RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HY49_LEIIN

TriTrypDb:

LINF_190007500

Length:

960

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HY49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY49

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	299	303	PF00656	0.656
CLV_C14_Caspase3-7	446	450	PF00656	0.819
CLV_C14_Caspase3-7	805	809	PF00656	0.552
CLV_NRD_NRD_1	15	17	PF00675	0.698
CLV_NRD_NRD_1	157	159	PF00675	0.721
CLV_NRD_NRD_1	423	425	PF00675	0.676
CLV_NRD_NRD_1	55	57	PF00675	0.748
CLV_NRD_NRD_1	729	731	PF00675	0.735
CLV_NRD_NRD_1	780	782	PF00675	0.589
CLV_NRD_NRD_1	895	897	PF00675	0.612
CLV_PCSK_FUR_1	421	425	PF00082	0.674
CLV_PCSK_KEX2_1	15	17	PF00082	0.698
CLV_PCSK_KEX2_1	157	159	PF00082	0.721
CLV_PCSK_KEX2_1	423	425	PF00082	0.676
CLV_PCSK_KEX2_1	54	56	PF00082	0.744
CLV_PCSK_KEX2_1	779	781	PF00082	0.592
CLV_PCSK_KEX2_1	895	897	PF00082	0.570
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.846
CLV_PCSK_SKI1_1	205	209	PF00082	0.731
CLV_PCSK_SKI1_1	290	294	PF00082	0.781
CLV_PCSK_SKI1_1	424	428	PF00082	0.687
CLV_PCSK_SKI1_1	436	440	PF00082	0.683
CLV_PCSK_SKI1_1	599	603	PF00082	0.632
CLV_PCSK_SKI1_1	816	820	PF00082	0.528
CLV_PCSK_SKI1_1	823	827	PF00082	0.415
CLV_PCSK_SKI1_1	952	956	PF00082	0.616
DEG_APCC_DBOX_1	435	443	PF00400	0.788
DEG_Nend_UBRbox_2	1	3	PF02207	0.749
DEG_SCF_FBW7_1	564	569	PF00400	0.613
DEG_SCF_FBW7_1	744	750	PF00400	0.774
DEG_SPOP_SBC_1	324	328	PF00917	0.717
DEG_SPOP_SBC_1	541	545	PF00917	0.747
DEG_SPOP_SBC_1	632	636	PF00917	0.795
DOC_CKS1_1	724	729	PF01111	0.778
DOC_CKS1_1	733	738	PF01111	0.679
DOC_CKS1_1	744	749	PF01111	0.513
DOC_CYCLIN_yCln2_LP_2	506	512	PF00134	0.806
DOC_MAPK_gen_1	676	685	PF00069	0.757
DOC_MAPK_gen_1	820	830	PF00069	0.481
DOC_MAPK_MEF2A_6	551	560	PF00069	0.733
DOC_PP2B_LxvP_1	286	289	PF13499	0.727
DOC_PP2B_LxvP_1	629	632	PF13499	0.796
DOC_PP2B_LxvP_1	757	760	PF13499	0.626
DOC_PP4_FxxP_1	498	501	PF00568	0.653
DOC_PP4_FxxP_1	799	802	PF00568	0.557
DOC_SPAK_OSR1_1	101	105	PF12202	0.748
DOC_USP7_MATH_1	194	198	PF00917	0.832
DOC_USP7_MATH_1	209	213	PF00917	0.731
DOC_USP7_MATH_1	230	234	PF00917	0.766
DOC_USP7_MATH_1	296	300	PF00917	0.752
DOC_USP7_MATH_1	34	38	PF00917	0.848
DOC_USP7_MATH_1	348	352	PF00917	0.737
DOC_USP7_MATH_1	353	357	PF00917	0.726
DOC_USP7_MATH_1	364	368	PF00917	0.555
DOC_USP7_MATH_1	477	481	PF00917	0.732
DOC_USP7_MATH_1	566	570	PF00917	0.816
DOC_USP7_MATH_1	711	715	PF00917	0.793
DOC_USP7_MATH_1	747	751	PF00917	0.723
DOC_USP7_MATH_1	956	960	PF00917	0.711
DOC_USP7_MATH_2	566	572	PF00917	0.828
DOC_WW_Pin1_4	221	226	PF00397	0.831
DOC_WW_Pin1_4	237	242	PF00397	0.597
DOC_WW_Pin1_4	251	256	PF00397	0.633
DOC_WW_Pin1_4	263	268	PF00397	0.728
DOC_WW_Pin1_4	290	295	PF00397	0.691
DOC_WW_Pin1_4	360	365	PF00397	0.692
DOC_WW_Pin1_4	505	510	PF00397	0.689
DOC_WW_Pin1_4	537	542	PF00397	0.714
DOC_WW_Pin1_4	544	549	PF00397	0.737
DOC_WW_Pin1_4	552	557	PF00397	0.726
DOC_WW_Pin1_4	562	567	PF00397	0.586
DOC_WW_Pin1_4	633	638	PF00397	0.714
DOC_WW_Pin1_4	666	671	PF00397	0.781
DOC_WW_Pin1_4	702	707	PF00397	0.749
DOC_WW_Pin1_4	723	728	PF00397	0.832
DOC_WW_Pin1_4	732	737	PF00397	0.727
DOC_WW_Pin1_4	743	748	PF00397	0.515
DOC_WW_Pin1_4	771	776	PF00397	0.611
DOC_WW_Pin1_4	83	88	PF00397	0.756
DOC_WW_Pin1_4	879	884	PF00397	0.629
LIG_14-3-3_CanoR_1	15	19	PF00244	0.692
LIG_14-3-3_CanoR_1	35	43	PF00244	0.514
LIG_14-3-3_CanoR_1	423	431	PF00244	0.680
LIG_14-3-3_CanoR_1	5	13	PF00244	0.728
LIG_14-3-3_CanoR_1	524	532	PF00244	0.672
LIG_14-3-3_CanoR_1	599	609	PF00244	0.839
LIG_14-3-3_CanoR_1	668	677	PF00244	0.760
LIG_14-3-3_CanoR_1	754	760	PF00244	0.665
LIG_14-3-3_CanoR_1	895	903	PF00244	0.581
LIG_BRCT_BRCA1_1	196	200	PF00533	0.831
LIG_BRCT_BRCA1_1	522	526	PF00533	0.723
LIG_BRCT_BRCA1_1	533	537	PF00533	0.640
LIG_BRCT_BRCA1_1	619	623	PF00533	0.691
LIG_BRCT_BRCA1_1	87	91	PF00533	0.787
LIG_CtBP_PxDLS_1	573	577	PF00389	0.828
LIG_eIF4E_1	903	909	PF01652	0.490
LIG_FHA_1	134	140	PF00498	0.766
LIG_FHA_1	242	248	PF00498	0.656
LIG_FHA_1	324	330	PF00498	0.716
LIG_FHA_1	353	359	PF00498	0.641
LIG_FHA_1	659	665	PF00498	0.727
LIG_FHA_1	724	730	PF00498	0.797
LIG_FHA_1	817	823	PF00498	0.608
LIG_FHA_2	121	127	PF00498	0.749
LIG_FHA_2	194	200	PF00498	0.730
LIG_FHA_2	467	473	PF00498	0.713
LIG_FHA_2	563	569	PF00498	0.733
LIG_FHA_2	929	935	PF00498	0.565
LIG_FHA_2	937	943	PF00498	0.517
LIG_FXI_DFP_1	487	491	PF00024	0.688
LIG_GSK3_LRP6_1	552	557	PF00069	0.750
LIG_IBAR_NPY_1	585	587	PF08397	0.617
LIG_Integrin_isoDGR_2	877	879	PF01839	0.573
LIG_LIR_Apic_2	497	501	PF02991	0.652
LIG_LIR_Apic_2	798	802	PF02991	0.548
LIG_LIR_Gen_1	278	288	PF02991	0.717
LIG_LIR_Gen_1	900	909	PF02991	0.513
