LeishMANIAdb
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Methionine aminopeptidase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Methionine aminopeptidase
Gene product:
metallo- peptidase - Clan MG - Family M24
Species:
Leishmania infantum
UniProt:
A4HY76_LEIIN
TriTrypDb:
LINF_190010300
Length:
401

Annotations

Annotations by Jardim et al.

Proteases, methionine aminopeptidase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 1
GO:0005829 cytosol 2 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HY76
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY76

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 13
GO:0006807 nitrogen compound metabolic process 2 13
GO:0008152 metabolic process 1 13
GO:0019538 protein metabolic process 3 13
GO:0036211 protein modification process 4 13
GO:0043170 macromolecule metabolic process 3 13
GO:0043412 macromolecule modification 4 13
GO:0044238 primary metabolic process 2 13
GO:0070084 protein initiator methionine removal 5 13
GO:0071704 organic substance metabolic process 2 13
GO:1901564 organonitrogen compound metabolic process 3 13
GO:0016485 protein processing 5 1
GO:0035551 protein initiator methionine removal involved in protein maturation 6 1
GO:0051604 protein maturation 4 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 13
GO:0004177 aminopeptidase activity 5 13
GO:0005488 binding 1 13
GO:0008233 peptidase activity 3 13
GO:0008235 metalloexopeptidase activity 5 13
GO:0008237 metallopeptidase activity 4 13
GO:0008238 exopeptidase activity 4 13
GO:0016787 hydrolase activity 2 13
GO:0043167 ion binding 2 13
GO:0043169 cation binding 3 13
GO:0046872 metal ion binding 4 13
GO:0070006 metalloaminopeptidase activity 6 13
GO:0140096 catalytic activity, acting on a protein 2 13

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 338 342 PF00656 0.275
CLV_C14_Caspase3-7 372 376 PF00656 0.376
CLV_C14_Caspase3-7 94 98 PF00656 0.456
CLV_NRD_NRD_1 130 132 PF00675 0.529
CLV_NRD_NRD_1 80 82 PF00675 0.403
CLV_PCSK_KEX2_1 130 132 PF00082 0.532
CLV_PCSK_KEX2_1 139 141 PF00082 0.365
CLV_PCSK_KEX2_1 175 177 PF00082 0.198
CLV_PCSK_KEX2_1 351 353 PF00082 0.255
CLV_PCSK_KEX2_1 80 82 PF00082 0.403
CLV_PCSK_PC1ET2_1 139 141 PF00082 0.398
CLV_PCSK_PC1ET2_1 175 177 PF00082 0.198
CLV_PCSK_PC1ET2_1 351 353 PF00082 0.269
CLV_PCSK_SKI1_1 146 150 PF00082 0.255
DOC_CKS1_1 361 366 PF01111 0.398
DOC_CYCLIN_RxL_1 16 26 PF00134 0.433
DOC_MAPK_gen_1 130 138 PF00069 0.459
DOC_MAPK_gen_1 382 391 PF00069 0.422
DOC_PP2B_LxvP_1 21 24 PF13499 0.433
DOC_PP4_FxxP_1 68 71 PF00568 0.402
DOC_USP7_MATH_1 279 283 PF00917 0.358
DOC_USP7_MATH_2 392 398 PF00917 0.524
DOC_WW_Pin1_4 178 183 PF00397 0.269
DOC_WW_Pin1_4 310 315 PF00397 0.366
DOC_WW_Pin1_4 360 365 PF00397 0.398
DOC_WW_Pin1_4 75 80 PF00397 0.392
LIG_14-3-3_CanoR_1 130 138 PF00244 0.401
LIG_Actin_WH2_2 58 75 PF00022 0.517
LIG_deltaCOP1_diTrp_1 336 343 PF00928 0.255
LIG_deltaCOP1_diTrp_1 372 379 PF00928 0.460
LIG_EVH1_2 24 28 PF00568 0.421
LIG_FHA_1 160 166 PF00498 0.280
LIG_FHA_1 232 238 PF00498 0.269
LIG_FHA_1 38 44 PF00498 0.515
LIG_FHA_1 67 73 PF00498 0.395
LIG_FHA_2 159 165 PF00498 0.304
LIG_FHA_2 331 337 PF00498 0.262
LIG_FHA_2 55 61 PF00498 0.429
LIG_LIR_Apic_2 386 390 PF02991 0.470
LIG_LIR_Gen_1 250 259 PF02991 0.330
LIG_LIR_Gen_1 333 340 PF02991 0.292
LIG_LIR_Nem_3 265 271 PF02991 0.287
LIG_LIR_Nem_3 333 337 PF02991 0.285
LIG_PDZ_Class_2 396 401 PF00595 0.544
LIG_Pex14_2 34 38 PF04695 0.421
LIG_SH2_CRK 186 190 PF00017 0.269
LIG_SH2_CRK 268 272 PF00017 0.305
LIG_SH2_GRB2like 185 188 PF00017 0.285
LIG_SH2_NCK_1 124 128 PF00017 0.422
LIG_SH2_SRC 223 226 PF00017 0.304
LIG_SH2_STAP1 252 256 PF00017 0.328
LIG_SH2_STAT3 380 383 PF00017 0.299
LIG_SH2_STAT5 223 226 PF00017 0.285
LIG_SH2_STAT5 270 273 PF00017 0.394
LIG_SH2_STAT5 290 293 PF00017 0.103
LIG_SH3_2 71 76 PF14604 0.444
LIG_SH3_3 234 240 PF00018 0.285
LIG_SH3_3 258 264 PF00018 0.285
LIG_SH3_3 334 340 PF00018 0.255
LIG_SH3_3 358 364 PF00018 0.358
LIG_SH3_3 68 74 PF00018 0.396
LIG_SUMO_SIM_anti_2 365 372 PF11976 0.468
LIG_TRAF2_1 209 212 PF00917 0.358
LIG_TRAF2_1 240 243 PF00917 0.385
LIG_UBA3_1 135 139 PF00899 0.398
LIG_UBA3_1 255 263 PF00899 0.358
MOD_CDK_SPK_2 75 80 PF00069 0.391
MOD_CDK_SPxK_1 75 81 PF00069 0.391
MOD_CK1_1 191 197 PF00069 0.255
MOD_CK1_1 282 288 PF00069 0.358
MOD_CK2_1 158 164 PF00069 0.305
MOD_CK2_1 192 198 PF00069 0.260
MOD_CK2_1 54 60 PF00069 0.525
MOD_CK2_1 97 103 PF00069 0.391
MOD_Cter_Amidation 349 352 PF01082 0.255
MOD_GlcNHglycan 280 284 PF01048 0.368
MOD_GlcNHglycan 344 347 PF01048 0.292
MOD_GSK3_1 188 195 PF00069 0.267
MOD_GSK3_1 19 26 PF00069 0.435
MOD_GSK3_1 282 289 PF00069 0.285
MOD_GSK3_1 356 363 PF00069 0.278
MOD_N-GLC_1 231 236 PF02516 0.269
MOD_N-GLC_1 310 315 PF02516 0.260
MOD_N-GLC_1 341 346 PF02516 0.285
MOD_N-GLC_1 66 71 PF02516 0.416
MOD_N-GLC_2 304 306 PF02516 0.373
MOD_NEK2_1 231 236 PF00069 0.290
MOD_NEK2_1 298 303 PF00069 0.261
MOD_NEK2_1 356 361 PF00069 0.258
MOD_NEK2_1 66 71 PF00069 0.368
MOD_PIKK_1 27 33 PF00454 0.412
MOD_PKA_1 130 136 PF00069 0.453
MOD_PKA_1 19 25 PF00069 0.496
MOD_PKA_2 106 112 PF00069 0.429
MOD_PKA_2 129 135 PF00069 0.456
MOD_Plk_1 170 176 PF00069 0.258
MOD_Plk_1 218 224 PF00069 0.279
MOD_Plk_1 231 237 PF00069 0.245
MOD_Plk_1 241 247 PF00069 0.269
MOD_Plk_1 335 341 PF00069 0.255
MOD_Plk_1 356 362 PF00069 0.269
MOD_Plk_2-3 97 103 PF00069 0.482
MOD_Plk_4 23 29 PF00069 0.431
MOD_Plk_4 231 237 PF00069 0.324
MOD_Plk_4 282 288 PF00069 0.269
MOD_Plk_4 356 362 PF00069 0.269
MOD_ProDKin_1 178 184 PF00069 0.269
MOD_ProDKin_1 310 316 PF00069 0.366
MOD_ProDKin_1 360 366 PF00069 0.398
MOD_ProDKin_1 75 81 PF00069 0.392
MOD_SUMO_rev_2 345 353 PF00179 0.285
MOD_SUMO_rev_2 394 401 PF00179 0.538
TRG_DiLeu_BaEn_1 365 370 PF01217 0.491
TRG_DiLeu_BaEn_3 242 248 PF01217 0.309
TRG_ENDOCYTIC_2 185 188 PF00928 0.255
TRG_ENDOCYTIC_2 252 255 PF00928 0.266
TRG_ENDOCYTIC_2 268 271 PF00928 0.218
TRG_ER_diArg_1 129 131 PF00400 0.469
TRG_ER_diArg_1 79 81 PF00400 0.403
TRG_Pf-PMV_PEXEL_1 118 122 PF00026 0.482
TRG_Pf-PMV_PEXEL_1 208 212 PF00026 0.269
TRG_Pf-PMV_PEXEL_1 269 273 PF00026 0.309
TRG_Pf-PMV_PEXEL_1 382 386 PF00026 0.480

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEB6 Leptomonas seymouri 85% 97%
A0A0S4IW90 Bodo saltans 66% 100%
A0A0S4IXB9 Bodo saltans 54% 100%
A0A1X0P6I6 Trypanosomatidae 72% 100%
A0A3R7P3I2 Trypanosoma rangeli 72% 100%
A0A3S7WVI9 Leishmania donovani 100% 100%
A4HA12 Leishmania braziliensis 93% 100%
A6QLA4 Bos taurus 53% 100%
D0A0J6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 68% 100%
E9AS06 Leishmania mexicana (strain MHOM/GT/2001/U1103) 98% 100%
O59730 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 46% 100%
P0A5J3 Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) 43% 100%
P53582 Homo sapiens 52% 100%
P9WK18 Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) 43% 100%
P9WK19 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) 43% 100%
Q01662 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 48% 100%
Q4QDG7 Leishmania major 98% 100%
Q4QRK0 Danio rerio 53% 100%
Q4VBS4 Danio rerio 41% 100%
Q54VU7 Dictyostelium discoideum 40% 99%
Q54WU3 Dictyostelium discoideum 51% 100%
Q5I0A0 Xenopus tropicalis 53% 100%
Q5RBF3 Pongo abelii 52% 100%
Q5ZIM5 Gallus gallus 52% 100%
Q6UB28 Homo sapiens 38% 100%
Q7ZWV9 Xenopus laevis 53% 100%
Q8BP48 Mus musculus 52% 100%
Q8IJP2 Plasmodium falciparum (isolate 3D7) 46% 78%
Q9CPW9 Mus musculus 40% 100%
Q9FV50 Arabidopsis thaliana 42% 100%
Q9FV51 Arabidopsis thaliana 41% 100%
Q9FV52 Arabidopsis thaliana 46% 100%
Q9SLN5 Arabidopsis thaliana 48% 100%
V5DTM6 Trypanosoma cruzi 72% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS