Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HY70_LEIIN

TriTrypDb:

LINF_190009700

Length:

256

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

A4HY70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY70

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	69	73	PF00656	0.709
CLV_NRD_NRD_1	226	228	PF00675	0.474
CLV_NRD_NRD_1	244	246	PF00675	0.476
CLV_NRD_NRD_1	252	254	PF00675	0.488
CLV_NRD_NRD_1	32	34	PF00675	0.617
CLV_NRD_NRD_1	46	48	PF00675	0.516
CLV_NRD_NRD_1	95	97	PF00675	0.487
CLV_PCSK_FUR_1	44	48	PF00082	0.513
CLV_PCSK_KEX2_1	194	196	PF00082	0.625
CLV_PCSK_KEX2_1	226	228	PF00082	0.474
CLV_PCSK_KEX2_1	244	246	PF00082	0.476
CLV_PCSK_KEX2_1	252	254	PF00082	0.488
CLV_PCSK_KEX2_1	32	34	PF00082	0.617
CLV_PCSK_KEX2_1	46	48	PF00082	0.507
CLV_PCSK_KEX2_1	95	97	PF00082	0.488
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.625
CLV_PCSK_SKI1_1	166	170	PF00082	0.387
CLV_PCSK_SKI1_1	194	198	PF00082	0.538
CLV_PCSK_SKI1_1	244	248	PF00082	0.483
CLV_Separin_Metazoa	170	174	PF03568	0.360
DEG_APCC_DBOX_1	243	251	PF00400	0.742
DEG_Nend_Nbox_1	1	3	PF02207	0.722
DEG_SPOP_SBC_1	102	106	PF00917	0.766
DOC_CKS1_1	53	58	PF01111	0.664
DOC_CYCLIN_RxL_1	191	201	PF00134	0.419
DOC_CYCLIN_yClb5_NLxxxL_5	210	219	PF00134	0.323
DOC_MAPK_RevD_3	229	245	PF00069	0.705
DOC_PP2B_LxvP_1	144	147	PF13499	0.743
DOC_WW_Pin1_4	111	116	PF00397	0.750
DOC_WW_Pin1_4	52	57	PF00397	0.702
DOC_WW_Pin1_4	80	85	PF00397	0.710
LIG_14-3-3_CanoR_1	107	115	PF00244	0.680
LIG_14-3-3_CanoR_1	153	162	PF00244	0.474
LIG_14-3-3_CanoR_1	252	256	PF00244	0.745
LIG_14-3-3_CanoR_1	40	48	PF00244	0.749
LIG_FHA_1	154	160	PF00498	0.474
LIG_FHA_1	16	22	PF00498	0.743
LIG_FHA_1	200	206	PF00498	0.513
LIG_FHA_1	48	54	PF00498	0.736
LIG_FHA_1	58	64	PF00498	0.735
LIG_FHA_2	40	46	PF00498	0.762
LIG_GBD_Chelix_1	85	93	PF00786	0.494
LIG_LIR_Nem_3	175	181	PF02991	0.416
LIG_PDZ_Class_1	251	256	PF00595	0.707
LIG_Pex14_1	182	186	PF04695	0.452
LIG_Pex14_2	213	217	PF04695	0.411
LIG_RPA_C_Fungi	28	40	PF08784	0.616
LIG_SH2_CRK	49	53	PF00017	0.644
LIG_SH2_NCK_1	132	136	PF00017	0.583
LIG_SH2_PTP2	240	243	PF00017	0.695
LIG_SH2_STAT3	48	51	PF00017	0.649
LIG_SH2_STAT5	163	166	PF00017	0.433
LIG_SH2_STAT5	240	243	PF00017	0.695
LIG_SH2_STAT5	49	52	PF00017	0.677
LIG_SH3_3	96	102	PF00018	0.789
LIG_SUMO_SIM_anti_2	142	147	PF11976	0.696
LIG_TYR_ITIM	176	181	PF00017	0.535
LIG_WRC_WIRS_1	210	215	PF05994	0.411
MOD_CDK_SPK_2	111	116	PF00069	0.697
MOD_CK2_1	39	45	PF00069	0.712
MOD_Cter_Amidation	224	227	PF01082	0.577
MOD_GlcNHglycan	219	222	PF01048	0.478
MOD_GlcNHglycan	77	80	PF01048	0.668
MOD_GSK3_1	10	17	PF00069	0.597
MOD_GSK3_1	103	110	PF00069	0.770
MOD_GSK3_1	34	41	PF00069	0.689
MOD_GSK3_1	75	82	PF00069	0.703
MOD_LATS_1	101	107	PF00433	0.587
MOD_NEK2_1	122	127	PF00069	0.696
MOD_NEK2_1	162	167	PF00069	0.411
MOD_NEK2_1	209	214	PF00069	0.459
MOD_NEK2_1	217	222	PF00069	0.504
MOD_PIKK_1	47	53	PF00454	0.762
MOD_PKA_2	102	108	PF00069	0.586
MOD_PKA_2	39	45	PF00069	0.681
MOD_Plk_4	139	145	PF00069	0.612
MOD_Plk_4	188	194	PF00069	0.520
MOD_Plk_4	59	65	PF00069	0.721
MOD_ProDKin_1	111	117	PF00069	0.689
MOD_ProDKin_1	52	58	PF00069	0.630
MOD_ProDKin_1	80	86	PF00069	0.637
TRG_DiLeu_BaEn_1	140	145	PF01217	0.643
TRG_DiLeu_BaLyEn_6	192	197	PF01217	0.639
TRG_DiLeu_BaLyEn_6	242	247	PF01217	0.570
TRG_ENDOCYTIC_2	178	181	PF00928	0.533
TRG_ER_diArg_1	126	129	PF00400	0.642
TRG_ER_diArg_1	243	245	PF00400	0.595
TRG_ER_diArg_1	251	253	PF00400	0.599
TRG_ER_diArg_1	46	48	PF00400	0.649
TRG_ER_diArg_1	95	97	PF00400	0.610
TRG_Pf-PMV_PEXEL_1	244	248	PF00026	0.570

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8L3	Leptomonas seymouri	50%	97%
A0A3Q8IJZ2	Leishmania donovani	100%	100%
A4HA06	Leishmania braziliensis	68%	100%
E9AS00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QDH3	Leishmania major	93%	100%