LIG_LIR_Nem_3	278	283	PF02991	0.712
LIG_LIR_Nem_3	620	626	PF02991	0.760
LIG_LIR_Nem_3	854	860	PF02991	0.481
LIG_LIR_Nem_3	900	906	PF02991	0.534
LIG_MLH1_MIPbox_1	620	624	PF16413	0.600
LIG_NRBOX	282	288	PF00104	0.712
LIG_NRP_CendR_1	958	960	PF00754	0.829
LIG_Pex14_2	490	494	PF04695	0.695
LIG_PTAP_UEV_1	86	91	PF05743	0.752
LIG_Rb_pABgroove_1	836	844	PF01858	0.510
LIG_SH2_CRK	587	591	PF00017	0.838
LIG_SH2_CRK	627	631	PF00017	0.723
LIG_SH2_CRK	926	930	PF00017	0.496
LIG_SH2_NCK_1	274	278	PF00017	0.713
LIG_SH2_NCK_1	587	591	PF00017	0.761
LIG_SH2_NCK_1	627	631	PF00017	0.723
LIG_SH2_SRC	903	906	PF00017	0.510
LIG_SH2_STAT5	274	277	PF00017	0.714
LIG_SH2_STAT5	587	590	PF00017	0.838
LIG_SH2_STAT5	627	630	PF00017	0.724
LIG_SH2_STAT5	745	748	PF00017	0.849
LIG_SH2_STAT5	861	864	PF00017	0.469
LIG_SH3_1	741	747	PF00018	0.843
LIG_SH3_2	953	958	PF14604	0.676
LIG_SH3_3	169	175	PF00018	0.742
LIG_SH3_3	222	228	PF00018	0.829
LIG_SH3_3	229	235	PF00018	0.725
LIG_SH3_3	264	270	PF00018	0.826
LIG_SH3_3	550	556	PF00018	0.762
LIG_SH3_3	592	598	PF00018	0.745
LIG_SH3_3	646	652	PF00018	0.734
LIG_SH3_3	721	727	PF00018	0.740
LIG_SH3_3	741	747	PF00018	0.513
LIG_SH3_3	749	755	PF00018	0.840
LIG_SH3_3	84	90	PF00018	0.832
LIG_SH3_3	950	956	PF00018	0.608
LIG_SUMO_SIM_anti_2	939	948	PF11976	0.508
LIG_TRFH_1	627	631	PF08558	0.801
LIG_UBA3_1	871	875	PF00899	0.550
LIG_UBA3_1	946	955	PF00899	0.540
LIG_WRC_WIRS_1	349	354	PF05994	0.628
LIG_WRC_WIRS_1	365	370	PF05994	0.698
LIG_WRC_WIRS_1	827	832	PF05994	0.570
LIG_WW_3	176	180	PF00397	0.734
LIG_WW_3	596	600	PF00397	0.758
MOD_CDK_SPK_2	253	258	PF00069	0.736
MOD_CDK_SPK_2	666	671	PF00069	0.851
MOD_CDK_SPxxK_3	241	248	PF00069	0.761
MOD_CDK_SPxxK_3	251	258	PF00069	0.649
MOD_CDK_SPxxK_3	544	551	PF00069	0.743
MOD_CDK_SPxxK_3	552	559	PF00069	0.723
MOD_CDK_SPxxK_3	723	730	PF00069	0.738
MOD_CK1_1	120	126	PF00069	0.822
MOD_CK1_1	14	20	PF00069	0.693
MOD_CK1_1	211	217	PF00069	0.752
MOD_CK1_1	240	246	PF00069	0.738
MOD_CK1_1	335	341	PF00069	0.614
MOD_CK1_1	384	390	PF00069	0.794
MOD_CK1_1	402	408	PF00069	0.552
MOD_CK1_1	536	542	PF00069	0.712
MOD_CK1_1	600	606	PF00069	0.799
MOD_CK1_1	669	675	PF00069	0.824
MOD_CK1_1	689	695	PF00069	0.507
MOD_CK1_1	702	708	PF00069	0.746
MOD_CK1_1	714	720	PF00069	0.767
MOD_CK2_1	120	126	PF00069	0.749
MOD_CK2_1	387	393	PF00069	0.630
MOD_CK2_1	416	422	PF00069	0.655
MOD_CK2_1	494	500	PF00069	0.701
MOD_CK2_1	562	568	PF00069	0.694
MOD_CK2_1	928	934	PF00069	0.562
MOD_GlcNHglycan	104	107	PF01048	0.658
MOD_GlcNHglycan	211	214	PF01048	0.813
MOD_GlcNHglycan	258	261	PF01048	0.842
MOD_GlcNHglycan	290	293	PF01048	0.765
MOD_GlcNHglycan	298	301	PF01048	0.696
MOD_GlcNHglycan	355	358	PF01048	0.670
MOD_GlcNHglycan	378	381	PF01048	0.795
MOD_GlcNHglycan	400	404	PF01048	0.700
MOD_GlcNHglycan	44	47	PF01048	0.828
MOD_GlcNHglycan	456	459	PF01048	0.748
MOD_GlcNHglycan	469	472	PF01048	0.649
MOD_GlcNHglycan	479	482	PF01048	0.765
MOD_GlcNHglycan	483	486	PF01048	0.570
MOD_GlcNHglycan	599	602	PF01048	0.715
MOD_GlcNHglycan	604	608	PF01048	0.804
MOD_GlcNHglycan	640	643	PF01048	0.779
MOD_GlcNHglycan	645	648	PF01048	0.724
MOD_GlcNHglycan	71	74	PF01048	0.822
MOD_GlcNHglycan	721	724	PF01048	0.742
MOD_GlcNHglycan	737	740	PF01048	0.736
MOD_GlcNHglycan	757	760	PF01048	0.398
MOD_GlcNHglycan	835	838	PF01048	0.490
MOD_GlcNHglycan	87	90	PF01048	0.625
MOD_GSK3_1	208	215	PF00069	0.844
MOD_GSK3_1	217	224	PF00069	0.690
MOD_GSK3_1	235	242	PF00069	0.720
MOD_GSK3_1	288	295	PF00069	0.714
MOD_GSK3_1	324	331	PF00069	0.711
MOD_GSK3_1	332	339	PF00069	0.686
MOD_GSK3_1	348	355	PF00069	0.810
MOD_GSK3_1	360	367	PF00069	0.660
MOD_GSK3_1	372	379	PF00069	0.589
MOD_GSK3_1	387	394	PF00069	0.692
MOD_GSK3_1	477	484	PF00069	0.706
MOD_GSK3_1	490	497	PF00069	0.689
MOD_GSK3_1	501	508	PF00069	0.589
MOD_GSK3_1	520	527	PF00069	0.721
MOD_GSK3_1	531	538	PF00069	0.635
MOD_GSK3_1	540	547	PF00069	0.497
MOD_GSK3_1	562	569	PF00069	0.801
MOD_GSK3_1	633	640	PF00069	0.733
MOD_GSK3_1	654	661	PF00069	0.762
MOD_GSK3_1	666	673	PF00069	0.773
MOD_GSK3_1	695	702	PF00069	0.845
MOD_GSK3_1	711	718	PF00069	0.670
MOD_GSK3_1	719	726	PF00069	0.711
MOD_GSK3_1	731	738	PF00069	0.497
MOD_GSK3_1	739	746	PF00069	0.512
MOD_LATS_1	206	212	PF00433	0.834
MOD_N-GLC_1	209	214	PF02516	0.758
MOD_N-GLC_1	251	256	PF02516	0.735
MOD_N-GLC_1	332	337	PF02516	0.597
MOD_N-GLC_1	372	377	PF02516	0.706
MOD_N-GLC_1	454	459	PF02516	0.815
MOD_N-GLC_1	520	525	PF02516	0.772
MOD_N-GLC_1	653	658	PF02516	0.791
MOD_N-GLC_1	816	821	PF02516	0.612
MOD_NEK2_1	102	107	PF00069	0.723
MOD_NEK2_1	272	277	PF00069	0.729
MOD_NEK2_1	323	328	PF00069	0.721
MOD_NEK2_1	336	341	PF00069	0.571
MOD_NEK2_1	352	357	PF00069	0.528
MOD_NEK2_1	376	381	PF00069	0.784
MOD_NEK2_1	494	499	PF00069	0.657
MOD_NEK2_1	696	701	PF00069	0.752
MOD_NEK2_1	737	742	PF00069	0.769
MOD_NEK2_1	841	846	PF00069	0.484
MOD_NEK2_2	364	369	PF00069	0.720
MOD_NEK2_2	897	902	PF00069	0.577
MOD_PIKK_1	17	23	PF00454	0.683
MOD_PIKK_1	384	390	PF00454	0.696
MOD_PIKK_1	590	596	PF00454	0.669
MOD_PIKK_1	739	745	PF00454	0.843
MOD_PKA_2	14	20	PF00069	0.741
MOD_PKA_2	34	40	PF00069	0.515
MOD_PKA_2	422	428	PF00069	0.666
MOD_PKA_2	654	660	PF00069	0.674
MOD_PKA_2	670	676	PF00069	0.767
MOD_PKA_2	69	75	PF00069	0.821
MOD_PKA_2	711	717	PF00069	0.731
MOD_PKA_2	753	759	PF00069	0.683
MOD_PKA_2	763	769	PF00069	0.499
MOD_PKB_1	814	822	PF00069	0.517
MOD_Plk_1	306	312	PF00069	0.715
MOD_Plk_1	332	338	PF00069	0.597
MOD_Plk_1	372	378	PF00069	0.708
MOD_Plk_2-3	422	428	PF00069	0.688
MOD_Plk_4	391	397	PF00069	0.784
MOD_Plk_4	501	507	PF00069	0.738
MOD_Plk_4	823	829	PF00069	0.446
MOD_Plk_4	942	948	PF00069	0.498
MOD_ProDKin_1	221	227	PF00069	0.830
MOD_ProDKin_1	237	243	PF00069	0.595
MOD_ProDKin_1	251	257	PF00069	0.633
MOD_ProDKin_1	263	269	PF00069	0.725
MOD_ProDKin_1	290	296	PF00069	0.695
MOD_ProDKin_1	360	366	PF00069	0.692
MOD_ProDKin_1	505	511	PF00069	0.689
MOD_ProDKin_1	537	543	PF00069	0.716
MOD_ProDKin_1	544	550	PF00069	0.737
MOD_ProDKin_1	552	558	PF00069	0.728
MOD_ProDKin_1	562	568	PF00069	0.586
MOD_ProDKin_1	633	639	PF00069	0.717
MOD_ProDKin_1	666	672	PF00069	0.780
MOD_ProDKin_1	702	708	PF00069	0.751
MOD_ProDKin_1	723	729	PF00069	0.833
MOD_ProDKin_1	732	738	PF00069	0.726
MOD_ProDKin_1	743	749	PF00069	0.513
MOD_ProDKin_1	771	777	PF00069	0.604
MOD_ProDKin_1	83	89	PF00069	0.754
MOD_ProDKin_1	879	885	PF00069	0.639
MOD_SUMO_for_1	601	604	PF00179	0.627
TRG_DiLeu_BaEn_1	391	396	PF01217	0.689
TRG_ENDOCYTIC_2	861	864	PF00928	0.461
TRG_ENDOCYTIC_2	903	906	PF00928	0.510
TRG_ENDOCYTIC_2	926	929	PF00928	0.500
TRG_ER_diArg_1	55	57	PF00400	0.635
TRG_ER_diArg_1	778	781	PF00400	0.696
TRG_ER_diArg_1	895	897	PF00400	0.612
TRG_NES_CRM1_1	927	942	PF08389	0.496
TRG_Pf-PMV_PEXEL_1	16	21	PF00026	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF30	Leptomonas seymouri	50%	98%
A0A3S7WVB1	Leishmania donovani	100%	100%
A4H9Y4	Leishmania braziliensis	79%	99%
E9ARX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QDJ4	Leishmania major	94%	100%