Putative U3 snoRNA-associated protein UTP11

Quick info Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania infantum

UniProt:

A4HY88_LEIIN

TriTrypDb:

Length:

186

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 2
NetGPI	no	yes: 0, no: 2

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0030684	preribosome	3	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HY88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY88

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016072	rRNA metabolic process	7	1
GO:0034470	ncRNA processing	7	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	52	56	PF00656	0.663
CLV_NRD_NRD_1	123	125	PF00675	0.586
CLV_NRD_NRD_1	158	160	PF00675	0.511
CLV_NRD_NRD_1	172	174	PF00675	0.438
CLV_NRD_NRD_1	183	185	PF00675	0.450
CLV_NRD_NRD_1	38	40	PF00675	0.523
CLV_NRD_NRD_1	42	44	PF00675	0.514
CLV_NRD_NRD_1	50	52	PF00675	0.550
CLV_PCSK_KEX2_1	123	125	PF00082	0.586
CLV_PCSK_KEX2_1	156	158	PF00082	0.565
CLV_PCSK_KEX2_1	166	168	PF00082	0.470
CLV_PCSK_KEX2_1	172	174	PF00082	0.393
CLV_PCSK_KEX2_1	183	185	PF00082	0.584
CLV_PCSK_KEX2_1	38	40	PF00082	0.523
CLV_PCSK_KEX2_1	42	44	PF00082	0.514
CLV_PCSK_KEX2_1	50	52	PF00082	0.550
CLV_PCSK_KEX2_1	87	89	PF00082	0.665
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.565
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.470
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.523
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.665
CLV_PCSK_SKI1_1	61	65	PF00082	0.588
CLV_PCSK_SKI1_1	72	76	PF00082	0.321
DOC_PP1_RVXF_1	116	123	PF00149	0.597
DOC_USP7_MATH_1	92	96	PF00917	0.636
DOC_USP7_UBL2_3	156	160	PF12436	0.599
DOC_USP7_UBL2_3	71	75	PF12436	0.491
DOC_WW_Pin1_4	54	59	PF00397	0.654
DOC_WW_Pin1_4	97	102	PF00397	0.767
LIG_14-3-3_CanoR_1	147	152	PF00244	0.590
LIG_BIR_III_2	55	59	PF00653	0.656
LIG_DLG_GKlike_1	147	154	PF00625	0.589
LIG_eIF4E_1	77	83	PF01652	0.640
LIG_FHA_1	115	121	PF00498	0.600
LIG_FHA_1	78	84	PF00498	0.638
LIG_FHA_2	98	104	PF00498	0.687
LIG_MAD2	13	21	PF02301	0.675
LIG_NRP_CendR_1	183	186	PF00754	0.590
LIG_PCNA_yPIPBox_3	113	124	PF02747	0.602
MOD_CDK_SPxxK_3	54	61	PF00069	0.643
MOD_CK1_1	97	103	PF00069	0.762
MOD_GlcNHglycan	151	154	PF01048	0.506
MOD_GlcNHglycan	26	29	PF01048	0.590
MOD_GlcNHglycan	33	36	PF01048	0.532
MOD_GlcNHglycan	51	54	PF01048	0.369
MOD_GSK3_1	145	152	PF00069	0.591
MOD_GSK3_1	90	97	PF00069	0.724
MOD_NEK2_1	15	20	PF00069	0.548
MOD_NEK2_1	49	54	PF00069	0.605
MOD_PIKK_1	159	165	PF00454	0.593
MOD_PKA_1	159	165	PF00069	0.593
MOD_PKA_1	172	178	PF00069	0.435
MOD_PKA_2	172	178	PF00069	0.577
MOD_PKA_2	49	55	PF00069	0.655
MOD_PKB_1	157	165	PF00069	0.593
MOD_Plk_1	114	120	PF00069	0.602
MOD_Plk_1	15	21	PF00069	0.675
MOD_Plk_4	15	21	PF00069	0.579
MOD_ProDKin_1	54	60	PF00069	0.649
MOD_ProDKin_1	97	103	PF00069	0.762
MOD_SUMO_for_1	70	73	PF00179	0.483
MOD_SUMO_for_1	86	89	PF00179	0.658
TRG_DiLeu_BaEn_1	115	120	PF01217	0.601
TRG_DiLeu_LyEn_5	115	120	PF01217	0.601
TRG_ER_diArg_1	122	124	PF00400	0.594
TRG_ER_diArg_1	183	186	PF00400	0.590
TRG_ER_diArg_1	49	51	PF00400	0.644
TRG_ER_diArg_1	8	11	PF00400	0.557
TRG_NLS_MonoExtC_3	155	160	PF00514	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
D0A0L7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	72%