LeishMANIAdb
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RNA binding protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
RNA binding protein
Gene product:
hypothetical protein
Species:
Leishmania infantum
UniProt:
A4HY39_LEIIN
TriTrypDb:
LINF_190007900
Length:
392

Annotations

Annotations by Jardim et al.

Nucleic acid binding, RNA binding

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 19
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0020022 acidocalcisome 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HY39
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY39

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 14
GO:0043167 ion binding 2 13
GO:0043169 cation binding 3 13
GO:0046872 metal ion binding 4 13
GO:0003824 catalytic activity 1 1
GO:0004842 ubiquitin-protein transferase activity 4 1
GO:0016740 transferase activity 2 1
GO:0019787 ubiquitin-like protein transferase activity 3 1
GO:0140096 catalytic activity, acting on a protein 2 1
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 144 146 PF00675 0.433
CLV_NRD_NRD_1 39 41 PF00675 0.476
CLV_NRD_NRD_1 71 73 PF00675 0.525
CLV_NRD_NRD_1 88 90 PF00675 0.538
CLV_PCSK_KEX2_1 144 146 PF00082 0.374
CLV_PCSK_KEX2_1 39 41 PF00082 0.502
CLV_PCSK_KEX2_1 71 73 PF00082 0.468
CLV_PCSK_KEX2_1 88 90 PF00082 0.478
CLV_PCSK_SKI1_1 164 168 PF00082 0.681
DEG_Nend_UBRbox_3 1 3 PF02207 0.593
DOC_CYCLIN_RxL_1 37 47 PF00134 0.326
DOC_MAPK_MEF2A_6 210 219 PF00069 0.478
DOC_MAPK_MEF2A_6 244 253 PF00069 0.397
DOC_MAPK_MEF2A_6 39 46 PF00069 0.327
DOC_MAPK_NFAT4_5 39 47 PF00069 0.326
DOC_USP7_MATH_1 186 190 PF00917 0.638
DOC_USP7_MATH_1 332 336 PF00917 0.629
DOC_USP7_MATH_1 342 346 PF00917 0.614
DOC_USP7_UBL2_3 119 123 PF12436 0.522
DOC_USP7_UBL2_3 367 371 PF12436 0.598
DOC_WW_Pin1_4 14 19 PF00397 0.496
DOC_WW_Pin1_4 2 7 PF00397 0.508
LIG_14-3-3_CanoR_1 282 292 PF00244 0.473
LIG_14-3-3_CanoR_1 39 43 PF00244 0.544
LIG_FHA_1 14 20 PF00498 0.542
LIG_FHA_1 22 28 PF00498 0.456
LIG_FHA_2 127 133 PF00498 0.389
LIG_FHA_2 284 290 PF00498 0.521
LIG_GBD_Chelix_1 44 52 PF00786 0.390
LIG_LIR_Gen_1 57 64 PF02991 0.499
LIG_LIR_Nem_3 262 268 PF02991 0.347
LIG_LIR_Nem_3 57 62 PF02991 0.500
LIG_LIR_Nem_3 68 73 PF02991 0.504
LIG_LRP6_Inhibitor_1 272 278 PF00058 0.339
LIG_NRBOX 145 151 PF00104 0.460
LIG_PTB_Apo_2 264 271 PF02174 0.354
LIG_PTB_Phospho_1 264 270 PF10480 0.373
LIG_SH2_CRK 234 238 PF00017 0.476
LIG_SH2_CRK 59 63 PF00017 0.395
LIG_SH2_CRK 70 74 PF00017 0.373
LIG_SH2_GRB2like 299 302 PF00017 0.486
LIG_SH2_SRC 90 93 PF00017 0.474
LIG_SH2_STAP1 270 274 PF00017 0.359
LIG_SH2_STAP1 8 12 PF00017 0.387
LIG_SH2_STAT3 125 128 PF00017 0.489
LIG_SH2_STAT5 103 106 PF00017 0.473
LIG_SH2_STAT5 113 116 PF00017 0.371
LIG_SH3_3 153 159 PF00018 0.626
LIG_SH3_3 171 177 PF00018 0.443
LIG_SH3_3 291 297 PF00018 0.538
LIG_SH3_3 90 96 PF00018 0.346
LIG_TRAF2_1 129 132 PF00917 0.411
MOD_CK1_1 126 132 PF00069 0.444
MOD_CK1_1 315 321 PF00069 0.554
MOD_CK1_1 345 351 PF00069 0.738
MOD_CK1_1 372 378 PF00069 0.617
MOD_CK2_1 126 132 PF00069 0.387
MOD_CK2_1 283 289 PF00069 0.520
MOD_CK2_1 352 358 PF00069 0.684
MOD_CK2_1 44 50 PF00069 0.425
MOD_GlcNHglycan 188 191 PF01048 0.607
MOD_GlcNHglycan 227 231 PF01048 0.579
MOD_GlcNHglycan 314 317 PF01048 0.587
MOD_GlcNHglycan 347 350 PF01048 0.639
MOD_GlcNHglycan 379 382 PF01048 0.703
MOD_GSK3_1 108 115 PF00069 0.452
MOD_GSK3_1 119 126 PF00069 0.457
MOD_GSK3_1 2 9 PF00069 0.437
MOD_GSK3_1 23 30 PF00069 0.543
MOD_GSK3_1 97 104 PF00069 0.387
MOD_N-GLC_1 139 144 PF02516 0.381
MOD_N-GLC_1 332 337 PF02516 0.666
MOD_NEK2_1 27 32 PF00069 0.468
MOD_NEK2_1 283 288 PF00069 0.524
MOD_NEK2_1 44 49 PF00069 0.389
MOD_OFUCOSY 281 287 PF10250 0.509
MOD_PIKK_1 123 129 PF00454 0.358
MOD_PIKK_1 21 27 PF00454 0.522
MOD_PIKK_1 332 338 PF00454 0.513
MOD_PKA_2 345 351 PF00069 0.543
MOD_PKA_2 38 44 PF00069 0.541
MOD_Plk_1 108 114 PF00069 0.475
MOD_Plk_1 139 145 PF00069 0.401
MOD_Plk_1 261 267 PF00069 0.372
MOD_Plk_2-3 101 107 PF00069 0.375
MOD_Plk_4 27 33 PF00069 0.549
MOD_ProDKin_1 14 20 PF00069 0.490
MOD_ProDKin_1 2 8 PF00069 0.509
MOD_SUMO_for_1 389 392 PF00179 0.645
MOD_SUMO_rev_2 111 120 PF00179 0.485
MOD_SUMO_rev_2 75 80 PF00179 0.503
TRG_DiLeu_BaLyEn_6 162 167 PF01217 0.414
TRG_ENDOCYTIC_2 59 62 PF00928 0.361
TRG_ENDOCYTIC_2 70 73 PF00928 0.369
TRG_ENDOCYTIC_2 90 93 PF00928 0.380
TRG_ER_diArg_1 143 145 PF00400 0.422
TRG_ER_diArg_1 38 40 PF00400 0.495
TRG_ER_diArg_1 70 72 PF00400 0.527
TRG_ER_diArg_1 87 89 PF00400 0.515
TRG_ER_diLys_1 388 392 PF00400 0.670
TRG_NES_CRM1_1 148 160 PF08389 0.589
TRG_NES_CRM1_1 37 50 PF08389 0.513
TRG_Pf-PMV_PEXEL_1 112 116 PF00026 0.451
TRG_Pf-PMV_PEXEL_1 144 148 PF00026 0.388
TRG_Pf-PMV_PEXEL_1 71 75 PF00026 0.422

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1I4 Leptomonas seymouri 70% 99%
A0A0N1PG85 Leptomonas seymouri 32% 100%
A0A0S4KEK3 Bodo saltans 37% 100%
A0A1X0P6E1 Trypanosomatidae 36% 100%
A0A3Q8IA61 Leishmania donovani 31% 100%
A0A3R7RSV6 Trypanosoma rangeli 34% 100%
A0A3S7WVD2 Leishmania donovani 99% 100%
A0A422P3A2 Trypanosoma rangeli 40% 96%
A4H9Y7 Leishmania braziliensis 32% 100%
A4H9Y8 Leishmania braziliensis 74% 100%
A4HY52 Leishmania infantum 31% 100%
D0A0F3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 34% 100%
D0A0F7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 42% 91%
E9ARY1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 99%
E9ARY2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4QDJ1 Leishmania major 30% 99%
V5BSB1 Trypanosoma cruzi 37% 82%
V5BWY8 Trypanosoma cruzi 33% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS