Complex1_LYR_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Complex 1 protein (LYR family)/Complex1 LYR-like - putative

Species:

Leishmania infantum

UniProt:

A4HY45_LEIIN

TriTrypDb:

LINF_190007100

Length:

653

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005747	mitochondrial respiratory chain complex I	4	11
GO:0030964	NADH dehydrogenase complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0045271	respiratory chain complex I	4	11
GO:0098796	membrane protein complex	2	11
GO:0098798	mitochondrial protein-containing complex	2	11
GO:0098800	inner mitochondrial membrane protein complex	3	11
GO:0098803	respiratory chain complex	3	11
GO:1902494	catalytic complex	2	11
GO:1902495	transmembrane transporter complex	3	11
GO:1990204	oxidoreductase complex	3	11
GO:1990351	transporter complex	2	11
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HY45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY45

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0006979	response to oxidative stress	3	1
GO:0050896	response to stimulus	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.678
CLV_NRD_NRD_1	197	199	PF00675	0.426
CLV_NRD_NRD_1	239	241	PF00675	0.544
CLV_NRD_NRD_1	310	312	PF00675	0.539
CLV_NRD_NRD_1	332	334	PF00675	0.516
CLV_NRD_NRD_1	336	338	PF00675	0.503
CLV_NRD_NRD_1	509	511	PF00675	0.562
CLV_NRD_NRD_1	561	563	PF00675	0.505
CLV_NRD_NRD_1	607	609	PF00675	0.392
CLV_PCSK_FUR_1	519	523	PF00082	0.477
CLV_PCSK_KEX2_1	111	113	PF00082	0.565
CLV_PCSK_KEX2_1	197	199	PF00082	0.426
CLV_PCSK_KEX2_1	239	241	PF00082	0.544
CLV_PCSK_KEX2_1	310	312	PF00082	0.557
CLV_PCSK_KEX2_1	332	334	PF00082	0.516
CLV_PCSK_KEX2_1	336	338	PF00082	0.503
CLV_PCSK_KEX2_1	509	511	PF00082	0.542
CLV_PCSK_KEX2_1	521	523	PF00082	0.508
CLV_PCSK_KEX2_1	561	563	PF00082	0.505
CLV_PCSK_KEX2_1	607	609	PF00082	0.404
CLV_PCSK_KEX2_1	77	79	PF00082	0.702
CLV_PCSK_PC1ET2_1	521	523	PF00082	0.476
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.702
CLV_PCSK_PC7_1	306	312	PF00082	0.541
CLV_PCSK_PC7_1	332	338	PF00082	0.507
CLV_PCSK_SKI1_1	137	141	PF00082	0.410
CLV_PCSK_SKI1_1	180	184	PF00082	0.324
CLV_PCSK_SKI1_1	257	261	PF00082	0.533
CLV_PCSK_SKI1_1	337	341	PF00082	0.487
CLV_PCSK_SKI1_1	399	403	PF00082	0.511
CLV_PCSK_SKI1_1	424	428	PF00082	0.509
CLV_PCSK_SKI1_1	88	92	PF00082	0.493
DEG_APCC_DBOX_1	136	144	PF00400	0.297
DEG_APCC_DBOX_1	423	431	PF00400	0.541
DEG_Nend_UBRbox_2	1	3	PF02207	0.555
DEG_ODPH_VHL_1	427	439	PF01847	0.507
DOC_CDC14_PxL_1	1	9	PF14671	0.591
DOC_CKS1_1	46	51	PF01111	0.640
DOC_CKS1_1	92	97	PF01111	0.602
DOC_CYCLIN_RxL_1	421	431	PF00134	0.543
DOC_CYCLIN_yCln2_LP_2	426	432	PF00134	0.462
DOC_MAPK_gen_1	160	167	PF00069	0.383
DOC_MAPK_gen_1	593	602	PF00069	0.402
DOC_MAPK_MEF2A_6	147	156	PF00069	0.472
DOC_MAPK_MEF2A_6	160	167	PF00069	0.344
DOC_MAPK_MEF2A_6	618	625	PF00069	0.526
DOC_MAPK_NFAT4_5	160	168	PF00069	0.410
DOC_PP1_RVXF_1	162	168	PF00149	0.410
DOC_PP2B_LxvP_1	152	155	PF13499	0.410
DOC_PP2B_LxvP_1	31	34	PF13499	0.751
DOC_PP2B_LxvP_1	426	429	PF13499	0.477
DOC_PP4_FxxP_1	196	199	PF00568	0.480
DOC_PP4_FxxP_1	553	556	PF00568	0.633
DOC_PP4_FxxP_1	619	622	PF00568	0.376
DOC_SPAK_OSR1_1	618	622	PF12202	0.499
DOC_USP7_MATH_1	131	135	PF00917	0.297
DOC_USP7_MATH_1	645	649	PF00917	0.527
DOC_USP7_UBL2_3	20	24	PF12436	0.569
DOC_USP7_UBL2_3	217	221	PF12436	0.572
DOC_USP7_UBL2_3	257	261	PF12436	0.480
DOC_WW_Pin1_4	367	372	PF00397	0.527
DOC_WW_Pin1_4	45	50	PF00397	0.644
DOC_WW_Pin1_4	91	96	PF00397	0.594
LIG_14-3-3_CanoR_1	265	271	PF00244	0.525
LIG_14-3-3_CanoR_1	412	421	PF00244	0.483
LIG_APCC_ABBA_1	623	628	PF00400	0.472
LIG_BRCT_BRCA1_1	192	196	PF00533	0.406
LIG_BRCT_BRCA1_1	390	394	PF00533	0.450
LIG_BRCT_BRCA1_1	461	465	PF00533	0.375
LIG_FHA_1	114	120	PF00498	0.594
LIG_FHA_1	33	39	PF00498	0.657
LIG_FHA_1	459	465	PF00498	0.427
LIG_FHA_1	493	499	PF00498	0.446
LIG_FHA_2	13	19	PF00498	0.618
LIG_FHA_2	218	224	PF00498	0.498
LIG_FHA_2	342	348	PF00498	0.502
LIG_FHA_2	390	396	PF00498	0.475
LIG_FHA_2	478	484	PF00498	0.464
LIG_FHA_2	92	98	PF00498	0.601
LIG_FXI_DFP_1	502	506	PF00024	0.479
LIG_LIR_Apic_2	193	199	PF02991	0.420
LIG_LIR_Apic_2	318	324	PF02991	0.526
LIG_LIR_Apic_2	35	39	PF02991	0.732
LIG_LIR_Apic_2	551	556	PF02991	0.554
LIG_LIR_Apic_2	560	566	PF02991	0.484
LIG_LIR_Gen_1	256	267	PF02991	0.600
LIG_LIR_Gen_1	359	366	PF02991	0.448
LIG_LIR_Gen_1	431	441	PF02991	0.457
LIG_LIR_Gen_1	462	470	PF02991	0.405
LIG_LIR_Gen_1	480	488	PF02991	0.484
LIG_LIR_Gen_1	613	622	PF02991	0.400
LIG_LIR_Nem_3	104	108	PF02991	0.671
LIG_LIR_Nem_3	134	139	PF02991	0.366
LIG_LIR_Nem_3	256	262	PF02991	0.581
LIG_LIR_Nem_3	359	365	PF02991	0.449
LIG_LIR_Nem_3	391	397	PF02991	0.455
LIG_LIR_Nem_3	417	423	PF02991	0.464
LIG_LIR_Nem_3	431	437	PF02991	0.473
LIG_LIR_Nem_3	462	468	PF02991	0.421
LIG_LIR_Nem_3	480	484	PF02991	0.463
LIG_LIR_Nem_3	542	546	PF02991	0.426
LIG_LIR_Nem_3	613	617	PF02991	0.407
LIG_LIR_Nem_3	86	90	PF02991	0.542
LIG_NRBOX	422	428	PF00104	0.543
LIG_PCNA_TLS_4	200	207	PF02747	0.438
LIG_Pex14_1	481	485	PF04695	0.481
LIG_Pex14_2	484	488	PF04695	0.503
LIG_PTB_Apo_2	613	620	PF02174	0.512
LIG_RPA_C_Fungi	107	119	PF08784	0.665
LIG_SH2_CRK	136	140	PF00017	0.410
LIG_SH2_CRK	321	325	PF00017	0.539
LIG_SH2_CRK	36	40	PF00017	0.658
LIG_SH2_CRK	563	567	PF00017	0.484
LIG_SH2_CRK	572	576	PF00017	0.386
LIG_SH2_GRB2like	546	549	PF00017	0.445
LIG_SH2_STAP1	390	394	PF00017	0.450
LIG_SH2_STAP1	397	401	PF00017	0.463
LIG_SH2_STAP1	460	464	PF00017	0.495
LIG_SH2_STAT5	16	19	PF00017	0.504
LIG_SH2_STAT5	206	209	PF00017	0.538
LIG_SH2_STAT5	219	222	PF00017	0.450
LIG_SH2_STAT5	276	279	PF00017	0.533
LIG_SH2_STAT5	298	301	PF00017	0.530
LIG_SH2_STAT5	354	357	PF00017	0.438
LIG_SH2_STAT5	364	367	PF00017	0.467
LIG_SH2_STAT5	420	423	PF00017	0.596
LIG_SH2_STAT5	425	428	PF00017	0.505
LIG_SH2_STAT5	460	463	PF00017	0.497
LIG_SH2_STAT5	485	488	PF00017	0.509
LIG_SH2_STAT5	535	538	PF00017	0.461
LIG_SH2_STAT5	546	549	PF00017	0.458
LIG_SH2_STAT5	63	66	PF00017	0.560
LIG_SH3_3	151	157	PF00018	0.306
LIG_SH3_3	487	493	PF00018	0.460
LIG_SH3_3	544	550	PF00018	0.455
LIG_SH3_3	89	95	PF00018	0.591
LIG_TRAF2_1	220	223	PF00917	0.518
LIG_TRAF2_1	441	444	PF00917	0.446
LIG_TRFH_1	425	429	PF08558	0.543
LIG_TYR_ITIM	85	90	PF00017	0.510
LIG_UBA3_1	139	147	PF00899	0.389
LIG_UBA3_1	152	160	PF00899	0.241
LIG_ULM_U2AF65_1	509	514	PF00076	0.470
LIG_WW_1	33	36	PF00397	0.657
MOD_CK1_1	370	376	PF00069	0.502
MOD_CK1_1	598	604	PF00069	0.411
MOD_CK1_1	641	647	PF00069	0.425
MOD_CK2_1	12	18	PF00069	0.526
MOD_CK2_1	208	214	PF00069	0.481
MOD_CK2_1	217	223	PF00069	0.485
MOD_CK2_1	225	231	PF00069	0.530
MOD_CK2_1	341	347	PF00069	0.477
MOD_CK2_1	366	372	PF00069	0.509
MOD_CK2_1	389	395	PF00069	0.525
MOD_CK2_1	91	97	PF00069	0.595
MOD_Cter_Amidation	109	112	PF01082	0.550
MOD_GlcNHglycan	318	321	PF01048	0.530
MOD_GlcNHglycan	525	528	PF01048	0.579
MOD_GlcNHglycan	557	560	PF01048	0.526
MOD_GlcNHglycan	647	650	PF01048	0.571
MOD_GSK3_1	131	138	PF00069	0.286
MOD_GSK3_1	213	220	PF00069	0.622
MOD_GSK3_1	266	273	PF00069	0.524
MOD_GSK3_1	341	348	PF00069	0.470
MOD_GSK3_1	366	373	PF00069	0.500
MOD_GSK3_1	459	466	PF00069	0.400
MOD_GSK3_1	641	648	PF00069	0.605
MOD_N-GLC_1	51	56	PF02516	0.610
MOD_N-GLC_2	638	640	PF02516	0.461
MOD_NEK2_1	106	111	PF00069	0.665
MOD_NEK2_1	135	140	PF00069	0.449
MOD_NEK2_1	190	195	PF00069	0.403
MOD_NEK2_1	345	350	PF00069	0.509
MOD_NEK2_1	389	394	PF00069	0.462
MOD_NEK2_1	477	482	PF00069	0.435
MOD_NEK2_1	51	56	PF00069	0.613
MOD_NEK2_2	131	136	PF00069	0.279
MOD_PIKK_1	439	445	PF00454	0.442
MOD_PIKK_1	463	469	PF00454	0.379
MOD_PKA_2	199	205	PF00069	0.403
MOD_PKA_2	366	372	PF00069	0.509
MOD_PKA_2	587	593	PF00069	0.537
MOD_Plk_1	346	352	PF00069	0.498
MOD_Plk_1	378	384	PF00069	0.456
MOD_Plk_1	51	57	PF00069	0.552
MOD_Plk_2-3	208	214	PF00069	0.548
MOD_Plk_2-3	341	347	PF00069	0.492
MOD_Plk_2-3	483	489	PF00069	0.566
MOD_Plk_4	113	119	PF00069	0.616
MOD_Plk_4	131	137	PF00069	0.224
MOD_Plk_4	190	196	PF00069	0.403
MOD_Plk_4	341	347	PF00069	0.492
MOD_Plk_4	535	541	PF00069	0.397
MOD_ProDKin_1	367	373	PF00069	0.524
MOD_ProDKin_1	45	51	PF00069	0.641
MOD_ProDKin_1	91	97	PF00069	0.595
MOD_SUMO_rev_2	13	22	PF00179	0.703
MOD_SUMO_rev_2	526	534	PF00179	0.531
TRG_DiLeu_BaEn_2	112	118	PF01217	0.658
TRG_DiLeu_BaEn_4	26	32	PF01217	0.588
TRG_ENDOCYTIC_2	136	139	PF00928	0.360
TRG_ENDOCYTIC_2	149	152	PF00928	0.201
TRG_ENDOCYTIC_2	335	338	PF00928	0.501
TRG_ENDOCYTIC_2	420	423	PF00928	0.472
TRG_ENDOCYTIC_2	485	488	PF00928	0.514
TRG_ENDOCYTIC_2	572	575	PF00928	0.433
TRG_ENDOCYTIC_2	87	90	PF00928	0.520
TRG_ER_diArg_1	163	166	PF00400	0.357
TRG_ER_diArg_1	196	198	PF00400	0.404
TRG_ER_diArg_1	335	337	PF00400	0.503
TRG_ER_diArg_1	421	424	PF00400	0.469
TRG_ER_diArg_1	561	563	PF00400	0.505
TRG_ER_diArg_1	607	609	PF00400	0.404
TRG_NES_CRM1_1	570	585	PF08389	0.443
TRG_Pf-PMV_PEXEL_1	166	171	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	380	385	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9Q5	Leptomonas seymouri	81%	94%
A0A0S4KEU9	Bodo saltans	61%	80%
A0A1X0P7G4	Trypanosomatidae	73%	92%
A0A3S7WVA4	Leishmania donovani	100%	100%
A4H9Y0	Leishmania braziliensis	93%	100%
D0A0E2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	75%	92%
E9ARX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q4QDJ8	Leishmania major	98%	100%
V5BSA4	Trypanosoma cruzi	74%	95%