Putative kinesin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative kinesin

Gene product:

kinesin - putative

Species:

Leishmania infantum

UniProt:

A4HY30_LEIIN

TriTrypDb:

LINF_180021600

Length:

796

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	1
GO:0005874	microtubule	6	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1
GO:0099080	supramolecular complex	2	1
GO:0099081	supramolecular polymer	3	1
GO:0099512	supramolecular fiber	4	1
GO:0099513	polymeric cytoskeletal fiber	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HY30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY30

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	11
GO:0007018	microtubule-based movement	3	11
GO:0009987	cellular process	1	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003774	cytoskeletal motor activity	1	11
GO:0003777	microtubule motor activity	2	11
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0005524	ATP binding	5	11
GO:0008017	microtubule binding	5	11
GO:0008092	cytoskeletal protein binding	3	11
GO:0015631	tubulin binding	4	11
GO:0016787	hydrolase activity	2	5
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140657	ATP-dependent activity	1	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0016462	pyrophosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	477	481	PF00656	0.387
CLV_C14_Caspase3-7	529	533	PF00656	0.440
CLV_C14_Caspase3-7	618	622	PF00656	0.610
CLV_NRD_NRD_1	151	153	PF00675	0.296
CLV_NRD_NRD_1	187	189	PF00675	0.279
CLV_NRD_NRD_1	367	369	PF00675	0.575
CLV_NRD_NRD_1	4	6	PF00675	0.400
CLV_NRD_NRD_1	403	405	PF00675	0.552
CLV_NRD_NRD_1	409	411	PF00675	0.489
CLV_NRD_NRD_1	47	49	PF00675	0.451
CLV_NRD_NRD_1	567	569	PF00675	0.468
CLV_NRD_NRD_1	774	776	PF00675	0.746
CLV_PCSK_FUR_1	313	317	PF00082	0.357
CLV_PCSK_KEX2_1	150	152	PF00082	0.293
CLV_PCSK_KEX2_1	187	189	PF00082	0.279
CLV_PCSK_KEX2_1	315	317	PF00082	0.394
CLV_PCSK_KEX2_1	366	368	PF00082	0.576
CLV_PCSK_KEX2_1	4	6	PF00082	0.400
CLV_PCSK_KEX2_1	403	405	PF00082	0.521
CLV_PCSK_KEX2_1	409	411	PF00082	0.454
CLV_PCSK_KEX2_1	47	49	PF00082	0.451
CLV_PCSK_KEX2_1	567	569	PF00082	0.468
CLV_PCSK_KEX2_1	773	775	PF00082	0.727
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.357
CLV_PCSK_PC1ET2_1	773	775	PF00082	0.707
CLV_PCSK_PC7_1	147	153	PF00082	0.282
CLV_PCSK_SKI1_1	280	284	PF00082	0.414
CLV_PCSK_SKI1_1	567	571	PF00082	0.474
CLV_PCSK_SKI1_1	63	67	PF00082	0.369
CLV_PCSK_SKI1_1	75	79	PF00082	0.334
CLV_PCSK_SKI1_1	783	787	PF00082	0.782
CLV_Separin_Metazoa	117	121	PF03568	0.410
DEG_SCF_FBW7_2	664	670	PF00400	0.618
DEG_SPOP_SBC_1	562	566	PF00917	0.495
DOC_ANK_TNKS_1	776	783	PF00023	0.616
DOC_CDC14_PxL_1	420	428	PF14671	0.443
DOC_CKS1_1	664	669	PF01111	0.616
DOC_MAPK_DCC_7	418	428	PF00069	0.452
DOC_MAPK_gen_1	208	216	PF00069	0.320
DOC_MAPK_gen_1	346	353	PF00069	0.467
DOC_MAPK_gen_1	4	12	PF00069	0.378
DOC_MAPK_MEF2A_6	120	129	PF00069	0.398
DOC_MAPK_MEF2A_6	208	216	PF00069	0.304
DOC_MAPK_MEF2A_6	270	278	PF00069	0.294
DOC_MAPK_MEF2A_6	4	12	PF00069	0.378
DOC_PP1_RVXF_1	211	217	PF00149	0.410
DOC_PP2B_LxvP_1	738	741	PF13499	0.595
DOC_PP2B_PxIxI_1	157	163	PF00149	0.410
DOC_USP7_MATH_1	196	200	PF00917	0.356
DOC_USP7_MATH_1	387	391	PF00917	0.651
DOC_USP7_MATH_1	392	396	PF00917	0.565
DOC_USP7_MATH_1	450	454	PF00917	0.541
DOC_USP7_MATH_1	524	528	PF00917	0.388
DOC_USP7_MATH_1	637	641	PF00917	0.747
DOC_USP7_MATH_1	690	694	PF00917	0.678
DOC_USP7_MATH_1	720	724	PF00917	0.637
DOC_USP7_MATH_1	732	736	PF00917	0.683
DOC_WW_Pin1_4	226	231	PF00397	0.279
DOC_WW_Pin1_4	595	600	PF00397	0.649
DOC_WW_Pin1_4	658	663	PF00397	0.533
DOC_WW_Pin1_4	703	708	PF00397	0.624
DOC_WW_Pin1_4	733	738	PF00397	0.657
DOC_WW_Pin1_4	745	750	PF00397	0.620
DOC_WW_Pin1_4	75	80	PF00397	0.410
LIG_14-3-3_CanoR_1	187	191	PF00244	0.302
LIG_14-3-3_CanoR_1	19	26	PF00244	0.352
LIG_14-3-3_CanoR_1	194	204	PF00244	0.307
LIG_14-3-3_CanoR_1	224	228	PF00244	0.298
LIG_14-3-3_CanoR_1	245	250	PF00244	0.279
LIG_14-3-3_CanoR_1	309	317	PF00244	0.279
LIG_14-3-3_CanoR_1	333	341	PF00244	0.461
LIG_14-3-3_CanoR_1	457	466	PF00244	0.361
LIG_14-3-3_CanoR_1	47	51	PF00244	0.375
LIG_14-3-3_CanoR_1	488	494	PF00244	0.550
LIG_14-3-3_CanoR_1	727	734	PF00244	0.631
LIG_Actin_WH2_2	301	317	PF00022	0.279
LIG_APCC_ABBA_1	130	135	PF00400	0.279
LIG_BIR_II_1	1	5	PF00653	0.535
LIG_BIR_III_4	532	536	PF00653	0.576
LIG_Clathr_ClatBox_1	649	653	PF01394	0.500
LIG_eIF4E_1	50	56	PF01652	0.410
LIG_FHA_1	165	171	PF00498	0.304
LIG_FHA_1	271	277	PF00498	0.354
LIG_FHA_1	28	34	PF00498	0.410
LIG_FHA_1	286	292	PF00498	0.323
LIG_FHA_1	309	315	PF00498	0.281
LIG_FHA_1	356	362	PF00498	0.534
LIG_FHA_1	406	412	PF00498	0.454
LIG_FHA_1	564	570	PF00498	0.571
LIG_FHA_1	659	665	PF00498	0.693
LIG_FHA_1	96	102	PF00498	0.279
LIG_FHA_2	169	175	PF00498	0.336
LIG_FHA_2	246	252	PF00498	0.306
LIG_FHA_2	320	326	PF00498	0.556
LIG_FHA_2	527	533	PF00498	0.418
LIG_FHA_2	776	782	PF00498	0.669
LIG_KLC1_Yacidic_2	131	135	PF13176	0.355
LIG_LIR_Apic_2	435	440	PF02991	0.448
LIG_LIR_Gen_1	174	184	PF02991	0.276
LIG_LIR_Gen_1	263	274	PF02991	0.259
LIG_LIR_Nem_3	174	179	PF02991	0.259
LIG_LIR_Nem_3	263	269	PF02991	0.259
LIG_LIR_Nem_3	431	437	PF02991	0.384
LIG_LIR_Nem_3	746	750	PF02991	0.568
LIG_LIR_Nem_3	84	90	PF02991	0.279
LIG_MYND_1	737	741	PF01753	0.542
LIG_NRBOX	273	279	PF00104	0.279
LIG_Pex14_2	434	438	PF04695	0.398
LIG_PTAP_UEV_1	709	714	PF05743	0.533
LIG_SH2_GRB2like	266	269	PF00017	0.279
LIG_SH2_NCK_1	99	103	PF00017	0.391
LIG_SH2_SRC	133	136	PF00017	0.444
LIG_SH2_STAP1	310	314	PF00017	0.279
LIG_SH2_STAP1	430	434	PF00017	0.502
LIG_SH2_STAP1	546	550	PF00017	0.307
LIG_SH2_STAT5	133	136	PF00017	0.457
LIG_SH2_STAT5	266	269	PF00017	0.298
LIG_SH2_STAT5	281	284	PF00017	0.369
LIG_SH2_STAT5	310	313	PF00017	0.287
LIG_SH2_STAT5	433	436	PF00017	0.362
LIG_SH2_STAT5	437	440	PF00017	0.358
LIG_SH2_STAT5	447	450	PF00017	0.339
LIG_SH2_STAT5	513	516	PF00017	0.421
LIG_SH2_STAT5	546	549	PF00017	0.438
LIG_SH2_STAT5	99	102	PF00017	0.475
LIG_SH3_3	224	230	PF00018	0.410
LIG_SH3_3	548	554	PF00018	0.385
LIG_SH3_3	704	710	PF00018	0.723
LIG_SH3_3	731	737	PF00018	0.609
LIG_SH3_3	746	752	PF00018	0.642
LIG_SH3_3	756	762	PF00018	0.715
LIG_SH3_3	76	82	PF00018	0.325
LIG_SH3_5	296	300	PF00018	0.355
LIG_SUMO_SIM_anti_2	271	278	PF11976	0.279
LIG_SUMO_SIM_par_1	157	163	PF11976	0.333
LIG_SUMO_SIM_par_1	648	653	PF11976	0.519
LIG_TRAF2_1	104	107	PF00917	0.306
LIG_TRAF2_1	667	670	PF00917	0.679
LIG_TRAF2_1	683	686	PF00917	0.517
LIG_UBA3_1	204	208	PF00899	0.279
LIG_WRC_WIRS_1	287	292	PF05994	0.410
LIG_WW_3	713	717	PF00397	0.662
MOD_CDC14_SPxK_1	706	709	PF00782	0.589
MOD_CDC14_SPxK_1	748	751	PF00782	0.590
MOD_CDK_SPxK_1	703	709	PF00069	0.749
MOD_CDK_SPxK_1	745	751	PF00069	0.622
MOD_CK1_1	169	175	PF00069	0.342
MOD_CK1_1	186	192	PF00069	0.344
MOD_CK1_1	198	204	PF00069	0.289
MOD_CK1_1	22	28	PF00069	0.344
MOD_CK1_1	244	250	PF00069	0.283
MOD_CK1_1	286	292	PF00069	0.321
MOD_CK1_1	492	498	PF00069	0.553
MOD_CK1_1	526	532	PF00069	0.498
MOD_CK1_1	600	606	PF00069	0.677
MOD_CK1_1	615	621	PF00069	0.583
MOD_CK1_1	638	644	PF00069	0.690
MOD_CK1_1	680	686	PF00069	0.665
MOD_CK1_1	708	714	PF00069	0.647
MOD_CK1_1	753	759	PF00069	0.749
MOD_CK1_1	95	101	PF00069	0.318
MOD_CK2_1	101	107	PF00069	0.297
MOD_CK2_1	168	174	PF00069	0.306
MOD_CK2_1	245	251	PF00069	0.306
MOD_CK2_1	46	52	PF00069	0.303
MOD_CK2_1	495	501	PF00069	0.475
MOD_CK2_1	626	632	PF00069	0.639
MOD_CK2_1	680	686	PF00069	0.573
MOD_CK2_1	775	781	PF00069	0.673
MOD_Cter_Amidation	45	48	PF01082	0.355
MOD_DYRK1A_RPxSP_1	75	79	PF00069	0.306
MOD_GlcNHglycan	296	299	PF01048	0.417
MOD_GlcNHglycan	328	332	PF01048	0.602
MOD_GlcNHglycan	33	36	PF01048	0.327
MOD_GlcNHglycan	389	392	PF01048	0.657
MOD_GlcNHglycan	394	397	PF01048	0.602
MOD_GlcNHglycan	448	451	PF01048	0.389
MOD_GlcNHglycan	526	529	PF01048	0.621
MOD_GlcNHglycan	548	551	PF01048	0.524
MOD_GlcNHglycan	614	617	PF01048	0.550
MOD_GlcNHglycan	634	640	PF01048	0.655
MOD_GlcNHglycan	644	647	PF01048	0.636
MOD_GlcNHglycan	670	676	PF01048	0.658
MOD_GlcNHglycan	692	695	PF01048	0.794
MOD_GlcNHglycan	710	713	PF01048	0.706
MOD_GlcNHglycan	721	725	PF01048	0.655
MOD_GlcNHglycan	752	755	PF01048	0.735
MOD_GlcNHglycan	756	759	PF01048	0.617
MOD_GlcNHglycan	94	97	PF01048	0.357
MOD_GSK3_1	15	22	PF00069	0.317
MOD_GSK3_1	164	171	PF00069	0.303
MOD_GSK3_1	182	189	PF00069	0.361
MOD_GSK3_1	219	226	PF00069	0.298
MOD_GSK3_1	235	242	PF00069	0.279
MOD_GSK3_1	27	34	PF00069	0.442
MOD_GSK3_1	304	311	PF00069	0.306
MOD_GSK3_1	351	358	PF00069	0.541
MOD_GSK3_1	387	394	PF00069	0.619
MOD_GSK3_1	42	49	PF00069	0.333
MOD_GSK3_1	446	453	PF00069	0.529
MOD_GSK3_1	492	499	PF00069	0.551
MOD_GSK3_1	520	527	PF00069	0.558
MOD_GSK3_1	591	598	PF00069	0.608
MOD_GSK3_1	600	607	PF00069	0.693
MOD_GSK3_1	626	633	PF00069	0.769
MOD_GSK3_1	637	644	PF00069	0.676
MOD_GSK3_1	673	680	PF00069	0.675
MOD_GSK3_1	750	757	PF00069	0.770
MOD_GSK3_1	91	98	PF00069	0.304
MOD_N-GLC_1	239	244	PF02516	0.318
MOD_N-GLC_1	355	360	PF02516	0.556
MOD_N-GLC_1	626	631	PF02516	0.796
MOD_N-GLC_1	775	780	PF02516	0.534
MOD_N-GLC_2	21	23	PF02516	0.355
MOD_NEK2_1	269	274	PF00069	0.293
MOD_NEK2_1	308	313	PF00069	0.290
MOD_NEK2_1	372	377	PF00069	0.557
MOD_NEK2_1	474	479	PF00069	0.376
MOD_NEK2_1	489	494	PF00069	0.440
MOD_NEK2_1	601	606	PF00069	0.694
MOD_NEK2_2	203	208	PF00069	0.297
MOD_OFUCOSY	679	684	PF10250	0.504
MOD_PIKK_1	308	314	PF00454	0.279
MOD_PIKK_1	505	511	PF00454	0.389
MOD_PKA_2	186	192	PF00069	0.297
MOD_PKA_2	196	202	PF00069	0.302
MOD_PKA_2	223	229	PF00069	0.298
MOD_PKA_2	244	250	PF00069	0.314
MOD_PKA_2	269	275	PF00069	0.285
MOD_PKA_2	308	314	PF00069	0.279
MOD_PKA_2	319	325	PF00069	0.491
MOD_PKA_2	332	338	PF00069	0.481
MOD_PKA_2	405	411	PF00069	0.548
MOD_PKA_2	46	52	PF00069	0.434
MOD_PKA_2	708	714	PF00069	0.667
MOD_PKA_2	750	756	PF00069	0.700
MOD_PKB_1	11	19	PF00069	0.355
MOD_Plk_1	239	245	PF00069	0.318
MOD_Plk_1	270	276	PF00069	0.297
MOD_Plk_1	372	378	PF00069	0.498
MOD_Plk_2-3	496	502	PF00069	0.440
MOD_Plk_2-3	630	636	PF00069	0.566
MOD_Plk_4	223	229	PF00069	0.413
MOD_Plk_4	245	251	PF00069	0.297
MOD_Plk_4	272	278	PF00069	0.357
MOD_Plk_4	286	292	PF00069	0.300
MOD_Plk_4	450	456	PF00069	0.536
MOD_Plk_4	474	480	PF00069	0.353
MOD_Plk_4	554	560	PF00069	0.470
MOD_Plk_4	601	607	PF00069	0.789
MOD_Plk_4	615	621	PF00069	0.635
MOD_ProDKin_1	226	232	PF00069	0.279
MOD_ProDKin_1	595	601	PF00069	0.651
MOD_ProDKin_1	658	664	PF00069	0.540
MOD_ProDKin_1	703	709	PF00069	0.626
MOD_ProDKin_1	733	739	PF00069	0.657
MOD_ProDKin_1	745	751	PF00069	0.623
MOD_ProDKin_1	75	81	PF00069	0.410
MOD_SUMO_for_1	569	572	PF00179	0.450
TRG_DiLeu_BaEn_1	336	341	PF01217	0.456
TRG_DiLeu_BaLyEn_6	548	553	PF01217	0.450
TRG_DiLeu_BaLyEn_6	734	739	PF01217	0.584
TRG_ENDOCYTIC_2	266	269	PF00928	0.279
TRG_ER_diArg_1	10	13	PF00400	0.273
TRG_ER_diArg_1	149	152	PF00400	0.289
TRG_ER_diArg_1	317	320	PF00400	0.524
TRG_ER_diArg_1	366	368	PF00400	0.585
TRG_ER_diArg_1	4	6	PF00400	0.406
TRG_ER_diArg_1	403	406	PF00400	0.469
TRG_ER_diArg_1	409	411	PF00400	0.449
TRG_ER_diArg_1	567	569	PF00400	0.468
TRG_ER_diArg_1	715	718	PF00400	0.559
TRG_ER_diArg_1	774	777	PF00400	0.794
TRG_NES_CRM1_1	342	355	PF08389	0.465
TRG_NLS_MonoExtC_3	772	777	PF00514	0.664
TRG_NLS_MonoExtN_4	313	319	PF00514	0.410
TRG_Pf-PMV_PEXEL_1	367	371	PF00026	0.582
TRG_Pf-PMV_PEXEL_1	418	422	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	698	703	PF00026	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2F8	Leptomonas seymouri	59%	95%
A0A1X0P728	Trypanosomatidae	51%	90%
A0A3R7KGY3	Trypanosoma rangeli	49%	91%
A0A3S5H747	Leishmania donovani	99%	100%
A4H9R1	Leishmania braziliensis	80%	99%
D0A556	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	92%
E9ARU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QDM9	Leishmania major	92%	100%
V5D4P5	Trypanosoma cruzi	53%	100%