LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HY78_LEIIN
TriTrypDb:
LINF_190010500
Length:
518

Annotations

LeishMANIAdb annotations

Belongs to a poorly known protein family found in basal Eukaryota (also containing A0A0A1U905_ENTIV, A0A0A1U245_ENTIV). Very distantly related to animal prominins.. The first TM segment can equally be a signal peptide, with no change in overall topology. If related to prominins, this massively expanded family could play a role in vesicular processes.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 9
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 18, no: 1
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0016020 membrane 2 17
GO:0110165 cellular anatomical entity 1 17

Expansion

Sequence features

A4HY78
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY78

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 513 515 PF00675 0.533
CLV_PCSK_SKI1_1 3 7 PF00082 0.657
CLV_PCSK_SKI1_1 367 371 PF00082 0.653
DOC_CKS1_1 171 176 PF01111 0.365
DOC_MAPK_gen_1 202 211 PF00069 0.452
DOC_MAPK_gen_1 95 104 PF00069 0.609
DOC_MAPK_MEF2A_6 106 115 PF00069 0.587
DOC_MAPK_MEF2A_6 496 504 PF00069 0.565
DOC_USP7_MATH_1 25 29 PF00917 0.516
DOC_USP7_MATH_1 421 425 PF00917 0.467
DOC_USP7_UBL2_3 382 386 PF12436 0.349
DOC_WW_Pin1_4 170 175 PF00397 0.475
LIG_14-3-3_CanoR_1 157 163 PF00244 0.396
LIG_14-3-3_CanoR_1 464 471 PF00244 0.388
LIG_14-3-3_CanoR_1 53 62 PF00244 0.459
LIG_BIR_II_1 1 5 PF00653 0.570
LIG_EH1_1 219 227 PF00400 0.427
LIG_EH1_1 479 487 PF00400 0.380
LIG_FHA_1 159 165 PF00498 0.466
LIG_FHA_1 188 194 PF00498 0.433
LIG_FHA_1 2 8 PF00498 0.646
LIG_FHA_1 258 264 PF00498 0.496
LIG_FHA_1 369 375 PF00498 0.429
LIG_FHA_1 406 412 PF00498 0.405
LIG_FHA_1 49 55 PF00498 0.452
LIG_FHA_2 456 462 PF00498 0.476
LIG_GBD_Chelix_1 250 258 PF00786 0.390
LIG_LIR_Apic_2 363 368 PF02991 0.404
LIG_LIR_Apic_2 428 432 PF02991 0.394
LIG_LIR_Apic_2 91 96 PF02991 0.614
LIG_LIR_Gen_1 180 189 PF02991 0.381
LIG_LIR_Gen_1 190 200 PF02991 0.395
LIG_LIR_Gen_1 297 305 PF02991 0.434
LIG_LIR_Nem_3 144 150 PF02991 0.496
LIG_LIR_Nem_3 180 185 PF02991 0.381
LIG_LIR_Nem_3 190 195 PF02991 0.362
LIG_LIR_Nem_3 242 248 PF02991 0.345
LIG_LIR_Nem_3 297 301 PF02991 0.462
LIG_LIR_Nem_3 428 434 PF02991 0.494
LIG_LIR_Nem_3 56 61 PF02991 0.388
LIG_LYPXL_S_1 62 66 PF13949 0.562
LIG_Pex14_1 241 245 PF04695 0.614
LIG_Pex14_2 248 252 PF04695 0.400
LIG_SH2_CRK 129 133 PF00017 0.447
LIG_SH2_GRB2like 152 155 PF00017 0.399
LIG_SH2_PTP2 192 195 PF00017 0.490
LIG_SH2_PTP2 365 368 PF00017 0.407
LIG_SH2_PTP2 429 432 PF00017 0.452
LIG_SH2_PTP2 93 96 PF00017 0.609
LIG_SH2_SRC 61 64 PF00017 0.434
LIG_SH2_STAP1 409 413 PF00017 0.464
LIG_SH2_STAT3 409 412 PF00017 0.366
LIG_SH2_STAT5 152 155 PF00017 0.378
LIG_SH2_STAT5 192 195 PF00017 0.394
LIG_SH2_STAT5 200 203 PF00017 0.377
LIG_SH2_STAT5 245 248 PF00017 0.370
LIG_SH2_STAT5 264 267 PF00017 0.308
LIG_SH2_STAT5 287 290 PF00017 0.345
LIG_SH2_STAT5 365 368 PF00017 0.457
LIG_SH2_STAT5 383 386 PF00017 0.404
LIG_SH2_STAT5 429 432 PF00017 0.439
LIG_SH2_STAT5 462 465 PF00017 0.527
LIG_SH2_STAT5 61 64 PF00017 0.375
LIG_SH2_STAT5 93 96 PF00017 0.609
LIG_SH3_3 168 174 PF00018 0.488
LIG_SUMO_SIM_anti_2 355 364 PF11976 0.464
LIG_TRFH_1 60 64 PF08558 0.468
LIG_TYR_ITIM 127 132 PF00017 0.501
LIG_Vh1_VBS_1 1 19 PF01044 0.410
MOD_CK1_1 391 397 PF00069 0.417
MOD_CK1_1 40 46 PF00069 0.434
MOD_CK1_1 454 460 PF00069 0.559
MOD_CK2_1 40 46 PF00069 0.492
MOD_CK2_1 85 91 PF00069 0.738
MOD_GlcNHglycan 167 170 PF01048 0.666
MOD_GlcNHglycan 178 182 PF01048 0.609
MOD_GlcNHglycan 23 26 PF01048 0.641
MOD_GlcNHglycan 233 236 PF01048 0.504
MOD_GlcNHglycan 266 269 PF01048 0.639
MOD_GlcNHglycan 314 317 PF01048 0.638
MOD_GlcNHglycan 466 469 PF01048 0.673
MOD_GSK3_1 142 149 PF00069 0.492
MOD_GSK3_1 158 165 PF00069 0.369
MOD_GSK3_1 173 180 PF00069 0.417
MOD_GSK3_1 21 28 PF00069 0.516
MOD_GSK3_1 346 353 PF00069 0.453
MOD_GSK3_1 36 43 PF00069 0.355
MOD_GSK3_1 421 428 PF00069 0.392
MOD_GSK3_1 451 458 PF00069 0.505
MOD_N-GLC_1 153 158 PF02516 0.562
MOD_N-GLC_1 165 170 PF02516 0.585
MOD_N-GLC_1 187 192 PF02516 0.626
MOD_N-GLC_1 328 333 PF02516 0.640
MOD_N-GLC_1 376 381 PF02516 0.743
MOD_N-GLC_1 40 45 PF02516 0.676
MOD_N-GLC_1 421 426 PF02516 0.576
MOD_N-GLC_1 452 457 PF02516 0.672
MOD_N-GLC_2 322 324 PF02516 0.573
MOD_NEK2_1 1 6 PF00069 0.674
MOD_NEK2_1 153 158 PF00069 0.456
MOD_NEK2_1 162 167 PF00069 0.446
MOD_NEK2_1 18 23 PF00069 0.560
MOD_NEK2_1 370 375 PF00069 0.440
MOD_NEK2_1 475 480 PF00069 0.394
MOD_NEK2_1 510 515 PF00069 0.631
MOD_NEK2_1 71 76 PF00069 0.439
MOD_OFUCOSY 237 243 PF10250 0.428
MOD_OFUCOSY 387 392 PF10250 0.572
MOD_OFUCOSY 83 89 PF10250 0.571
MOD_PIKK_1 304 310 PF00454 0.490
MOD_PIKK_1 346 352 PF00454 0.447
MOD_PIKK_1 455 461 PF00454 0.468
MOD_PIKK_1 53 59 PF00454 0.453
MOD_PK_1 407 413 PF00069 0.353
MOD_PK_1 470 476 PF00069 0.365
MOD_PKA_2 231 237 PF00069 0.629
MOD_PKA_2 469 475 PF00069 0.427
MOD_Plk_1 158 164 PF00069 0.442
MOD_Plk_1 177 183 PF00069 0.386
MOD_Plk_1 187 193 PF00069 0.424
MOD_Plk_1 328 334 PF00069 0.425
MOD_Plk_1 40 46 PF00069 0.473
MOD_Plk_1 452 458 PF00069 0.489
MOD_Plk_2-3 146 152 PF00069 0.497
MOD_Plk_4 128 134 PF00069 0.388
MOD_Plk_4 187 193 PF00069 0.365
MOD_Plk_4 361 367 PF00069 0.373
MOD_Plk_4 40 46 PF00069 0.408
MOD_Plk_4 425 431 PF00069 0.428
MOD_Plk_4 470 476 PF00069 0.329
MOD_ProDKin_1 170 176 PF00069 0.477
MOD_SUMO_for_1 96 99 PF00179 0.623
TRG_DiLeu_BaLyEn_6 429 434 PF01217 0.383
TRG_ENDOCYTIC_2 129 132 PF00928 0.420
TRG_ENDOCYTIC_2 147 150 PF00928 0.497
TRG_ENDOCYTIC_2 192 195 PF00928 0.460
TRG_ENDOCYTIC_2 245 248 PF00928 0.335
TRG_ENDOCYTIC_2 399 402 PF00928 0.353
TRG_ENDOCYTIC_2 63 66 PF00928 0.327
TRG_Pf-PMV_PEXEL_1 27 32 PF00026 0.641

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8Y8 Leptomonas seymouri 54% 100%
A0A0S4IXB1 Bodo saltans 28% 100%
A0A0S4IXU4 Bodo saltans 28% 98%
A0A1X0NVP9 Trypanosomatidae 39% 100%
A0A1X0NWC8 Trypanosomatidae 36% 100%
A0A1X0P6A6 Trypanosomatidae 31% 100%
A0A3Q8IB78 Leishmania donovani 99% 100%
A0A3S7WVB2 Leishmania donovani 95% 98%
A0A422N059 Trypanosoma rangeli 38% 100%
A4HA16 Leishmania braziliensis 73% 100%
A4HY79 Leishmania infantum 95% 98%
C9ZWF5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 95%
D0A5X9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 91%
E9AS08 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
E9AS09 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4QDG4 Leishmania major 87% 100%
Q4QDG5 Leishmania major 89% 100%
V5C1U9 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS