LeishMANIAdb
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Putative intraflagellar transport protein component

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative intraflagellar transport protein component
Gene product:
intraflagellar transport protein 52 - putative
Species:
Leishmania infantum
UniProt:
A4HY54_LEIIN
TriTrypDb:
LINF_190008100
Length:
674

Annotations

Annotations by Jardim et al.

Flagella, intraflagellar transport component

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 6
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005929 cilium 4 12
GO:0031514 motile cilium 5 12
GO:0042995 cell projection 2 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0110165 cellular anatomical entity 1 12
GO:0120025 plasma membrane bounded cell projection 3 12
GO:0005814 centriole 5 1
GO:0005815 microtubule organizing center 2 1
GO:0030990 intraciliary transport particle 2 1
GO:0030992 intraciliary transport particle B 2 1
GO:0032991 protein-containing complex 1 1
GO:0035869 ciliary transition zone 2 1
GO:0036064 ciliary basal body 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HY54
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY54

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 1
GO:0006996 organelle organization 4 1
GO:0007017 microtubule-based process 2 1
GO:0007018 microtubule-based movement 3 1
GO:0009987 cellular process 1 1
GO:0010970 transport along microtubule 4 1
GO:0016043 cellular component organization 3 1
GO:0022607 cellular component assembly 4 1
GO:0030030 cell projection organization 4 1
GO:0030031 cell projection assembly 5 1
GO:0030705 cytoskeleton-dependent intracellular transport 4 1
GO:0031503 protein-containing complex localization 2 1
GO:0035735 intraciliary transport involved in cilium assembly 4 1
GO:0042073 intraciliary transport 3 1
GO:0044782 cilium organization 5 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0060271 cilium assembly 6 1
GO:0070925 organelle assembly 5 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0099111 microtubule-based transport 4 1
GO:0120031 plasma membrane bounded cell projection assembly 6 1
GO:0120036 plasma membrane bounded cell projection organization 5 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 632 636 PF00656 0.407
CLV_NRD_NRD_1 305 307 PF00675 0.499
CLV_NRD_NRD_1 39 41 PF00675 0.470
CLV_NRD_NRD_1 62 64 PF00675 0.551
CLV_PCSK_KEX2_1 305 307 PF00082 0.500
CLV_PCSK_SKI1_1 150 154 PF00082 0.567
CLV_PCSK_SKI1_1 179 183 PF00082 0.588
CLV_PCSK_SKI1_1 203 207 PF00082 0.723
CLV_PCSK_SKI1_1 385 389 PF00082 0.514
CLV_PCSK_SKI1_1 505 509 PF00082 0.460
CLV_PCSK_SKI1_1 665 669 PF00082 0.551
CLV_Separin_Metazoa 382 386 PF03568 0.525
DEG_APCC_DBOX_1 463 471 PF00400 0.553
DEG_APCC_DBOX_1 504 512 PF00400 0.459
DEG_APCC_DBOX_1 664 672 PF00400 0.560
DEG_SCF_FBW7_2 94 100 PF00400 0.612
DOC_ANK_TNKS_1 106 113 PF00023 0.584
DOC_CKS1_1 427 432 PF01111 0.606
DOC_CKS1_1 94 99 PF01111 0.603
DOC_CYCLIN_yCln2_LP_2 286 292 PF00134 0.423
DOC_CYCLIN_yCln2_LP_2 422 425 PF00134 0.562
DOC_MAPK_DCC_7 412 422 PF00069 0.646
DOC_MAPK_DCC_7 444 453 PF00069 0.578
DOC_MAPK_FxFP_2 259 262 PF00069 0.388
DOC_MAPK_gen_1 305 314 PF00069 0.435
DOC_MAPK_gen_1 63 73 PF00069 0.439
DOC_MAPK_MEF2A_6 444 453 PF00069 0.566
DOC_MAPK_RevD_3 506 520 PF00069 0.489
DOC_PP1_RVXF_1 38 45 PF00149 0.482
DOC_PP2B_LxvP_1 422 425 PF13499 0.562
DOC_PP4_FxxP_1 259 262 PF00568 0.388
DOC_PP4_FxxP_1 427 430 PF00568 0.576
DOC_PP4_FxxP_1 91 94 PF00568 0.474
DOC_USP7_UBL2_3 175 179 PF12436 0.512
DOC_USP7_UBL2_3 412 416 PF12436 0.505
DOC_WW_Pin1_4 185 190 PF00397 0.694
DOC_WW_Pin1_4 3 8 PF00397 0.729
DOC_WW_Pin1_4 426 431 PF00397 0.610
DOC_WW_Pin1_4 495 500 PF00397 0.535
DOC_WW_Pin1_4 567 572 PF00397 0.491
DOC_WW_Pin1_4 93 98 PF00397 0.575
LIG_14-3-3_CanoR_1 82 92 PF00244 0.574
LIG_Actin_WH2_2 637 655 PF00022 0.463
LIG_BIR_II_1 1 5 PF00653 0.683
LIG_BIR_III_2 568 572 PF00653 0.543
LIG_BRCT_BRCA1_1 189 193 PF00533 0.723
LIG_BRCT_BRCA1_1 255 259 PF00533 0.446
LIG_BRCT_BRCA1_1 277 281 PF00533 0.414
LIG_BRCT_BRCA1_1 334 338 PF00533 0.547
LIG_BRCT_BRCA1_1 600 604 PF00533 0.516
LIG_CaM_NSCaTE_8 627 634 PF13499 0.559
LIG_Clathr_ClatBox_1 390 394 PF01394 0.582
LIG_Clathr_ClatBox_1 453 457 PF01394 0.563
LIG_FHA_1 163 169 PF00498 0.500
LIG_FHA_1 18 24 PF00498 0.738
LIG_FHA_1 195 201 PF00498 0.763
LIG_FHA_1 206 212 PF00498 0.791
LIG_FHA_1 253 259 PF00498 0.456
LIG_FHA_1 264 270 PF00498 0.392
LIG_FHA_1 364 370 PF00498 0.559
LIG_FHA_1 398 404 PF00498 0.522
LIG_FHA_1 491 497 PF00498 0.501
LIG_FHA_1 68 74 PF00498 0.443
LIG_FHA_2 132 138 PF00498 0.457
LIG_FHA_2 140 146 PF00498 0.439
LIG_FHA_2 568 574 PF00498 0.519
LIG_FHA_2 668 674 PF00498 0.611
LIG_GBD_Chelix_1 333 341 PF00786 0.520
LIG_LIR_Apic_2 14 19 PF02991 0.810
LIG_LIR_Apic_2 256 262 PF02991 0.412
LIG_LIR_Apic_2 426 430 PF02991 0.577
LIG_LIR_Gen_1 335 345 PF02991 0.415
LIG_LIR_Gen_1 358 367 PF02991 0.530
LIG_LIR_Gen_1 386 393 PF02991 0.513
LIG_LIR_Gen_1 408 417 PF02991 0.502
LIG_LIR_Nem_3 136 141 PF02991 0.425
LIG_LIR_Nem_3 278 284 PF02991 0.421
LIG_LIR_Nem_3 335 341 PF02991 0.477
LIG_LIR_Nem_3 358 363 PF02991 0.542
LIG_LIR_Nem_3 386 390 PF02991 0.506
LIG_LIR_Nem_3 408 413 PF02991 0.492
LIG_LIR_Nem_3 478 484 PF02991 0.479
LIG_LIR_Nem_3 509 515 PF02991 0.467
LIG_LIR_Nem_3 517 521 PF02991 0.519
LIG_LIR_Nem_3 55 61 PF02991 0.400
LIG_LIR_Nem_3 626 630 PF02991 0.464
LIG_PDZ_Class_3 669 674 PF00595 0.506
LIG_Pex14_2 320 324 PF04695 0.539
LIG_Pex14_2 387 391 PF04695 0.505
LIG_SH2_CRK 128 132 PF00017 0.448
LIG_SH2_CRK 410 414 PF00017 0.515
LIG_SH2_CRK 518 522 PF00017 0.570
LIG_SH2_GRB2like 130 133 PF00017 0.457
LIG_SH2_PTP2 641 644 PF00017 0.537
LIG_SH2_SRC 109 112 PF00017 0.485
LIG_SH2_SRC 156 159 PF00017 0.487
LIG_SH2_SRC 340 343 PF00017 0.521
LIG_SH2_SRC 581 584 PF00017 0.549
LIG_SH2_STAT3 482 485 PF00017 0.460
LIG_SH2_STAT5 109 112 PF00017 0.428
LIG_SH2_STAT5 130 133 PF00017 0.467
LIG_SH2_STAT5 156 159 PF00017 0.472
LIG_SH2_STAT5 340 343 PF00017 0.485
LIG_SH2_STAT5 482 485 PF00017 0.444
LIG_SH2_STAT5 510 513 PF00017 0.499
LIG_SH2_STAT5 581 584 PF00017 0.549
LIG_SH2_STAT5 641 644 PF00017 0.537
LIG_SH2_STAT5 669 672 PF00017 0.553
LIG_SH3_1 48 54 PF00018 0.471
LIG_SH3_2 430 435 PF14604 0.586
LIG_SH3_2 51 56 PF14604 0.485
LIG_SH3_3 1 7 PF00018 0.718
LIG_SH3_3 266 272 PF00018 0.459
LIG_SH3_3 427 433 PF00018 0.571
LIG_SH3_3 443 449 PF00018 0.561
LIG_SH3_3 48 54 PF00018 0.471
LIG_SH3_3 522 528 PF00018 0.567
LIG_SH3_3 86 92 PF00018 0.533
LIG_SUMO_SIM_anti_2 418 424 PF11976 0.549
LIG_SUMO_SIM_anti_2 99 107 PF11976 0.480
LIG_SUMO_SIM_par_1 115 122 PF11976 0.500
LIG_SUMO_SIM_par_1 310 316 PF11976 0.402
LIG_TRAF2_1 250 253 PF00917 0.679
LIG_TRAF2_1 527 530 PF00917 0.795
LIG_TRAF2_1 670 673 PF00917 0.580
LIG_TYR_ITIM 479 484 PF00017 0.583
LIG_TYR_ITIM 516 521 PF00017 0.547
LIG_TYR_ITIM 639 644 PF00017 0.544
LIG_UBA3_1 337 346 PF00899 0.420
LIG_UBA3_1 390 397 PF00899 0.561
LIG_WRC_WIRS_1 393 398 PF05994 0.535
MOD_CDC14_SPxK_1 6 9 PF00782 0.716
MOD_CDK_SPK_2 495 500 PF00069 0.535
MOD_CDK_SPxK_1 3 9 PF00069 0.718
MOD_CDK_SPxxK_3 495 502 PF00069 0.528
MOD_CK1_1 17 23 PF00069 0.736
MOD_CK1_1 188 194 PF00069 0.767
MOD_CK1_1 411 417 PF00069 0.655
MOD_CK1_1 468 474 PF00069 0.487
MOD_CK2_1 139 145 PF00069 0.435
MOD_CK2_1 365 371 PF00069 0.525
MOD_CK2_1 667 673 PF00069 0.595
MOD_Cter_Amidation 177 180 PF01082 0.558
MOD_Cter_Amidation 303 306 PF01082 0.550
MOD_GlcNHglycan 114 117 PF01048 0.475
MOD_GlcNHglycan 16 19 PF01048 0.731
MOD_GlcNHglycan 190 193 PF01048 0.781
MOD_GlcNHglycan 235 238 PF01048 0.696
MOD_GlcNHglycan 240 243 PF01048 0.660
MOD_GlcNHglycan 278 281 PF01048 0.410
MOD_GlcNHglycan 315 318 PF01048 0.411
MOD_GlcNHglycan 522 525 PF01048 0.699
MOD_GlcNHglycan 83 86 PF01048 0.547
MOD_GSK3_1 162 169 PF00069 0.492
MOD_GSK3_1 210 217 PF00069 0.675
MOD_GSK3_1 328 335 PF00069 0.537
MOD_GSK3_1 363 370 PF00069 0.563
MOD_GSK3_1 559 566 PF00069 0.621
MOD_N-GLC_1 131 136 PF02516 0.391
MOD_N-GLC_1 218 223 PF02516 0.659
MOD_N-GLC_1 329 334 PF02516 0.517
MOD_N-GLC_2 45 47 PF02516 0.465
MOD_N-GLC_2 472 474 PF02516 0.486
MOD_NEK2_1 218 223 PF00069 0.683
MOD_NEK2_1 233 238 PF00069 0.459
MOD_NEK2_1 276 281 PF00069 0.504
MOD_NEK2_1 490 495 PF00069 0.506
MOD_NEK2_1 598 603 PF00069 0.532
MOD_PIKK_1 34 40 PF00454 0.696
MOD_PIKK_1 385 391 PF00454 0.631
MOD_PIKK_1 465 471 PF00454 0.490
MOD_PKA_2 465 471 PF00069 0.490
MOD_PKA_2 559 565 PF00069 0.540
MOD_PKA_2 81 87 PF00069 0.590
MOD_Plk_1 101 107 PF00069 0.430
MOD_Plk_1 131 137 PF00069 0.421
MOD_Plk_1 218 224 PF00069 0.689
MOD_Plk_1 252 258 PF00069 0.576
MOD_Plk_1 328 334 PF00069 0.505
MOD_Plk_1 385 391 PF00069 0.606
MOD_Plk_1 599 605 PF00069 0.600
MOD_Plk_1 76 82 PF00069 0.495
MOD_Plk_2-3 365 371 PF00069 0.525
MOD_Plk_2-3 76 82 PF00069 0.495
MOD_Plk_4 101 107 PF00069 0.421
MOD_Plk_4 126 132 PF00069 0.503
MOD_Plk_4 211 217 PF00069 0.700
MOD_Plk_4 253 259 PF00069 0.447
MOD_Plk_4 332 338 PF00069 0.424
MOD_Plk_4 418 424 PF00069 0.561
MOD_ProDKin_1 185 191 PF00069 0.696
MOD_ProDKin_1 3 9 PF00069 0.731
MOD_ProDKin_1 426 432 PF00069 0.607
MOD_ProDKin_1 495 501 PF00069 0.527
MOD_ProDKin_1 567 573 PF00069 0.497
MOD_ProDKin_1 93 99 PF00069 0.578
MOD_SUMO_for_1 415 418 PF00179 0.519
MOD_SUMO_rev_2 339 345 PF00179 0.488
MOD_SUMO_rev_2 608 618 PF00179 0.629
TRG_DiLeu_BaEn_1 253 258 PF01217 0.574
TRG_DiLeu_BaEn_1 418 423 PF01217 0.547
TRG_DiLeu_BaEn_4 328 334 PF01217 0.429
TRG_DiLeu_BaLyEn_6 272 277 PF01217 0.529
TRG_ENDOCYTIC_2 128 131 PF00928 0.445
TRG_ENDOCYTIC_2 360 363 PF00928 0.547
TRG_ENDOCYTIC_2 410 413 PF00928 0.496
TRG_ENDOCYTIC_2 481 484 PF00928 0.572
TRG_ENDOCYTIC_2 518 521 PF00928 0.561
TRG_ENDOCYTIC_2 58 61 PF00928 0.490
TRG_ENDOCYTIC_2 641 644 PF00928 0.537
TRG_ER_diArg_1 372 375 PF00400 0.568
TRG_ER_diArg_1 464 467 PF00400 0.558
TRG_ER_diArg_1 499 502 PF00400 0.537
TRG_ER_diArg_1 8 11 PF00400 0.722
TRG_NES_CRM1_1 381 394 PF08389 0.628
TRG_Pf-PMV_PEXEL_1 505 509 PF00026 0.460
TRG_Pf-PMV_PEXEL_1 63 67 PF00026 0.500

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDM4 Leptomonas seymouri 80% 99%
A0A0S4KG78 Bodo saltans 55% 100%
A0A1X0P7F0 Trypanosomatidae 65% 100%
A0A3R7NUY6 Trypanosoma rangeli 64% 100%
A0A3S5H752 Leishmania donovani 100% 100%
A4H9Z0 Leishmania braziliensis 87% 99%
D0A0G1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 62% 100%
E9ARY4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QDI9 Leishmania major 95% 100%
V5DTK4 Trypanosoma cruzi 65% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS