LeishMANIAdb
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Putative nucleosome assembly protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative nucleosome assembly protein
Gene product:
nucleosome assembly protein - putative
Species:
Leishmania infantum
UniProt:
A4HY66_LEIIN
TriTrypDb:
LINF_190009300
Length:
350

Annotations

Annotations by Jardim et al.

Histone/chromosome structure, nucleosome assembly

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. no yes: 6
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:0000785 chromatin 2 1
GO:0005737 cytoplasm 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HY66
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY66

Function

Biological processes
Term Name Level Count
GO:0006325 chromatin organization 4 12
GO:0006334 nucleosome assembly 7 12
GO:0006338 chromatin remodeling 5 12
GO:0009987 cellular process 1 12
GO:0016043 cellular component organization 3 12
GO:0022607 cellular component assembly 4 12
GO:0034728 nucleosome organization 6 12
GO:0043933 protein-containing complex organization 4 12
GO:0065003 protein-containing complex assembly 5 12
GO:0065004 protein-DNA complex assembly 6 12
GO:0071824 protein-DNA complex subunit organization 5 12
GO:0071840 cellular component organization or biogenesis 2 12
Molecular functions
Term Name Level Count
GO:0003682 chromatin binding 2 1
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0042393 histone binding 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 132 136 PF00656 0.335
CLV_C14_Caspase3-7 151 155 PF00656 0.363
CLV_NRD_NRD_1 81 83 PF00675 0.234
CLV_NRD_NRD_1 93 95 PF00675 0.259
CLV_PCSK_FUR_1 236 240 PF00082 0.283
CLV_PCSK_KEX2_1 238 240 PF00082 0.188
CLV_PCSK_KEX2_1 81 83 PF00082 0.196
CLV_PCSK_KEX2_1 93 95 PF00082 0.194
CLV_PCSK_PC1ET2_1 238 240 PF00082 0.188
DEG_SPOP_SBC_1 243 247 PF00917 0.468
DOC_MAPK_gen_1 207 215 PF00069 0.426
DOC_MAPK_gen_1 4 13 PF00069 0.521
DOC_MAPK_gen_1 70 79 PF00069 0.521
DOC_MAPK_MEF2A_6 207 215 PF00069 0.363
DOC_MAPK_MEF2A_6 248 255 PF00069 0.398
DOC_USP7_MATH_1 101 105 PF00917 0.426
DOC_USP7_MATH_1 202 206 PF00917 0.430
DOC_USP7_UBL2_3 234 238 PF12436 0.402
DOC_WW_Pin1_4 187 192 PF00397 0.516
DOC_WW_Pin1_4 213 218 PF00397 0.410
LIG_14-3-3_CanoR_1 148 153 PF00244 0.363
LIG_14-3-3_CanoR_1 172 176 PF00244 0.403
LIG_14-3-3_CanoR_1 244 251 PF00244 0.507
LIG_14-3-3_CanoR_1 283 287 PF00244 0.483
LIG_APCC_ABBA_1 157 162 PF00400 0.426
LIG_BIR_III_4 135 139 PF00653 0.426
LIG_BRCT_BRCA1_1 39 43 PF00533 0.344
LIG_FHA_1 199 205 PF00498 0.453
LIG_FHA_1 238 244 PF00498 0.411
LIG_FHA_1 245 251 PF00498 0.395
LIG_FHA_1 261 267 PF00498 0.398
LIG_FHA_1 290 296 PF00498 0.435
LIG_FHA_2 130 136 PF00498 0.433
LIG_FHA_2 149 155 PF00498 0.500
LIG_FHA_2 244 250 PF00498 0.398
LIG_LIR_Gen_1 140 147 PF02991 0.480
LIG_LIR_Gen_1 182 191 PF02991 0.418
LIG_LIR_Nem_3 140 146 PF02991 0.480
LIG_LIR_Nem_3 177 183 PF02991 0.394
LIG_LIR_Nem_3 254 259 PF02991 0.421
LIG_LIR_Nem_3 30 34 PF02991 0.416
LIG_LIR_Nem_3 84 90 PF02991 0.388
LIG_Pex14_2 183 187 PF04695 0.400
LIG_Pex14_2 255 259 PF04695 0.421
LIG_Pex14_2 39 43 PF04695 0.392
LIG_SH2_CRK 83 87 PF00017 0.426
LIG_SH2_SRC 34 37 PF00017 0.503
LIG_SH2_STAP1 61 65 PF00017 0.426
LIG_SH2_STAP1 83 87 PF00017 0.388
LIG_SH2_STAT5 302 305 PF00017 0.422
LIG_SH2_STAT5 34 37 PF00017 0.386
LIG_SH3_3 8 14 PF00018 0.620
LIG_SUMO_SIM_anti_2 285 292 PF11976 0.483
LIG_SUMO_SIM_par_1 118 123 PF11976 0.398
LIG_SUMO_SIM_par_1 167 174 PF11976 0.443
LIG_SUMO_SIM_par_1 201 209 PF11976 0.426
LIG_SUMO_SIM_par_1 9 19 PF11976 0.509
LIG_TRAF2_1 104 107 PF00917 0.422
LIG_UBA3_1 86 95 PF00899 0.398
LIG_WRC_WIRS_1 180 185 PF05994 0.398
LIG_WRC_WIRS_1 186 191 PF05994 0.404
MOD_CK1_1 216 222 PF00069 0.428
MOD_CK1_1 37 43 PF00069 0.292
MOD_CK2_1 101 107 PF00069 0.422
MOD_CK2_1 152 158 PF00069 0.415
MOD_CK2_1 171 177 PF00069 0.519
MOD_CK2_1 282 288 PF00069 0.483
MOD_GlcNHglycan 58 61 PF01048 0.283
MOD_GlcNHglycan 64 68 PF01048 0.198
MOD_GSK3_1 148 155 PF00069 0.389
MOD_GSK3_1 196 203 PF00069 0.430
MOD_NEK2_1 227 232 PF00069 0.543
MOD_NEK2_2 202 207 PF00069 0.430
MOD_NEK2_2 251 256 PF00069 0.476
MOD_PKA_1 260 266 PF00069 0.398
MOD_PKA_2 171 177 PF00069 0.384
MOD_PKA_2 243 249 PF00069 0.433
MOD_PKA_2 282 288 PF00069 0.483
MOD_Plk_1 153 159 PF00069 0.426
MOD_Plk_1 196 202 PF00069 0.421
MOD_Plk_1 211 217 PF00069 0.444
MOD_Plk_4 148 154 PF00069 0.417
MOD_Plk_4 251 257 PF00069 0.421
MOD_ProDKin_1 187 193 PF00069 0.516
MOD_ProDKin_1 213 219 PF00069 0.410
MOD_SUMO_rev_2 205 211 PF00179 0.547
TRG_DiLeu_BaEn_3 325 331 PF01217 0.665
TRG_DiLeu_BaLyEn_6 86 91 PF01217 0.443
TRG_ENDOCYTIC_2 180 183 PF00928 0.381
TRG_ENDOCYTIC_2 83 86 PF00928 0.469
TRG_ER_diArg_1 332 335 PF00400 0.661
TRG_ER_diArg_1 51 54 PF00400 0.445
TRG_ER_diArg_1 80 82 PF00400 0.405

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1J2 Leptomonas seymouri 70% 100%
A0A0N1IJI7 Leptomonas seymouri 30% 86%
A0A1X0P6J1 Trypanosomatidae 47% 84%
A0A3Q8IA70 Leishmania donovani 100% 100%
A0A3R7KRI5 Trypanosoma rangeli 49% 100%
A0A3S7X4M4 Leishmania donovani 31% 87%
A2ZX50 Oryza sativa subsp. japonica 24% 100%
A4HA02 Leishmania braziliensis 81% 100%
A4HJF7 Leishmania braziliensis 31% 100%
A4I6V2 Leishmania infantum 31% 87%
A6H767 Bos taurus 29% 90%
B8AW64 Oryza sativa subsp. indica 28% 96%
B8B4K9 Oryza sativa subsp. indica 24% 100%
B9FU45 Oryza sativa subsp. japonica 24% 100%
C9ZXT4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 83%
D0A0I6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 96%
E9ARZ6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
E9B1X5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 86%
O59797 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 89%
P25293 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 84%
P28656 Mus musculus 30% 90%
P51860 Mus musculus 27% 76%
P55209 Homo sapiens 29% 90%
P78920 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 29% 92%
Q28EB4 Xenopus tropicalis 29% 89%
Q2TA40 Bos taurus 30% 91%
Q4Q687 Leishmania major 31% 100%
Q4QDH7 Leishmania major 96% 100%
Q4U0Y4 Xenopus laevis 29% 89%
Q53WK4 Oryza sativa subsp. japonica 28% 96%
Q55ED1 Dictyostelium discoideum 32% 100%
Q5AAI8 Candida albicans (strain SC5314 / ATCC MYA-2876) 27% 80%
Q5MGA9 Oryza sativa subsp. indica 25% 100%
Q5R4D4 Pongo abelii 29% 90%
Q5U2Z3 Rattus norvegicus 31% 91%
Q70Z16 Nicotiana tabacum 25% 98%
Q70Z17 Nicotiana tabacum 26% 93%
Q70Z18 Nicotiana tabacum 25% 93%
Q70Z19 Nicotiana tabacum 24% 94%
Q78ZA7 Mus musculus 31% 93%
Q7ZY81 Xenopus laevis 28% 89%
Q94K07 Arabidopsis thaliana 28% 94%
Q99733 Homo sapiens 32% 93%
Q9SZI2 Arabidopsis thaliana 28% 94%
Q9ULW6 Homo sapiens 26% 76%
Q9Z2G8 Rattus norvegicus 30% 90%
V5BX23 Trypanosoma cruzi 48% 98%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS