LeishMANIAdb
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Noc2-domain-containing protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Noc2-domain-containing protein
Gene product:
Noc2p family - putative
Species:
Leishmania infantum
UniProt:
A4HY31_LEIIN
TriTrypDb:
LINF_180021700
Length:
654

Annotations

Annotations by Jardim et al.

Nuclear proteins, Noc2p family

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 11
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 11
GO:0110165 cellular anatomical entity 1 12
GO:0005654 nucleoplasm 2 1
GO:0005730 nucleolus 5 1
GO:0030689 Noc complex 3 1
GO:0030690 Noc1p-Noc2p complex 4 1
GO:0030691 Noc2p-Noc3p complex 4 1
GO:0032991 protein-containing complex 1 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0140513 nuclear protein-containing complex 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HY31
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY31

Function

Biological processes
Term Name Level Count
GO:0009987 cellular process 1 1
GO:0022613 ribonucleoprotein complex biogenesis 4 1
GO:0042273 ribosomal large subunit biogenesis 5 1
GO:0044085 cellular component biogenesis 3 1
GO:0071840 cellular component organization or biogenesis 2 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 128 132 PF00656 0.566
CLV_C14_Caspase3-7 446 450 PF00656 0.259
CLV_C14_Caspase3-7 94 98 PF00656 0.484
CLV_NRD_NRD_1 136 138 PF00675 0.613
CLV_NRD_NRD_1 182 184 PF00675 0.386
CLV_NRD_NRD_1 25 27 PF00675 0.428
CLV_NRD_NRD_1 40 42 PF00675 0.418
CLV_NRD_NRD_1 538 540 PF00675 0.324
CLV_NRD_NRD_1 651 653 PF00675 0.606
CLV_PCSK_KEX2_1 136 138 PF00082 0.580
CLV_PCSK_KEX2_1 226 228 PF00082 0.263
CLV_PCSK_KEX2_1 25 27 PF00082 0.429
CLV_PCSK_KEX2_1 571 573 PF00082 0.203
CLV_PCSK_KEX2_1 644 646 PF00082 0.547
CLV_PCSK_KEX2_1 651 653 PF00082 0.555
CLV_PCSK_PC1ET2_1 226 228 PF00082 0.357
CLV_PCSK_PC1ET2_1 571 573 PF00082 0.262
CLV_PCSK_PC1ET2_1 644 646 PF00082 0.559
CLV_PCSK_PC7_1 222 228 PF00082 0.267
CLV_PCSK_PC7_1 647 653 PF00082 0.666
CLV_PCSK_SKI1_1 192 196 PF00082 0.357
CLV_PCSK_SKI1_1 226 230 PF00082 0.300
CLV_PCSK_SKI1_1 264 268 PF00082 0.271
CLV_PCSK_SKI1_1 27 31 PF00082 0.369
CLV_PCSK_SKI1_1 313 317 PF00082 0.203
CLV_PCSK_SKI1_1 368 372 PF00082 0.203
CLV_PCSK_SKI1_1 45 49 PF00082 0.448
CLV_PCSK_SKI1_1 461 465 PF00082 0.218
CLV_PCSK_SKI1_1 8 12 PF00082 0.400
DEG_APCC_DBOX_1 624 632 PF00400 0.521
DEG_Kelch_Keap1_1 116 121 PF01344 0.541
DOC_CDC14_PxL_1 453 461 PF14671 0.218
DOC_CYCLIN_RxL_1 220 233 PF00134 0.298
DOC_CYCLIN_yCln2_LP_2 451 457 PF00134 0.348
DOC_MAPK_gen_1 217 225 PF00069 0.337
DOC_MAPK_gen_1 226 232 PF00069 0.216
DOC_MAPK_gen_1 539 547 PF00069 0.202
DOC_MAPK_MEF2A_6 429 437 PF00069 0.203
DOC_MAPK_MEF2A_6 447 455 PF00069 0.203
DOC_MAPK_MEF2A_6 461 470 PF00069 0.199
DOC_PP2B_LxvP_1 451 454 PF13499 0.348
DOC_PP4_FxxP_1 185 188 PF00568 0.354
DOC_PP4_FxxP_1 425 428 PF00568 0.203
DOC_USP7_MATH_1 194 198 PF00917 0.429
DOC_USP7_MATH_1 231 235 PF00917 0.452
DOC_USP7_MATH_1 281 285 PF00917 0.378
DOC_USP7_MATH_1 396 400 PF00917 0.251
DOC_USP7_MATH_1 497 501 PF00917 0.267
DOC_USP7_MATH_1 519 523 PF00917 0.195
DOC_USP7_MATH_1 533 537 PF00917 0.219
DOC_USP7_MATH_1 598 602 PF00917 0.286
DOC_USP7_UBL2_3 12 16 PF12436 0.383
DOC_USP7_UBL2_3 213 217 PF12436 0.328
DOC_USP7_UBL2_3 268 272 PF12436 0.267
DOC_USP7_UBL2_3 567 571 PF12436 0.262
DOC_USP7_UBL2_3 7 11 PF12436 0.402
DOC_WW_Pin1_4 424 429 PF00397 0.203
DOC_WW_Pin1_4 462 467 PF00397 0.218
LIG_14-3-3_CanoR_1 178 185 PF00244 0.489
LIG_14-3-3_CanoR_1 461 466 PF00244 0.203
LIG_14-3-3_CanoR_1 491 501 PF00244 0.192
LIG_14-3-3_CanoR_1 539 548 PF00244 0.234
LIG_14-3-3_CanoR_1 559 568 PF00244 0.189
LIG_14-3-3_CanoR_1 625 629 PF00244 0.480
LIG_Actin_WH2_2 256 274 PF00022 0.260
LIG_Actin_WH2_2 353 370 PF00022 0.218
LIG_BIR_II_1 1 5 PF00653 0.464
LIG_BIR_III_4 620 624 PF00653 0.551
LIG_BRCT_BRCA1_1 308 312 PF00533 0.203
LIG_FHA_1 219 225 PF00498 0.289
LIG_FHA_1 265 271 PF00498 0.287
LIG_FHA_1 487 493 PF00498 0.218
LIG_FHA_1 513 519 PF00498 0.253
LIG_FHA_2 101 107 PF00498 0.502
LIG_FHA_2 139 145 PF00498 0.360
LIG_FHA_2 345 351 PF00498 0.203
LIG_FHA_2 398 404 PF00498 0.296
LIG_FHA_2 65 71 PF00498 0.426
LIG_FHA_2 79 85 PF00498 0.448
LIG_GBD_Chelix_1 224 232 PF00786 0.347
LIG_GBD_Chelix_1 363 371 PF00786 0.203
LIG_LIR_Apic_2 182 188 PF02991 0.421
LIG_LIR_Apic_2 399 404 PF02991 0.262
LIG_LIR_Apic_2 423 428 PF02991 0.203
LIG_LIR_Gen_1 356 365 PF02991 0.193
LIG_LIR_Gen_1 601 611 PF02991 0.362
LIG_LIR_Gen_1 70 80 PF02991 0.415
LIG_LIR_Nem_3 309 315 PF02991 0.218
LIG_LIR_Nem_3 356 360 PF02991 0.193
LIG_LIR_Nem_3 393 397 PF02991 0.286
LIG_LIR_Nem_3 449 455 PF02991 0.203
LIG_LIR_Nem_3 529 534 PF02991 0.203
LIG_LIR_Nem_3 68 74 PF02991 0.406
LIG_LIR_Nem_3 9 13 PF02991 0.400
LIG_PCNA_PIPBox_1 338 347 PF02747 0.262
LIG_Pex14_2 312 316 PF04695 0.203
LIG_Pex14_2 527 531 PF04695 0.203
LIG_PTB_Apo_2 381 388 PF02174 0.203
LIG_PTB_Phospho_1 381 387 PF10480 0.203
LIG_SH2_CRK 290 294 PF00017 0.389
LIG_SH2_GRB2like 387 390 PF00017 0.203
LIG_SH2_NCK_1 401 405 PF00017 0.203
LIG_SH2_PTP2 452 455 PF00017 0.296
LIG_SH2_SRC 387 390 PF00017 0.203
LIG_SH2_SRC 452 455 PF00017 0.296
LIG_SH2_STAT3 359 362 PF00017 0.203
LIG_SH2_STAT5 262 265 PF00017 0.322
LIG_SH2_STAT5 359 362 PF00017 0.203
LIG_SH2_STAT5 366 369 PF00017 0.203
LIG_SH2_STAT5 387 390 PF00017 0.203
LIG_SH2_STAT5 452 455 PF00017 0.221
LIG_SH2_STAT5 458 461 PF00017 0.184
LIG_SH2_STAT5 512 515 PF00017 0.203
LIG_SH2_STAT5 74 77 PF00017 0.414
LIG_SH3_3 252 258 PF00018 0.269
LIG_SH3_3 451 457 PF00018 0.213
LIG_SH3_3 522 528 PF00018 0.296
LIG_SH3_3 542 548 PF00018 0.081
LIG_SUMO_SIM_anti_2 482 489 PF11976 0.224
LIG_SUMO_SIM_anti_2 88 95 PF11976 0.564
LIG_TRAF2_1 141 144 PF00917 0.411
LIG_TRAF2_1 280 283 PF00917 0.305
LIG_TRAF2_1 51 54 PF00917 0.554
LIG_UBA3_1 486 494 PF00899 0.348
LIG_WRC_WIRS_1 206 211 PF05994 0.389
MOD_CDK_SPK_2 424 429 PF00069 0.203
MOD_CK1_1 150 156 PF00069 0.479
MOD_CK1_1 215 221 PF00069 0.384
MOD_CK1_1 295 301 PF00069 0.378
MOD_CK1_1 399 405 PF00069 0.196
MOD_CK2_1 138 144 PF00069 0.388
MOD_CK2_1 150 156 PF00069 0.376
MOD_CK2_1 28 34 PF00069 0.431
MOD_CK2_1 344 350 PF00069 0.203
MOD_CK2_1 397 403 PF00069 0.296
MOD_CK2_1 64 70 PF00069 0.416
MOD_CK2_1 78 84 PF00069 0.423
MOD_CK2_1 96 102 PF00069 0.419
MOD_Cter_Amidation 642 645 PF01082 0.650
MOD_GlcNHglycan 149 152 PF01048 0.467
MOD_GlcNHglycan 163 166 PF01048 0.221
MOD_GlcNHglycan 245 248 PF01048 0.371
MOD_GlcNHglycan 479 482 PF01048 0.246
MOD_GlcNHglycan 596 599 PF01048 0.278
MOD_GlcNHglycan 620 624 PF01048 0.554
MOD_GSK3_1 143 150 PF00069 0.487
MOD_GSK3_1 204 211 PF00069 0.344
MOD_GSK3_1 21 28 PF00069 0.517
MOD_GSK3_1 302 309 PF00069 0.333
MOD_GSK3_1 315 322 PF00069 0.275
MOD_GSK3_1 464 471 PF00069 0.268
MOD_GSK3_1 594 601 PF00069 0.263
MOD_GSK3_1 96 103 PF00069 0.521
MOD_LATS_1 176 182 PF00433 0.540
MOD_N-GLC_1 329 334 PF02516 0.238
MOD_NEK2_1 230 235 PF00069 0.269
MOD_NEK2_1 245 250 PF00069 0.192
MOD_NEK2_1 271 276 PF00069 0.310
MOD_NEK2_1 306 311 PF00069 0.203
MOD_NEK2_1 319 324 PF00069 0.203
MOD_NEK2_1 486 491 PF00069 0.203
MOD_NEK2_2 212 217 PF00069 0.386
MOD_NEK2_2 281 286 PF00069 0.368
MOD_NEK2_2 302 307 PF00069 0.333
MOD_NEK2_2 497 502 PF00069 0.267
MOD_NEK2_2 602 607 PF00069 0.262
MOD_PIKK_1 143 149 PF00454 0.374
MOD_PIKK_1 372 378 PF00454 0.203
MOD_PIKK_1 492 498 PF00454 0.214
MOD_PIKK_1 540 546 PF00454 0.273
MOD_PIKK_1 562 568 PF00454 0.260
MOD_PKA_1 25 31 PF00069 0.433
MOD_PKA_2 138 144 PF00069 0.410
MOD_PKA_2 25 31 PF00069 0.433
MOD_PKA_2 497 503 PF00069 0.179
MOD_PKA_2 624 630 PF00069 0.474
MOD_Plk_1 143 149 PF00069 0.533
MOD_Plk_1 281 287 PF00069 0.289
MOD_Plk_1 329 335 PF00069 0.238
MOD_Plk_1 534 540 PF00069 0.203
MOD_Plk_2-3 100 106 PF00069 0.503
MOD_Plk_2-3 624 630 PF00069 0.489
MOD_Plk_2-3 70 76 PF00069 0.401
MOD_Plk_2-3 78 84 PF00069 0.408
MOD_Plk_4 205 211 PF00069 0.478
MOD_Plk_4 231 237 PF00069 0.286
MOD_Plk_4 245 251 PF00069 0.231
MOD_Plk_4 266 272 PF00069 0.269
MOD_Plk_4 315 321 PF00069 0.215
MOD_Plk_4 353 359 PF00069 0.193
MOD_Plk_4 497 503 PF00069 0.267
MOD_Plk_4 598 604 PF00069 0.339
MOD_Plk_4 70 76 PF00069 0.359
MOD_Plk_4 78 84 PF00069 0.366
MOD_ProDKin_1 424 430 PF00069 0.203
MOD_ProDKin_1 462 468 PF00069 0.218
MOD_SUMO_rev_2 34 44 PF00179 0.406
TRG_DiLeu_BaEn_1 186 191 PF01217 0.393
TRG_DiLeu_BaEn_1 509 514 PF01217 0.218
TRG_DiLeu_BaEn_1 78 83 PF01217 0.409
TRG_DiLeu_BaEn_4 143 149 PF01217 0.396
TRG_DiLeu_BaLyEn_6 224 229 PF01217 0.289
TRG_DiLeu_BaLyEn_6 255 260 PF01217 0.402
TRG_DiLeu_BaLyEn_6 406 411 PF01217 0.218
TRG_ENDOCYTIC_2 290 293 PF00928 0.238
TRG_ENDOCYTIC_2 452 455 PF00928 0.296
TRG_ENDOCYTIC_2 603 606 PF00928 0.239
TRG_ENDOCYTIC_2 72 75 PF00928 0.394
TRG_ER_diArg_1 135 137 PF00400 0.650
TRG_ER_diArg_1 645 648 PF00400 0.646
TRG_ER_diArg_1 650 652 PF00400 0.619
TRG_NLS_MonoExtC_3 643 648 PF00514 0.614
TRG_Pf-PMV_PEXEL_1 167 172 PF00026 0.426
TRG_Pf-PMV_PEXEL_1 539 544 PF00026 0.324

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P383 Leptomonas seymouri 86% 100%
A0A0S4IWR5 Bodo saltans 62% 99%
A0A1X0P734 Trypanosomatidae 68% 100%
A0A3R7MKH6 Trypanosoma rangeli 66% 100%
A0A3S7WV72 Leishmania donovani 99% 100%
A4H9R2 Leishmania braziliensis 88% 100%
D0A554 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 68% 100%
E9ARU5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
P39744 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 92%
Q0WVH0 Arabidopsis thaliana 22% 100%
Q4QDM8 Leishmania major 97% 100%
Q9P7G0 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 93%
Q9WV70 Mus musculus 26% 88%
Q9ZPV5 Arabidopsis thaliana 25% 86%
V5B4B0 Trypanosoma cruzi 66% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS