Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HY75_LEIIN

TriTrypDb:

LINF_190010200

Length:

742

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	9
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1

Expansion

Sequence features

A4HY75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY75

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.743
CLV_C14_Caspase3-7	441	445	PF00656	0.579
CLV_C14_Caspase3-7	562	566	PF00656	0.759
CLV_C14_Caspase3-7	593	597	PF00656	0.713
CLV_NRD_NRD_1	132	134	PF00675	0.666
CLV_NRD_NRD_1	216	218	PF00675	0.720
CLV_NRD_NRD_1	399	401	PF00675	0.461
CLV_NRD_NRD_1	470	472	PF00675	0.678
CLV_NRD_NRD_1	585	587	PF00675	0.590
CLV_PCSK_FUR_1	56	60	PF00082	0.802
CLV_PCSK_KEX2_1	132	134	PF00082	0.736
CLV_PCSK_KEX2_1	216	218	PF00082	0.629
CLV_PCSK_KEX2_1	399	401	PF00082	0.461
CLV_PCSK_KEX2_1	470	472	PF00082	0.650
CLV_PCSK_KEX2_1	58	60	PF00082	0.753
CLV_PCSK_KEX2_1	584	586	PF00082	0.590
CLV_PCSK_PC1ET2_1	58	60	PF00082	0.755
CLV_PCSK_SKI1_1	229	233	PF00082	0.583
CLV_PCSK_SKI1_1	330	334	PF00082	0.504
CLV_PCSK_SKI1_1	391	395	PF00082	0.583
CLV_PCSK_SKI1_1	543	547	PF00082	0.753
CLV_PCSK_SKI1_1	735	739	PF00082	0.611
DEG_APCC_DBOX_1	725	733	PF00400	0.625
DEG_SCF_TRCP1_1	629	635	PF00400	0.541
DEG_SPOP_SBC_1	687	691	PF00917	0.614
DOC_CKS1_1	165	170	PF01111	0.753
DOC_CKS1_1	196	201	PF01111	0.602
DOC_CYCLIN_RxL_1	294	303	PF00134	0.480
DOC_MAPK_gen_1	470	476	PF00069	0.698
DOC_MAPK_gen_1	548	556	PF00069	0.700
DOC_PIKK_1	484	491	PF02985	0.602
DOC_PP1_RVXF_1	97	104	PF00149	0.791
DOC_PP2B_LxvP_1	322	325	PF13499	0.468
DOC_PP2B_LxvP_1	434	437	PF13499	0.551
DOC_PP2B_LxvP_1	472	475	PF13499	0.752
DOC_PP2B_LxvP_1	77	80	PF13499	0.734
DOC_USP7_MATH_1	110	114	PF00917	0.710
DOC_USP7_MATH_1	25	29	PF00917	0.724
DOC_USP7_MATH_1	41	45	PF00917	0.550
DOC_USP7_MATH_1	522	526	PF00917	0.615
DOC_USP7_MATH_1	544	548	PF00917	0.686
DOC_USP7_MATH_1	579	583	PF00917	0.608
DOC_USP7_MATH_1	588	592	PF00917	0.693
DOC_USP7_MATH_1	655	659	PF00917	0.649
DOC_USP7_MATH_1	694	698	PF00917	0.734
DOC_USP7_MATH_1	711	715	PF00917	0.655
DOC_USP7_MATH_1	737	741	PF00917	0.635
DOC_WW_Pin1_4	164	169	PF00397	0.744
DOC_WW_Pin1_4	195	200	PF00397	0.622
DOC_WW_Pin1_4	330	335	PF00397	0.434
DOC_WW_Pin1_4	410	415	PF00397	0.677
LIG_14-3-3_CanoR_1	148	156	PF00244	0.760
LIG_14-3-3_CanoR_1	216	225	PF00244	0.720
LIG_14-3-3_CanoR_1	229	236	PF00244	0.575
LIG_14-3-3_CanoR_1	521	531	PF00244	0.624
LIG_14-3-3_CanoR_1	586	594	PF00244	0.530
LIG_14-3-3_CanoR_1	672	682	PF00244	0.726
LIG_14-3-3_CanoR_1	81	91	PF00244	0.823
LIG_BIR_III_2	331	335	PF00653	0.436
LIG_BIR_III_4	126	130	PF00653	0.704
LIG_BRCT_BRCA1_1	590	594	PF00533	0.655
LIG_deltaCOP1_diTrp_1	238	242	PF00928	0.494
LIG_deltaCOP1_diTrp_1	659	666	PF00928	0.673
LIG_FHA_1	106	112	PF00498	0.672
LIG_FHA_1	191	197	PF00498	0.718
LIG_FHA_1	230	236	PF00498	0.449
LIG_FHA_1	248	254	PF00498	0.382
LIG_FHA_1	339	345	PF00498	0.427
LIG_FHA_1	34	40	PF00498	0.702
LIG_FHA_1	43	49	PF00498	0.688
LIG_FHA_1	569	575	PF00498	0.610
LIG_FHA_1	578	584	PF00498	0.569
LIG_FHA_1	637	643	PF00498	0.685
LIG_FHA_2	21	27	PF00498	0.722
LIG_FHA_2	216	222	PF00498	0.686
LIG_FHA_2	238	244	PF00498	0.432
LIG_FHA_2	439	445	PF00498	0.483
LIG_FHA_2	476	482	PF00498	0.621
LIG_FHA_2	702	708	PF00498	0.741
LIG_LIR_Gen_1	240	249	PF02991	0.459
LIG_LIR_Gen_1	291	301	PF02991	0.359
LIG_LIR_Gen_1	502	511	PF02991	0.595
LIG_LIR_Gen_1	660	671	PF02991	0.668
LIG_LIR_Gen_1	697	703	PF02991	0.714
LIG_LIR_Nem_3	240	245	PF02991	0.506
LIG_LIR_Nem_3	291	296	PF02991	0.366
LIG_LIR_Nem_3	321	326	PF02991	0.378
LIG_LIR_Nem_3	388	393	PF02991	0.507
LIG_LIR_Nem_3	419	424	PF02991	0.468
LIG_LIR_Nem_3	502	507	PF02991	0.571
LIG_LIR_Nem_3	660	666	PF02991	0.530
LIG_LIR_Nem_3	697	701	PF02991	0.721
LIG_MYND_1	531	535	PF01753	0.728
LIG_MYND_3	436	440	PF01753	0.502
LIG_Pex14_2	545	549	PF04695	0.762
LIG_SH2_CRK	15	19	PF00017	0.731
LIG_SH2_CRK	519	523	PF00017	0.605
LIG_SH2_CRK	698	702	PF00017	0.709
LIG_SH2_NCK_1	15	19	PF00017	0.628
LIG_SH2_NCK_1	519	523	PF00017	0.587
LIG_SH2_STAP1	226	230	PF00017	0.569
LIG_SH2_STAT5	118	121	PF00017	0.761
LIG_SH2_STAT5	298	301	PF00017	0.453
LIG_SH2_STAT5	323	326	PF00017	0.478
LIG_SH2_STAT5	519	522	PF00017	0.608
LIG_SH2_STAT5	632	635	PF00017	0.658
LIG_SH2_STAT5	703	706	PF00017	0.679
LIG_SH3_3	193	199	PF00018	0.658
LIG_SH3_3	408	414	PF00018	0.732
LIG_SUMO_SIM_anti_2	243	250	PF11976	0.523
LIG_SUMO_SIM_anti_2	341	346	PF11976	0.398
LIG_SUMO_SIM_par_1	339	346	PF11976	0.425
LIG_TRAF2_1	464	467	PF00917	0.729
LIG_TRAF2_1	658	661	PF00917	0.672
LIG_TYR_ITIM	296	301	PF00017	0.477
LIG_UBA3_1	50	58	PF00899	0.798
LIG_WRPW_2	421	424	PF00400	0.371
LIG_WW_3	78	82	PF00397	0.695
MOD_CK1_1	138	144	PF00069	0.665
MOD_CK1_1	17	23	PF00069	0.730
MOD_CK1_1	190	196	PF00069	0.720
MOD_CK1_1	271	277	PF00069	0.502
MOD_CK1_1	28	34	PF00069	0.773
MOD_CK1_1	450	456	PF00069	0.648
MOD_CK1_1	547	553	PF00069	0.642
MOD_CK1_1	567	573	PF00069	0.609
MOD_CK1_1	590	596	PF00069	0.635
MOD_CK1_1	65	71	PF00069	0.723
MOD_CK1_1	673	679	PF00069	0.708
MOD_CK2_1	138	144	PF00069	0.788
MOD_CK2_1	215	221	PF00069	0.692
MOD_CK2_1	237	243	PF00069	0.417
MOD_CK2_1	315	321	PF00069	0.484
MOD_CK2_1	37	43	PF00069	0.635
MOD_CK2_1	460	466	PF00069	0.750
MOD_CK2_1	655	661	PF00069	0.646
MOD_CK2_1	701	707	PF00069	0.697
MOD_CMANNOS	239	242	PF00535	0.486
MOD_Cter_Amidation	397	400	PF01082	0.438
MOD_GlcNHglycan	135	138	PF01048	0.719
MOD_GlcNHglycan	176	180	PF01048	0.756
MOD_GlcNHglycan	30	33	PF01048	0.750
MOD_GlcNHglycan	338	341	PF01048	0.564
MOD_GlcNHglycan	39	42	PF01048	0.759
MOD_GlcNHglycan	407	410	PF01048	0.743
MOD_GlcNHglycan	526	529	PF01048	0.634
MOD_GlcNHglycan	600	605	PF01048	0.727
MOD_GlcNHglycan	607	610	PF01048	0.692
MOD_GlcNHglycan	622	625	PF01048	0.666
MOD_GlcNHglycan	629	632	PF01048	0.709
MOD_GlcNHglycan	639	642	PF01048	0.579
MOD_GlcNHglycan	64	67	PF01048	0.706
MOD_GlcNHglycan	676	679	PF01048	0.712
MOD_GlcNHglycan	690	693	PF01048	0.600
MOD_GlcNHglycan	85	88	PF01048	0.801
MOD_GlcNHglycan	94	97	PF01048	0.665
MOD_GSK3_1	133	140	PF00069	0.695
MOD_GSK3_1	143	150	PF00069	0.585
MOD_GSK3_1	216	223	PF00069	0.697
MOD_GSK3_1	225	232	PF00069	0.617
MOD_GSK3_1	268	275	PF00069	0.522
MOD_GSK3_1	300	307	PF00069	0.392
MOD_GSK3_1	33	40	PF00069	0.741
MOD_GSK3_1	447	454	PF00069	0.575
MOD_GSK3_1	462	469	PF00069	0.611
MOD_GSK3_1	50	57	PF00069	0.585
MOD_GSK3_1	517	524	PF00069	0.572
MOD_GSK3_1	543	550	PF00069	0.708
MOD_GSK3_1	555	562	PF00069	0.706
MOD_GSK3_1	564	571	PF00069	0.613
MOD_GSK3_1	61	68	PF00069	0.665
MOD_GSK3_1	616	623	PF00069	0.671
MOD_GSK3_1	632	639	PF00069	0.642
MOD_GSK3_1	666	673	PF00069	0.613
MOD_GSK3_1	83	90	PF00069	0.811
MOD_N-GLC_1	138	143	PF02516	0.741
MOD_N-GLC_1	278	283	PF02516	0.398
MOD_N-GLC_1	577	582	PF02516	0.697
MOD_N-GLC_1	605	610	PF02516	0.722
MOD_N-GLC_2	302	304	PF02516	0.485
MOD_NEK2_1	103	108	PF00069	0.785
MOD_NEK2_1	175	180	PF00069	0.707
MOD_NEK2_1	225	230	PF00069	0.579
MOD_NEK2_1	247	252	PF00069	0.464
MOD_NEK2_1	278	283	PF00069	0.405
MOD_NEK2_1	336	341	PF00069	0.509
MOD_NEK2_1	460	465	PF00069	0.730
MOD_NEK2_1	50	55	PF00069	0.734
MOD_NEK2_1	587	592	PF00069	0.620
MOD_NEK2_1	666	671	PF00069	0.609
MOD_NEK2_1	688	693	PF00069	0.749
MOD_NEK2_1	701	706	PF00069	0.738
MOD_NEK2_1	72	77	PF00069	0.776
MOD_NEK2_2	300	305	PF00069	0.469
MOD_NEK2_2	579	584	PF00069	0.604
MOD_PIKK_1	65	71	PF00454	0.764
MOD_PIKK_1	701	707	PF00454	0.718
MOD_PK_1	148	154	PF00069	0.577
MOD_PK_1	369	375	PF00069	0.321
MOD_PK_1	616	622	PF00069	0.576
MOD_PKA_1	216	222	PF00069	0.651
MOD_PKA_2	147	153	PF00069	0.757
MOD_PKA_2	215	221	PF00069	0.650
MOD_PKA_2	520	526	PF00069	0.641
MOD_PKA_2	547	553	PF00069	0.706
MOD_PKA_2	83	89	PF00069	0.833
MOD_PKB_1	59	67	PF00069	0.808
MOD_Plk_1	143	149	PF00069	0.714
MOD_Plk_1	187	193	PF00069	0.669
MOD_Plk_1	220	226	PF00069	0.638
MOD_Plk_1	25	31	PF00069	0.683
MOD_Plk_1	447	453	PF00069	0.592
MOD_Plk_1	564	570	PF00069	0.702
MOD_Plk_1	727	733	PF00069	0.573
MOD_Plk_2-3	221	227	PF00069	0.658
MOD_Plk_4	221	227	PF00069	0.636
MOD_Plk_4	315	321	PF00069	0.519
MOD_Plk_4	369	375	PF00069	0.499
MOD_Plk_4	564	570	PF00069	0.691
MOD_Plk_4	666	672	PF00069	0.586
MOD_ProDKin_1	164	170	PF00069	0.746
MOD_ProDKin_1	195	201	PF00069	0.620
MOD_ProDKin_1	330	336	PF00069	0.435
MOD_ProDKin_1	410	416	PF00069	0.673
MOD_SUMO_for_1	205	208	PF00179	0.701
MOD_SUMO_rev_2	419	424	PF00179	0.476
TRG_DiLeu_BaEn_1	243	248	PF01217	0.471
TRG_DiLeu_BaEn_1	489	494	PF01217	0.593
TRG_DiLeu_BaLyEn_6	430	435	PF01217	0.479
TRG_ENDOCYTIC_2	15	18	PF00928	0.811
TRG_ENDOCYTIC_2	298	301	PF00928	0.439
TRG_ENDOCYTIC_2	323	326	PF00928	0.379
TRG_ENDOCYTIC_2	390	393	PF00928	0.534
TRG_ENDOCYTIC_2	421	424	PF00928	0.371
TRG_ENDOCYTIC_2	698	701	PF00928	0.756
TRG_ER_diArg_1	131	133	PF00400	0.702
TRG_ER_diArg_1	470	472	PF00400	0.750
TRG_ER_diArg_1	583	586	PF00400	0.566
TRG_ER_diArg_1	59	62	PF00400	0.800
TRG_ER_diArg_1	731	734	PF00400	0.529
TRG_NES_CRM1_1	243	258	PF08389	0.475
TRG_NES_CRM1_1	481	496	PF08389	0.601
TRG_NLS_MonoExtN_4	56	62	PF00514	0.806
TRG_Pf-PMV_PEXEL_1	391	396	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	433	438	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I334	Leptomonas seymouri	46%	84%
A0A1X0P7D2	Trypanosomatidae	33%	85%
A0A3Q8IBC8	Leishmania donovani	99%	100%
A0A422P3D4	Trypanosoma rangeli	30%	94%
A4HA11	Leishmania braziliensis	71%	99%
E9AS05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QDG8	Leishmania major	91%	100%
V5BBW9	Trypanosoma cruzi	31%	94%