LeishMANIAdb
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Intraflagellar transport protein 80

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Intraflagellar transport protein 80
Gene product:
intraflagellar transport protein 80 - putative
Species:
Leishmania infantum
UniProt:
A4HY55_LEIIN
TriTrypDb:
LINF_190008200
Length:
594

Annotations

Annotations by Jardim et al.

Flagella, intraflagellar transport 80 Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005813 centrosome 3 1
GO:0005815 microtubule organizing center 2 1
GO:0005929 cilium 4 4
GO:0030990 intraciliary transport particle 2 1
GO:0030992 intraciliary transport particle B 2 1
GO:0032991 protein-containing complex 1 1
GO:0042995 cell projection 2 4
GO:0043226 organelle 2 4
GO:0043227 membrane-bounded organelle 3 4
GO:0110165 cellular anatomical entity 1 4
GO:0120025 plasma membrane bounded cell projection 3 4
GO:0031514 motile cilium 5 3

Expansion

Sequence features

A4HY55
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY55

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006996 organelle organization 4 1
GO:0007017 microtubule-based process 2 1
GO:0007018 microtubule-based movement 3 1
GO:0009987 cellular process 1 1
GO:0010970 transport along microtubule 4 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0030030 cell projection organization 4 1
GO:0030031 cell projection assembly 5 1
GO:0030705 cytoskeleton-dependent intracellular transport 4 1
GO:0031503 protein-containing complex localization 2 1
GO:0035735 intraciliary transport involved in cilium assembly 4 1
GO:0042073 intraciliary transport 3 1
GO:0044782 cilium organization 5 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0060271 cilium assembly 6 1
GO:0070925 organelle assembly 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0099111 microtubule-based transport 4 1
GO:0120031 plasma membrane bounded cell projection assembly 6 1
GO:0120036 plasma membrane bounded cell projection organization 5 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 134 138 PF00656 0.297
CLV_C14_Caspase3-7 370 374 PF00656 0.378
CLV_NRD_NRD_1 123 125 PF00675 0.323
CLV_NRD_NRD_1 139 141 PF00675 0.292
CLV_NRD_NRD_1 299 301 PF00675 0.283
CLV_NRD_NRD_1 396 398 PF00675 0.309
CLV_NRD_NRD_1 531 533 PF00675 0.363
CLV_NRD_NRD_1 542 544 PF00675 0.334
CLV_PCSK_KEX2_1 139 141 PF00082 0.499
CLV_PCSK_KEX2_1 396 398 PF00082 0.309
CLV_PCSK_KEX2_1 542 544 PF00082 0.353
CLV_PCSK_PC7_1 392 398 PF00082 0.327
CLV_PCSK_SKI1_1 139 143 PF00082 0.487
CLV_PCSK_SKI1_1 159 163 PF00082 0.271
CLV_PCSK_SKI1_1 206 210 PF00082 0.266
CLV_PCSK_SKI1_1 263 267 PF00082 0.270
CLV_PCSK_SKI1_1 3 7 PF00082 0.388
CLV_PCSK_SKI1_1 301 305 PF00082 0.258
CLV_PCSK_SKI1_1 362 366 PF00082 0.324
CLV_PCSK_SKI1_1 433 437 PF00082 0.450
CLV_PCSK_SKI1_1 501 505 PF00082 0.326
CLV_PCSK_SKI1_1 518 522 PF00082 0.335
DEG_Nend_UBRbox_1 1 4 PF02207 0.401
DEG_ODPH_VHL_1 556 568 PF01847 0.407
DEG_SPOP_SBC_1 172 176 PF00917 0.319
DOC_ANK_TNKS_1 395 402 PF00023 0.359
DOC_ANK_TNKS_1 58 65 PF00023 0.442
DOC_CKS1_1 479 484 PF01111 0.314
DOC_CYCLIN_RxL_1 260 271 PF00134 0.295
DOC_CYCLIN_yCln2_LP_2 186 192 PF00134 0.362
DOC_CYCLIN_yCln2_LP_2 404 410 PF00134 0.436
DOC_MAPK_gen_1 518 528 PF00069 0.423
DOC_MAPK_gen_1 6 15 PF00069 0.312
DOC_MAPK_HePTP_8 393 408 PF00069 0.441
DOC_MAPK_MEF2A_6 195 203 PF00069 0.281
DOC_MAPK_MEF2A_6 225 234 PF00069 0.431
DOC_MAPK_RevD_3 287 301 PF00069 0.350
DOC_PP1_RVXF_1 1 8 PF00149 0.402
DOC_PP1_RVXF_1 122 129 PF00149 0.330
DOC_PP1_RVXF_1 261 268 PF00149 0.261
DOC_PP1_RVXF_1 298 305 PF00149 0.277
DOC_PP1_RVXF_1 565 571 PF00149 0.397
DOC_PP2B_LxvP_1 186 189 PF13499 0.327
DOC_PP2B_LxvP_1 404 407 PF13499 0.444
DOC_PP2B_PxIxI_1 196 202 PF00149 0.418
DOC_USP7_MATH_1 211 215 PF00917 0.431
DOC_USP7_MATH_1 54 58 PF00917 0.318
DOC_USP7_MATH_1 68 72 PF00917 0.209
DOC_USP7_UBL2_3 2 6 PF12436 0.393
DOC_WW_Pin1_4 246 251 PF00397 0.350
DOC_WW_Pin1_4 406 411 PF00397 0.301
DOC_WW_Pin1_4 478 483 PF00397 0.327
LIG_14-3-3_CanoR_1 124 129 PF00244 0.427
LIG_14-3-3_CanoR_1 139 144 PF00244 0.321
LIG_14-3-3_CanoR_1 225 230 PF00244 0.298
LIG_14-3-3_CanoR_1 231 237 PF00244 0.322
LIG_14-3-3_CanoR_1 532 540 PF00244 0.326
LIG_14-3-3_CanoR_1 89 96 PF00244 0.423
LIG_Actin_WH2_2 436 452 PF00022 0.278
LIG_APCC_ABBA_1 556 561 PF00400 0.365
LIG_BRCT_BRCA1_1 355 359 PF00533 0.398
LIG_BRCT_BRCA1_1 56 60 PF00533 0.381
LIG_FHA_1 103 109 PF00498 0.334
LIG_FHA_1 111 117 PF00498 0.374
LIG_FHA_1 130 136 PF00498 0.200
LIG_FHA_1 240 246 PF00498 0.377
LIG_FHA_1 327 333 PF00498 0.341
LIG_FHA_1 366 372 PF00498 0.321
LIG_FHA_1 389 395 PF00498 0.437
LIG_FHA_1 403 409 PF00498 0.320
LIG_FHA_1 410 416 PF00498 0.418
LIG_FHA_2 132 138 PF00498 0.290
LIG_FHA_2 140 146 PF00498 0.303
LIG_FHA_2 148 154 PF00498 0.339
LIG_FHA_2 26 32 PF00498 0.276
LIG_FHA_2 331 337 PF00498 0.235
LIG_FHA_2 358 364 PF00498 0.358
LIG_FHA_2 368 374 PF00498 0.296
LIG_FHA_2 378 384 PF00498 0.233
LIG_FHA_2 532 538 PF00498 0.361
LIG_LIR_Apic_2 310 315 PF02991 0.399
LIG_LIR_Apic_2 351 355 PF02991 0.246
LIG_LIR_Gen_1 18 27 PF02991 0.299
LIG_LIR_Gen_1 409 419 PF02991 0.330
LIG_LIR_Gen_1 569 577 PF02991 0.334
LIG_LIR_Gen_1 71 77 PF02991 0.292
LIG_LIR_Nem_3 127 131 PF02991 0.453
LIG_LIR_Nem_3 310 316 PF02991 0.316
LIG_LIR_Nem_3 458 464 PF02991 0.291
LIG_LIR_Nem_3 569 573 PF02991 0.332
LIG_LIR_Nem_3 71 75 PF02991 0.278
LIG_Pex14_1 83 87 PF04695 0.347
LIG_SH2_CRK 461 465 PF00017 0.290
LIG_SH2_STAP1 131 135 PF00017 0.330
LIG_SH2_STAP1 411 415 PF00017 0.292
LIG_SH2_STAT5 131 134 PF00017 0.278
LIG_SH2_STAT5 169 172 PF00017 0.261
LIG_SH2_STAT5 312 315 PF00017 0.320
LIG_SH2_STAT5 411 414 PF00017 0.298
LIG_SH2_STAT5 472 475 PF00017 0.295
LIG_SH2_STAT5 546 549 PF00017 0.389
LIG_SH3_3 34 40 PF00018 0.305
LIG_SH3_3 404 410 PF00018 0.391
LIG_SUMO_SIM_anti_2 132 138 PF11976 0.340
LIG_SUMO_SIM_par_1 131 138 PF11976 0.297
LIG_SUMO_SIM_par_1 242 249 PF11976 0.309
LIG_SUMO_SIM_par_1 363 368 PF11976 0.445
LIG_TRAF2_1 150 153 PF00917 0.366
LIG_TYR_ITIM 459 464 PF00017 0.276
LIG_TYR_ITIM 508 513 PF00017 0.300
LIG_UBA3_1 364 369 PF00899 0.392
LIG_UBA3_1 414 422 PF00899 0.392
LIG_WRC_WIRS_1 69 74 PF05994 0.271
MOD_CDK_SPxxK_3 478 485 PF00069 0.322
MOD_CK1_1 20 26 PF00069 0.305
MOD_CK1_1 249 255 PF00069 0.278
MOD_CK1_1 326 332 PF00069 0.308
MOD_CK1_1 409 415 PF00069 0.484
MOD_CK2_1 147 153 PF00069 0.395
MOD_CK2_1 25 31 PF00069 0.278
MOD_CK2_1 548 554 PF00069 0.545
MOD_Cter_Amidation 540 543 PF01082 0.443
MOD_GlcNHglycan 22 25 PF01048 0.451
MOD_GlcNHglycan 270 273 PF01048 0.440
MOD_GlcNHglycan 293 296 PF01048 0.451
MOD_GlcNHglycan 47 50 PF01048 0.335
MOD_GlcNHglycan 561 565 PF01048 0.424
MOD_GlcNHglycan 92 96 PF01048 0.333
MOD_GSK3_1 110 117 PF00069 0.444
MOD_GSK3_1 131 138 PF00069 0.377
MOD_GSK3_1 240 247 PF00069 0.404
MOD_GSK3_1 285 292 PF00069 0.275
MOD_GSK3_1 323 330 PF00069 0.303
MOD_GSK3_1 353 360 PF00069 0.253
MOD_GSK3_1 363 370 PF00069 0.304
MOD_GSK3_1 402 409 PF00069 0.386
MOD_GSK3_1 41 48 PF00069 0.307
MOD_GSK3_1 531 538 PF00069 0.342
MOD_GSK3_1 548 555 PF00069 0.413
MOD_GSK3_1 83 90 PF00069 0.392
MOD_N-GLC_1 110 115 PF02516 0.482
MOD_NEK2_1 135 140 PF00069 0.394
MOD_NEK2_1 232 237 PF00069 0.318
MOD_NEK2_1 25 30 PF00069 0.285
MOD_NEK2_1 291 296 PF00069 0.297
MOD_NEK2_1 328 333 PF00069 0.339
MOD_NEK2_1 365 370 PF00069 0.368
MOD_NEK2_1 388 393 PF00069 0.342
MOD_NEK2_2 41 46 PF00069 0.316
MOD_NEK2_2 54 59 PF00069 0.307
MOD_PIKK_1 102 108 PF00454 0.308
MOD_PIKK_1 173 179 PF00454 0.259
MOD_PIKK_1 211 217 PF00454 0.453
MOD_PIKK_1 289 295 PF00454 0.342
MOD_PIKK_1 315 321 PF00454 0.342
MOD_PIKK_1 417 423 PF00454 0.457
MOD_PIKK_1 548 554 PF00454 0.417
MOD_PK_1 225 231 PF00069 0.439
MOD_PKA_1 124 130 PF00069 0.455
MOD_PKA_1 139 145 PF00069 0.430
MOD_PKA_2 139 145 PF00069 0.451
MOD_PKA_2 20 26 PF00069 0.400
MOD_PKA_2 383 389 PF00069 0.372
MOD_PKA_2 531 537 PF00069 0.341
MOD_PKA_2 88 94 PF00069 0.431
MOD_Plk_1 17 23 PF00069 0.309
MOD_Plk_4 131 137 PF00069 0.302
MOD_Plk_4 348 354 PF00069 0.230
MOD_Plk_4 409 415 PF00069 0.316
MOD_Plk_4 41 47 PF00069 0.370
MOD_Plk_4 535 541 PF00069 0.326
MOD_Plk_4 68 74 PF00069 0.282
MOD_ProDKin_1 246 252 PF00069 0.349
MOD_ProDKin_1 406 412 PF00069 0.296
MOD_ProDKin_1 478 484 PF00069 0.323
MOD_SUMO_for_1 161 164 PF00179 0.276
MOD_SUMO_for_1 236 239 PF00179 0.463
MOD_SUMO_for_1 520 523 PF00179 0.435
MOD_SUMO_for_1 577 580 PF00179 0.425
MOD_SUMO_rev_2 117 127 PF00179 0.440
MOD_SUMO_rev_2 294 303 PF00179 0.336
MOD_SUMO_rev_2 527 534 PF00179 0.333
MOD_SUMO_rev_2 569 577 PF00179 0.396
TRG_DiLeu_BaLyEn_6 435 440 PF01217 0.301
TRG_ENDOCYTIC_2 169 172 PF00928 0.311
TRG_ENDOCYTIC_2 411 414 PF00928 0.277
TRG_ENDOCYTIC_2 461 464 PF00928 0.279
TRG_ENDOCYTIC_2 510 513 PF00928 0.295
TRG_ER_diArg_1 139 141 PF00400 0.499
TRG_ER_diArg_1 395 397 PF00400 0.305
TRG_NES_CRM1_1 226 239 PF08389 0.437
TRG_NES_CRM1_1 437 453 PF08389 0.354
TRG_Pf-PMV_PEXEL_1 139 144 PF00026 0.436
TRG_Pf-PMV_PEXEL_1 263 268 PF00026 0.403
TRG_Pf-PMV_PEXEL_1 433 437 PF00026 0.305
TRG_Pf-PMV_PEXEL_1 501 505 PF00026 0.326
TRG_Pf-PMV_PEXEL_1 545 549 PF00026 0.478

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMK4 Leptomonas seymouri 88% 76%
A0A0S4KKI7 Bodo saltans 57% 89%
A0A1X0P6J7 Trypanosomatidae 67% 76%
A0A3Q8IJX2 Leishmania donovani 100% 100%
A0A3R7N3D3 Trypanosoma rangeli 67% 76%
A4H9Z1 Leishmania braziliensis 94% 100%
D0A0G3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 64% 76%
E9ARY5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
Q4QDI8 Leishmania major 98% 100%
Q66HB3 Rattus norvegicus 40% 76%
Q8K057 Mus musculus 40% 76%
Q9P2H3 Homo sapiens 40% 76%
V5BWZ3 Trypanosoma cruzi 67% 76%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS