570 PF00026 0.272

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0H2VBH0 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 38% 96%
A0A0H2VFI8 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 27% 100%
A0A0N0P4L2 Leptomonas seymouri 42% 85%
A0A0N1I593 Leptomonas seymouri 38% 91%
A0A0N1PAH6 Leptomonas seymouri 88% 100%
A0A0S4IYK6 Bodo saltans 33% 100%
A0A0S4JRN6 Bodo saltans 40% 90%
A0A0S4JUD9 Bodo saltans 39% 100%
A0A1X0P0L3 Trypanosomatidae 41% 91%
A0A1X0P688 Trypanosomatidae 79% 100%
A0A1X0P8V9 Trypanosomatidae 43% 85%
A0A3Q8IHB5 Leishmania donovani 42% 92%
A0A3R7LWT1 Trypanosoma rangeli 81% 100%
A0A3S5H525 Leishmania donovani 41% 85%
A0A3S7WVI6 Leishmania donovani 100% 100%
A0A422N7J4 Trypanosoma rangeli 42% 85%
A0A422NHP3 Trypanosoma rangeli 41% 91%
A4H3I8 Leishmania braziliensis 41% 100%
A4HA37 Leishmania braziliensis 93% 100%
A4HL68 Leishmania braziliensis 40% 100%
A4HRS7 Leishmania infantum 42% 100%
A4I8P8 Leishmania infantum 42% 92%
D0A0N6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 80% 100%
D0A223 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 85%
D0A4N3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 89%
E9ACG3 Leishmania major 42% 100%
E9AJQ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 42% 100%
E9AS32 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
E9B3L1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
O05519 Bacillus subtilis (strain 168) 29% 95%
O06476 Bacillus subtilis (strain 168) 29% 97%
O31716 Bacillus subtilis (strain 168) 30% 100%
O34362 Bacillus subtilis (strain 168) 22% 100%
O34512 Bacillus subtilis (strain 168) 28% 100%
O42943 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 44% 99%
O59672 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 40% 83%
P0A9U3 Escherichia coli (strain K12) 32% 100%
P0A9U4 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 32% 100%
P0A9U5 Escherichia coli O157:H7 32% 100%
P0A9W3 Escherichia coli (strain K12) 27% 100%
P0A9W4 Escherichia coli O157:H7 27% 100%
P0A9W5 Shigella flexneri 27% 100%
P25256 Streptomyces fradiae 28% 100%
P39115 Bacillus subtilis (strain 168) 25% 100%
P40024 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 45% 100%
P43535 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 41% 81%
P43672 Escherichia coli (strain K12) 31% 96%
P44808 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 37% 96%
P45127 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 29% 100%
P63389 Escherichia coli (strain K12) 37% 96%
P63390 Escherichia coli O157:H7 37% 96%
P9WQK2 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 28% 100%
P9WQK3 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 28% 100%
Q2KJA2 Bos taurus 51% 98%
Q45978 Caulobacter vibrioides (strain ATCC 19089 / CB15) 27% 100%
Q4Q4I8 Leishmania major 41% 100%
Q4QDE1 Leishmania major 98% 100%
Q57242 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 28% 95%
Q5R9Z5 Pongo abelii 39% 86%
Q66H39 Rattus norvegicus 39% 86%
Q6MG08 Rattus norvegicus 41% 73%
Q6P542 Mus musculus 41% 73%
Q73P93 Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104) 22% 100%
Q73R11 Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104) 21% 100%
Q767L0 Sus scrofa 41% 76%
Q7MFH3 Vibrio vulnificus (strain YJ016) 23% 100%
Q7YR37 Pan troglodytes 42% 76%
Q88ZZ2 Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) 24% 100%
Q8D3Z9 Vibrio vulnificus (strain CMCP6) 22% 100%
Q8DQY5 Streptococcus pneumoniae (strain ATCC BAA-255 / R6) 23% 100%
Q8G838 Bifidobacterium longum (strain NCC 2705) 25% 78%
Q8H0V6 Arabidopsis thaliana 44% 86%
Q8K268 Mus musculus 39% 86%
Q8K9I3 Buchnera aphidicola subsp. Schizaphis graminum (strain Sg) 25% 100%
Q8NE71 Homo sapiens 43% 72%
Q8PSR0 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) 24% 100%
Q8R9L8 Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4) 23% 100%
Q8SRV5 Encephalitozoon cuniculi (strain GB-M1) 37% 100%
Q8T6B7 Dictyostelium discoideum 45% 100%
Q8TQ05 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) 24% 100%
Q8TQW9 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) 22% 100%
Q99LE6 Mus musculus 53% 97%
Q9FIB4 Arabidopsis thaliana 31% 90%
Q9FJH6 Arabidopsis thaliana 58% 100%
Q9LV93 Arabidopsis thaliana 32% 88%
Q9M1H3 Arabidopsis thaliana 43% 85%
Q9NUQ8 Homo sapiens 39% 86%
Q9UG63 Homo sapiens 51% 98%
Q9USH9 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 43% 74%
V5AVV7 Trypanosoma cruzi 41% 100%
V5BD93 Trypanosoma cruzi 43% 96%
V5DFD4 Trypanosoma cruzi 77% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS