LeishMANIAdb
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Putative extracellular receptor

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative extracellular receptor
Gene product:
extracellular receptor - putative
Species:
Leishmania infantum
UniProt:
A4HY85_LEIIN
TriTrypDb:
LINF_190011300
Length:
918

Annotations

Annotations by Jardim et al.

Receptors, extracellular receptor

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 2, no: 8
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

A4HY85
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY85

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0004888 transmembrane signaling receptor activity 3 4
GO:0004930 G protein-coupled receptor activity 4 4
GO:0004965 G protein-coupled GABA receptor activity 5 2
GO:0016917 GABA receptor activity 4 2
GO:0038023 signaling receptor activity 2 4
GO:0060089 molecular transducer activity 1 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 199 203 PF00656 0.292
CLV_C14_Caspase3-7 779 783 PF00656 0.262
CLV_C14_Caspase3-7 846 850 PF00656 0.354
CLV_NRD_NRD_1 10 12 PF00675 0.369
CLV_NRD_NRD_1 261 263 PF00675 0.611
CLV_NRD_NRD_1 271 273 PF00675 0.567
CLV_NRD_NRD_1 717 719 PF00675 0.420
CLV_PCSK_FUR_1 269 273 PF00082 0.534
CLV_PCSK_KEX2_1 10 12 PF00082 0.369
CLV_PCSK_KEX2_1 261 263 PF00082 0.546
CLV_PCSK_KEX2_1 271 273 PF00082 0.505
CLV_PCSK_SKI1_1 176 180 PF00082 0.438
CLV_PCSK_SKI1_1 433 437 PF00082 0.447
CLV_PCSK_SKI1_1 912 916 PF00082 0.414
DEG_APCC_DBOX_1 175 183 PF00400 0.244
DEG_APCC_DBOX_1 282 290 PF00400 0.283
DEG_APCC_DBOX_1 53 61 PF00400 0.234
DEG_SPOP_SBC_1 230 234 PF00917 0.469
DOC_CDC14_PxL_1 286 294 PF14671 0.277
DOC_CYCLIN_yCln2_LP_2 108 114 PF00134 0.276
DOC_CYCLIN_yCln2_LP_2 633 639 PF00134 0.209
DOC_CYCLIN_yCln2_LP_2 83 89 PF00134 0.273
DOC_MAPK_gen_1 269 279 PF00069 0.295
DOC_MAPK_gen_1 680 689 PF00069 0.233
DOC_MAPK_gen_1 8 17 PF00069 0.412
DOC_MAPK_HePTP_8 622 634 PF00069 0.253
DOC_MAPK_MEF2A_6 625 634 PF00069 0.225
DOC_MAPK_MEF2A_6 821 828 PF00069 0.269
DOC_PP4_FxxP_1 523 526 PF00568 0.252
DOC_USP7_MATH_1 124 128 PF00917 0.290
DOC_USP7_MATH_1 148 152 PF00917 0.277
DOC_USP7_MATH_1 207 211 PF00917 0.325
DOC_USP7_MATH_1 273 277 PF00917 0.263
DOC_USP7_MATH_1 3 7 PF00917 0.596
DOC_USP7_MATH_1 375 379 PF00917 0.412
DOC_USP7_MATH_1 440 444 PF00917 0.260
DOC_USP7_MATH_1 670 674 PF00917 0.291
DOC_USP7_MATH_1 9 13 PF00917 0.568
DOC_USP7_MATH_2 314 320 PF00917 0.279
DOC_USP7_UBL2_3 621 625 PF12436 0.220
DOC_WW_Pin1_4 309 314 PF00397 0.297
DOC_WW_Pin1_4 427 432 PF00397 0.271
DOC_WW_Pin1_4 438 443 PF00397 0.241
DOC_WW_Pin1_4 514 519 PF00397 0.213
DOC_WW_Pin1_4 736 741 PF00397 0.294
DOC_WW_Pin1_4 820 825 PF00397 0.289
DOC_WW_Pin1_4 858 863 PF00397 0.357
LIG_14-3-3_CanoR_1 10 17 PF00244 0.411
LIG_14-3-3_CanoR_1 272 278 PF00244 0.330
LIG_14-3-3_CanoR_1 499 504 PF00244 0.213
LIG_14-3-3_CanoR_1 54 62 PF00244 0.287
LIG_14-3-3_CanoR_1 586 591 PF00244 0.253
LIG_14-3-3_CanoR_1 647 655 PF00244 0.220
LIG_14-3-3_CanoR_1 718 727 PF00244 0.256
LIG_14-3-3_CanoR_1 777 784 PF00244 0.221
LIG_Actin_WH2_2 419 435 PF00022 0.277
LIG_BRCT_BRCA1_1 115 119 PF00533 0.304
LIG_BRCT_BRCA1_1 318 322 PF00533 0.292
LIG_BRCT_BRCA1_1 452 456 PF00533 0.228
LIG_BRCT_BRCA1_1 810 814 PF00533 0.342
LIG_BRCT_BRCA1_1 854 858 PF00533 0.344
LIG_Clathr_ClatBox_1 346 350 PF01394 0.314
LIG_deltaCOP1_diTrp_1 830 835 PF00928 0.255
LIG_DLG_GKlike_1 848 856 PF00625 0.288
LIG_EH_1 634 638 PF12763 0.220
LIG_EH1_1 885 893 PF00400 0.520
LIG_eIF4E_1 886 892 PF01652 0.484
LIG_FHA_1 103 109 PF00498 0.327
LIG_FHA_1 121 127 PF00498 0.214
LIG_FHA_1 138 144 PF00498 0.264
LIG_FHA_1 216 222 PF00498 0.320
LIG_FHA_1 258 264 PF00498 0.395
LIG_FHA_1 291 297 PF00498 0.400
LIG_FHA_1 369 375 PF00498 0.247
LIG_FHA_1 401 407 PF00498 0.287
LIG_FHA_1 421 427 PF00498 0.240
LIG_FHA_1 432 438 PF00498 0.242
LIG_FHA_1 515 521 PF00498 0.212
LIG_FHA_1 536 542 PF00498 0.327
LIG_FHA_1 602 608 PF00498 0.262
LIG_FHA_1 65 71 PF00498 0.338
LIG_FHA_1 873 879 PF00498 0.266
LIG_FHA_2 137 143 PF00498 0.283
LIG_FHA_2 231 237 PF00498 0.303
LIG_FHA_2 327 333 PF00498 0.408
LIG_FHA_2 54 60 PF00498 0.252
LIG_FHA_2 553 559 PF00498 0.259
LIG_FHA_2 575 581 PF00498 0.220
LIG_FHA_2 612 618 PF00498 0.220
LIG_FHA_2 694 700 PF00498 0.199
LIG_FHA_2 704 710 PF00498 0.211
LIG_FHA_2 711 717 PF00498 0.203
LIG_FHA_2 777 783 PF00498 0.233
LIG_FHA_2 844 850 PF00498 0.334
LIG_FHA_2 902 908 PF00498 0.531
LIG_GBD_Chelix_1 44 52 PF00786 0.501
LIG_LIR_Apic_2 309 314 PF02991 0.315
LIG_LIR_Apic_2 522 526 PF02991 0.239
LIG_LIR_Gen_1 19 29 PF02991 0.212
LIG_LIR_Gen_1 378 388 PF02991 0.297
LIG_LIR_Gen_1 555 564 PF02991 0.226
LIG_LIR_Gen_1 620 631 PF02991 0.294
LIG_LIR_Gen_1 747 756 PF02991 0.224
LIG_LIR_Gen_1 829 836 PF02991 0.268
LIG_LIR_Nem_3 113 117 PF02991 0.329
LIG_LIR_Nem_3 19 25 PF02991 0.212
LIG_LIR_Nem_3 332 337 PF02991 0.283
LIG_LIR_Nem_3 378 384 PF02991 0.308
LIG_LIR_Nem_3 385 391 PF02991 0.240
LIG_LIR_Nem_3 471 477 PF02991 0.274
LIG_LIR_Nem_3 543 547 PF02991 0.237
LIG_LIR_Nem_3 555 559 PF02991 0.219
LIG_LIR_Nem_3 620 626 PF02991 0.286
LIG_LIR_Nem_3 643 648 PF02991 0.253
LIG_LIR_Nem_3 649 654 PF02991 0.231
LIG_LIR_Nem_3 739 744 PF02991 0.234
LIG_LIR_Nem_3 747 753 PF02991 0.210
LIG_LIR_Nem_3 829 834 PF02991 0.311
LIG_LYPXL_S_1 689 693 PF13949 0.420
LIG_LYPXL_yS_3 690 693 PF13949 0.220
LIG_NRBOX 24 30 PF00104 0.212
LIG_NRBOX 338 344 PF00104 0.303
LIG_OCRL_FandH_1 880 892 PF00620 0.331
LIG_PDZ_Class_3 913 918 PF00595 0.627
LIG_Pex14_1 303 307 PF04695 0.249
LIG_Pex14_2 814 818 PF04695 0.241
LIG_PTB_Apo_2 194 201 PF02174 0.285
LIG_PTB_Apo_2 531 538 PF02174 0.277
LIG_PTB_Apo_2 78 85 PF02174 0.255
LIG_PTB_Phospho_1 194 200 PF10480 0.286
LIG_REV1ctd_RIR_1 643 651 PF16727 0.400
LIG_SH2_CRK 311 315 PF00017 0.317
LIG_SH2_CRK 623 627 PF00017 0.286
LIG_SH2_GRB2like 79 82 PF00017 0.343
LIG_SH2_NCK_1 311 315 PF00017 0.285
LIG_SH2_PTP2 750 753 PF00017 0.294
LIG_SH2_SRC 600 603 PF00017 0.215
LIG_SH2_STAP1 189 193 PF00017 0.269
LIG_SH2_STAP1 409 413 PF00017 0.379
LIG_SH2_STAP1 623 627 PF00017 0.250
LIG_SH2_STAP1 801 805 PF00017 0.294
LIG_SH2_STAT3 654 657 PF00017 0.220
LIG_SH2_STAT3 886 889 PF00017 0.490
LIG_SH2_STAT5 311 314 PF00017 0.254
LIG_SH2_STAT5 370 373 PF00017 0.323
LIG_SH2_STAT5 536 539 PF00017 0.252
LIG_SH2_STAT5 546 549 PF00017 0.206
LIG_SH2_STAT5 600 603 PF00017 0.220
LIG_SH2_STAT5 606 609 PF00017 0.206
LIG_SH2_STAT5 651 654 PF00017 0.235
LIG_SH2_STAT5 658 661 PF00017 0.200
LIG_SH2_STAT5 705 708 PF00017 0.262
LIG_SH2_STAT5 750 753 PF00017 0.231
LIG_SH2_STAT5 775 778 PF00017 0.294
LIG_SH2_STAT5 79 82 PF00017 0.323
LIG_SH2_STAT5 880 883 PF00017 0.426
LIG_SH3_3 394 400 PF00018 0.258
LIG_SH3_5 526 530 PF00018 0.253
LIG_SUMO_SIM_anti_2 102 109 PF11976 0.330
LIG_SUMO_SIM_anti_2 12 19 PF11976 0.227
LIG_SUMO_SIM_anti_2 138 147 PF11976 0.283
LIG_SUMO_SIM_anti_2 571 578 PF11976 0.213
LIG_SUMO_SIM_anti_2 628 634 PF11976 0.233
LIG_SUMO_SIM_par_1 104 109 PF11976 0.298
LIG_SUMO_SIM_par_1 12 19 PF11976 0.193
LIG_SUMO_SIM_par_1 138 147 PF11976 0.356
LIG_SUMO_SIM_par_1 177 183 PF11976 0.315
LIG_SUMO_SIM_par_1 344 350 PF11976 0.311
LIG_SUMO_SIM_par_1 477 483 PF11976 0.259
LIG_SUMO_SIM_par_1 571 578 PF11976 0.253
LIG_SUMO_SIM_par_1 87 93 PF11976 0.289
LIG_SxIP_EBH_1 488 499 PF03271 0.309
LIG_TRAF2_1 713 716 PF00917 0.363
LIG_TRAF2_1 904 907 PF00917 0.545
LIG_TYR_ITIM 379 384 PF00017 0.292
LIG_UBA3_1 346 353 PF00899 0.243
LIG_WRC_WIRS_1 844 849 PF05994 0.343
MOD_CDC14_SPxK_1 430 433 PF00782 0.256
MOD_CDK_SPxK_1 427 433 PF00069 0.269
MOD_CK1_1 147 153 PF00069 0.273
MOD_CK1_1 282 288 PF00069 0.305
MOD_CK1_1 309 315 PF00069 0.283
MOD_CK1_1 389 395 PF00069 0.260
MOD_CK1_1 53 59 PF00069 0.320
MOD_CK1_1 589 595 PF00069 0.412
MOD_CK1_1 729 735 PF00069 0.260
MOD_CK1_1 736 742 PF00069 0.221
MOD_CK1_1 820 826 PF00069 0.281
MOD_CK2_1 53 59 PF00069 0.320
MOD_CK2_1 693 699 PF00069 0.190
MOD_CK2_1 710 716 PF00069 0.211
MOD_CK2_1 725 731 PF00069 0.186
MOD_CK2_1 901 907 PF00069 0.537
MOD_GlcNHglycan 11 14 PF01048 0.206
MOD_GlcNHglycan 125 129 PF01048 0.487
MOD_GlcNHglycan 146 149 PF01048 0.462
MOD_GlcNHglycan 308 311 PF01048 0.554
MOD_GlcNHglycan 31 34 PF01048 0.415
MOD_GlcNHglycan 359 362 PF01048 0.489
MOD_GlcNHglycan 41 44 PF01048 0.503
MOD_GlcNHglycan 423 426 PF01048 0.574
MOD_GlcNHglycan 485 488 PF01048 0.470
MOD_GlcNHglycan 5 8 PF01048 0.386
MOD_GlcNHglycan 663 666 PF01048 0.420
MOD_GlcNHglycan 672 675 PF01048 0.400
MOD_GlcNHglycan 73 76 PF01048 0.563
MOD_GlcNHglycan 858 861 PF01048 0.566
MOD_GSK3_1 102 109 PF00069 0.285
MOD_GSK3_1 120 127 PF00069 0.235
MOD_GSK3_1 144 151 PF00069 0.274
MOD_GSK3_1 157 164 PF00069 0.305
MOD_GSK3_1 189 196 PF00069 0.252
MOD_GSK3_1 207 214 PF00069 0.380
MOD_GSK3_1 27 34 PF00069 0.212
MOD_GSK3_1 322 329 PF00069 0.407
MOD_GSK3_1 35 42 PF00069 0.496
MOD_GSK3_1 389 396 PF00069 0.249
MOD_GSK3_1 427 434 PF00069 0.300
MOD_GSK3_1 479 486 PF00069 0.244
MOD_GSK3_1 502 509 PF00069 0.260
MOD_GSK3_1 582 589 PF00069 0.219
MOD_GSK3_1 60 67 PF00069 0.326
MOD_GSK3_1 601 608 PF00069 0.185
MOD_GSK3_1 646 653 PF00069 0.281
MOD_GSK3_1 700 707 PF00069 0.385
MOD_GSK3_1 725 732 PF00069 0.215
MOD_GSK3_1 786 793 PF00069 0.229
MOD_GSK3_1 848 855 PF00069 0.305
MOD_N-GLC_1 136 141 PF02516 0.558
MOD_N-GLC_1 296 301 PF02516 0.635
MOD_N-GLC_1 357 362 PF02516 0.496
MOD_N-GLC_1 39 44 PF02516 0.580
MOD_N-GLC_1 407 412 PF02516 0.497
MOD_N-GLC_1 420 425 PF02516 0.536
MOD_N-GLC_1 467 472 PF02516 0.577
MOD_N-GLC_1 611 616 PF02516 0.457
MOD_N-GLC_1 691 696 PF02516 0.497
MOD_N-GLC_1 71 76 PF02516 0.580
MOD_N-GLC_1 762 767 PF02516 0.426
MOD_N-GLC_1 808 813 PF02516 0.476
MOD_N-GLC_1 837 842 PF02516 0.570
MOD_NEK2_1 144 149 PF00069 0.302
MOD_NEK2_1 16 21 PF00069 0.218
MOD_NEK2_1 29 34 PF00069 0.563
MOD_NEK2_1 337 342 PF00069 0.316
MOD_NEK2_1 426 431 PF00069 0.309
MOD_NEK2_1 450 455 PF00069 0.346
MOD_NEK2_1 456 461 PF00069 0.426
MOD_NEK2_1 52 57 PF00069 0.263
MOD_NEK2_1 547 552 PF00069 0.220
MOD_NEK2_1 582 587 PF00069 0.283
MOD_NEK2_1 661 666 PF00069 0.380
MOD_NEK2_1 70 75 PF00069 0.375
MOD_NEK2_1 752 757 PF00069 0.267
MOD_NEK2_1 808 813 PF00069 0.358
MOD_NEK2_1 814 819 PF00069 0.252
MOD_NEK2_1 836 841 PF00069 0.352
MOD_NEK2_1 852 857 PF00069 0.273
MOD_NEK2_1 872 877 PF00069 0.204
MOD_NEK2_2 273 278 PF00069 0.326
MOD_NEK2_2 375 380 PF00069 0.419
MOD_NEK2_2 393 398 PF00069 0.242
MOD_NEK2_2 700 705 PF00069 0.209
MOD_NEK2_2 79 84 PF00069 0.269
MOD_NEK2_2 843 848 PF00069 0.259
MOD_PIKK_1 316 322 PF00454 0.293
MOD_PIKK_1 445 451 PF00454 0.242
MOD_PIKK_1 559 565 PF00454 0.209
MOD_PIKK_1 691 697 PF00454 0.321
MOD_PIKK_1 99 105 PF00454 0.403
MOD_PK_1 777 783 PF00069 0.229
MOD_PKA_2 282 288 PF00069 0.239
MOD_PKA_2 53 59 PF00069 0.262
MOD_PKA_2 646 652 PF00069 0.220
MOD_PKA_2 776 782 PF00069 0.213
MOD_PKA_2 9 15 PF00069 0.412
MOD_PKB_1 366 374 PF00069 0.327
MOD_Plk_1 357 363 PF00069 0.312
MOD_Plk_1 58 64 PF00069 0.301
MOD_Plk_1 601 607 PF00069 0.226
MOD_Plk_1 611 617 PF00069 0.223
MOD_Plk_1 733 739 PF00069 0.215
MOD_Plk_1 762 768 PF00069 0.238
MOD_Plk_1 786 792 PF00069 0.331
MOD_Plk_1 829 835 PF00069 0.377
MOD_Plk_1 837 843 PF00069 0.419
MOD_Plk_1 848 854 PF00069 0.251
MOD_Plk_4 113 119 PF00069 0.229
MOD_Plk_4 126 132 PF00069 0.302
MOD_Plk_4 217 223 PF00069 0.316
MOD_Plk_4 239 245 PF00069 0.255
MOD_Plk_4 273 279 PF00069 0.360
MOD_Plk_4 375 381 PF00069 0.304
MOD_Plk_4 383 389 PF00069 0.230
MOD_Plk_4 469 475 PF00069 0.264
MOD_Plk_4 490 496 PF00069 0.319
MOD_Plk_4 499 505 PF00069 0.208
MOD_Plk_4 601 607 PF00069 0.273
MOD_Plk_4 641 647 PF00069 0.267
MOD_Plk_4 650 656 PF00069 0.236
MOD_Plk_4 700 706 PF00069 0.320
MOD_Plk_4 79 85 PF00069 0.302
MOD_Plk_4 809 815 PF00069 0.245
MOD_Plk_4 848 854 PF00069 0.338
MOD_ProDKin_1 309 315 PF00069 0.305
MOD_ProDKin_1 427 433 PF00069 0.268
MOD_ProDKin_1 438 444 PF00069 0.243
MOD_ProDKin_1 514 520 PF00069 0.213
MOD_ProDKin_1 736 742 PF00069 0.294
MOD_ProDKin_1 820 826 PF00069 0.284
MOD_ProDKin_1 858 864 PF00069 0.353
MOD_SUMO_rev_2 151 160 PF00179 0.291
TRG_DiLeu_BaEn_1 716 721 PF01217 0.209
TRG_DiLeu_BaEn_2 332 338 PF01217 0.307
TRG_DiLeu_BaEn_4 906 912 PF01217 0.540
TRG_ENDOCYTIC_2 334 337 PF00928 0.260
TRG_ENDOCYTIC_2 381 384 PF00928 0.274
TRG_ENDOCYTIC_2 544 547 PF00928 0.213
TRG_ENDOCYTIC_2 623 626 PF00928 0.294
TRG_ENDOCYTIC_2 658 661 PF00928 0.213
TRG_ENDOCYTIC_2 690 693 PF00928 0.220
TRG_ENDOCYTIC_2 741 744 PF00928 0.230
TRG_ENDOCYTIC_2 750 753 PF00928 0.205
TRG_ER_diArg_1 246 249 PF00400 0.399
TRG_ER_diArg_1 261 263 PF00400 0.290
TRG_ER_diArg_1 269 272 PF00400 0.304
TRG_ER_diArg_1 9 11 PF00400 0.578
TRG_NES_CRM1_1 171 185 PF08389 0.284
TRG_Pf-PMV_PEXEL_1 176 180 PF00026 0.519
TRG_Pf-PMV_PEXEL_1 718 723 PF00026 0.480
TRG_Pf-PMV_PEXEL_1 912 916 PF00026 0.358

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMK8 Leptomonas seymouri 66% 93%
A0A0S4ITA9 Bodo saltans 36% 100%
A0A1X0P7Q8 Trypanosomatidae 43% 100%
A0A3S7WVK2 Leishmania donovani 100% 100%
A0A422NN34 Trypanosoma rangeli 40% 100%
A4HA22 Leishmania braziliensis 80% 100%
E9AS16 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4QDF7 Leishmania major 96% 100%
V5C1V3 Trypanosoma cruzi 43% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS