t-SNARE coiled-coil homology domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qb-SNARE protein - putative

Species:

Leishmania infantum

UniProt:

A4HY40_LEIIN

TriTrypDb:

LINF_190005000

Length:

295

Annotations

Annotations by Jardim et al.

Vesicle mediated transport, Qb-SNARE

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14
GO:0012505	endomembrane system	2	1
GO:0031201	SNARE complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A4HY40

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY40

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0022406	membrane docking	2	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048278	vesicle docking	4	1
GO:0048284	organelle fusion	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1
GO:0140056	organelle localization by membrane tethering	3	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.679
CLV_NRD_NRD_1	108	110	PF00675	0.429
CLV_NRD_NRD_1	159	161	PF00675	0.498
CLV_NRD_NRD_1	257	259	PF00675	0.340
CLV_NRD_NRD_1	59	61	PF00675	0.334
CLV_NRD_NRD_1	82	84	PF00675	0.446
CLV_PCSK_KEX2_1	108	110	PF00082	0.393
CLV_PCSK_KEX2_1	147	149	PF00082	0.447
CLV_PCSK_KEX2_1	159	161	PF00082	0.404
CLV_PCSK_KEX2_1	257	259	PF00082	0.336
CLV_PCSK_KEX2_1	82	84	PF00082	0.436
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.527
CLV_PCSK_PC7_1	253	259	PF00082	0.379
CLV_PCSK_SKI1_1	257	261	PF00082	0.360
CLV_PCSK_SKI1_1	27	31	PF00082	0.322
CLV_PCSK_SKI1_1	75	79	PF00082	0.421
CLV_PCSK_SKI1_1	83	87	PF00082	0.427
DEG_APCC_DBOX_1	151	159	PF00400	0.638
DEG_APCC_DBOX_1	59	67	PF00400	0.622
DEG_APCC_KENBOX_2	85	89	PF00400	0.569
DEG_APCC_KENBOX_2	93	97	PF00400	0.588
DOC_MAPK_gen_1	89	100	PF00069	0.577
DOC_MAPK_MEF2A_6	219	227	PF00069	0.555
DOC_USP7_UBL2_3	193	197	PF12436	0.595
DOC_USP7_UBL2_3	260	264	PF12436	0.635
DOC_USP7_UBL2_3	86	90	PF12436	0.595
LIG_14-3-3_CanoR_1	108	116	PF00244	0.655
LIG_Actin_WH2_2	248	266	PF00022	0.541
LIG_AP2alpha_2	16	18	PF02296	0.569
LIG_BIR_II_1	1	5	PF00653	0.629
LIG_BIR_III_3	1	5	PF00653	0.629
LIG_CaM_IQ_9	140	156	PF13499	0.678
LIG_EH1_1	278	286	PF00400	0.381
LIG_FHA_1	239	245	PF00498	0.603
LIG_FHA_2	137	143	PF00498	0.703
LIG_FHA_2	67	73	PF00498	0.534
LIG_LIR_Gen_1	16	26	PF02991	0.639
LIG_LIR_Nem_3	16	21	PF02991	0.612
LIG_LRP6_Inhibitor_1	54	60	PF00058	0.342
LIG_PCNA_yPIPBox_3	253	263	PF02747	0.531
LIG_Pex14_2	288	292	PF04695	0.434
LIG_SH2_GRB2like	112	115	PF00017	0.571
LIG_SH2_STAP1	112	116	PF00017	0.573
LIG_SH2_STAT5	274	277	PF00017	0.354
LIG_SUMO_SIM_anti_2	173	178	PF11976	0.679
LIG_TRAF2_1	139	142	PF00917	0.718
LIG_TRAF2_1	69	72	PF00917	0.641
LIG_UBA3_1	155	161	PF00899	0.710
MOD_CK2_1	136	142	PF00069	0.694
MOD_CK2_1	66	72	PF00069	0.534
MOD_Cter_Amidation	106	109	PF01082	0.428
MOD_Cter_Amidation	145	148	PF01082	0.404
MOD_GlcNHglycan	116	119	PF01048	0.427
MOD_GlcNHglycan	12	16	PF01048	0.485
MOD_GSK3_1	7	14	PF00069	0.644
MOD_NEK2_1	263	268	PF00069	0.606
MOD_PIKK_1	107	113	PF00454	0.587
MOD_PKA_2	107	113	PF00069	0.600
MOD_Plk_1	177	183	PF00069	0.642
MOD_Plk_1	66	72	PF00069	0.568
MOD_Plk_2-3	136	142	PF00069	0.712
MOD_SUMO_for_1	4	7	PF00179	0.747
TRG_DiLeu_BaEn_1	72	77	PF01217	0.617
TRG_ER_diArg_1	158	160	PF00400	0.661
TRG_ER_diArg_1	257	259	PF00400	0.537
TRG_ER_diArg_1	82	84	PF00400	0.682
TRG_NES_CRM1_1	68	81	PF08389	0.529
TRG_NLS_MonoCore_2	88	93	PF00514	0.616
TRG_NLS_MonoExtC_3	88	93	PF00514	0.582
TRG_NLS_MonoExtN_4	86	93	PF00514	0.584
TRG_Pf-PMV_PEXEL_1	261	265	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9J7	Leptomonas seymouri	72%	92%
A0A0S4IV64	Bodo saltans	44%	86%
A0A0S4IVZ4	Bodo saltans	37%	89%
A0A0S4IZ68	Bodo saltans	42%	89%
A0A1X0P6H2	Trypanosomatidae	58%	91%
A0A3R7LL06	Trypanosoma rangeli	51%	91%
A0A3S7WV65	Leishmania donovani	99%	100%
A4H9V8	Leishmania braziliensis	78%	100%
D0A0C4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	91%
E9ARV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QDM0	Leishmania major	92%	100%
V5BS89	Trypanosoma cruzi	54%	91%