Putative polyprenyl synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

polyprenyl synthase - putative

Species:

Leishmania infantum

UniProt:

A4HY44_LEIIN

TriTrypDb:

LINF_190007000

Length:

742

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HY44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY44

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	10
GO:0006720	isoprenoid metabolic process	4	10
GO:0008152	metabolic process	1	10
GO:0008299	isoprenoid biosynthetic process	4	10
GO:0008610	lipid biosynthetic process	4	10
GO:0009058	biosynthetic process	2	10
GO:0009987	cellular process	1	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044255	cellular lipid metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:1901576	organic substance biosynthetic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004659	prenyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.418
CLV_C14_Caspase3-7	285	289	PF00656	0.399
CLV_C14_Caspase3-7	406	410	PF00656	0.581
CLV_C14_Caspase3-7	488	492	PF00656	0.410
CLV_C14_Caspase3-7	570	574	PF00656	0.360
CLV_C14_Caspase3-7	579	583	PF00656	0.312
CLV_C14_Caspase3-7	647	651	PF00656	0.295
CLV_NRD_NRD_1	110	112	PF00675	0.400
CLV_NRD_NRD_1	166	168	PF00675	0.302
CLV_NRD_NRD_1	470	472	PF00675	0.359
CLV_NRD_NRD_1	496	498	PF00675	0.295
CLV_NRD_NRD_1	676	678	PF00675	0.359
CLV_PCSK_KEX2_1	166	168	PF00082	0.337
CLV_PCSK_KEX2_1	223	225	PF00082	0.344
CLV_PCSK_KEX2_1	470	472	PF00082	0.359
CLV_PCSK_KEX2_1	496	498	PF00082	0.295
CLV_PCSK_PC1ET2_1	223	225	PF00082	0.344
CLV_PCSK_SKI1_1	134	138	PF00082	0.341
CLV_PCSK_SKI1_1	220	224	PF00082	0.498
CLV_PCSK_SKI1_1	245	249	PF00082	0.308
CLV_PCSK_SKI1_1	369	373	PF00082	0.382
DEG_APCC_DBOX_1	668	676	PF00400	0.388
DEG_APCC_DBOX_1	706	714	PF00400	0.437
DOC_MAPK_gen_1	111	118	PF00069	0.430
DOC_MAPK_gen_1	445	455	PF00069	0.320
DOC_MAPK_gen_1	496	504	PF00069	0.320
DOC_MAPK_gen_1	535	544	PF00069	0.320
DOC_MAPK_gen_1	649	659	PF00069	0.315
DOC_MAPK_HePTP_8	108	120	PF00069	0.344
DOC_MAPK_MEF2A_6	111	120	PF00069	0.352
DOC_MAPK_MEF2A_6	616	625	PF00069	0.388
DOC_MAPK_MEF2A_6	652	661	PF00069	0.478
DOC_MAPK_NFAT4_5	616	624	PF00069	0.388
DOC_PP4_FxxP_1	520	523	PF00568	0.390
DOC_USP7_MATH_1	209	213	PF00917	0.337
DOC_USP7_MATH_1	287	291	PF00917	0.375
DOC_USP7_MATH_1	407	411	PF00917	0.472
DOC_USP7_MATH_1	438	442	PF00917	0.320
DOC_USP7_MATH_1	595	599	PF00917	0.344
DOC_USP7_MATH_2	532	538	PF00917	0.388
DOC_WW_Pin1_4	376	381	PF00397	0.514
LIG_14-3-3_CanoR_1	166	171	PF00244	0.333
LIG_14-3-3_CanoR_1	319	327	PF00244	0.475
LIG_14-3-3_CanoR_1	445	451	PF00244	0.404
LIG_14-3-3_CanoR_1	669	673	PF00244	0.400
LIG_14-3-3_CanoR_1	731	737	PF00244	0.408
LIG_Actin_WH2_2	109	127	PF00022	0.390
LIG_BIR_II_1	1	5	PF00653	0.632
LIG_BRCT_BRCA1_1	47	51	PF00533	0.428
LIG_BRCT_BRCA1_1	574	578	PF00533	0.359
LIG_BRCT_BRCA1_1	699	703	PF00533	0.377
LIG_Clathr_ClatBox_1	78	82	PF01394	0.355
LIG_deltaCOP1_diTrp_1	3	9	PF00928	0.538
LIG_eIF4E_1	559	565	PF01652	0.410
LIG_FHA_1	212	218	PF00498	0.417
LIG_FHA_1	238	244	PF00498	0.653
LIG_FHA_1	340	346	PF00498	0.469
LIG_FHA_1	382	388	PF00498	0.455
LIG_FHA_1	652	658	PF00498	0.265
LIG_FHA_2	12	18	PF00498	0.503
LIG_FHA_2	283	289	PF00498	0.357
LIG_FHA_2	404	410	PF00498	0.484
LIG_FHA_2	574	580	PF00498	0.388
LIG_KLC1_Yacidic_2	177	182	PF13176	0.272
LIG_LIR_Apic_2	505	509	PF02991	0.272
LIG_LIR_Apic_2	562	566	PF02991	0.410
LIG_LIR_Gen_1	177	185	PF02991	0.403
LIG_LIR_Gen_1	19	27	PF02991	0.425
LIG_LIR_Gen_1	214	222	PF02991	0.388
LIG_LIR_Gen_1	250	261	PF02991	0.323
LIG_LIR_Gen_1	304	312	PF02991	0.305
LIG_LIR_Gen_1	575	584	PF02991	0.359
LIG_LIR_Gen_1	671	679	PF02991	0.348
LIG_LIR_Gen_1	712	721	PF02991	0.379
LIG_LIR_Gen_1	732	738	PF02991	0.177
LIG_LIR_Nem_3	177	183	PF02991	0.348
LIG_LIR_Nem_3	19	24	PF02991	0.529
LIG_LIR_Nem_3	214	219	PF02991	0.396
LIG_LIR_Nem_3	250	256	PF02991	0.320
LIG_LIR_Nem_3	304	308	PF02991	0.305
LIG_LIR_Nem_3	310	314	PF02991	0.310
LIG_LIR_Nem_3	433	439	PF02991	0.295
LIG_LIR_Nem_3	449	453	PF02991	0.295
LIG_LIR_Nem_3	537	543	PF02991	0.399
LIG_LIR_Nem_3	575	581	PF02991	0.359
LIG_LIR_Nem_3	671	676	PF02991	0.341
LIG_LIR_Nem_3	712	717	PF02991	0.351
LIG_LIR_Nem_3	722	728	PF02991	0.332
LIG_LIR_Nem_3	732	736	PF02991	0.175
LIG_NBox_RRM_1	617	627	PF00076	0.382
LIG_NRBOX	119	125	PF00104	0.388
LIG_Pex14_1	5	9	PF04695	0.533
LIG_Pex14_2	51	55	PF04695	0.297
LIG_REV1ctd_RIR_1	369	379	PF16727	0.392
LIG_REV1ctd_RIR_1	53	61	PF16727	0.355
LIG_SH2_CRK	21	25	PF00017	0.301
LIG_SH2_CRK	506	510	PF00017	0.272
LIG_SH2_GRB2like	34	37	PF00017	0.295
LIG_SH2_PTP2	180	183	PF00017	0.315
LIG_SH2_PTP2	216	219	PF00017	0.344
LIG_SH2_PTP2	472	475	PF00017	0.320
LIG_SH2_SRC	180	183	PF00017	0.369
LIG_SH2_SRC	34	37	PF00017	0.388
LIG_SH2_SRC	394	397	PF00017	0.409
LIG_SH2_SRC	87	90	PF00017	0.355
LIG_SH2_STAP1	168	172	PF00017	0.445
LIG_SH2_STAP1	21	25	PF00017	0.446
LIG_SH2_STAP1	232	236	PF00017	0.295
LIG_SH2_STAP1	249	253	PF00017	0.295
LIG_SH2_STAP1	71	75	PF00017	0.344
LIG_SH2_STAP1	87	91	PF00017	0.355
LIG_SH2_STAT3	142	145	PF00017	0.373
LIG_SH2_STAT5	142	145	PF00017	0.388
LIG_SH2_STAT5	168	171	PF00017	0.351
LIG_SH2_STAT5	180	183	PF00017	0.361
LIG_SH2_STAT5	207	210	PF00017	0.374
LIG_SH2_STAT5	216	219	PF00017	0.392
LIG_SH2_STAT5	390	393	PF00017	0.475
LIG_SH2_STAT5	394	397	PF00017	0.449
LIG_SH2_STAT5	466	469	PF00017	0.329
LIG_SH2_STAT5	472	475	PF00017	0.308
LIG_SH2_STAT5	519	522	PF00017	0.320
LIG_SH2_STAT5	543	546	PF00017	0.295
LIG_SH2_STAT5	563	566	PF00017	0.155
LIG_SH3_3	126	132	PF00018	0.427
LIG_SUMO_SIM_anti_2	117	122	PF11976	0.344
LIG_SUMO_SIM_anti_2	452	457	PF11976	0.308
LIG_SUMO_SIM_par_1	452	457	PF11976	0.308
LIG_SUMO_SIM_par_1	77	82	PF11976	0.246
LIG_TRAF2_1	336	339	PF00917	0.355
LIG_TRAF2_1	398	401	PF00917	0.516
LIG_TYR_ITSM	212	219	PF00017	0.390
LIG_UBA3_1	120	126	PF00899	0.410
LIG_UBA3_1	78	85	PF00899	0.388
LIG_WRC_WIRS_1	308	313	PF05994	0.320
LIG_WRC_WIRS_1	52	57	PF05994	0.355
LIG_WRC_WIRS_1	730	735	PF05994	0.334
LIG_WW_3	9	13	PF00397	0.506
MOD_CK1_1	252	258	PF00069	0.343
MOD_CK1_1	259	265	PF00069	0.293
MOD_CK1_1	26	32	PF00069	0.455
MOD_CK1_1	307	313	PF00069	0.319
MOD_CK1_1	410	416	PF00069	0.459
MOD_CK1_1	449	455	PF00069	0.410
MOD_CK2_1	236	242	PF00069	0.494
MOD_Cter_Amidation	109	112	PF01082	0.415
MOD_GlcNHglycan	162	166	PF01048	0.382
MOD_GlcNHglycan	25	28	PF01048	0.564
MOD_GlcNHglycan	321	324	PF01048	0.468
MOD_GlcNHglycan	356	360	PF01048	0.454
MOD_GlcNHglycan	515	518	PF01048	0.353
MOD_GlcNHglycan	89	92	PF01048	0.344
MOD_GSK3_1	166	173	PF00069	0.344
MOD_GSK3_1	207	214	PF00069	0.351
MOD_GSK3_1	252	259	PF00069	0.347
MOD_GSK3_1	303	310	PF00069	0.308
MOD_GSK3_1	403	410	PF00069	0.565
MOD_GSK3_1	568	575	PF00069	0.388
MOD_N-GLC_1	259	264	PF02516	0.383
MOD_N-GLC_1	272	277	PF02516	0.247
MOD_N-GLC_1	301	306	PF02516	0.402
MOD_N-GLC_1	381	386	PF02516	0.444
MOD_NEK2_1	151	156	PF00069	0.388
MOD_NEK2_1	170	175	PF00069	0.368
MOD_NEK2_1	211	216	PF00069	0.388
MOD_NEK2_1	236	241	PF00069	0.444
MOD_NEK2_1	256	261	PF00069	0.314
MOD_NEK2_1	327	332	PF00069	0.424
MOD_NEK2_1	51	56	PF00069	0.320
MOD_NEK2_1	721	726	PF00069	0.404
MOD_NEK2_1	729	734	PF00069	0.327
MOD_NEK2_2	37	42	PF00069	0.344
MOD_PIKK_1	140	146	PF00454	0.410
MOD_PIKK_1	184	190	PF00454	0.388
MOD_PIKK_1	259	265	PF00454	0.428
MOD_PKA_1	166	172	PF00069	0.394
MOD_PKA_1	677	683	PF00069	0.359
MOD_PKA_2	11	17	PF00069	0.485
MOD_PKA_2	166	172	PF00069	0.447
MOD_PKA_2	668	674	PF00069	0.400
MOD_Plk_1	151	157	PF00069	0.398
MOD_Plk_1	259	265	PF00069	0.356
MOD_Plk_1	301	307	PF00069	0.419
MOD_Plk_1	327	333	PF00069	0.388
MOD_Plk_1	44	50	PF00069	0.316
MOD_Plk_1	490	496	PF00069	0.320
MOD_Plk_1	572	578	PF00069	0.388
MOD_Plk_1	721	727	PF00069	0.437
MOD_Plk_2-3	573	579	PF00069	0.388
MOD_Plk_2-3	93	99	PF00069	0.388
MOD_Plk_4	262	268	PF00069	0.344
MOD_Plk_4	304	310	PF00069	0.298
MOD_Plk_4	339	345	PF00069	0.288
MOD_Plk_4	390	396	PF00069	0.443
MOD_Plk_4	407	413	PF00069	0.381
MOD_Plk_4	431	437	PF00069	0.295
MOD_Plk_4	480	486	PF00069	0.295
MOD_Plk_4	490	496	PF00069	0.295
MOD_Plk_4	51	57	PF00069	0.295
MOD_Plk_4	573	579	PF00069	0.388
MOD_Plk_4	605	611	PF00069	0.344
MOD_Plk_4	668	674	PF00069	0.484
MOD_Plk_4	732	738	PF00069	0.431
MOD_ProDKin_1	376	382	PF00069	0.517
MOD_SUMO_for_1	222	225	PF00179	0.388
MOD_SUMO_for_1	41	44	PF00179	0.388
MOD_SUMO_for_1	641	644	PF00179	0.344
MOD_SUMO_rev_2	241	250	PF00179	0.521
MOD_SUMO_rev_2	644	654	PF00179	0.318
TRG_DiLeu_BaEn_4	400	406	PF01217	0.472
TRG_DiLeu_BaLyEn_6	131	136	PF01217	0.469
TRG_DiLeu_BaLyEn_6	716	721	PF01217	0.409
TRG_ENDOCYTIC_2	180	183	PF00928	0.350
TRG_ENDOCYTIC_2	205	208	PF00928	0.324
TRG_ENDOCYTIC_2	21	24	PF00928	0.404
TRG_ENDOCYTIC_2	216	219	PF00928	0.310
TRG_ENDOCYTIC_2	351	354	PF00928	0.424
TRG_ENDOCYTIC_2	472	475	PF00928	0.320
TRG_ENDOCYTIC_2	543	546	PF00928	0.295
TRG_ER_diArg_1	166	168	PF00400	0.337
TRG_ER_diArg_1	470	472	PF00400	0.359
TRG_ER_diArg_1	495	497	PF00400	0.295
TRG_ER_diArg_1	707	710	PF00400	0.418
TRG_NES_CRM1_1	477	488	PF08389	0.295
TRG_NES_CRM1_1	685	697	PF08389	0.359
TRG_Pf-PMV_PEXEL_1	440	444	PF00026	0.278

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IRK5	Bodo saltans	48%	94%
A0A1X0P7U9	Trypanosomatidae	49%	100%
A0A3S7WV99	Leishmania donovani	100%	100%
A0A422ND06	Trypanosoma rangeli	51%	99%
A4H9X9	Leishmania braziliensis	82%	100%
E9ARX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QDJ9	Leishmania major	94%	100%
V5C1S4	Trypanosoma cruzi	43%	99%