Putative RNA binding protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein - putative

Species:

Leishmania infantum

UniProt:

A4HY52_LEIIN

TriTrypDb:

LINF_190007800

Length:

302

Annotations

Annotations by Jardim et al.

Nucleic acid binding, RNA binding

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HY52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY52

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	200	202	PF00675	0.656
CLV_PCSK_KEX2_1	200	202	PF00082	0.657
CLV_PCSK_KEX2_1	29	31	PF00082	0.606
CLV_PCSK_KEX2_1	85	87	PF00082	0.511
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.404
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.474
CLV_PCSK_SKI1_1	138	142	PF00082	0.452
CLV_PCSK_SKI1_1	148	152	PF00082	0.420
CLV_PCSK_SKI1_1	156	160	PF00082	0.478
CLV_PCSK_SKI1_1	181	185	PF00082	0.539
CLV_PCSK_SKI1_1	53	57	PF00082	0.460
DOC_MAPK_gen_1	219	229	PF00069	0.470
DOC_MAPK_MEF2A_6	222	229	PF00069	0.364
DOC_PP1_RVXF_1	264	271	PF00149	0.414
DOC_PP2B_LxvP_1	143	146	PF13499	0.541
DOC_PP2B_PxIxI_1	224	230	PF00149	0.405
DOC_PP4_FxxP_1	270	273	PF00568	0.414
DOC_USP7_MATH_1	12	16	PF00917	0.624
DOC_USP7_MATH_1	139	143	PF00917	0.429
DOC_USP7_MATH_1	146	150	PF00917	0.352
DOC_USP7_UBL2_3	256	260	PF12436	0.539
DOC_WW_Pin1_4	127	132	PF00397	0.547
DOC_WW_Pin1_4	163	168	PF00397	0.631
LIG_14-3-3_CanoR_1	148	154	PF00244	0.542
LIG_14-3-3_CanoR_1	156	161	PF00244	0.578
LIG_14-3-3_CanoR_1	53	58	PF00244	0.543
LIG_APCC_ABBA_1	31	36	PF00400	0.362
LIG_APCC_ABBAyCdc20_2	30	36	PF00400	0.363
LIG_BRCT_BRCA1_1	106	110	PF00533	0.373
LIG_FHA_1	139	145	PF00498	0.444
LIG_FHA_1	54	60	PF00498	0.523
LIG_FHA_2	150	156	PF00498	0.497
LIG_KLC1_Yacidic_2	72	77	PF13176	0.398
LIG_LIR_Apic_2	269	273	PF02991	0.418
LIG_LIR_Nem_3	238	244	PF02991	0.362
LIG_LIR_Nem_3	95	100	PF02991	0.548
LIG_PCNA_yPIPBox_3	147	156	PF02747	0.442
LIG_SH2_PTP2	97	100	PF00017	0.494
LIG_SH2_SRC	120	123	PF00017	0.530
LIG_SH2_SRC	66	69	PF00017	0.524
LIG_SH2_STAP1	246	250	PF00017	0.400
LIG_SH2_STAP1	41	45	PF00017	0.390
LIG_SH2_STAP1	66	70	PF00017	0.394
LIG_SH2_STAT3	41	44	PF00017	0.388
LIG_SH2_STAT5	120	123	PF00017	0.406
LIG_SH2_STAT5	232	235	PF00017	0.359
LIG_SH2_STAT5	75	78	PF00017	0.488
LIG_SH2_STAT5	97	100	PF00017	0.451
LIG_SH3_1	162	168	PF00018	0.524
LIG_SH3_3	162	168	PF00018	0.627
LIG_SH3_5	273	277	PF00018	0.562
LIG_TRAF2_1	287	290	PF00917	0.557
LIG_TRAF2_1	69	72	PF00917	0.559
MOD_CK1_1	133	139	PF00069	0.452
MOD_CK1_1	149	155	PF00069	0.412
MOD_CK2_1	116	122	PF00069	0.523
MOD_CK2_1	12	18	PF00069	0.672
MOD_GlcNHglycan	14	17	PF01048	0.515
MOD_GlcNHglycan	209	213	PF01048	0.583
MOD_GSK3_1	104	111	PF00069	0.395
MOD_GSK3_1	129	136	PF00069	0.522
MOD_GSK3_1	177	184	PF00069	0.699
MOD_LATS_1	179	185	PF00433	0.539
MOD_N-GLC_1	146	151	PF02516	0.414
MOD_N-GLC_1	189	194	PF02516	0.677
MOD_N-GLC_1	235	240	PF02516	0.493
MOD_N-GLC_1	24	29	PF02516	0.530
MOD_N-GLC_2	255	257	PF02516	0.525
MOD_N-GLC_2	261	263	PF02516	0.551
MOD_NEK2_1	34	39	PF00069	0.478
MOD_NEK2_2	146	151	PF00069	0.395
MOD_OFUCOSY	233	239	PF10250	0.376
MOD_PIKK_1	24	30	PF00454	0.559
MOD_PKA_2	113	119	PF00069	0.537
MOD_PKA_2	34	40	PF00069	0.559
MOD_Plk_1	146	152	PF00069	0.432
MOD_Plk_1	189	195	PF00069	0.563
MOD_Plk_2-3	108	114	PF00069	0.395
MOD_Plk_4	116	122	PF00069	0.473
MOD_Plk_4	139	145	PF00069	0.427
MOD_Plk_4	149	155	PF00069	0.417
MOD_Plk_4	34	40	PF00069	0.558
MOD_ProDKin_1	127	133	PF00069	0.539
MOD_ProDKin_1	163	169	PF00069	0.633
MOD_SUMO_for_1	218	221	PF00179	0.582
MOD_SUMO_rev_2	84	93	PF00179	0.528
TRG_DiLeu_BaEn_4	50	56	PF01217	0.361
TRG_ENDOCYTIC_2	97	100	PF00928	0.369
TRG_Pf-PMV_PEXEL_1	53	58	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1I4	Leptomonas seymouri	30%	76%
A0A0N1PG85	Leptomonas seymouri	72%	95%
A0A0S4KEK3	Bodo saltans	29%	93%
A0A0S4KMM7	Bodo saltans	38%	79%
A0A1X0P6E1	Trypanosomatidae	39%	92%
A0A3Q8IA61	Leishmania donovani	100%	96%
A0A3R7RSV6	Trypanosoma rangeli	44%	100%
A0A3S7WVD2	Leishmania donovani	31%	77%
A4H9Y7	Leishmania braziliensis	80%	100%
A4H9Y8	Leishmania braziliensis	32%	100%
A4HY39	Leishmania infantum	31%	100%
D0A0F3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
D0A0F7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	70%
E9ARY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9ARY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q4QDJ1	Leishmania major	97%	100%
V5BWY8	Trypanosoma cruzi	42%	100%