VASt domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4HY29_LEIIN

TriTrypDb:

LINF_180021500

Length:

213

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HY29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY29

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	195	197	PF00675	0.501
CLV_NRD_NRD_1	40	42	PF00675	0.669
CLV_PCSK_KEX2_1	14	16	PF00082	0.707
CLV_PCSK_KEX2_1	194	196	PF00082	0.463
CLV_PCSK_KEX2_1	39	41	PF00082	0.690
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.707
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.637
CLV_PCSK_SKI1_1	127	131	PF00082	0.618
CLV_PCSK_SKI1_1	196	200	PF00082	0.499
DOC_MAPK_gen_1	12	21	PF00069	0.413
DOC_MAPK_gen_1	39	47	PF00069	0.450
DOC_MAPK_gen_1	52	60	PF00069	0.347
DOC_PP1_RVXF_1	194	201	PF00149	0.699
DOC_PP4_FxxP_1	125	128	PF00568	0.421
DOC_USP7_MATH_1	166	170	PF00917	0.539
DOC_USP7_MATH_1	206	210	PF00917	0.749
DOC_USP7_MATH_1	75	79	PF00917	0.422
DOC_WW_Pin1_4	145	150	PF00397	0.543
LIG_14-3-3_CanoR_1	170	178	PF00244	0.349
LIG_14-3-3_CanoR_1	195	201	PF00244	0.699
LIG_14-3-3_CanoR_1	205	211	PF00244	0.692
LIG_BIR_II_1	1	5	PF00653	0.502
LIG_BIR_III_2	146	150	PF00653	0.552
LIG_BRCT_BRCA1_1	56	60	PF00533	0.405
LIG_BRCT_BRCA1_2	56	62	PF00533	0.407
LIG_FHA_1	157	163	PF00498	0.574
LIG_FHA_1	61	67	PF00498	0.393
LIG_FHA_1	97	103	PF00498	0.353
LIG_FHA_2	104	110	PF00498	0.443
LIG_FHA_2	141	147	PF00498	0.465
LIG_FHA_2	77	83	PF00498	0.458
LIG_LIR_Apic_2	122	128	PF02991	0.437
LIG_LIR_Gen_1	103	112	PF02991	0.395
LIG_LIR_Gen_1	78	87	PF02991	0.474
LIG_LIR_Nem_3	103	107	PF02991	0.385
LIG_LIR_Nem_3	209	213	PF02991	0.747
LIG_LIR_Nem_3	43	49	PF02991	0.373
LIG_LIR_Nem_3	61	67	PF02991	0.393
LIG_LIR_Nem_3	78	83	PF02991	0.480
LIG_PDZ_Class_1	208	213	PF00595	0.790
LIG_Pex14_2	125	129	PF04695	0.416
LIG_REV1ctd_RIR_1	127	136	PF16727	0.422
LIG_RPA_C_Fungi	36	48	PF08784	0.468
LIG_SH2_CRK	64	68	PF00017	0.457
LIG_SH2_CRK	86	90	PF00017	0.463
LIG_SH2_NCK_1	86	90	PF00017	0.601
LIG_SH2_PTP2	104	107	PF00017	0.467
LIG_SH2_STAT5	104	107	PF00017	0.437
LIG_TYR_ITIM	102	107	PF00017	0.462
LIG_UBA3_1	47	54	PF00899	0.451
MOD_CK1_1	148	154	PF00069	0.762
MOD_CK1_1	169	175	PF00069	0.697
MOD_CK1_1	7	13	PF00069	0.396
MOD_CK2_1	103	109	PF00069	0.472
MOD_CK2_1	32	38	PF00069	0.522
MOD_CK2_1	76	82	PF00069	0.575
MOD_Cter_Amidation	12	15	PF01082	0.636
MOD_GlcNHglycan	172	175	PF01048	0.489
MOD_GlcNHglycan	201	204	PF01048	0.658
MOD_GSK3_1	128	135	PF00069	0.504
MOD_GSK3_1	166	173	PF00069	0.701
MOD_GSK3_1	19	26	PF00069	0.541
MOD_GSK3_1	28	35	PF00069	0.409
MOD_GSK3_1	54	61	PF00069	0.502
MOD_NEK2_1	19	24	PF00069	0.413
MOD_NEK2_1	28	33	PF00069	0.383
MOD_NEK2_1	60	65	PF00069	0.427
MOD_PK_1	54	60	PF00069	0.501
MOD_PKA_2	169	175	PF00069	0.644
MOD_PKB_1	194	202	PF00069	0.724
MOD_Plk_1	19	25	PF00069	0.456
MOD_Plk_1	54	60	PF00069	0.462
MOD_Plk_2-3	103	109	PF00069	0.536
MOD_Plk_4	176	182	PF00069	0.522
MOD_Plk_4	4	10	PF00069	0.436
MOD_Plk_4	54	60	PF00069	0.462
MOD_ProDKin_1	145	151	PF00069	0.700
TRG_DiLeu_BaEn_1	111	116	PF01217	0.492
TRG_DiLeu_BaEn_1	43	48	PF01217	0.555
TRG_ENDOCYTIC_2	104	107	PF00928	0.460
TRG_ENDOCYTIC_2	64	67	PF00928	0.457
TRG_ER_diArg_1	194	196	PF00400	0.703
TRG_ER_diArg_1	49	52	PF00400	0.453
TRG_NES_CRM1_1	43	55	PF08389	0.469
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I127	Leptomonas seymouri	60%	100%
A0A3S7WV60	Leishmania donovani	100%	100%
A4H9R0	Leishmania braziliensis	84%	100%
E9ARU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QDN0	Leishmania major	94%	100%