LeishMANIAdb
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EF-hand domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
EF-hand domain-containing protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4HY56_LEIIN
TriTrypDb:
LINF_190008300 *
Length:
458

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 11
GO:0043226 organelle 2 11
GO:0043227 membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 11
GO:0043231 intracellular membrane-bounded organelle 4 11
GO:0110165 cellular anatomical entity 1 11

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HY56
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY56

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005509 calcium ion binding 5 1
GO:0043167 ion binding 2 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 202 206 PF00656 0.521
CLV_NRD_NRD_1 166 168 PF00675 0.534
CLV_NRD_NRD_1 194 196 PF00675 0.473
CLV_NRD_NRD_1 225 227 PF00675 0.444
CLV_NRD_NRD_1 292 294 PF00675 0.337
CLV_NRD_NRD_1 402 404 PF00675 0.367
CLV_PCSK_FUR_1 192 196 PF00082 0.486
CLV_PCSK_KEX2_1 166 168 PF00082 0.508
CLV_PCSK_KEX2_1 194 196 PF00082 0.473
CLV_PCSK_KEX2_1 292 294 PF00082 0.340
CLV_PCSK_KEX2_1 402 404 PF00082 0.360
CLV_PCSK_PC7_1 162 168 PF00082 0.369
CLV_PCSK_SKI1_1 226 230 PF00082 0.481
CLV_PCSK_SKI1_1 341 345 PF00082 0.450
CLV_PCSK_SKI1_1 447 451 PF00082 0.489
DEG_Nend_Nbox_1 1 3 PF02207 0.569
DEG_SPOP_SBC_1 95 99 PF00917 0.604
DOC_CYCLIN_RxL_1 192 203 PF00134 0.452
DOC_MAPK_gen_1 192 199 PF00069 0.430
DOC_MAPK_gen_1 314 324 PF00069 0.393
DOC_PP1_RVXF_1 315 322 PF00149 0.474
DOC_PP2B_LxvP_1 274 277 PF13499 0.405
DOC_PP4_FxxP_1 371 374 PF00568 0.480
DOC_USP7_MATH_1 147 151 PF00917 0.583
DOC_USP7_MATH_1 200 204 PF00917 0.538
DOC_USP7_MATH_1 277 281 PF00917 0.278
DOC_USP7_MATH_1 329 333 PF00917 0.530
DOC_USP7_MATH_1 343 347 PF00917 0.354
DOC_USP7_MATH_1 367 371 PF00917 0.461
DOC_USP7_MATH_1 432 436 PF00917 0.437
DOC_USP7_MATH_1 90 94 PF00917 0.666
DOC_USP7_MATH_1 95 99 PF00917 0.640
DOC_USP7_UBL2_3 227 231 PF12436 0.343
DOC_USP7_UBL2_3 415 419 PF12436 0.517
DOC_WW_Pin1_4 103 108 PF00397 0.629
DOC_WW_Pin1_4 305 310 PF00397 0.482
DOC_WW_Pin1_4 349 354 PF00397 0.462
DOC_WW_Pin1_4 453 458 PF00397 0.500
LIG_14-3-3_CanoR_1 10 17 PF00244 0.688
LIG_14-3-3_CanoR_1 114 124 PF00244 0.614
LIG_14-3-3_CanoR_1 128 134 PF00244 0.639
LIG_14-3-3_CanoR_1 68 78 PF00244 0.619
LIG_AP2alpha_1 362 366 PF02296 0.461
LIG_eIF4E_1 38 44 PF01652 0.669
LIG_FHA_1 104 110 PF00498 0.675
LIG_FHA_1 119 125 PF00498 0.562
LIG_FHA_1 185 191 PF00498 0.453
LIG_FHA_1 208 214 PF00498 0.674
LIG_FHA_1 240 246 PF00498 0.499
LIG_FHA_1 352 358 PF00498 0.506
LIG_FHA_1 376 382 PF00498 0.449
LIG_FHA_1 38 44 PF00498 0.594
LIG_FHA_2 108 114 PF00498 0.571
LIG_FHA_2 141 147 PF00498 0.537
LIG_FHA_2 412 418 PF00498 0.427
LIG_Integrin_isoDGR_2 290 292 PF01839 0.300
LIG_Integrin_isoDGR_2 410 412 PF01839 0.430
LIG_LIR_Apic_2 158 163 PF02991 0.463
LIG_LIR_Apic_2 368 374 PF02991 0.466
LIG_LIR_Gen_1 121 127 PF02991 0.617
LIG_LIR_Gen_1 275 285 PF02991 0.463
LIG_LIR_Gen_1 320 329 PF02991 0.493
LIG_LIR_Nem_3 121 125 PF02991 0.613
LIG_LIR_Nem_3 275 281 PF02991 0.462
LIG_LIR_Nem_3 298 304 PF02991 0.333
LIG_LIR_Nem_3 320 324 PF02991 0.459
LIG_MYND_1 138 142 PF01753 0.603
LIG_NRBOX 432 438 PF00104 0.507
LIG_PDZ_Class_1 453 458 PF00595 0.500
LIG_Pex14_1 71 75 PF04695 0.543
LIG_Pex14_2 344 348 PF04695 0.345
LIG_Pex14_2 362 366 PF04695 0.312
LIG_SH2_CRK 301 305 PF00017 0.472
LIG_SH2_PTP2 160 163 PF00017 0.532
LIG_SH2_PTP2 173 176 PF00017 0.473
LIG_SH2_PTP2 278 281 PF00017 0.393
LIG_SH2_SRC 173 176 PF00017 0.555
LIG_SH2_SRC 27 30 PF00017 0.569
LIG_SH2_STAT5 160 163 PF00017 0.496
LIG_SH2_STAT5 173 176 PF00017 0.436
LIG_SH2_STAT5 267 270 PF00017 0.506
LIG_SH2_STAT5 27 30 PF00017 0.569
LIG_SH2_STAT5 278 281 PF00017 0.159
LIG_SH3_3 212 218 PF00018 0.260
LIG_SH3_3 451 457 PF00018 0.536
LIG_SH3_3 79 85 PF00018 0.650
LIG_SH3_4 181 188 PF00018 0.554
LIG_SUMO_SIM_anti_2 260 266 PF11976 0.390
LIG_TRAF2_1 143 146 PF00917 0.604
LIG_TRAF2_1 414 417 PF00917 0.363
LIG_WRC_WIRS_1 304 309 PF05994 0.413
MOD_CK1_1 118 124 PF00069 0.576
MOD_CK1_1 132 138 PF00069 0.643
MOD_CK1_1 151 157 PF00069 0.595
MOD_CK1_1 183 189 PF00069 0.514
MOD_CK2_1 140 146 PF00069 0.502
MOD_CK2_1 277 283 PF00069 0.434
MOD_CK2_1 411 417 PF00069 0.399
MOD_Cter_Amidation 290 293 PF01082 0.286
MOD_DYRK1A_RPxSP_1 305 309 PF00069 0.501
MOD_DYRK1A_RPxSP_1 453 457 PF00069 0.479
MOD_GlcNHglycan 331 334 PF01048 0.440
MOD_GlcNHglycan 335 338 PF01048 0.395
MOD_GlcNHglycan 389 392 PF01048 0.351
MOD_GlcNHglycan 90 93 PF01048 0.629
MOD_GSK3_1 103 110 PF00069 0.555
MOD_GSK3_1 147 154 PF00069 0.490
MOD_GSK3_1 180 187 PF00069 0.555
MOD_GSK3_1 28 35 PF00069 0.560
MOD_GSK3_1 329 336 PF00069 0.382
MOD_GSK3_1 351 358 PF00069 0.467
MOD_GSK3_1 375 382 PF00069 0.423
MOD_GSK3_1 9 16 PF00069 0.678
MOD_GSK3_1 90 97 PF00069 0.661
MOD_N-GLC_1 397 402 PF02516 0.369
MOD_N-GLC_1 45 50 PF02516 0.604
MOD_N-GLC_1 80 85 PF02516 0.565
MOD_NEK2_1 156 161 PF00069 0.523
MOD_NEK2_1 296 301 PF00069 0.453
MOD_NEK2_1 303 308 PF00069 0.429
MOD_NEK2_1 379 384 PF00069 0.433
MOD_NEK2_1 88 93 PF00069 0.647
MOD_OFUCOSY 396 401 PF10250 0.489
MOD_PIKK_1 112 118 PF00454 0.598
MOD_PIKK_1 181 187 PF00454 0.534
MOD_PIKK_1 343 349 PF00454 0.444
MOD_PIKK_1 355 361 PF00454 0.497
MOD_PKA_2 411 417 PF00069 0.389
MOD_PKA_2 9 15 PF00069 0.578
MOD_Plk_1 112 118 PF00069 0.642
MOD_Plk_1 367 373 PF00069 0.303
MOD_Plk_1 375 381 PF00069 0.470
MOD_Plk_4 118 124 PF00069 0.512
MOD_Plk_4 156 162 PF00069 0.562
MOD_Plk_4 209 215 PF00069 0.578
MOD_Plk_4 277 283 PF00069 0.434
MOD_Plk_4 296 302 PF00069 0.316
MOD_Plk_4 39 45 PF00069 0.667
MOD_Plk_4 432 438 PF00069 0.507
MOD_ProDKin_1 103 109 PF00069 0.628
MOD_ProDKin_1 305 311 PF00069 0.478
MOD_ProDKin_1 349 355 PF00069 0.453
MOD_SUMO_rev_2 164 172 PF00179 0.567
MOD_SUMO_rev_2 53 62 PF00179 0.575
TRG_DiLeu_BaEn_1 260 265 PF01217 0.349
TRG_ENDOCYTIC_2 278 281 PF00928 0.442
TRG_ENDOCYTIC_2 301 304 PF00928 0.369
TRG_ENDOCYTIC_2 75 78 PF00928 0.528
TRG_ER_diArg_1 165 167 PF00400 0.571
TRG_ER_diArg_1 191 194 PF00400 0.423
TRG_ER_diArg_1 402 404 PF00400 0.367

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8K5 Leptomonas seymouri 58% 100%
A0A0S4J8I1 Bodo saltans 38% 100%
A0A0S4J9L9 Bodo saltans 38% 100%
A0A1X0P6D5 Trypanosomatidae 45% 100%
A0A3R7KYH1 Trypanosoma rangeli 43% 100%
A0A3S5H753 Leishmania donovani 99% 100%
A4H9Z2 Leishmania braziliensis 82% 97%
D0A0G4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
E9ARY6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4QDI7 Leishmania major 93% 100%
V5C1T2 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS