Vacuolar protein-sorting-associated protein 36

Quick info Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar protein sorting protein 36 Vps36/EAP30/Vps36 family - putative

Species:

Leishmania infantum

UniProt:

A4HY94_LEIIN

TriTrypDb:

LINF_190012300

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	yes	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Show entries

Cellular components
Term	Name	Level	Count
GO:0000814	ESCRT II complex	3	11
GO:0005737	cytoplasm	2	1
GO:0010008	endosome membrane	5	11
GO:0012506	vesicle membrane	4	11
GO:0016020	membrane	2	11
GO:0030659	cytoplasmic vesicle membrane	5	11
GO:0031090	organelle membrane	3	11
GO:0031902	late endosome membrane	6	11
GO:0032991	protein-containing complex	1	11
GO:0036452	ESCRT complex	2	11

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HY94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY94

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0007034	vacuolar transport	4	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0016192	vesicle-mediated transport	4	11
GO:0016197	endosomal transport	4	11
GO:0032509	endosome transport via multivesicular body sorting pathway	5	11
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	11

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0005543	phospholipid binding	3	11
GO:0008289	lipid binding	2	11
GO:0032182	ubiquitin-like protein binding	3	11
GO:0032266	phosphatidylinositol-3-phosphate binding	6	11
GO:0035091	phosphatidylinositol binding	4	11
GO:0043130	ubiquitin binding	4	11
GO:1901981	phosphatidylinositol phosphate binding	5	11

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Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	357	361	PF00656	0.494
CLV_NRD_NRD_1	200	202	PF00675	0.351
CLV_NRD_NRD_1	326	328	PF00675	0.306
CLV_NRD_NRD_1	69	71	PF00675	0.328
CLV_PCSK_KEX2_1	200	202	PF00082	0.351
CLV_PCSK_KEX2_1	69	71	PF00082	0.328
CLV_PCSK_SKI1_1	327	331	PF00082	0.263
CLV_PCSK_SKI1_1	394	398	PF00082	0.290
CLV_Separin_Metazoa	66	70	PF03568	0.528
DEG_COP1_1	143	153	PF00400	0.532

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3P0	Leptomonas seymouri	65%	98%
A0A1X0P698	Trypanosomatidae	44%	99%
A0A3R7M0G6	Trypanosoma rangeli	40%	96%
A0A3S7WVL4	Leishmania donovani	99%	100%
A4HA31	Leishmania braziliensis	77%	100%
A5PK00	Bos taurus	28%	100%
D0A0M8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AS26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P0C0A2	Rattus norvegicus	28%	100%
Q4QDE7	Leishmania major	94%	100%

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