Histone H2B

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone H2B

Gene product:

histone H2B

Species:

Leishmania infantum

UniProt:

A4HY42_LEIIN

TriTrypDb:

LINF_190005300

Length:

135

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 51

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0000786	nucleosome	3	23
GO:0005634	nucleus	5	22
GO:0032991	protein-containing complex	1	23
GO:0032993	protein-DNA complex	2	23
GO:0043226	organelle	2	22
GO:0043227	membrane-bounded organelle	3	22
GO:0043229	intracellular organelle	3	22
GO:0043231	intracellular membrane-bounded organelle	4	22
GO:0044815	DNA packaging complex	2	23
GO:0110165	cellular anatomical entity	1	22

Expansion

Sequence features

A4HY42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY42

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	3
GO:0006334	nucleosome assembly	7	3
GO:0006338	chromatin remodeling	5	3
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0022607	cellular component assembly	4	3
GO:0034728	nucleosome organization	6	3
GO:0043933	protein-containing complex organization	4	3
GO:0065003	protein-containing complex assembly	5	3
GO:0065004	protein-DNA complex assembly	6	3
GO:0071824	protein-DNA complex subunit organization	5	3
GO:0071840	cellular component organization or biogenesis	2	3

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	23
GO:0003677	DNA binding	4	23
GO:0005198	structural molecule activity	1	23
GO:0005488	binding	1	23
GO:0005515	protein binding	2	23
GO:0030527	structural constituent of chromatin	2	23
GO:0046982	protein heterodimerization activity	4	23
GO:0046983	protein dimerization activity	3	23
GO:0097159	organic cyclic compound binding	2	23
GO:1901363	heterocyclic compound binding	2	23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	32	34	PF00675	0.342
CLV_NRD_NRD_1	42	44	PF00675	0.281
CLV_PCSK_KEX2_1	46	48	PF00082	0.316
CLV_PCSK_KEX2_1	98	100	PF00082	0.297
CLV_PCSK_PC1ET2_1	46	48	PF00082	0.312
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.297
CLV_PCSK_PC7_1	94	100	PF00082	0.297
CLV_PCSK_SKI1_1	111	115	PF00082	0.377
CLV_PCSK_SKI1_1	55	59	PF00082	0.371
CLV_PCSK_SKI1_1	69	73	PF00082	0.278
DOC_MAPK_gen_1	43	53	PF00069	0.500
DOC_USP7_MATH_1	129	133	PF00917	0.496
DOC_USP7_MATH_1	38	42	PF00917	0.557
DOC_USP7_MATH_1	4	8	PF00917	0.528
DOC_USP7_MATH_1	62	66	PF00917	0.607
DOC_USP7_UBL2_3	40	44	PF12436	0.538
LIG_14-3-3_CanoR_1	84	93	PF00244	0.522
LIG_FHA_1	125	131	PF00498	0.500
LIG_FHA_1	46	52	PF00498	0.454
LIG_FHA_1	68	74	PF00498	0.495
LIG_FHA_1	8	14	PF00498	0.411
LIG_LIR_Nem_3	48	52	PF02991	0.494
LIG_SH2_GRB2like	77	80	PF00017	0.568
LIG_SH2_STAT5	20	23	PF00017	0.403
LIG_SH2_STAT5	52	55	PF00017	0.503
LIG_SH2_STAT5	77	80	PF00017	0.583
LIG_SH3_3	10	16	PF00018	0.409
MOD_CK1_1	67	73	PF00069	0.571
MOD_CK1_1	7	13	PF00069	0.495
MOD_GlcNHglycan	131	134	PF01048	0.608
MOD_GlcNHglycan	2	5	PF01048	0.417
MOD_GSK3_1	124	131	PF00069	0.487
MOD_GSK3_1	24	31	PF00069	0.581
MOD_GSK3_1	84	91	PF00069	0.507
MOD_NEK2_1	29	34	PF00069	0.691
MOD_NEK2_1	64	69	PF00069	0.498
MOD_NMyristoyl	1	7	PF02799	0.422
MOD_PIKK_1	4	10	PF00454	0.407
MOD_PKA_1	33	39	PF00069	0.589
MOD_PKA_1	97	103	PF00069	0.503
MOD_Plk_4	14	20	PF00069	0.404
MOD_Plk_4	73	79	PF00069	0.503
MOD_Plk_4	88	94	PF00069	0.503
TRG_NLS_Bipartite_1	33	47	PF00514	0.513
TRG_NLS_MonoCore_2	42	47	PF00514	0.530
TRG_NLS_MonoExtC_3	42	47	PF00514	0.504
TRG_NLS_MonoExtN_4	40	47	PF00514	0.504
TRG_NLS_MonoExtN_4	94	101	PF00514	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD10	Leptomonas seymouri	43%	95%
A0A0N1PDG4	Leptomonas seymouri	91%	100%
A0A0S4IT56	Bodo saltans	46%	92%
A0A1X0NWS2	Trypanosomatidae	41%	94%
A0A381MG06	Leishmania infantum	100%	100%
A0A3R7NJN4	Trypanosoma rangeli	75%	100%
A0A3S5H748	Leishmania donovani	100%	100%
A0A3S5H7I6	Leishmania donovani	41%	95%
A0A3S7WUK6	Leishmania donovani	90%	100%
A0A422N4F4	Trypanosoma rangeli	40%	100%
A0A422NDW8	Trypanosoma rangeli	74%	100%
A2WKT4	Oryza sativa subsp. indica	47%	87%
A3LZZ1	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	46%	100%
A4H5W2	Leishmania braziliensis	79%	100%
A4H9W0	Leishmania braziliensis	75%	100%
A4H9W1	Leishmania braziliensis	76%	100%
A4H9W2	Leishmania braziliensis	81%	100%
A4HG62	Leishmania braziliensis	42%	100%
A4HU57	Leishmania infantum	96%	100%
A4HXJ9	Leishmania infantum	90%	100%
A4I394	Leishmania infantum	41%	95%
A5DBG5	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	42%	100%
D0A4I4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
D0A4I8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
D0A7S0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	82%
E9AMY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AR94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9ARV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
E9AZI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
O60814	Homo sapiens	47%	100%
O97484	Euplotes crassus	47%	100%
P02287	Psammechinus miliaris	50%	100%
P02288	Psammechinus miliaris	48%	100%
P02289	Strongylocentrotus purpuratus	46%	100%
P04913	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	100%
P06899	Homo sapiens	46%	100%
P08993	Tetrahymena thermophila (strain SB210)	47%	100%
P08994	Tetrahymena thermophila (strain SB210)	45%	100%
P0C1H5	Gallus gallus	48%	100%
P0CO02	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	42%	97%
P0CO03	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	42%	97%
P10853	Mus musculus	49%	100%
P10854	Mus musculus	47%	100%
P23527	Homo sapiens	46%	100%
P27795	Trypanosoma cruzi	73%	100%
P27893	Leishmania enriettii	83%	100%
P33778	Homo sapiens	46%	100%
P35067	Acropora formosa	43%	100%
P35068	Tigriopus californicus	48%	100%
P35069	Tigriopus californicus	48%	100%
P40284	Entamoeba invadens	31%	100%
P48557	Holothuria tubulosa	45%	100%
P57053	Homo sapiens	47%	100%
P58876	Homo sapiens	47%	100%
P62807	Homo sapiens	47%	100%
P62808	Bos taurus	47%	100%
P69069	Oncorhynchus mykiss	47%	100%
P69070	Salmo trutta	47%	100%
P70696	Mus musculus	46%	100%
Q00729	Rattus norvegicus	46%	100%
Q16778	Homo sapiens	46%	100%
Q1E5N0	Coccidioides immitis (strain RS)	44%	97%
Q2M2T1	Bos taurus	47%	100%
Q2PFX4	Macaca fascicularis	47%	100%
Q32L48	Bos taurus	48%	100%
Q41575	Triticum aestivum	44%	100%
Q4JHM7	Leishmania donovani	96%	100%
Q4Q8P9	Leishmania major	43%	100%
Q4QDL6	Leishmania major	99%	100%
Q4QHP1	Leishmania major	97%	100%
Q54LP8	Dictyostelium discoideum	35%	88%
Q5BJA5	Danio rerio	48%	100%
Q5QNW6	Homo sapiens	47%	100%
Q5R893	Pongo abelii	47%	100%
Q5RCP8	Pongo abelii	46%	100%
Q64475	Mus musculus	49%	100%
Q64478	Mus musculus	47%	100%
Q64524	Mus musculus	45%	100%
Q64525	Mus musculus	47%	100%
Q6BRG2	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	46%	100%
Q6CK60	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	47%	100%
Q6CMV8	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	48%	100%
Q6FM30	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	46%	100%
Q6ZWY9	Mus musculus	47%	100%
Q7M400	Tetrahymena pyriformis	47%	100%
Q7Z2G1	Homo sapiens	31%	77%
Q875B7	Podospora anserina	44%	99%
Q8CGP1	Mus musculus	49%	100%
Q8CGP2	Mus musculus	49%	100%
Q8J1K2	Rosellinia necatrix	44%	99%
Q93079	Homo sapiens	47%	100%
Q94JE1	Oryza sativa subsp. japonica	47%	87%
Q96A08	Homo sapiens	45%	100%
Q99285	Pisum sativum	42%	100%
Q99877	Homo sapiens	47%	100%
Q99879	Homo sapiens	49%	100%
Q99880	Homo sapiens	47%	100%
Q9U8C0	Leishmania major	82%	97%