LeishMANIAdb
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Glutamate--cysteine ligase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Glutamate--cysteine ligase
Gene product:
gamma-glutamylcysteine synthetase - putative
Species:
Leishmania infantum
UniProt:
A4HY37_LEIIN
TriTrypDb:
LINF_180022300
Length:
687

Annotations

Annotations by Jardim et al.

Redox homeostasis, Gamma-glutamylcysteine synthetase GSH1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005654 nucleoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HY37
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY37

Function

Biological processes
Term Name Level Count
GO:0006518 peptide metabolic process 4 12
GO:0006575 cellular modified amino acid metabolic process 3 12
GO:0006749 glutathione metabolic process 4 12
GO:0006750 glutathione biosynthetic process 5 12
GO:0006790 sulfur compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009058 biosynthetic process 2 12
GO:0009987 cellular process 1 12
GO:0019184 nonribosomal peptide biosynthetic process 6 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0042398 cellular modified amino acid biosynthetic process 4 12
GO:0043043 peptide biosynthetic process 5 12
GO:0043603 amide metabolic process 3 12
GO:0043604 amide biosynthetic process 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044249 cellular biosynthetic process 3 12
GO:0044271 cellular nitrogen compound biosynthetic process 4 12
GO:0044272 sulfur compound biosynthetic process 4 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1901566 organonitrogen compound biosynthetic process 4 12
GO:1901576 organic substance biosynthetic process 3 12
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 12
GO:0003824 catalytic activity 1 12
GO:0004357 glutamate-cysteine ligase activity 5 12
GO:0005488 binding 1 12
GO:0005524 ATP binding 5 12
GO:0016874 ligase activity 2 12
GO:0016879 ligase activity, forming carbon-nitrogen bonds 3 12
GO:0016881 acid-amino acid ligase activity 4 12
GO:0017076 purine nucleotide binding 4 12
GO:0030554 adenyl nucleotide binding 5 12
GO:0032553 ribonucleotide binding 3 12
GO:0032555 purine ribonucleotide binding 4 12
GO:0032559 adenyl ribonucleotide binding 5 12
GO:0035639 purine ribonucleoside triphosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:0097367 carbohydrate derivative binding 2 12
GO:1901265 nucleoside phosphate binding 3 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 111 115 PF00656 0.440
CLV_C14_Caspase3-7 413 417 PF00656 0.374
CLV_NRD_NRD_1 122 124 PF00675 0.319
CLV_NRD_NRD_1 18 20 PF00675 0.300
CLV_NRD_NRD_1 189 191 PF00675 0.296
CLV_NRD_NRD_1 290 292 PF00675 0.458
CLV_NRD_NRD_1 384 386 PF00675 0.253
CLV_NRD_NRD_1 556 558 PF00675 0.258
CLV_NRD_NRD_1 631 633 PF00675 0.330
CLV_PCSK_FUR_1 187 191 PF00082 0.297
CLV_PCSK_KEX2_1 122 124 PF00082 0.321
CLV_PCSK_KEX2_1 189 191 PF00082 0.296
CLV_PCSK_KEX2_1 290 292 PF00082 0.453
CLV_PCSK_KEX2_1 384 386 PF00082 0.295
CLV_PCSK_KEX2_1 604 606 PF00082 0.294
CLV_PCSK_PC1ET2_1 604 606 PF00082 0.458
CLV_PCSK_SKI1_1 235 239 PF00082 0.560
CLV_PCSK_SKI1_1 271 275 PF00082 0.595
CLV_PCSK_SKI1_1 364 368 PF00082 0.235
CLV_PCSK_SKI1_1 373 377 PF00082 0.235
CLV_PCSK_SKI1_1 391 395 PF00082 0.235
CLV_PCSK_SKI1_1 558 562 PF00082 0.268
CLV_PCSK_SKI1_1 633 637 PF00082 0.329
CLV_Separin_Metazoa 388 392 PF03568 0.230
DEG_COP1_1 162 170 PF00400 0.315
DEG_SPOP_SBC_1 253 257 PF00917 0.530
DOC_CKS1_1 273 278 PF01111 0.416
DOC_CKS1_1 503 508 PF01111 0.235
DOC_CKS1_1 624 629 PF01111 0.256
DOC_CYCLIN_RxL_1 268 278 PF00134 0.580
DOC_CYCLIN_RxL_1 361 371 PF00134 0.329
DOC_CYCLIN_yCln2_LP_2 273 279 PF00134 0.458
DOC_MAPK_DCC_7 193 202 PF00069 0.360
DOC_MAPK_gen_1 187 196 PF00069 0.296
DOC_MAPK_gen_1 38 48 PF00069 0.470
DOC_MAPK_gen_1 394 402 PF00069 0.269
DOC_MAPK_GRA24_9 186 202 PF00069 0.362
DOC_MAPK_HePTP_8 186 198 PF00069 0.294
DOC_MAPK_MEF2A_6 189 198 PF00069 0.295
DOC_MAPK_MEF2A_6 396 404 PF00069 0.269
DOC_MAPK_MEF2A_6 430 438 PF00069 0.245
DOC_PP1_RVXF_1 492 498 PF00149 0.235
DOC_PP2B_LxvP_1 165 168 PF13499 0.315
DOC_PP2B_LxvP_1 251 254 PF13499 0.511
DOC_PP4_FxxP_1 482 485 PF00568 0.329
DOC_USP7_MATH_1 254 258 PF00917 0.552
DOC_USP7_MATH_1 355 359 PF00917 0.235
DOC_USP7_MATH_1 573 577 PF00917 0.256
DOC_USP7_MATH_1 682 686 PF00917 0.410
DOC_WW_Pin1_4 156 161 PF00397 0.355
DOC_WW_Pin1_4 217 222 PF00397 0.423
DOC_WW_Pin1_4 272 277 PF00397 0.423
DOC_WW_Pin1_4 357 362 PF00397 0.235
DOC_WW_Pin1_4 502 507 PF00397 0.235
DOC_WW_Pin1_4 603 608 PF00397 0.380
DOC_WW_Pin1_4 623 628 PF00397 0.256
DOC_WW_Pin1_4 98 103 PF00397 0.439
LIG_14-3-3_CanoR_1 235 242 PF00244 0.551
LIG_14-3-3_CanoR_1 632 641 PF00244 0.333
LIG_Actin_WH2_2 175 191 PF00022 0.315
LIG_APCC_ABBA_1 198 203 PF00400 0.305
LIG_APCC_ABBAyCdc20_2 557 563 PF00400 0.299
LIG_deltaCOP1_diTrp_1 490 497 PF00928 0.294
LIG_eIF4E_1 589 595 PF01652 0.250
LIG_FHA_1 136 142 PF00498 0.295
LIG_FHA_1 181 187 PF00498 0.288
LIG_FHA_1 236 242 PF00498 0.653
LIG_FHA_1 265 271 PF00498 0.500
LIG_FHA_1 328 334 PF00498 0.250
LIG_FHA_1 406 412 PF00498 0.306
LIG_FHA_1 518 524 PF00498 0.269
LIG_FHA_1 63 69 PF00498 0.463
LIG_FHA_1 646 652 PF00498 0.247
LIG_FHA_2 204 210 PF00498 0.371
LIG_FHA_2 462 468 PF00498 0.250
LIG_FHA_2 503 509 PF00498 0.235
LIG_FHA_2 564 570 PF00498 0.294
LIG_FHA_2 635 641 PF00498 0.420
LIG_GBD_Chelix_1 651 659 PF00786 0.256
LIG_HCF-1_HBM_1 103 106 PF13415 0.358
LIG_Integrin_isoDGR_2 233 235 PF01839 0.523
LIG_LIR_Apic_2 479 485 PF02991 0.380
LIG_LIR_Gen_1 121 132 PF02991 0.443
LIG_LIR_Gen_1 138 146 PF02991 0.476
LIG_LIR_Gen_1 371 381 PF02991 0.235
LIG_LIR_Gen_1 395 404 PF02991 0.244
LIG_LIR_Gen_1 424 429 PF02991 0.298
LIG_LIR_Gen_1 474 485 PF02991 0.235
LIG_LIR_Gen_1 611 620 PF02991 0.238
LIG_LIR_Nem_3 121 127 PF02991 0.443
LIG_LIR_Nem_3 138 143 PF02991 0.482
LIG_LIR_Nem_3 371 377 PF02991 0.235
LIG_LIR_Nem_3 395 400 PF02991 0.244
LIG_LIR_Nem_3 424 428 PF02991 0.273
LIG_LIR_Nem_3 466 472 PF02991 0.235
LIG_LIR_Nem_3 474 480 PF02991 0.234
LIG_LIR_Nem_3 585 591 PF02991 0.249
LIG_LIR_Nem_3 611 615 PF02991 0.238
LIG_LIR_Nem_3 92 96 PF02991 0.320
LIG_Pex14_1 493 497 PF04695 0.235
LIG_Pex14_1 89 93 PF04695 0.324
LIG_Pex14_2 33 37 PF04695 0.419
LIG_PTB_Apo_2 506 513 PF02174 0.238
LIG_PTB_Apo_2 87 94 PF02174 0.357
LIG_PTB_Phospho_1 87 93 PF10480 0.359
LIG_SH2_CRK 124 128 PF00017 0.390
LIG_SH2_CRK 343 347 PF00017 0.235
LIG_SH2_CRK 397 401 PF00017 0.269
LIG_SH2_CRK 531 535 PF00017 0.287
LIG_SH2_CRK 589 593 PF00017 0.250
LIG_SH2_NCK_1 397 401 PF00017 0.282
LIG_SH2_NCK_1 531 535 PF00017 0.300
LIG_SH2_STAP1 106 110 PF00017 0.302
LIG_SH2_STAP1 161 165 PF00017 0.374
LIG_SH2_STAP1 282 286 PF00017 0.317
LIG_SH2_STAP1 343 347 PF00017 0.294
LIG_SH2_STAP1 454 458 PF00017 0.269
LIG_SH2_STAT3 281 284 PF00017 0.310
LIG_SH2_STAT5 285 288 PF00017 0.414
LIG_SH2_STAT5 425 428 PF00017 0.356
LIG_SH2_STAT5 531 534 PF00017 0.235
LIG_SH2_STAT5 554 557 PF00017 0.235
LIG_SH2_STAT5 598 601 PF00017 0.365
LIG_SH2_STAT5 612 615 PF00017 0.124
LIG_SH2_STAT5 672 675 PF00017 0.377
LIG_SH3_3 138 144 PF00018 0.281
LIG_SH3_3 193 199 PF00018 0.236
LIG_SH3_3 305 311 PF00018 0.350
LIG_SH3_3 511 517 PF00018 0.329
LIG_SH3_3 85 91 PF00018 0.377
LIG_SH3_3 99 105 PF00018 0.272
LIG_SH3_5 260 264 PF00018 0.722
LIG_SUMO_SIM_anti_2 344 350 PF11976 0.329
LIG_SUMO_SIM_anti_2 532 539 PF11976 0.329
LIG_SUMO_SIM_par_1 449 455 PF11976 0.224
LIG_SUMO_SIM_par_1 456 464 PF11976 0.246
LIG_SUMO_SIM_par_1 63 72 PF11976 0.469
LIG_TRAF2_1 568 571 PF00917 0.256
LIG_TRFH_1 589 593 PF08558 0.250
LIG_WRC_WIRS_1 93 98 PF05994 0.314
MOD_CDK_SPxxK_3 217 224 PF00069 0.447
MOD_CDK_SPxxK_3 357 364 PF00069 0.235
MOD_CK1_1 109 115 PF00069 0.347
MOD_CK1_1 155 161 PF00069 0.370
MOD_CK1_1 357 363 PF00069 0.214
MOD_CK1_1 405 411 PF00069 0.306
MOD_CK1_1 645 651 PF00069 0.257
MOD_CK1_1 676 682 PF00069 0.430
MOD_CK1_1 69 75 PF00069 0.469
MOD_CK2_1 226 232 PF00069 0.541
MOD_CK2_1 421 427 PF00069 0.306
MOD_CK2_1 461 467 PF00069 0.246
MOD_CK2_1 502 508 PF00069 0.235
MOD_CK2_1 565 571 PF00069 0.292
MOD_CK2_1 573 579 PF00069 0.207
MOD_Cter_Amidation 602 605 PF01082 0.256
MOD_GlcNHglycan 246 250 PF01048 0.676
MOD_GlcNHglycan 324 327 PF01048 0.300
MOD_GlcNHglycan 357 360 PF01048 0.294
MOD_GlcNHglycan 431 434 PF01048 0.272
MOD_GlcNHglycan 620 623 PF01048 0.343
MOD_GlcNHglycan 71 74 PF01048 0.394
MOD_GSK3_1 135 142 PF00069 0.295
MOD_GSK3_1 152 159 PF00069 0.403
MOD_GSK3_1 203 210 PF00069 0.347
MOD_GSK3_1 392 399 PF00069 0.365
MOD_GSK3_1 472 479 PF00069 0.253
MOD_GSK3_1 565 572 PF00069 0.280
MOD_GSK3_1 614 621 PF00069 0.293
MOD_GSK3_1 62 69 PF00069 0.408
MOD_N-GLC_1 172 177 PF02516 0.332
MOD_N-GLC_1 180 185 PF02516 0.277
MOD_N-GLC_1 235 240 PF02516 0.651
MOD_N-GLC_1 414 419 PF02516 0.278
MOD_N-GLC_1 421 426 PF02516 0.259
MOD_N-GLC_2 299 301 PF02516 0.390
MOD_NEK2_1 3 8 PF00069 0.420
MOD_NEK2_1 322 327 PF00069 0.250
MOD_NEK2_1 354 359 PF00069 0.235
MOD_NEK2_1 414 419 PF00069 0.294
MOD_NEK2_1 429 434 PF00069 0.188
MOD_NEK2_1 608 613 PF00069 0.339
MOD_NEK2_1 618 623 PF00069 0.277
MOD_NEK2_1 634 639 PF00069 0.223
MOD_NEK2_1 647 652 PF00069 0.272
MOD_NEK2_1 97 102 PF00069 0.296
MOD_NEK2_2 161 166 PF00069 0.346
MOD_NMyristoyl 1 7 PF02799 0.438
MOD_PIKK_1 159 165 PF00454 0.387
MOD_PIKK_1 414 420 PF00454 0.234
MOD_PK_1 396 402 PF00069 0.269
MOD_PKA_2 573 579 PF00069 0.330
MOD_PKA_2 618 624 PF00069 0.294
MOD_PKA_2 645 651 PF00069 0.266
MOD_Plk_1 414 420 PF00069 0.282
MOD_Plk_1 421 427 PF00069 0.255
MOD_Plk_1 62 68 PF00069 0.389
MOD_Plk_2-3 203 209 PF00069 0.371
MOD_Plk_4 136 142 PF00069 0.304
MOD_Plk_4 161 167 PF00069 0.342
MOD_Plk_4 275 281 PF00069 0.433
MOD_Plk_4 303 309 PF00069 0.510
MOD_Plk_4 608 614 PF00069 0.384
MOD_Plk_4 673 679 PF00069 0.331
MOD_Plk_4 92 98 PF00069 0.317
MOD_ProDKin_1 156 162 PF00069 0.347
MOD_ProDKin_1 217 223 PF00069 0.419
MOD_ProDKin_1 272 278 PF00069 0.414
MOD_ProDKin_1 357 363 PF00069 0.235
MOD_ProDKin_1 502 508 PF00069 0.235
MOD_ProDKin_1 603 609 PF00069 0.380
MOD_ProDKin_1 623 629 PF00069 0.256
MOD_ProDKin_1 98 104 PF00069 0.449
MOD_SUMO_rev_2 600 606 PF00179 0.289
TRG_DiLeu_BaEn_2 91 97 PF01217 0.320
TRG_DiLeu_BaEn_3 387 393 PF01217 0.214
TRG_DiLeu_BaLyEn_6 514 519 PF01217 0.329
TRG_ENDOCYTIC_2 124 127 PF00928 0.337
TRG_ENDOCYTIC_2 343 346 PF00928 0.235
TRG_ENDOCYTIC_2 397 400 PF00928 0.243
TRG_ENDOCYTIC_2 425 428 PF00928 0.270
TRG_ENDOCYTIC_2 454 457 PF00928 0.269
TRG_ENDOCYTIC_2 531 534 PF00928 0.284
TRG_ENDOCYTIC_2 589 592 PF00928 0.249
TRG_ENDOCYTIC_2 612 615 PF00928 0.235
TRG_ENDOCYTIC_2 672 675 PF00928 0.506
TRG_ENDOCYTIC_2 93 96 PF00928 0.315
TRG_ER_diArg_1 122 124 PF00400 0.325
TRG_ER_diArg_1 186 189 PF00400 0.284
TRG_ER_diArg_1 384 386 PF00400 0.372
TRG_ER_diArg_1 79 82 PF00400 0.346
TRG_Pf-PMV_PEXEL_1 597 601 PF00026 0.294
TRG_Pf-PMV_PEXEL_1 653 657 PF00026 0.300

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1P9N5 Leptomonas seymouri 73% 100%
A0A0S4IM75 Bodo saltans 53% 100%
A0A1X0P757 Trypanosomatidae 59% 100%
A0A3S5IRL4 Trypanosoma rangeli 59% 100%
A0A3S7WV51 Leishmania donovani 99% 100%
A4H9R8 Leishmania braziliensis 77% 100%
D0A548 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 58% 100%
E9ARV1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
P32477 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 100%
Q09768 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 35% 100%
Q4QDM2 Leishmania major 94% 100%
V5BDE4 Trypanosoma cruzi 59% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS