Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HY98_LEIIN

TriTrypDb:

LINF_190012700

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	7
GO:0020023	kinetoplast	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HY98

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY98

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.362
CLV_NRD_NRD_1	148	150	PF00675	0.444
CLV_NRD_NRD_1	22	24	PF00675	0.394
CLV_NRD_NRD_1	224	226	PF00675	0.483
CLV_PCSK_FUR_1	146	150	PF00082	0.443
CLV_PCSK_KEX2_1	127	129	PF00082	0.375
CLV_PCSK_KEX2_1	148	150	PF00082	0.447
CLV_PCSK_KEX2_1	22	24	PF00082	0.418
CLV_PCSK_KEX2_1	224	226	PF00082	0.474
CLV_PCSK_SKI1_1	138	142	PF00082	0.410
CLV_PCSK_SKI1_1	64	68	PF00082	0.612
CLV_PCSK_SKI1_1	98	102	PF00082	0.634
DEG_APCC_DBOX_1	68	76	PF00400	0.397
DEG_Nend_UBRbox_2	1	3	PF02207	0.738
DEG_SIAH_1	8	16	PF03145	0.715
DEG_SPOP_SBC_1	37	41	PF00917	0.272
DOC_MAPK_gen_1	133	141	PF00069	0.586
DOC_MAPK_gen_1	214	223	PF00069	0.659
DOC_USP7_MATH_1	131	135	PF00917	0.643
DOC_WW_Pin1_4	209	214	PF00397	0.559
LIG_14-3-3_CanoR_1	162	170	PF00244	0.573
LIG_14-3-3_CanoR_1	22	28	PF00244	0.598
LIG_14-3-3_CanoR_1	56	63	PF00244	0.488
LIG_APCC_ABBA_1	13	18	PF00400	0.702
LIG_CSL_BTD_1	154	157	PF09270	0.708
LIG_deltaCOP1_diTrp_1	165	174	PF00928	0.583
LIG_deltaCOP1_diTrp_1	245	252	PF00928	0.711
LIG_FHA_1	162	168	PF00498	0.594
LIG_FHA_1	173	179	PF00498	0.542
LIG_FHA_1	39	45	PF00498	0.408
LIG_FHA_1	81	87	PF00498	0.344
LIG_LIR_Apic_2	208	213	PF02991	0.551
LIG_LIR_Gen_1	168	178	PF02991	0.564
LIG_LIR_Gen_1	196	202	PF02991	0.609
LIG_LIR_Nem_3	14	19	PF02991	0.655
LIG_LIR_Nem_3	158	163	PF02991	0.631
LIG_LIR_Nem_3	166	172	PF02991	0.579
LIG_LIR_Nem_3	177	182	PF02991	0.552
LIG_LIR_Nem_3	196	201	PF02991	0.610
LIG_LIR_Nem_3	217	221	PF02991	0.608
LIG_NRBOX	177	183	PF00104	0.655
LIG_Pex14_2	201	205	PF04695	0.624
LIG_PTB_Apo_2	201	208	PF02174	0.683
LIG_PTB_Phospho_1	201	207	PF10480	0.689
LIG_SH2_SRC	129	132	PF00017	0.667
LIG_SH2_STAP1	198	202	PF00017	0.587
LIG_SH2_STAT5	129	132	PF00017	0.667
LIG_SH3_3	151	157	PF00018	0.739
LIG_SH3_3	6	12	PF00018	0.695
LIG_TRAF2_1	15	18	PF00917	0.664
MOD_CDK_SPK_2	209	214	PF00069	0.559
MOD_CDK_SPxxK_3	209	216	PF00069	0.560
MOD_CK1_1	107	113	PF00069	0.302
MOD_CK1_1	91	97	PF00069	0.422
MOD_CMANNOS	215	218	PF00535	0.374
MOD_GlcNHglycan	106	109	PF01048	0.543
MOD_GSK3_1	116	123	PF00069	0.254
MOD_GSK3_1	205	212	PF00069	0.559
MOD_GSK3_1	38	45	PF00069	0.470
MOD_GSK3_1	98	105	PF00069	0.450
MOD_N-GLC_1	110	115	PF02516	0.420
MOD_NEK2_1	121	126	PF00069	0.396
MOD_NEK2_1	3	8	PF00069	0.716
MOD_NEK2_1	36	41	PF00069	0.389
MOD_NEK2_1	42	47	PF00069	0.346
MOD_NEK2_1	88	93	PF00069	0.381
MOD_NEK2_2	174	179	PF00069	0.567
MOD_PIKK_1	3	9	PF00454	0.752
MOD_PIKK_1	98	104	PF00454	0.439
MOD_PKA_1	23	29	PF00069	0.575
MOD_PKA_2	161	167	PF00069	0.628
MOD_PKA_2	55	61	PF00069	0.487
MOD_Plk_1	110	116	PF00069	0.420
MOD_Plk_4	110	116	PF00069	0.402
MOD_Plk_4	155	161	PF00069	0.673
MOD_Plk_4	174	180	PF00069	0.430
MOD_Plk_4	184	190	PF00069	0.557
MOD_Plk_4	237	243	PF00069	0.649
MOD_Plk_4	42	48	PF00069	0.438
MOD_Plk_4	88	94	PF00069	0.357
MOD_ProDKin_1	209	215	PF00069	0.559
TRG_ENDOCYTIC_2	170	173	PF00928	0.554
TRG_ENDOCYTIC_2	179	182	PF00928	0.545
TRG_ENDOCYTIC_2	198	201	PF00928	0.495
TRG_ER_diArg_1	127	129	PF00400	0.610
TRG_ER_diArg_1	146	149	PF00400	0.501
TRG_ER_diArg_1	21	23	PF00400	0.653
TRG_ER_diArg_1	223	225	PF00400	0.688
TRG_ER_diArg_1	247	250	PF00400	0.680

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBN8	Leptomonas seymouri	75%	100%
A0A0S4IWK7	Bodo saltans	39%	82%
A0A1X0P7P1	Trypanosomatidae	58%	100%
A0A3Q8IA89	Leishmania donovani	100%	100%
A4HA35	Leishmania braziliensis	88%	100%
D0A0N4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AS30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QDE3	Leishmania major	95%	100%