WASH_WAHD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Predicted coiled-coil domain-containing protein (DUF2360) - putative

Species:

Leishmania infantum

UniProt:

A4HY68_LEIIN

TriTrypDb:

LINF_190009500

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	8
GO:0071203	WASH complex	2	8
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HY68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY68

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006887	exocytosis	4	1
GO:0007015	actin filament organization	5	1
GO:0008154	actin polymerization or depolymerization	6	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0022607	cellular component assembly	4	1
GO:0030041	actin filament polymerization	7	1
GO:0032940	secretion by cell	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0046903	secretion	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051258	protein polymerization	6	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097435	supramolecular fiber organization	4	1
GO:0140352	export from cell	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.328
CLV_C14_Caspase3-7	273	277	PF00656	0.497
CLV_NRD_NRD_1	135	137	PF00675	0.385
CLV_NRD_NRD_1	140	142	PF00675	0.387
CLV_NRD_NRD_1	163	165	PF00675	0.424
CLV_NRD_NRD_1	175	177	PF00675	0.231
CLV_PCSK_FUR_1	133	137	PF00082	0.335
CLV_PCSK_FUR_1	138	142	PF00082	0.338
CLV_PCSK_KEX2_1	135	137	PF00082	0.394
CLV_PCSK_KEX2_1	140	142	PF00082	0.399
CLV_PCSK_KEX2_1	163	165	PF00082	0.474
CLV_PCSK_PC7_1	136	142	PF00082	0.374
CLV_PCSK_SKI1_1	200	204	PF00082	0.360
DOC_CDC14_PxL_1	206	214	PF14671	0.360
DOC_CKS1_1	272	277	PF01111	0.489
DOC_CYCLIN_yCln2_LP_2	153	159	PF00134	0.291
DOC_CYCLIN_yCln2_LP_2	251	257	PF00134	0.307
DOC_MAPK_JIP1_4	230	236	PF00069	0.360
DOC_PP2B_LxvP_1	153	156	PF13499	0.368
DOC_PP2B_LxvP_1	251	254	PF13499	0.300
DOC_SPAK_OSR1_1	38	42	PF12202	0.300
DOC_USP7_MATH_1	13	17	PF00917	0.562
DOC_USP7_MATH_1	278	282	PF00917	0.577
DOC_USP7_MATH_1	7	11	PF00917	0.648
DOC_WW_Pin1_4	271	276	PF00397	0.504
LIG_14-3-3_CanoR_1	200	205	PF00244	0.369
LIG_14-3-3_CanoR_1	38	47	PF00244	0.326
LIG_14-3-3_CanoR_1	57	65	PF00244	0.403
LIG_BIR_II_1	1	5	PF00653	0.559
LIG_CtBP_PxDLS_1	226	230	PF00389	0.360
LIG_EVH1_1	155	159	PF00568	0.328
LIG_FHA_1	1	7	PF00498	0.690
LIG_FHA_1	70	76	PF00498	0.300
LIG_FHA_1	9	15	PF00498	0.517
LIG_MYND_1	210	214	PF01753	0.360
LIG_NRBOX	74	80	PF00104	0.356
LIG_PCNA_PIPBox_1	71	80	PF02747	0.328
LIG_Pex14_2	267	271	PF04695	0.376
LIG_Pex14_2	46	50	PF04695	0.300
LIG_SH2_STAT5	109	112	PF00017	0.328
LIG_SH2_STAT5	245	248	PF00017	0.424
LIG_SH3_1	176	182	PF00018	0.335
LIG_SH3_2	156	161	PF14604	0.243
LIG_SH3_3	153	159	PF00018	0.399
LIG_SH3_3	165	171	PF00018	0.368
LIG_SH3_3	176	182	PF00018	0.339
LIG_SH3_3	204	210	PF00018	0.306
LIG_SH3_3	218	224	PF00018	0.324
LIG_SH3_3	272	278	PF00018	0.576
LIG_SH3_3	288	294	PF00018	0.610
LIG_TRAF2_1	192	195	PF00917	0.360
LIG_TRAF2_1	92	95	PF00917	0.496
LIG_WW_3	178	182	PF00397	0.376
MOD_CK1_1	124	130	PF00069	0.507
MOD_CK1_1	281	287	PF00069	0.556
MOD_Cter_Amidation	138	141	PF01082	0.346
MOD_GlcNHglycan	125	129	PF01048	0.388
MOD_GlcNHglycan	15	18	PF01048	0.483
MOD_GlcNHglycan	164	167	PF01048	0.393
MOD_GlcNHglycan	216	219	PF01048	0.460
MOD_GlcNHglycan	280	283	PF01048	0.584
MOD_GlcNHglycan	3	6	PF01048	0.601
MOD_GlcNHglycan	82	85	PF01048	0.348
MOD_GSK3_1	9	16	PF00069	0.557
MOD_N-GLC_1	8	13	PF02516	0.565
MOD_NEK2_1	1	6	PF00069	0.617
MOD_NEK2_1	39	44	PF00069	0.321
MOD_NEK2_1	78	83	PF00069	0.360
MOD_NEK2_1	8	13	PF00069	0.519
MOD_PIKK_1	69	75	PF00454	0.360
MOD_PKA_2	162	168	PF00069	0.369
MOD_PKA_2	48	54	PF00069	0.382
MOD_Plk_1	61	67	PF00069	0.360
MOD_Plk_4	105	111	PF00069	0.328
MOD_Plk_4	148	154	PF00069	0.353
MOD_ProDKin_1	271	277	PF00069	0.501
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.384
TRG_ENDOCYTIC_2	245	248	PF00928	0.300
TRG_ER_diArg_1	132	135	PF00400	0.397
TRG_ER_diArg_1	138	141	PF00400	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Y5	Leptomonas seymouri	56%	96%
A0A1X0P6B5	Trypanosomatidae	35%	100%
A0A3Q8ID87	Leishmania donovani	99%	100%
A4HA04	Leishmania braziliensis	80%	100%
E9ARZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QDH5	Leishmania major	94%	100%