LeishMANIAdb
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ANK_REP_REGION domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
ANK_REP_REGION domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HY74_LEIIN
TriTrypDb:
LINF_190010100 *
Length:
493

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HY74
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY74

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 394 398 PF00656 0.554
CLV_NRD_NRD_1 100 102 PF00675 0.454
CLV_NRD_NRD_1 138 140 PF00675 0.487
CLV_NRD_NRD_1 211 213 PF00675 0.554
CLV_NRD_NRD_1 214 216 PF00675 0.528
CLV_NRD_NRD_1 255 257 PF00675 0.518
CLV_NRD_NRD_1 357 359 PF00675 0.502
CLV_NRD_NRD_1 360 362 PF00675 0.478
CLV_NRD_NRD_1 66 68 PF00675 0.623
CLV_PCSK_FUR_1 212 216 PF00082 0.660
CLV_PCSK_FUR_1 358 362 PF00082 0.527
CLV_PCSK_FUR_1 60 64 PF00082 0.722
CLV_PCSK_KEX2_1 213 215 PF00082 0.582
CLV_PCSK_KEX2_1 357 359 PF00082 0.536
CLV_PCSK_KEX2_1 360 362 PF00082 0.515
CLV_PCSK_KEX2_1 480 482 PF00082 0.681
CLV_PCSK_KEX2_1 62 64 PF00082 0.717
CLV_PCSK_KEX2_1 66 68 PF00082 0.673
CLV_PCSK_KEX2_1 99 101 PF00082 0.458
CLV_PCSK_PC1ET2_1 213 215 PF00082 0.636
CLV_PCSK_PC1ET2_1 480 482 PF00082 0.692
CLV_PCSK_PC1ET2_1 62 64 PF00082 0.666
CLV_PCSK_SKI1_1 144 148 PF00082 0.485
CLV_PCSK_SKI1_1 250 254 PF00082 0.678
CLV_PCSK_SKI1_1 323 327 PF00082 0.465
CLV_PCSK_SKI1_1 332 336 PF00082 0.441
CLV_PCSK_SKI1_1 38 42 PF00082 0.521
CLV_PCSK_SKI1_1 45 49 PF00082 0.526
CLV_PCSK_SKI1_1 484 488 PF00082 0.737
CLV_PCSK_SKI1_1 94 98 PF00082 0.435
DEG_APCC_DBOX_1 128 136 PF00400 0.416
DEG_SCF_TRCP1_1 3 8 PF00400 0.575
DOC_MAPK_gen_1 348 356 PF00069 0.444
DOC_MAPK_gen_1 445 454 PF00069 0.594
DOC_MAPK_gen_1 462 469 PF00069 0.539
DOC_MAPK_MEF2A_6 348 356 PF00069 0.514
DOC_MAPK_RevD_3 467 481 PF00069 0.470
DOC_PP1_RVXF_1 157 164 PF00149 0.445
DOC_PP1_RVXF_1 176 183 PF00149 0.502
DOC_PP2B_LxvP_1 288 291 PF13499 0.460
DOC_PP2B_LxvP_1 47 50 PF13499 0.621
DOC_PP4_FxxP_1 48 51 PF00568 0.677
DOC_USP7_UBL2_3 140 144 PF12436 0.500
LIG_14-3-3_CanoR_1 103 109 PF00244 0.423
LIG_14-3-3_CanoR_1 149 155 PF00244 0.517
LIG_14-3-3_CanoR_1 365 374 PF00244 0.524
LIG_14-3-3_CanoR_1 484 489 PF00244 0.622
LIG_Actin_WH2_2 89 105 PF00022 0.523
LIG_BIR_III_4 228 232 PF00653 0.516
LIG_CaM_IQ_9 116 131 PF13499 0.521
LIG_CaM_IQ_9 173 189 PF13499 0.420
LIG_CaM_IQ_9 349 365 PF13499 0.474
LIG_eIF4E_1 42 48 PF01652 0.548
LIG_EVH1_2 29 33 PF00568 0.549
LIG_FHA_1 156 162 PF00498 0.533
LIG_FHA_1 299 305 PF00498 0.644
LIG_FHA_1 329 335 PF00498 0.433
LIG_FHA_1 340 346 PF00498 0.456
LIG_FHA_2 105 111 PF00498 0.587
LIG_FHA_2 240 246 PF00498 0.660
LIG_FHA_2 264 270 PF00498 0.500
LIG_FHA_2 75 81 PF00498 0.454
LIG_LIR_Apic_2 46 51 PF02991 0.583
LIG_LIR_Gen_1 421 429 PF02991 0.565
LIG_LIR_Nem_3 32 36 PF02991 0.587
LIG_LIR_Nem_3 421 425 PF02991 0.511
LIG_LIR_Nem_3 90 96 PF02991 0.532
LIG_PCNA_yPIPBox_3 81 93 PF02747 0.472
LIG_PTAP_UEV_1 428 433 PF05743 0.557
LIG_SH2_CRK 422 426 PF00017 0.557
LIG_SH2_CRK 434 438 PF00017 0.494
LIG_SH2_GRB2like 71 74 PF00017 0.581
LIG_SH2_NCK_1 422 426 PF00017 0.621
LIG_SH2_SRC 471 474 PF00017 0.704
LIG_SH2_STAP1 71 75 PF00017 0.552
LIG_SH2_STAT3 190 193 PF00017 0.509
LIG_SH2_STAT5 150 153 PF00017 0.512
LIG_SH2_STAT5 190 193 PF00017 0.448
LIG_SH2_STAT5 338 341 PF00017 0.433
LIG_SH2_STAT5 468 471 PF00017 0.621
LIG_SH3_3 23 29 PF00018 0.604
LIG_SH3_3 255 261 PF00018 0.590
LIG_SH3_3 426 432 PF00018 0.598
LIG_SH3_3 47 53 PF00018 0.603
LIG_WW_3 57 61 PF00397 0.652
MOD_CK1_1 43 49 PF00069 0.574
MOD_CK2_1 104 110 PF00069 0.562
MOD_CK2_1 263 269 PF00069 0.492
MOD_CK2_1 292 298 PF00069 0.543
MOD_CK2_1 74 80 PF00069 0.452
MOD_GlcNHglycan 237 242 PF01048 0.576
MOD_GlcNHglycan 285 288 PF01048 0.437
MOD_GlcNHglycan 3 6 PF01048 0.586
MOD_GlcNHglycan 397 401 PF01048 0.564
MOD_GSK3_1 1 8 PF00069 0.594
MOD_GSK3_1 144 151 PF00069 0.426
MOD_GSK3_1 319 326 PF00069 0.454
MOD_GSK3_1 328 335 PF00069 0.386
MOD_N-GLC_2 19 21 PF02516 0.578
MOD_NEK2_1 1 6 PF00069 0.644
MOD_NEK2_1 15 20 PF00069 0.715
MOD_NEK2_1 319 324 PF00069 0.517
MOD_NEK2_1 339 344 PF00069 0.291
MOD_NEK2_1 396 401 PF00069 0.550
MOD_PIKK_1 263 269 PF00454 0.627
MOD_PKA_2 148 154 PF00069 0.401
MOD_PKA_2 283 289 PF00069 0.515
MOD_PKB_1 330 338 PF00069 0.472
MOD_PKB_1 363 371 PF00069 0.555
MOD_Plk_1 87 93 PF00069 0.528
MOD_Plk_4 473 479 PF00069 0.549
MOD_SUMO_for_1 385 388 PF00179 0.539
MOD_SUMO_rev_2 292 301 PF00179 0.612
MOD_SUMO_rev_2 368 372 PF00179 0.542
TRG_ENDOCYTIC_2 37 40 PF00928 0.664
TRG_ENDOCYTIC_2 422 425 PF00928 0.604
TRG_ENDOCYTIC_2 434 437 PF00928 0.502
TRG_ER_diArg_1 130 133 PF00400 0.448
TRG_ER_diArg_1 212 215 PF00400 0.542
TRG_ER_diArg_1 356 358 PF00400 0.510
TRG_ER_diArg_1 359 361 PF00400 0.493
TRG_ER_diArg_1 363 366 PF00400 0.483
TRG_ER_diArg_1 65 67 PF00400 0.706
TRG_ER_diArg_1 99 101 PF00400 0.458
TRG_NLS_MonoCore_2 211 216 PF00514 0.624
TRG_NLS_MonoExtC_3 211 216 PF00514 0.624
TRG_NLS_MonoExtN_4 209 216 PF00514 0.555
TRG_Pf-PMV_PEXEL_1 100 104 PF00026 0.443
TRG_Pf-PMV_PEXEL_1 106 110 PF00026 0.442
TRG_Pf-PMV_PEXEL_1 189 193 PF00026 0.503
TRG_Pf-PMV_PEXEL_1 250 254 PF00026 0.678
TRG_Pf-PMV_PEXEL_1 332 337 PF00026 0.520
TRG_Pf-PMV_PEXEL_1 348 353 PF00026 0.434
TRG_Pf-PMV_PEXEL_1 393 397 PF00026 0.507

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I9S0 Leptomonas seymouri 50% 82%
A0A1X0P7R9 Trypanosomatidae 33% 95%
A0A3S7WVD7 Leishmania donovani 100% 87%
A0A422P367 Trypanosoma rangeli 34% 100%
A4HA10 Leishmania braziliensis 69% 100%
D0A0J3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E9AS04 Leishmania mexicana (strain MHOM/GT/2001/U1103) 82% 100%
Q4QDG9 Leishmania major 90% 100%
V5BSD1 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS