DNA translocase FtsK

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HY41_LEIIN

TriTrypDb:

LINF_190005100

Length:

257

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Phosphorylation

Amastigote: 155, 6, 7

Expansion

Sequence features

A4HY41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY41

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	23	25	PF00082	0.635
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.635
DEG_SCF_FBW7_1	129	135	PF00400	0.594
DOC_CKS1_1	129	134	PF01111	0.531
DOC_CKS1_1	29	34	PF01111	0.785
DOC_USP7_MATH_1	171	175	PF00917	0.694
DOC_USP7_MATH_1	202	206	PF00917	0.679
DOC_USP7_MATH_1	54	58	PF00917	0.683
DOC_WW_Pin1_4	128	133	PF00397	0.530
DOC_WW_Pin1_4	15	20	PF00397	0.655
DOC_WW_Pin1_4	28	33	PF00397	0.689
LIG_14-3-3_CanoR_1	152	157	PF00244	0.681
LIG_14-3-3_CanoR_1	225	232	PF00244	0.607
LIG_14-3-3_CanoR_1	237	244	PF00244	0.568
LIG_14-3-3_CanoR_1	24	33	PF00244	0.511
LIG_14-3-3_CanoR_1	246	250	PF00244	0.676
LIG_14-3-3_CanoR_1	3	9	PF00244	0.596
LIG_14-3-3_CanoR_1	99	104	PF00244	0.551
LIG_BRCT_BRCA1_1	190	194	PF00533	0.685
LIG_FHA_1	144	150	PF00498	0.654
LIG_MAD2	99	107	PF02301	0.536
LIG_Pex14_2	222	226	PF04695	0.649
LIG_SH2_GRB2like	180	183	PF00017	0.582
LIG_SH2_STAT5	93	96	PF00017	0.474
LIG_SH3_3	100	106	PF00018	0.389
LIG_SH3_3	126	132	PF00018	0.540
LIG_SH3_3	138	144	PF00018	0.555
LIG_SH3_3	26	32	PF00018	0.808
LIG_SH3_3	33	39	PF00018	0.679
LIG_SH3_3	48	54	PF00018	0.729
LIG_SH3_3	64	70	PF00018	0.716
LIG_SH3_3	76	82	PF00018	0.417
LIG_SH3_3	85	91	PF00018	0.516
LIG_SUMO_SIM_par_1	93	98	PF11976	0.475
LIG_TRAF2_1	57	60	PF00917	0.685
LIG_WW_3	105	109	PF00397	0.530
MOD_CDC14_SPxK_1	20	23	PF00782	0.618
MOD_CDK_SPxK_1	17	23	PF00069	0.614
MOD_CDK_SPxxK_3	17	24	PF00069	0.594
MOD_CK1_1	155	161	PF00069	0.642
MOD_CK1_1	205	211	PF00069	0.676
MOD_CK1_1	248	254	PF00069	0.662
MOD_CK2_1	38	44	PF00069	0.758
MOD_CK2_1	54	60	PF00069	0.582
MOD_GlcNHglycan	122	125	PF01048	0.556
MOD_GlcNHglycan	173	176	PF01048	0.747
MOD_GlcNHglycan	207	210	PF01048	0.632
MOD_GlcNHglycan	233	236	PF01048	0.539
MOD_GlcNHglycan	239	242	PF01048	0.590
MOD_GSK3_1	128	135	PF00069	0.603
MOD_GSK3_1	148	155	PF00069	0.655
MOD_GSK3_1	24	31	PF00069	0.777
MOD_GSK3_1	38	45	PF00069	0.616
MOD_NEK2_1	194	199	PF00069	0.656
MOD_PIKK_1	107	113	PF00454	0.621
MOD_PIKK_1	173	179	PF00454	0.664
MOD_PIKK_1	194	200	PF00454	0.642
MOD_PIKK_1	24	30	PF00454	0.618
MOD_PIKK_1	245	251	PF00454	0.680
MOD_PIKK_1	38	44	PF00454	0.690
MOD_PK_1	99	105	PF00069	0.599
MOD_PKA_2	107	113	PF00069	0.587
MOD_PKA_2	215	221	PF00069	0.741
MOD_PKA_2	226	232	PF00069	0.505
MOD_PKA_2	245	251	PF00069	0.431
MOD_PKA_2	4	10	PF00069	0.667
MOD_Plk_2-3	55	61	PF00069	0.686
MOD_ProDKin_1	128	134	PF00069	0.531
MOD_ProDKin_1	15	21	PF00069	0.654
MOD_ProDKin_1	28	34	PF00069	0.684
TRG_ER_diArg_1	2	5	PF00400	0.683

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYE1	Leptomonas seymouri	74%	68%
A0A1X0P6F6	Trypanosomatidae	38%	77%
A0A3Q8IB46	Leishmania donovani	99%	100%
A0A3R7JZB4	Trypanosoma rangeli	37%	76%
A4H9V9	Leishmania braziliensis	83%	98%
E9ARV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QDL9	Leishmania major	92%	100%
V5BBT3	Trypanosoma cruzi	34%	76%