GDT1 family protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

GDT1 family protein

Gene product:

membrane protein - putative

Species:

Leishmania infantum

UniProt:

A4HY53_LEIIN

TriTrypDb:

LINF_190008000

Length:

252

Annotations

Annotations by Jardim et al.

Membrane associated proteins, membrane

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Phosphorylation

Promastigote: 106

Expansion

Sequence features

A4HY53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY53

Function

Biological processes
Term	Name	Level	Count
GO:0000041	transition metal ion transport	7	1
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006816	calcium ion transport	7	1
GO:0006828	manganese ion transport	8	1
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0006874	intracellular calcium ion homeostasis	7	1
GO:0006875	obsolete intracellular metal ion homeostasis	6	1
GO:0009987	cellular process	1	1
GO:0019725	cellular homeostasis	2	1
GO:0030001	metal ion transport	6	1
GO:0030003	intracellular monoatomic cation homeostasis	5	1
GO:0032468	Golgi calcium ion homeostasis	8	1
GO:0032472	Golgi calcium ion transport	8	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0042592	homeostatic process	3	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055074	calcium ion homeostasis	8	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0055085	transmembrane transport	2	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0070588	calcium ion transmembrane transport	6	1
GO:0071421	manganese ion transmembrane transport	6	1
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	1
GO:0072507	obsolete divalent inorganic cation homeostasis	7	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098662	inorganic cation transmembrane transport	5	1
GO:0098771	inorganic ion homeostasis	6	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0005384	manganese ion transmembrane transporter activity	7	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015085	calcium ion transmembrane transporter activity	6	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022890	inorganic cation transmembrane transporter activity	4	1
GO:0046873	metal ion transmembrane transporter activity	5	1
GO:0046915	transition metal ion transmembrane transporter activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	206	212	PF00089	0.269
CLV_NRD_NRD_1	119	121	PF00675	0.394
CLV_NRD_NRD_1	142	144	PF00675	0.360
CLV_NRD_NRD_1	97	99	PF00675	0.427
CLV_PCSK_KEX2_1	118	120	PF00082	0.411
CLV_PCSK_KEX2_1	142	144	PF00082	0.360
CLV_PCSK_SKI1_1	145	149	PF00082	0.306
CLV_PCSK_SKI1_1	28	32	PF00082	0.212
DEG_APCC_DBOX_1	144	152	PF00400	0.506
DEG_APCC_DBOX_1	166	174	PF00400	0.212
DEG_Nend_UBRbox_2	1	3	PF02207	0.638
DOC_CYCLIN_yCln2_LP_2	147	153	PF00134	0.329
DOC_MAPK_DCC_7	143	153	PF00069	0.470
DOC_MAPK_gen_1	142	153	PF00069	0.452
DOC_MAPK_gen_1	39	47	PF00069	0.412
DOC_MAPK_MEF2A_6	39	47	PF00069	0.426
DOC_USP7_MATH_1	135	139	PF00917	0.581
DOC_USP7_MATH_2	125	131	PF00917	0.680
LIG_14-3-3_CanoR_1	209	213	PF00244	0.446
LIG_14-3-3_CterR_2	247	252	PF00244	0.417
LIG_EH1_1	29	37	PF00400	0.412
LIG_FHA_1	170	176	PF00498	0.212
LIG_FHA_1	212	218	PF00498	0.469
LIG_FHA_1	27	33	PF00498	0.464
LIG_FHA_1	42	48	PF00498	0.412
LIG_FHA_1	5	11	PF00498	0.535
LIG_FHA_1	74	80	PF00498	0.278
LIG_FHA_2	228	234	PF00498	0.250
LIG_IBAR_NPY_1	180	182	PF08397	0.227
LIG_PCNA_PIPBox_1	225	234	PF02747	0.280
LIG_Pex14_2	156	160	PF04695	0.269
LIG_SH2_STAP1	232	236	PF00017	0.378
LIG_SH2_STAP1	93	97	PF00017	0.507
LIG_SH2_STAT5	136	139	PF00017	0.700
LIG_SH2_STAT5	46	49	PF00017	0.381
LIG_SH3_1	119	125	PF00018	0.674
LIG_SH3_3	119	125	PF00018	0.691
LIG_SH3_3	134	140	PF00018	0.582
LIG_SH3_3	62	68	PF00018	0.269
LIG_SUMO_SIM_par_1	149	154	PF11976	0.294
LIG_SUMO_SIM_par_1	18	24	PF11976	0.426
LIG_SUMO_SIM_par_1	227	233	PF11976	0.280
LIG_TYR_ITIM	91	96	PF00017	0.395
LIG_UBA3_1	35	42	PF00899	0.426
MOD_CK1_1	130	136	PF00069	0.598
MOD_CK1_1	15	21	PF00069	0.437
MOD_CK1_1	211	217	PF00069	0.425
MOD_CK2_1	103	109	PF00069	0.554
MOD_CK2_1	227	233	PF00069	0.250
MOD_GlcNHglycan	133	136	PF01048	0.446
MOD_GlcNHglycan	137	140	PF01048	0.418
MOD_GlcNHglycan	59	62	PF01048	0.254
MOD_GSK3_1	127	134	PF00069	0.614
MOD_GSK3_1	165	172	PF00069	0.212
MOD_GSK3_1	69	76	PF00069	0.227
MOD_NEK2_1	13	18	PF00069	0.458
MOD_NEK2_1	131	136	PF00069	0.693
MOD_NEK2_1	156	161	PF00069	0.250
MOD_NEK2_2	227	232	PF00069	0.269
MOD_NEK2_2	26	31	PF00069	0.412
MOD_NEK2_2	41	46	PF00069	0.412
MOD_PIKK_1	165	171	PF00454	0.212
MOD_PIKK_1	73	79	PF00454	0.290
MOD_PKA_2	208	214	PF00069	0.510
MOD_Plk_1	165	171	PF00069	0.212
MOD_Plk_1	232	238	PF00069	0.442
MOD_Plk_1	26	32	PF00069	0.412
MOD_Plk_2-3	103	109	PF00069	0.564
MOD_Plk_4	15	21	PF00069	0.460
MOD_Plk_4	156	162	PF00069	0.262
MOD_Plk_4	227	233	PF00069	0.250
MOD_Plk_4	26	32	PF00069	0.377
MOD_Plk_4	41	47	PF00069	0.412
MOD_Plk_4	54	60	PF00069	0.187
TRG_ENDOCYTIC_2	93	96	PF00928	0.496
TRG_ER_diArg_1	117	120	PF00400	0.600
TRG_ER_diArg_1	142	144	PF00400	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD2	Leptomonas seymouri	80%	98%
A0A0S4KKH4	Bodo saltans	71%	100%
A0A1X0P7U1	Trypanosomatidae	68%	97%
A0A3Q8ID79	Leishmania donovani	100%	100%
A0A422P389	Trypanosoma rangeli	70%	100%
A2YXC7	Oryza sativa subsp. indica	46%	90%
A2ZE50	Oryza sativa subsp. indica	46%	90%
A4H9Y9	Leishmania braziliensis	89%	100%
B8AAM2	Oryza sativa subsp. indica	36%	74%
B9G125	Oryza sativa subsp. japonica	41%	100%
E9ARY3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
P38301	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	38%	90%
P52875	Mus musculus	44%	78%
P52876	Synechocystis sp. (strain PCC 6803 / Kazusa)	43%	100%
Q10320	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	88%
Q2R2Z4	Oryza sativa subsp. japonica	36%	73%
Q2R4J1	Oryza sativa subsp. japonica	46%	90%
Q4QDJ0	Leishmania major	98%	100%
Q4V899	Rattus norvegicus	44%	78%
Q5NAY7	Oryza sativa subsp. japonica	36%	74%
Q6ZIB9	Oryza sativa subsp. japonica	46%	89%
Q93Y38	Arabidopsis thaliana	45%	86%
Q94AX5	Arabidopsis thaliana	36%	68%
Q9C6M1	Arabidopsis thaliana	40%	100%
Q9HC07	Homo sapiens	44%	78%
Q9P7Q0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	96%
Q9SX28	Arabidopsis thaliana	39%	100%
Q9T0H9	Arabidopsis thaliana	37%	70%
V5BBV0	Trypanosoma cruzi	64%	100%