LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
GNL3L/Grn1 putative GTPase - putative
Species:
Leishmania infantum
UniProt:
A4HY46_LEIIN
TriTrypDb:
LINF_190007200
Length:
672

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HY46
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY46

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 124 128 PF00656 0.550
CLV_C14_Caspase3-7 182 186 PF00656 0.443
CLV_C14_Caspase3-7 514 518 PF00656 0.612
CLV_NRD_NRD_1 117 119 PF00675 0.581
CLV_NRD_NRD_1 197 199 PF00675 0.394
CLV_NRD_NRD_1 21 23 PF00675 0.291
CLV_NRD_NRD_1 296 298 PF00675 0.383
CLV_NRD_NRD_1 437 439 PF00675 0.476
CLV_NRD_NRD_1 89 91 PF00675 0.356
CLV_PCSK_FUR_1 22 26 PF00082 0.267
CLV_PCSK_KEX2_1 10 12 PF00082 0.525
CLV_PCSK_KEX2_1 117 119 PF00082 0.581
CLV_PCSK_KEX2_1 24 26 PF00082 0.310
CLV_PCSK_KEX2_1 28 30 PF00082 0.291
CLV_PCSK_KEX2_1 296 298 PF00082 0.383
CLV_PCSK_KEX2_1 437 439 PF00082 0.497
CLV_PCSK_KEX2_1 46 48 PF00082 0.291
CLV_PCSK_KEX2_1 572 574 PF00082 0.467
CLV_PCSK_KEX2_1 89 91 PF00082 0.350
CLV_PCSK_PC1ET2_1 10 12 PF00082 0.525
CLV_PCSK_PC1ET2_1 24 26 PF00082 0.310
CLV_PCSK_PC1ET2_1 28 30 PF00082 0.291
CLV_PCSK_PC1ET2_1 46 48 PF00082 0.291
CLV_PCSK_PC1ET2_1 572 574 PF00082 0.470
CLV_PCSK_SKI1_1 118 122 PF00082 0.443
CLV_PCSK_SKI1_1 137 141 PF00082 0.474
CLV_PCSK_SKI1_1 198 202 PF00082 0.314
CLV_PCSK_SKI1_1 256 260 PF00082 0.432
CLV_PCSK_SKI1_1 29 33 PF00082 0.345
CLV_PCSK_SKI1_1 346 350 PF00082 0.383
CLV_PCSK_SKI1_1 36 40 PF00082 0.267
CLV_PCSK_SKI1_1 420 424 PF00082 0.512
CLV_PCSK_SKI1_1 527 531 PF00082 0.485
CLV_PCSK_SKI1_1 56 60 PF00082 0.092
CLV_PCSK_SKI1_1 83 87 PF00082 0.345
DEG_APCC_DBOX_1 116 124 PF00400 0.544
DEG_APCC_DBOX_1 255 263 PF00400 0.477
DEG_APCC_DBOX_1 526 534 PF00400 0.485
DOC_CKS1_1 615 620 PF01111 0.484
DOC_CYCLIN_RxL_1 371 380 PF00134 0.523
DOC_CYCLIN_yCln2_LP_2 142 148 PF00134 0.456
DOC_CYCLIN_yCln2_LP_2 159 165 PF00134 0.486
DOC_MAPK_gen_1 117 123 PF00069 0.434
DOC_MAPK_gen_1 198 204 PF00069 0.331
DOC_MAPK_gen_1 253 261 PF00069 0.389
DOC_MAPK_gen_1 49 59 PF00069 0.291
DOC_MAPK_MEF2A_6 52 61 PF00069 0.291
DOC_PP1_RVXF_1 130 136 PF00149 0.478
DOC_PP1_RVXF_1 372 379 PF00149 0.523
DOC_PP2B_LxvP_1 159 162 PF13499 0.476
DOC_PP2B_LxvP_1 363 366 PF13499 0.550
DOC_PP2B_LxvP_1 616 619 PF13499 0.546
DOC_PP4_FxxP_1 340 343 PF00568 0.428
DOC_PP4_FxxP_1 406 409 PF00568 0.443
DOC_PP4_FxxP_1 615 618 PF00568 0.575
DOC_SPAK_OSR1_1 173 177 PF12202 0.415
DOC_USP7_MATH_1 112 116 PF00917 0.585
DOC_USP7_MATH_1 125 129 PF00917 0.529
DOC_USP7_MATH_1 150 154 PF00917 0.588
DOC_USP7_MATH_1 175 179 PF00917 0.357
DOC_USP7_MATH_1 216 220 PF00917 0.378
DOC_USP7_MATH_1 307 311 PF00917 0.587
DOC_USP7_MATH_1 45 49 PF00917 0.326
DOC_USP7_MATH_1 488 492 PF00917 0.561
DOC_USP7_MATH_1 6 10 PF00917 0.636
DOC_USP7_MATH_1 650 654 PF00917 0.721
DOC_USP7_MATH_1 658 662 PF00917 0.748
DOC_USP7_UBL2_3 15 19 PF12436 0.306
DOC_USP7_UBL2_3 24 28 PF12436 0.268
DOC_USP7_UBL2_3 32 36 PF12436 0.228
DOC_USP7_UBL2_3 335 339 PF12436 0.586
DOC_USP7_UBL2_3 419 423 PF12436 0.549
DOC_USP7_UBL2_3 46 50 PF12436 0.266
DOC_USP7_UBL2_3 502 506 PF12436 0.586
DOC_WW_Pin1_4 242 247 PF00397 0.446
DOC_WW_Pin1_4 442 447 PF00397 0.469
DOC_WW_Pin1_4 486 491 PF00397 0.530
DOC_WW_Pin1_4 550 555 PF00397 0.552
DOC_WW_Pin1_4 609 614 PF00397 0.447
LIG_14-3-3_CanoR_1 137 145 PF00244 0.492
LIG_14-3-3_CanoR_1 296 300 PF00244 0.356
LIG_14-3-3_CanoR_1 326 336 PF00244 0.611
LIG_APCC_ABBA_1 247 252 PF00400 0.489
LIG_BRCT_BRCA1_1 127 131 PF00533 0.393
LIG_BRCT_BRCA1_1 374 378 PF00533 0.515
LIG_BRCT_BRCA1_1 444 448 PF00533 0.481
LIG_BRCT_BRCA1_1 560 564 PF00533 0.359
LIG_BRCT_BRCA1_1 611 615 PF00533 0.450
LIG_FHA_1 105 111 PF00498 0.677
LIG_FHA_1 138 144 PF00498 0.469
LIG_FHA_1 147 153 PF00498 0.622
LIG_FHA_1 156 162 PF00498 0.401
LIG_FHA_1 279 285 PF00498 0.467
LIG_FHA_1 312 318 PF00498 0.458
LIG_FHA_1 575 581 PF00498 0.552
LIG_FHA_1 79 85 PF00498 0.417
LIG_FHA_2 180 186 PF00498 0.408
LIG_FHA_2 205 211 PF00498 0.330
LIG_FHA_2 328 334 PF00498 0.594
LIG_FHA_2 627 633 PF00498 0.673
LIG_FHA_2 93 99 PF00498 0.641
LIG_LIR_Apic_2 338 343 PF02991 0.478
LIG_LIR_Apic_2 612 618 PF02991 0.557
LIG_LIR_Gen_1 178 188 PF02991 0.376
LIG_LIR_Gen_1 508 518 PF02991 0.635
LIG_LIR_Nem_3 178 184 PF02991 0.370
LIG_LIR_Nem_3 370 376 PF02991 0.368
LIG_LIR_Nem_3 508 513 PF02991 0.610
LIG_PCNA_yPIPBox_3 132 143 PF02747 0.455
LIG_Pex14_2 131 135 PF04695 0.356
LIG_PTB_Apo_2 479 486 PF02174 0.619
LIG_PTB_Phospho_1 479 485 PF10480 0.621
LIG_SH2_CRK 510 514 PF00017 0.626
LIG_SH2_GRB2like 485 488 PF00017 0.593
LIG_SH2_NCK_1 485 489 PF00017 0.616
LIG_SH2_STAT5 122 125 PF00017 0.429
LIG_SH2_STAT5 166 169 PF00017 0.313
LIG_SH2_STAT5 194 197 PF00017 0.489
LIG_SH3_3 209 215 PF00018 0.422
LIG_SH3_3 348 354 PF00018 0.442
LIG_SH3_3 599 605 PF00018 0.448
LIG_SUMO_SIM_anti_2 219 225 PF11976 0.377
LIG_SUMO_SIM_anti_2 599 604 PF11976 0.492
LIG_SUMO_SIM_par_1 166 171 PF11976 0.317
LIG_SUMO_SIM_par_1 199 205 PF11976 0.427
LIG_TRAF2_1 330 333 PF00917 0.629
LIG_TRAF2_1 629 632 PF00917 0.675
LIG_TRAF2_1 653 656 PF00917 0.682
LIG_UBA3_1 120 126 PF00899 0.512
LIG_UBA3_1 202 208 PF00899 0.304
LIG_WW_1 618 621 PF00397 0.578
MOD_CDK_SPxK_1 486 492 PF00069 0.524
MOD_CK1_1 248 254 PF00069 0.477
MOD_CK1_1 278 284 PF00069 0.471
MOD_CK1_1 310 316 PF00069 0.394
MOD_CK1_1 327 333 PF00069 0.620
MOD_CK1_1 461 467 PF00069 0.589
MOD_CK1_1 476 482 PF00069 0.541
MOD_CK1_1 48 54 PF00069 0.332
MOD_CK1_1 486 492 PF00069 0.490
MOD_CK2_1 327 333 PF00069 0.620
MOD_CK2_1 626 632 PF00069 0.615
MOD_CK2_1 645 651 PF00069 0.676
MOD_CK2_1 92 98 PF00069 0.303
MOD_Cter_Amidation 196 199 PF01082 0.456
MOD_Cter_Amidation 294 297 PF01082 0.352
MOD_Cter_Amidation 570 573 PF01082 0.446
MOD_GlcNHglycan 123 126 PF01048 0.549
MOD_GlcNHglycan 151 155 PF01048 0.555
MOD_GlcNHglycan 212 215 PF01048 0.467
MOD_GlcNHglycan 309 312 PF01048 0.487
MOD_GlcNHglycan 326 329 PF01048 0.525
MOD_GlcNHglycan 460 463 PF01048 0.658
MOD_GlcNHglycan 470 473 PF01048 0.631
MOD_GSK3_1 121 128 PF00069 0.490
MOD_GSK3_1 146 153 PF00069 0.600
MOD_GSK3_1 175 182 PF00069 0.389
MOD_GSK3_1 291 298 PF00069 0.354
MOD_GSK3_1 307 314 PF00069 0.246
MOD_GSK3_1 447 454 PF00069 0.515
MOD_GSK3_1 457 464 PF00069 0.562
MOD_GSK3_1 558 565 PF00069 0.490
MOD_GSK3_1 6 13 PF00069 0.524
MOD_GSK3_1 626 633 PF00069 0.600
MOD_GSK3_1 92 99 PF00069 0.668
MOD_N-GLC_1 104 109 PF02516 0.614
MOD_N-GLC_1 278 283 PF02516 0.446
MOD_N-GLC_1 307 312 PF02516 0.538
MOD_N-GLC_1 481 486 PF02516 0.603
MOD_NEK2_1 121 126 PF00069 0.527
MOD_NEK2_1 202 207 PF00069 0.294
MOD_NEK2_1 299 304 PF00069 0.438
MOD_NEK2_1 324 329 PF00069 0.577
MOD_NEK2_1 372 377 PF00069 0.438
MOD_NEK2_1 38 43 PF00069 0.310
MOD_NEK2_1 481 486 PF00069 0.614
MOD_NEK2_1 59 64 PF00069 0.277
MOD_PIKK_1 216 222 PF00454 0.304
MOD_PIKK_1 251 257 PF00454 0.521
MOD_PIKK_1 473 479 PF00454 0.567
MOD_PKA_1 10 16 PF00069 0.524
MOD_PKA_1 92 98 PF00069 0.386
MOD_PKA_2 10 16 PF00069 0.524
MOD_PKA_2 295 301 PF00069 0.376
MOD_PKA_2 78 84 PF00069 0.422
MOD_PKB_1 90 98 PF00069 0.344
MOD_Plk_1 104 110 PF00069 0.628
MOD_Plk_1 397 403 PF00069 0.464
MOD_Plk_1 481 487 PF00069 0.543
MOD_Plk_1 548 554 PF00069 0.512
MOD_Plk_1 626 632 PF00069 0.620
MOD_Plk_2-3 155 161 PF00069 0.496
MOD_Plk_2-3 626 632 PF00069 0.615
MOD_Plk_4 346 352 PF00069 0.394
MOD_Plk_4 476 482 PF00069 0.566
MOD_Plk_4 495 501 PF00069 0.360
MOD_ProDKin_1 242 248 PF00069 0.447
MOD_ProDKin_1 442 448 PF00069 0.474
MOD_ProDKin_1 486 492 PF00069 0.524
MOD_ProDKin_1 550 556 PF00069 0.550
MOD_ProDKin_1 609 615 PF00069 0.452
MOD_SUMO_for_1 85 88 PF00179 0.396
MOD_SUMO_rev_2 26 34 PF00179 0.402
MOD_SUMO_rev_2 327 336 PF00179 0.621
MOD_SUMO_rev_2 415 422 PF00179 0.564
MOD_SUMO_rev_2 565 574 PF00179 0.507
MOD_SUMO_rev_2 578 583 PF00179 0.520
TRG_ENDOCYTIC_2 510 513 PF00928 0.621
TRG_ER_diArg_1 436 438 PF00400 0.443
TRG_ER_diArg_1 89 92 PF00400 0.432
TRG_NLS_Bipartite_1 28 50 PF00514 0.310
TRG_NLS_MonoExtC_3 45 50 PF00514 0.310
TRG_NLS_MonoExtN_4 45 50 PF00514 0.310
TRG_Pf-PMV_PEXEL_1 137 141 PF00026 0.369
TRG_Pf-PMV_PEXEL_1 260 264 PF00026 0.422
TRG_Pf-PMV_PEXEL_1 301 306 PF00026 0.446
TRG_Pf-PMV_PEXEL_1 427 431 PF00026 0.461

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I322 Leptomonas seymouri 80% 100%
A0A0S4KI95 Bodo saltans 42% 94%
A0A1X0P6K8 Trypanosomatidae 50% 97%
A0A3S7WV83 Leishmania donovani 100% 100%
A0A422NCV7 Trypanosoma rangeli 46% 98%
A4H9Y1 Leishmania braziliensis 90% 100%
D0A0E3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 46% 93%
E9ARX5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
Q4QDJ7 Leishmania major 98% 100%
V5BBU4 Trypanosoma cruzi 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS