Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HY82_LEIIN

TriTrypDb:

LINF_190011000

Length:

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 2
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	1
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	6
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HY82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY82

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_Nend_UBRbox_3	1	3	PF02207	0.479
LIG_Clathr_ClatBox_1	79	83	PF01394	0.523
LIG_eIF4E_1	74	80	PF01652	0.493
LIG_FHA_1	1	7	PF00498	0.454
LIG_FHA_1	36	42	PF00498	0.524
LIG_LIR_Apic_2	29	35	PF02991	0.535
LIG_LIR_Gen_1	54	63	PF02991	0.430
LIG_LIR_Nem_3	54	58	PF02991	0.431
LIG_SH2_PTP2	32	35	PF00017	0.520
LIG_SH2_SRC	48	51	PF00017	0.447
LIG_SH2_STAT5	32	35	PF00017	0.520
LIG_SH2_STAT5	48	51	PF00017	0.450
LIG_SH3_3	79	85	PF00018	0.581
LIG_SUMO_SIM_par_1	75	83	PF11976	0.509
LIG_WRC_WIRS_1	52	57	PF05994	0.489
MOD_CK1_1	26	32	PF00069	0.567
MOD_CK2_1	40	46	PF00069	0.525
MOD_GlcNHglycan	25	28	PF01048	0.546
MOD_GSK3_1	35	42	PF00069	0.525
MOD_N-GLC_1	1	6	PF02516	0.423
MOD_NEK2_1	1	6	PF00069	0.446
MOD_NEK2_1	17	22	PF00069	0.484
MOD_Plk_1	1	7	PF00069	0.420
MOD_Plk_1	75	81	PF00069	0.498
MOD_Plk_4	28	34	PF00069	0.579
MOD_Plk_4	65	71	PF00069	0.585
MOD_Plk_4	75	81	PF00069	0.478
MOD_SUMO_rev_2	26	31	PF00179	0.474

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1K0	Leptomonas seymouri	66%	100%
A0A0S4ITJ3	Bodo saltans	36%	100%
A0A3Q8IA80	Leishmania donovani	100%	100%
A4HA19	Leishmania braziliensis	68%	100%
E9AS13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QDG0	Leishmania major	87%	100%