Putative nuclear cap binding complex subunit CBP30

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear cap binding complex subunit CBP30 - putative

Species:

Leishmania infantum

UniProt:

A4HY69_LEIIN

TriTrypDb:

LINF_190009600

Length:

359

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005846	nuclear cap binding complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0034518	RNA cap binding complex	2	11
GO:0140535	intracellular protein-containing complex	2	11
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HY69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY69

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	153	157	PF00656	0.403
CLV_C14_Caspase3-7	172	176	PF00656	0.244
CLV_NRD_NRD_1	104	106	PF00675	0.410
CLV_NRD_NRD_1	276	278	PF00675	0.375
CLV_NRD_NRD_1	305	307	PF00675	0.470
CLV_NRD_NRD_1	318	320	PF00675	0.393
CLV_NRD_NRD_1	43	45	PF00675	0.276
CLV_PCSK_KEX2_1	103	105	PF00082	0.300
CLV_PCSK_KEX2_1	305	307	PF00082	0.399
CLV_PCSK_KEX2_1	318	320	PF00082	0.267
CLV_PCSK_SKI1_1	278	282	PF00082	0.306
CLV_PCSK_SKI1_1	61	65	PF00082	0.279
DEG_SPOP_SBC_1	147	151	PF00917	0.303
DEG_SPOP_SBC_1	158	162	PF00917	0.223
DOC_CKS1_1	22	27	PF01111	0.279
DOC_CYCLIN_RxL_1	29	39	PF00134	0.341
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.297
DOC_MAPK_DCC_7	238	247	PF00069	0.355
DOC_MAPK_FxFP_2	207	210	PF00069	0.279
DOC_MAPK_gen_1	318	325	PF00069	0.306
DOC_MAPK_gen_1	44	53	PF00069	0.255
DOC_PP2B_PxIxI_1	221	227	PF00149	0.355
DOC_PP4_FxxP_1	207	210	PF00568	0.279
DOC_USP7_MATH_1	147	151	PF00917	0.388
DOC_USP7_MATH_1	158	162	PF00917	0.380
DOC_USP7_MATH_1	178	182	PF00917	0.320
DOC_USP7_MATH_1	194	198	PF00917	0.442
DOC_USP7_MATH_1	286	290	PF00917	0.355
DOC_WW_Pin1_4	119	124	PF00397	0.462
DOC_WW_Pin1_4	21	26	PF00397	0.279
DOC_WW_Pin1_4	240	245	PF00397	0.297
LIG_14-3-3_CanoR_1	265	272	PF00244	0.410
LIG_Actin_WH2_2	342	359	PF00022	0.410
LIG_BIR_II_1	1	5	PF00653	0.737
LIG_BRCT_BRCA1_1	267	271	PF00533	0.410
LIG_CtBP_PxDLS_1	54	58	PF00389	0.410
LIG_DLG_GKlike_1	267	275	PF00625	0.410
LIG_FHA_1	33	39	PF00498	0.412
LIG_FHA_2	133	139	PF00498	0.445
LIG_FHA_2	151	157	PF00498	0.272
LIG_FHA_2	170	176	PF00498	0.362
LIG_FHA_2	225	231	PF00498	0.369
LIG_FHA_2	244	250	PF00498	0.366
LIG_FHA_2	331	337	PF00498	0.363
LIG_LIR_Gen_1	17	26	PF02991	0.322
LIG_LIR_Gen_1	70	80	PF02991	0.412
LIG_LIR_Nem_3	17	22	PF02991	0.322
LIG_LIR_Nem_3	211	215	PF02991	0.306
LIG_LIR_Nem_3	62	67	PF02991	0.335
LIG_LIR_Nem_3	70	76	PF02991	0.305
LIG_MYND_1	89	93	PF01753	0.297
LIG_Pex14_1	60	64	PF04695	0.279
LIG_SH2_CRK	212	216	PF00017	0.306
LIG_SH2_NCK_1	328	332	PF00017	0.355
LIG_SH2_PTP2	241	244	PF00017	0.322
LIG_SH2_SRC	328	331	PF00017	0.355
LIG_SH2_STAP1	73	77	PF00017	0.378
LIG_SH2_STAT5	241	244	PF00017	0.318
LIG_SH2_STAT5	30	33	PF00017	0.410
LIG_SH3_2	301	306	PF14604	0.294
LIG_SH3_2	93	98	PF14604	0.355
LIG_SH3_3	280	286	PF00018	0.357
LIG_SH3_3	298	304	PF00018	0.463
LIG_SH3_3	320	326	PF00018	0.282
LIG_SH3_3	48	54	PF00018	0.252
LIG_SH3_3	86	92	PF00018	0.279
LIG_SUMO_SIM_par_1	34	39	PF11976	0.410
LIG_TRAF2_1	227	230	PF00917	0.279
LIG_TRAF2_1	248	251	PF00917	0.287
LIG_TRAF2_1	254	257	PF00917	0.292
LIG_TRAF2_1	334	337	PF00917	0.475
LIG_TRAF2_1	68	71	PF00917	0.355
LIG_WRC_WIRS_1	73	78	PF05994	0.306
MOD_CK1_1	150	156	PF00069	0.413
MOD_CK1_1	157	163	PF00069	0.433
MOD_CK1_1	173	179	PF00069	0.280
MOD_CK1_1	2	8	PF00069	0.658
MOD_CK1_1	243	249	PF00069	0.396
MOD_CK1_1	314	320	PF00069	0.483
MOD_CK2_1	224	230	PF00069	0.279
MOD_CK2_1	243	249	PF00069	0.335
MOD_CK2_1	330	336	PF00069	0.397
MOD_CK2_1	43	49	PF00069	0.338
MOD_CK2_1	65	71	PF00069	0.355
MOD_GlcNHglycan	128	131	PF01048	0.488
MOD_GlcNHglycan	156	159	PF01048	0.403
MOD_GlcNHglycan	16	19	PF01048	0.280
MOD_GlcNHglycan	172	175	PF01048	0.249
MOD_GlcNHglycan	216	219	PF01048	0.311
MOD_GlcNHglycan	288	291	PF01048	0.352
MOD_GlcNHglycan	38	41	PF01048	0.414
MOD_GlcNHglycan	4	7	PF01048	0.654
MOD_GlcNHglycan	8	11	PF01048	0.619
MOD_GSK3_1	128	135	PF00069	0.460
MOD_GSK3_1	146	153	PF00069	0.324
MOD_GSK3_1	154	161	PF00069	0.386
MOD_GSK3_1	162	169	PF00069	0.477
MOD_GSK3_1	178	185	PF00069	0.261
MOD_GSK3_1	2	9	PF00069	0.602
MOD_GSK3_1	24	31	PF00069	0.368
MOD_GSK3_1	261	268	PF00069	0.306
MOD_GSK3_1	32	39	PF00069	0.368
MOD_N-GLC_1	166	171	PF02516	0.442
MOD_NEK2_1	1	6	PF00069	0.754
MOD_NEK2_1	117	122	PF00069	0.494
MOD_NEK2_1	126	131	PF00069	0.460
MOD_NEK2_1	261	266	PF00069	0.279
MOD_NEK2_1	36	41	PF00069	0.410
MOD_PKA_2	14	20	PF00069	0.322
MOD_PKA_2	162	168	PF00069	0.299
MOD_PKA_2	43	49	PF00069	0.408
MOD_PKA_2	65	71	PF00069	0.355
MOD_PKB_1	265	273	PF00069	0.325
MOD_Plk_4	267	273	PF00069	0.357
MOD_Plk_4	55	61	PF00069	0.357
MOD_ProDKin_1	119	125	PF00069	0.462
MOD_ProDKin_1	21	27	PF00069	0.279
MOD_ProDKin_1	240	246	PF00069	0.297
MOD_SUMO_rev_2	332	341	PF00179	0.306
TRG_DiLeu_BaEn_4	256	262	PF01217	0.319
TRG_DiLeu_BaEn_4	336	342	PF01217	0.355
TRG_ENDOCYTIC_2	212	215	PF00928	0.306
TRG_ENDOCYTIC_2	73	76	PF00928	0.416
TRG_ER_diArg_1	102	105	PF00400	0.395
TRG_ER_diArg_1	304	306	PF00400	0.363
TRG_ER_diArg_1	41	44	PF00400	0.277
TRG_NLS_MonoExtC_3	43	49	PF00514	0.385
TRG_NLS_MonoExtN_4	42	48	PF00514	0.385
TRG_Pf-PMV_PEXEL_1	343	347	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD4	Leptomonas seymouri	58%	100%
A0A1X0P6J9	Trypanosomatidae	45%	100%
A0A3R7N3C2	Trypanosoma rangeli	43%	100%
A0A3S5H755	Leishmania donovani	100%	100%
A4HA05	Leishmania braziliensis	76%	100%
D0A0I9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ARZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QDH4	Leishmania major	94%	100%
V5BBW3	Trypanosoma cruzi	37%	100%