LeishMANIAdb
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Kinesin-like protein

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Kinesin-like protein
Gene product:
C-terminal motor kinesin - putative
Species:
Leishmania infantum
UniProt:
A4HY48_LEIIN
TriTrypDb:
LINF_190007400
Length:
841

Annotations

Annotations by Jardim et al.

Structural Proteins, Kinesin-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 2
Forrest at al. (procyclic) yes yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 12
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 5
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 5
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005874 microtubule 6 12
GO:0099080 supramolecular complex 2 12
GO:0099081 supramolecular polymer 3 12
GO:0099512 supramolecular fiber 4 12
GO:0099513 polymeric cytoskeletal fiber 5 12
GO:0110165 cellular anatomical entity 1 12
GO:0005871 kinesin complex 3 1
GO:0005875 microtubule associated complex 2 1
GO:0032991 protein-containing complex 1 1

Phosphorylation

Promastigote: 289, 291

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HY48
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY48

Function

Biological processes
Term Name Level Count
GO:0007017 microtubule-based process 2 12
GO:0007018 microtubule-based movement 3 12
GO:0009987 cellular process 1 12
GO:0006810 transport 3 1
GO:0030705 cytoskeleton-dependent intracellular transport 4 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003774 cytoskeletal motor activity 1 12
GO:0003777 microtubule motor activity 2 12
GO:0005488 binding 1 12
GO:0005515 protein binding 2 12
GO:0005524 ATP binding 5 12
GO:0005543 phospholipid binding 3 12
GO:0008017 microtubule binding 5 12
GO:0008092 cytoskeletal protein binding 3 12
GO:0008289 lipid binding 2 12
GO:0015631 tubulin binding 4 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032182 ubiquitin-like protein binding 3 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035091 phosphatidylinositol binding 4 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043130 ubiquitin binding 4 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:0140657 ATP-dependent activity 1 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12
GO:0003824 catalytic activity 1 1
GO:0016462 pyrophosphatase activity 5 1
GO:0016787 hydrolase activity 2 1
GO:0016817 hydrolase activity, acting on acid anhydrides 3 1
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 1
GO:0016887 ATP hydrolysis activity 7 1
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 287 291 PF00656 0.644
CLV_C14_Caspase3-7 571 575 PF00656 0.195
CLV_MEL_PAP_1 251 257 PF00089 0.281
CLV_NRD_NRD_1 278 280 PF00675 0.573
CLV_NRD_NRD_1 304 306 PF00675 0.464
CLV_NRD_NRD_1 428 430 PF00675 0.409
CLV_NRD_NRD_1 472 474 PF00675 0.444
CLV_NRD_NRD_1 484 486 PF00675 0.323
CLV_NRD_NRD_1 489 491 PF00675 0.319
CLV_NRD_NRD_1 50 52 PF00675 0.441
CLV_NRD_NRD_1 618 620 PF00675 0.206
CLV_PCSK_FUR_1 301 305 PF00082 0.594
CLV_PCSK_KEX2_1 277 279 PF00082 0.569
CLV_PCSK_KEX2_1 303 305 PF00082 0.470
CLV_PCSK_KEX2_1 308 310 PF00082 0.477
CLV_PCSK_KEX2_1 484 486 PF00082 0.436
CLV_PCSK_KEX2_1 50 52 PF00082 0.411
CLV_PCSK_PC1ET2_1 277 279 PF00082 0.444
CLV_PCSK_PC1ET2_1 308 310 PF00082 0.630
CLV_PCSK_PC7_1 304 310 PF00082 0.457
CLV_PCSK_SKI1_1 103 107 PF00082 0.286
CLV_PCSK_SKI1_1 155 159 PF00082 0.362
CLV_PCSK_SKI1_1 175 179 PF00082 0.502
CLV_PCSK_SKI1_1 243 247 PF00082 0.533
CLV_PCSK_SKI1_1 305 309 PF00082 0.540
CLV_PCSK_SKI1_1 356 360 PF00082 0.380
CLV_PCSK_SKI1_1 422 426 PF00082 0.575
CLV_PCSK_SKI1_1 433 437 PF00082 0.540
CLV_PCSK_SKI1_1 473 477 PF00082 0.423
CLV_PCSK_SKI1_1 485 489 PF00082 0.460
CLV_PCSK_SKI1_1 511 515 PF00082 0.325
CLV_PCSK_SKI1_1 590 594 PF00082 0.276
CLV_PCSK_SKI1_1 640 644 PF00082 0.195
CLV_PCSK_SKI1_1 833 837 PF00082 0.391
DEG_APCC_DBOX_1 337 345 PF00400 0.388
DEG_APCC_DBOX_1 421 429 PF00400 0.349
DEG_SPOP_SBC_1 108 112 PF00917 0.375
DOC_CDC14_PxL_1 390 398 PF14671 0.597
DOC_CYCLIN_RxL_1 793 804 PF00134 0.206
DOC_MAPK_gen_1 329 337 PF00069 0.418
DOC_MAPK_gen_1 748 755 PF00069 0.312
DOC_MAPK_MEF2A_6 704 713 PF00069 0.195
DOC_MAPK_MEF2A_6 796 803 PF00069 0.221
DOC_MAPK_NFAT4_5 704 712 PF00069 0.195
DOC_PP1_RVXF_1 472 479 PF00149 0.370
DOC_PP1_RVXF_1 794 801 PF00149 0.195
DOC_PP1_RVXF_1 822 829 PF00149 0.321
DOC_USP7_MATH_1 403 407 PF00917 0.607
DOC_USP7_MATH_1 673 677 PF00917 0.182
DOC_USP7_MATH_1 770 774 PF00917 0.253
DOC_USP7_MATH_1 810 814 PF00917 0.205
DOC_USP7_UBL2_3 359 363 PF12436 0.400
DOC_WW_Pin1_4 1 6 PF00397 0.583
DOC_WW_Pin1_4 169 174 PF00397 0.476
DOC_WW_Pin1_4 388 393 PF00397 0.462
DOC_WW_Pin1_4 411 416 PF00397 0.526
DOC_WW_Pin1_4 801 806 PF00397 0.206
LIG_14-3-3_CanoR_1 130 139 PF00244 0.343
LIG_14-3-3_CanoR_1 243 252 PF00244 0.380
LIG_14-3-3_CanoR_1 254 262 PF00244 0.275
LIG_14-3-3_CanoR_1 429 433 PF00244 0.347
LIG_14-3-3_CanoR_1 779 787 PF00244 0.221
LIG_Actin_WH2_2 418 435 PF00022 0.324
LIG_APCC_ABBA_1 632 637 PF00400 0.195
LIG_BIR_II_1 1 5 PF00653 0.524
LIG_BIR_III_4 538 542 PF00653 0.253
LIG_BRCT_BRCA1_1 815 819 PF00533 0.195
LIG_CaM_IQ_9 476 492 PF13499 0.375
LIG_Clathr_ClatBox_1 545 549 PF01394 0.242
LIG_deltaCOP1_diTrp_1 98 105 PF00928 0.329
LIG_eIF4E_1 725 731 PF01652 0.242
LIG_FHA_1 13 19 PF00498 0.425
LIG_FHA_1 156 162 PF00498 0.412
LIG_FHA_1 192 198 PF00498 0.329
LIG_FHA_1 321 327 PF00498 0.406
LIG_FHA_1 330 336 PF00498 0.383
LIG_FHA_1 40 46 PF00498 0.425
LIG_FHA_1 477 483 PF00498 0.455
LIG_FHA_1 563 569 PF00498 0.195
LIG_FHA_1 604 610 PF00498 0.213
LIG_FHA_1 624 630 PF00498 0.124
LIG_FHA_1 651 657 PF00498 0.276
LIG_FHA_1 782 788 PF00498 0.195
LIG_FHA_1 99 105 PF00498 0.338
LIG_FHA_2 110 116 PF00498 0.369
LIG_FHA_2 14 20 PF00498 0.598
LIG_FHA_2 264 270 PF00498 0.343
LIG_FHA_2 287 293 PF00498 0.527
LIG_FHA_2 494 500 PF00498 0.360
LIG_FHA_2 528 534 PF00498 0.182
LIG_FHA_2 595 601 PF00498 0.322
LIG_FHA_2 643 649 PF00498 0.264
LIG_FHA_2 76 82 PF00498 0.301
LIG_LIR_Gen_1 151 161 PF02991 0.315
LIG_LIR_Gen_1 176 183 PF02991 0.491
LIG_LIR_Gen_1 260 270 PF02991 0.333
LIG_LIR_Gen_1 519 529 PF02991 0.177
LIG_LIR_Gen_1 547 556 PF02991 0.195
LIG_LIR_Gen_1 610 618 PF02991 0.186
LIG_LIR_Nem_3 151 156 PF02991 0.311
LIG_LIR_Nem_3 176 180 PF02991 0.499
LIG_LIR_Nem_3 519 525 PF02991 0.177
LIG_LIR_Nem_3 547 551 PF02991 0.195
LIG_LIR_Nem_3 610 616 PF02991 0.206
LIG_NRBOX 782 788 PF00104 0.195
LIG_PCNA_yPIPBox_3 66 80 PF02747 0.426
LIG_Pex14_1 127 131 PF04695 0.280
LIG_Pex14_2 153 157 PF04695 0.431
LIG_PTAP_UEV_1 553 558 PF05743 0.213
LIG_SH2_CRK 494 498 PF00017 0.331
LIG_SH2_CRK 507 511 PF00017 0.206
LIG_SH2_CRK 67 71 PF00017 0.465
LIG_SH2_CRK 725 729 PF00017 0.242
LIG_SH2_GRB2like 493 496 PF00017 0.430
LIG_SH2_NCK_1 494 498 PF00017 0.331
LIG_SH2_NCK_1 67 71 PF00017 0.465
LIG_SH2_PTP2 710 713 PF00017 0.195
LIG_SH2_SRC 710 713 PF00017 0.242
LIG_SH2_STAP1 372 376 PF00017 0.398
LIG_SH2_STAP1 450 454 PF00017 0.338
LIG_SH2_STAP1 522 526 PF00017 0.192
LIG_SH2_STAT3 450 453 PF00017 0.321
LIG_SH2_STAT3 528 531 PF00017 0.213
LIG_SH2_STAT3 635 638 PF00017 0.276
LIG_SH2_STAT5 439 442 PF00017 0.456
LIG_SH2_STAT5 507 510 PF00017 0.241
LIG_SH2_STAT5 635 638 PF00017 0.195
LIG_SH2_STAT5 665 668 PF00017 0.195
LIG_SH2_STAT5 710 713 PF00017 0.195
LIG_SH3_1 509 515 PF00018 0.177
LIG_SH3_3 509 515 PF00018 0.205
LIG_SH3_3 548 554 PF00018 0.203
LIG_SUMO_SIM_anti_2 628 633 PF11976 0.203
LIG_SUMO_SIM_par_1 190 198 PF11976 0.402
LIG_SUMO_SIM_par_1 625 633 PF11976 0.202
LIG_SUMO_SIM_par_1 75 81 PF11976 0.299
LIG_TRAF2_1 319 322 PF00917 0.536
LIG_TRAF2_1 496 499 PF00917 0.354
LIG_TYR_ITIM 708 713 PF00017 0.195
LIG_UBA3_1 156 162 PF00899 0.342
LIG_UBA3_1 612 620 PF00899 0.212
LIG_WRC_WIRS_1 421 426 PF05994 0.322
MOD_CDC14_SPxK_1 172 175 PF00782 0.458
MOD_CDC14_SPxK_1 4 7 PF00782 0.478
MOD_CDK_SPxK_1 1 7 PF00069 0.480
MOD_CDK_SPxK_1 169 175 PF00069 0.456
MOD_CK1_1 169 175 PF00069 0.506
MOD_CK1_1 388 394 PF00069 0.641
MOD_CK1_1 527 533 PF00069 0.336
MOD_CK1_1 588 594 PF00069 0.195
MOD_CK1_1 625 631 PF00069 0.206
MOD_CK1_1 702 708 PF00069 0.202
MOD_CK1_1 781 787 PF00069 0.203
MOD_CK1_1 804 810 PF00069 0.200
MOD_CK1_1 811 817 PF00069 0.192
MOD_CK2_1 109 115 PF00069 0.440
MOD_CK2_1 13 19 PF00069 0.608
MOD_CK2_1 247 253 PF00069 0.325
MOD_CK2_1 257 263 PF00069 0.263
MOD_CK2_1 428 434 PF00069 0.337
MOD_CK2_1 493 499 PF00069 0.362
MOD_CK2_1 527 533 PF00069 0.214
MOD_CK2_1 594 600 PF00069 0.192
MOD_CK2_1 627 633 PF00069 0.195
MOD_CK2_1 642 648 PF00069 0.195
MOD_CK2_1 739 745 PF00069 0.206
MOD_GlcNHglycan 133 136 PF01048 0.267
MOD_GlcNHglycan 237 240 PF01048 0.386
MOD_GlcNHglycan 405 408 PF01048 0.563
MOD_GlcNHglycan 450 453 PF01048 0.336
MOD_GlcNHglycan 538 542 PF01048 0.280
MOD_GlcNHglycan 587 590 PF01048 0.195
MOD_GlcNHglycan 675 678 PF01048 0.182
MOD_GlcNHglycan 740 744 PF01048 0.206
MOD_GlcNHglycan 759 762 PF01048 0.151
MOD_GlcNHglycan 780 783 PF01048 0.309
MOD_GlcNHglycan 86 89 PF01048 0.399
MOD_GSK3_1 13 20 PF00069 0.472
MOD_GSK3_1 24 31 PF00069 0.326
MOD_GSK3_1 243 250 PF00069 0.338
MOD_GSK3_1 253 260 PF00069 0.269
MOD_GSK3_1 411 418 PF00069 0.389
MOD_GSK3_1 448 455 PF00069 0.338
MOD_GSK3_1 520 527 PF00069 0.343
MOD_GSK3_1 590 597 PF00069 0.322
MOD_GSK3_1 619 626 PF00069 0.181
MOD_GSK3_1 689 696 PF00069 0.203
MOD_GSK3_1 713 720 PF00069 0.199
MOD_GSK3_1 804 811 PF00069 0.206
MOD_GSK3_1 834 841 PF00069 0.481
MOD_GSK3_1 94 101 PF00069 0.306
MOD_LATS_1 241 247 PF00433 0.344
MOD_N-GLC_1 594 599 PF02516 0.192
MOD_N-GLC_1 755 760 PF02516 0.195
MOD_N-GLC_1 808 813 PF02516 0.196
MOD_N-GLC_1 833 838 PF02516 0.401
MOD_N-GLC_2 223 225 PF02516 0.297
MOD_N-GLC_2 577 579 PF02516 0.195
MOD_NEK2_1 143 148 PF00069 0.302
MOD_NEK2_1 235 240 PF00069 0.371
MOD_NEK2_1 378 383 PF00069 0.547
MOD_NEK2_1 396 401 PF00069 0.438
MOD_NEK2_1 562 567 PF00069 0.195
MOD_NEK2_1 568 573 PF00069 0.195
MOD_NEK2_1 642 647 PF00069 0.276
MOD_NEK2_1 778 783 PF00069 0.206
MOD_NEK2_1 787 792 PF00069 0.218
MOD_NEK2_1 818 823 PF00069 0.336
MOD_NEK2_1 84 89 PF00069 0.387
MOD_PIKK_1 441 447 PF00454 0.361
MOD_PIKK_1 476 482 PF00454 0.397
MOD_PIKK_1 527 533 PF00454 0.213
MOD_PIKK_1 69 75 PF00454 0.432
MOD_PKA_1 619 625 PF00069 0.206
MOD_PKA_2 167 173 PF00069 0.579
MOD_PKA_2 253 259 PF00069 0.293
MOD_PKA_2 428 434 PF00069 0.354
MOD_PKA_2 713 719 PF00069 0.206
MOD_PKA_2 778 784 PF00069 0.195
MOD_Plk_1 175 181 PF00069 0.731
MOD_Plk_1 191 197 PF00069 0.328
MOD_Plk_1 310 316 PF00069 0.663
MOD_Plk_1 39 45 PF00069 0.557
MOD_Plk_1 622 628 PF00069 0.195
MOD_Plk_1 755 761 PF00069 0.195
MOD_Plk_2-3 202 208 PF00069 0.288
MOD_Plk_2-3 247 253 PF00069 0.521
MOD_Plk_2-3 257 263 PF00069 0.263
MOD_Plk_2-3 288 294 PF00069 0.640
MOD_Plk_4 120 126 PF00069 0.273
MOD_Plk_4 191 197 PF00069 0.339
MOD_Plk_4 247 253 PF00069 0.546
MOD_Plk_4 257 263 PF00069 0.263
MOD_Plk_4 568 574 PF00069 0.195
MOD_Plk_4 627 633 PF00069 0.207
MOD_Plk_4 661 667 PF00069 0.213
MOD_Plk_4 726 732 PF00069 0.195
MOD_Plk_4 75 81 PF00069 0.282
MOD_Plk_4 781 787 PF00069 0.205
MOD_Plk_4 813 819 PF00069 0.327
MOD_ProDKin_1 1 7 PF00069 0.585
MOD_ProDKin_1 169 175 PF00069 0.477
MOD_ProDKin_1 388 394 PF00069 0.462
MOD_ProDKin_1 411 417 PF00069 0.519
MOD_ProDKin_1 801 807 PF00069 0.206
MOD_SUMO_rev_2 224 231 PF00179 0.371
MOD_SUMO_rev_2 431 438 PF00179 0.442
MOD_SUMO_rev_2 466 476 PF00179 0.376
MOD_SUMO_rev_2 481 489 PF00179 0.329
MOD_SUMO_rev_2 598 604 PF00179 0.236
MOD_SUMO_rev_2 614 622 PF00179 0.163
TRG_DiLeu_BaEn_1 192 197 PF01217 0.481
TRG_DiLeu_BaEn_1 21 26 PF01217 0.320
TRG_DiLeu_BaEn_1 247 252 PF01217 0.329
TRG_DiLeu_BaEn_1 322 327 PF01217 0.537
TRG_DiLeu_BaEn_4 192 198 PF01217 0.341
TRG_DiLeu_BaLyEn_6 295 300 PF01217 0.409
TRG_DiLeu_BaLyEn_6 564 569 PF01217 0.195
TRG_ENDOCYTIC_2 494 497 PF00928 0.340
TRG_ENDOCYTIC_2 507 510 PF00928 0.241
TRG_ENDOCYTIC_2 522 525 PF00928 0.124
TRG_ENDOCYTIC_2 710 713 PF00928 0.195
TRG_ENDOCYTIC_2 725 728 PF00928 0.195
TRG_ER_diArg_1 300 303 PF00400 0.442
TRG_ER_diArg_1 483 485 PF00400 0.340
TRG_ER_diArg_1 49 51 PF00400 0.436
TRG_ER_diArg_1 509 512 PF00400 0.195
TRG_Pf-PMV_PEXEL_1 147 151 PF00026 0.436
TRG_Pf-PMV_PEXEL_1 284 288 PF00026 0.613
TRG_Pf-PMV_PEXEL_1 298 302 PF00026 0.487
TRG_Pf-PMV_PEXEL_1 430 434 PF00026 0.328

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8X9 Leptomonas seymouri 77% 100%
A0A0S4KHP9 Bodo saltans 51% 93%
A0A1X0P6D6 Trypanosomatidae 61% 100%
A0A3S5H751 Leishmania donovani 100% 100%
A0A422P3A3 Trypanosoma rangeli 59% 100%
A4H9Y3 Leishmania braziliensis 80% 100%
B3H6Z8 Arabidopsis thaliana 36% 79%
D0A0E6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
E9ARX7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4QDJ5 Leishmania major 96% 100%
V5BWY3 Trypanosoma cruzi 61% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS