LeishMANIAdb
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Plastid-encoded RNA polymerase subunit alpha

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Plastid-encoded RNA polymerase subunit alpha
Gene product:
DNA-directed RNA polymerases I and III subunit RPAC1 - putative
Species:
Leishmania infantum
UniProt:
A4HY87_LEIIN
TriTrypDb:
LINF_190011500
Length:
442

Annotations

Annotations by Jardim et al.

Polymerase, DNA-directed RNA polymerase, alpha subunit

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0000428 DNA-directed RNA polymerase complex 4 12
GO:0030880 RNA polymerase complex 3 12
GO:0032991 protein-containing complex 1 12
GO:0061695 transferase complex, transferring phosphorus-containing groups 4 12
GO:0140535 intracellular protein-containing complex 2 12
GO:1902494 catalytic complex 2 12
GO:1990234 transferase complex 3 12
GO:0005634 nucleus 5 1
GO:0005666 RNA polymerase III complex 4 1
GO:0005730 nucleolus 5 1
GO:0005736 RNA polymerase I complex 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0055029 nuclear DNA-directed RNA polymerase complex 3 1
GO:0110165 cellular anatomical entity 1 1
GO:0140513 nuclear protein-containing complex 2 1

Expansion

Sequence features

A4HY87
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY87

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006351 DNA-templated transcription 7 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0009058 biosynthetic process 2 1
GO:0009059 macromolecule biosynthetic process 4 1
GO:0009987 cellular process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0018130 heterocycle biosynthetic process 4 1
GO:0019438 aromatic compound biosynthetic process 4 1
GO:0032774 RNA biosynthetic process 5 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034654 nucleobase-containing compound biosynthetic process 4 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:0097659 nucleic acid-templated transcription 6 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1901362 organic cyclic compound biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
Molecular functions
Term Name Level Count
GO:0001054 RNA polymerase I activity 7 12
GO:0001056 RNA polymerase III activity 7 12
GO:0003824 catalytic activity 1 12
GO:0003899 DNA-directed 5'-3' RNA polymerase activity 6 12
GO:0005488 binding 1 12
GO:0005515 protein binding 2 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016779 nucleotidyltransferase activity 4 12
GO:0034062 5'-3' RNA polymerase activity 5 12
GO:0046983 protein dimerization activity 3 12
GO:0097747 RNA polymerase activity 4 12
GO:0140098 catalytic activity, acting on RNA 3 12
GO:0140640 catalytic activity, acting on a nucleic acid 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 105 109 PF00656 0.651
CLV_C14_Caspase3-7 154 158 PF00656 0.429
CLV_NRD_NRD_1 115 117 PF00675 0.460
CLV_NRD_NRD_1 136 138 PF00675 0.229
CLV_NRD_NRD_1 5 7 PF00675 0.723
CLV_PCSK_KEX2_1 115 117 PF00082 0.456
CLV_PCSK_KEX2_1 136 138 PF00082 0.229
CLV_PCSK_KEX2_1 5 7 PF00082 0.723
CLV_PCSK_KEX2_1 73 75 PF00082 0.700
CLV_PCSK_PC1ET2_1 73 75 PF00082 0.731
CLV_PCSK_SKI1_1 136 140 PF00082 0.256
CLV_PCSK_SKI1_1 199 203 PF00082 0.258
DEG_APCC_DBOX_1 167 175 PF00400 0.440
DEG_APCC_DBOX_1 198 206 PF00400 0.472
DEG_APCC_DBOX_1 283 291 PF00400 0.429
DEG_SCF_FBW7_1 215 220 PF00400 0.497
DEG_SPOP_SBC_1 38 42 PF00917 0.672
DOC_ANK_TNKS_1 103 110 PF00023 0.653
DOC_CYCLIN_RxL_1 196 206 PF00134 0.440
DOC_MAPK_gen_1 115 122 PF00069 0.411
DOC_MAPK_gen_1 284 292 PF00069 0.429
DOC_MAPK_gen_1 3 13 PF00069 0.702
DOC_MAPK_gen_1 383 393 PF00069 0.450
DOC_PIKK_1 156 164 PF02985 0.526
DOC_PP1_RVXF_1 197 204 PF00149 0.429
DOC_PP1_RVXF_1 219 226 PF00149 0.491
DOC_USP7_MATH_1 31 35 PF00917 0.706
DOC_USP7_MATH_1 374 378 PF00917 0.434
DOC_USP7_MATH_1 433 437 PF00917 0.545
DOC_USP7_MATH_1 47 51 PF00917 0.583
DOC_USP7_MATH_1 86 90 PF00917 0.752
DOC_USP7_MATH_1 91 95 PF00917 0.738
DOC_WW_Pin1_4 125 130 PF00397 0.465
DOC_WW_Pin1_4 155 160 PF00397 0.530
DOC_WW_Pin1_4 213 218 PF00397 0.482
DOC_WW_Pin1_4 23 28 PF00397 0.636
DOC_WW_Pin1_4 300 305 PF00397 0.425
LIG_14-3-3_CanoR_1 104 108 PF00244 0.629
LIG_14-3-3_CanoR_1 119 123 PF00244 0.288
LIG_14-3-3_CanoR_1 136 146 PF00244 0.357
LIG_14-3-3_CanoR_1 53 62 PF00244 0.580
LIG_Actin_WH2_2 272 290 PF00022 0.429
LIG_Actin_WH2_2 394 410 PF00022 0.513
LIG_APCC_ABBA_1 268 273 PF00400 0.429
LIG_APCC_ABBA_1 411 416 PF00400 0.440
LIG_BIR_II_1 1 5 PF00653 0.642
LIG_BIR_III_4 206 210 PF00653 0.526
LIG_BRCT_BRCA1_1 131 135 PF00533 0.456
LIG_Clathr_ClatBox_1 202 206 PF01394 0.495
LIG_Clathr_ClatBox_1 392 396 PF01394 0.468
LIG_EVH1_2 62 66 PF00568 0.667
LIG_FHA_1 112 118 PF00498 0.465
LIG_FHA_1 138 144 PF00498 0.507
LIG_FHA_1 19 25 PF00498 0.710
LIG_FHA_1 233 239 PF00498 0.411
LIG_FHA_1 387 393 PF00498 0.482
LIG_FHA_2 103 109 PF00498 0.616
LIG_FHA_2 242 248 PF00498 0.500
LIG_FHA_2 312 318 PF00498 0.528
LIG_FHA_2 40 46 PF00498 0.668
LIG_LIR_Gen_1 145 153 PF02991 0.495
LIG_LIR_Gen_1 191 200 PF02991 0.463
LIG_LIR_Nem_3 132 138 PF02991 0.533
LIG_LIR_Nem_3 145 151 PF02991 0.459
LIG_LIR_Nem_3 191 195 PF02991 0.463
LIG_NRBOX 160 166 PF00104 0.526
LIG_PDZ_Class_2 437 442 PF00595 0.524
LIG_SH2_SRC 30 33 PF00017 0.693
LIG_SH2_STAP1 219 223 PF00017 0.522
LIG_SH2_STAT3 219 222 PF00017 0.526
LIG_SH2_STAT5 183 186 PF00017 0.454
LIG_SH3_3 124 130 PF00018 0.495
LIG_SH3_3 171 177 PF00018 0.459
LIG_SH3_3 21 27 PF00018 0.667
LIG_SH3_3 223 229 PF00018 0.517
LIG_SH3_3 349 355 PF00018 0.495
LIG_SH3_3 41 47 PF00018 0.445
MOD_CK1_1 26 32 PF00069 0.617
MOD_CK1_1 303 309 PF00069 0.455
MOD_CK1_1 34 40 PF00069 0.614
MOD_CK1_1 436 442 PF00069 0.547
MOD_CK1_1 89 95 PF00069 0.648
MOD_CK2_1 241 247 PF00069 0.400
MOD_CK2_1 311 317 PF00069 0.531
MOD_CK2_1 322 328 PF00069 0.528
MOD_GlcNHglycan 257 261 PF01048 0.362
MOD_GlcNHglycan 305 308 PF01048 0.254
MOD_GlcNHglycan 324 327 PF01048 0.164
MOD_GlcNHglycan 33 36 PF01048 0.592
MOD_GlcNHglycan 434 438 PF01048 0.623
MOD_GlcNHglycan 55 58 PF01048 0.481
MOD_GlcNHglycan 82 85 PF01048 0.707
MOD_GlcNHglycan 89 92 PF01048 0.759
MOD_GSK3_1 125 132 PF00069 0.536
MOD_GSK3_1 138 145 PF00069 0.459
MOD_GSK3_1 18 25 PF00069 0.605
MOD_GSK3_1 184 191 PF00069 0.479
MOD_GSK3_1 213 220 PF00069 0.435
MOD_GSK3_1 26 33 PF00069 0.626
MOD_GSK3_1 34 41 PF00069 0.614
MOD_GSK3_1 78 85 PF00069 0.724
MOD_GSK3_1 86 93 PF00069 0.651
MOD_GSK3_1 98 105 PF00069 0.622
MOD_N-GLC_1 125 130 PF02516 0.307
MOD_N-GLC_1 155 160 PF02516 0.254
MOD_NEK2_1 205 210 PF00069 0.488
MOD_NEK2_1 322 327 PF00069 0.492
MOD_NEK2_1 330 335 PF00069 0.490
MOD_PKA_2 103 109 PF00069 0.666
MOD_PKA_2 118 124 PF00069 0.364
MOD_PKA_2 320 326 PF00069 0.533
MOD_Plk_1 386 392 PF00069 0.454
MOD_Plk_2-3 118 124 PF00069 0.308
MOD_Plk_4 348 354 PF00069 0.513
MOD_Plk_4 91 97 PF00069 0.699
MOD_ProDKin_1 125 131 PF00069 0.465
MOD_ProDKin_1 155 161 PF00069 0.530
MOD_ProDKin_1 213 219 PF00069 0.482
MOD_ProDKin_1 23 29 PF00069 0.638
MOD_ProDKin_1 300 306 PF00069 0.425
MOD_SUMO_for_1 72 75 PF00179 0.649
MOD_SUMO_rev_2 306 315 PF00179 0.440
MOD_SUMO_rev_2 363 372 PF00179 0.445
TRG_ENDOCYTIC_2 309 312 PF00928 0.526
TRG_ER_diArg_1 115 117 PF00400 0.461
TRG_ER_diArg_1 135 137 PF00400 0.320
TRG_ER_diArg_1 381 384 PF00400 0.507
TRG_ER_diArg_1 4 6 PF00400 0.581
TRG_Pf-PMV_PEXEL_1 137 142 PF00026 0.285
TRG_Pf-PMV_PEXEL_1 150 154 PF00026 0.188
TRG_Pf-PMV_PEXEL_1 199 204 PF00026 0.240
TRG_Pf-PMV_PEXEL_1 419 423 PF00026 0.508

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8L4 Leptomonas seymouri 74% 99%
A0A0N1I3K4 Leptomonas seymouri 24% 100%
A0A0S4IYI3 Bodo saltans 45% 100%
A0A1X0NZD0 Trypanosomatidae 25% 100%
A0A1X0P6H8 Trypanosomatidae 52% 100%
A0A3R7MJ28 Trypanosoma rangeli 49% 100%
A0A3S5H758 Leishmania donovani 100% 100%
A0A3S7X218 Leishmania donovani 27% 100%
A0A422NUV2 Trypanosoma rangeli 26% 100%
A4HA24 Leishmania braziliensis 84% 100%
A4HH22 Leishmania braziliensis 26% 100%
A4I451 Leishmania infantum 27% 100%
D0A0L6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
E9ADL6 Leishmania major 27% 100%
E9AM65 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9AS18 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 98%
O15160 Homo sapiens 29% 100%
O94616 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 32% 100%
P07703 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 29% 100%
P16925 Tetrahymena thermophila 25% 100%
P52432 Mus musculus 30% 100%
Q32L22 Bos taurus 30% 100%
Q39211 Arabidopsis thaliana 27% 100%
Q39212 Arabidopsis thaliana 27% 100%
Q4QDF5 Leishmania major 94% 100%
Q54DH7 Dictyostelium discoideum 27% 100%
Q54SN4 Dictyostelium discoideum 28% 100%
V5BBX7 Trypanosoma cruzi 48% 100%
V5BUI6 Trypanosoma cruzi 26% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS