Putative P-type H+-ATPase

Quick info Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

P-type H+-ATPase - putative

Species:

Leishmania infantum

UniProt:

A4HY21_LEIIN

TriTrypDb:

LINF_180020800

Length:

514

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4
GO:0005886	plasma membrane	3	1

Phosphorylation

Promastigote: 19, 21, 26

Expansion

Sequence features

A4HY21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY21

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0009987	cellular process	1	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098662	inorganic cation transmembrane transport	5	1
GO:0120029	proton export across plasma membrane	4	1
GO:0140115	export across plasma membrane	3	1
GO:0140352	export from cell	2	1
GO:1902600	proton transmembrane transport	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	4
GO:0003824	catalytic activity	1	4
GO:0005488	binding	1	4
GO:0005524	ATP binding	5	4
GO:0016462	pyrophosphatase activity	5	4
GO:0016787	hydrolase activity	2	4
GO:0016817	hydrolase activity, acting on acid anhydrides	3	4
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	4
GO:0016887	ATP hydrolysis activity	7	4
GO:0017076	purine nucleotide binding	4	4
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	4
GO:0030554	adenyl nucleotide binding	5	4
GO:0032553	ribonucleotide binding	3	4
GO:0032555	purine ribonucleotide binding	4	4
GO:0032559	adenyl ribonucleotide binding	5	4
GO:0035639	purine ribonucleoside triphosphate binding	4	4
GO:0036094	small molecule binding	2	4
GO:0043167	ion binding	2	4
GO:0043168	anion binding	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:0097367	carbohydrate derivative binding	2	4
GO:1901265	nucleoside phosphate binding	3	4
GO:1901363	heterocyclic compound binding	2	4
GO:0005215	transporter activity	1	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0008553	P-type proton-exporting transporter activity	4	1
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015078	proton transmembrane transporter activity	5	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	1
GO:0015399	primary active transmembrane transporter activity	4	1
GO:0015662	P-type ion transporter activity	4	1
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022853	active monoatomic ion transmembrane transporter activity	4	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022890	inorganic cation transmembrane transporter activity	4	1
GO:0042626	ATPase-coupled transmembrane transporter activity	2	1
GO:0140358	P-type transmembrane transporter activity	3	1
GO:0140657	ATP-dependent activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.618
CLV_C14_Caspase3-7	467	471	PF00656	0.449
CLV_NRD_NRD_1	263	265	PF00675	0.185
CLV_NRD_NRD_1	32	34	PF00675	0.450
CLV_NRD_NRD_1	435	437	PF00675	0.289
CLV_NRD_NRD_1	512	514	PF00675	0.342
CLV_PCSK_KEX2_1	263	265	PF00082	0.185
CLV_PCSK_KEX2_1	32	34	PF00082	0.450
CLV_PCSK_KEX2_1	426	428	PF00082	0.325
CLV_PCSK_KEX2_1	435	437	PF00082	0.312
CLV_PCSK_KEX2_1	512	514	PF00082	0.342
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.325
CLV_PCSK_SKI1_1	264	268	PF00082	0.200
CLV_PCSK_SKI1_1	293	297	PF00082	0.208
CLV_PCSK_SKI1_1	394	398	PF00082	0.475
CLV_PCSK_SKI1_1	60	64	PF00082	0.214
CLV_Separin_Metazoa	391	395	PF03568	0.510
DEG_APCC_DBOX_1	393	401	PF00400	0.570
DEG_SCF_SKP2-CKS1_1	22	29	PF00560	0.618
DEG_SPOP_SBC_1	314	318	PF00917	0.408
DOC_ANK_TNKS_1	224	231	PF00023	0.408
DOC_CYCLIN_yCln2_LP_2	55	58	PF00134	0.547
DOC_CYCLIN_yCln2_LP_2	94	100	PF00134	0.223
DOC_MAPK_gen_1	263	269	PF00069	0.385
DOC_MAPK_MEF2A_6	445	454	PF00069	0.441
DOC_PP2B_LxvP_1	500	503	PF13499	0.461
DOC_PP2B_LxvP_1	55	58	PF13499	0.547
DOC_PP4_FxxP_1	499	502	PF00568	0.449
DOC_USP7_MATH_1	179	183	PF00917	0.409
DOC_USP7_MATH_1	186	190	PF00917	0.452
DOC_USP7_MATH_1	320	324	PF00917	0.408
DOC_USP7_UBL2_3	147	151	PF12436	0.533
DOC_USP7_UBL2_3	324	328	PF12436	0.414
DOC_WW_Pin1_4	23	28	PF00397	0.635
DOC_WW_Pin1_4	81	86	PF00397	0.408
LIG_14-3-3_CanoR_1	32	37	PF00244	0.598
LIG_14-3-3_CanoR_1	427	433	PF00244	0.475
LIG_14-3-3_CanoR_1	478	483	PF00244	0.433
LIG_14-3-3_CterR_2	512	514	PF00244	0.543
LIG_Actin_WH2_2	248	265	PF00022	0.385
LIG_BIR_II_1	1	5	PF00653	0.573
LIG_BRCT_BRCA1_1	236	240	PF00533	0.385
LIG_deltaCOP1_diTrp_1	113	122	PF00928	0.185
LIG_EH1_1	297	305	PF00400	0.408
LIG_EH1_1	448	456	PF00400	0.446
LIG_FHA_1	151	157	PF00498	0.414
LIG_FHA_1	233	239	PF00498	0.509
LIG_FHA_1	242	248	PF00498	0.431
LIG_FHA_1	314	320	PF00498	0.505
LIG_FHA_1	351	357	PF00498	0.483
LIG_FHA_1	377	383	PF00498	0.448
LIG_FHA_1	397	403	PF00498	0.478
LIG_FHA_1	51	57	PF00498	0.555
LIG_FHA_2	367	373	PF00498	0.489
LIG_FHA_2	429	435	PF00498	0.633
LIG_FHA_2	496	502	PF00498	0.498
LIG_FHA_2	61	67	PF00498	0.576
LIG_GBD_Chelix_1	104	112	PF00786	0.232
LIG_LIR_Apic_2	498	502	PF02991	0.446
LIG_LIR_Gen_1	159	170	PF02991	0.408
LIG_LIR_Gen_1	411	421	PF02991	0.484
LIG_LIR_Nem_3	159	165	PF02991	0.408
LIG_LIR_Nem_3	411	416	PF02991	0.474
LIG_LIR_Nem_3	84	90	PF02991	0.467
LIG_NBox_RRM_1	292	302	PF00076	0.414
LIG_PCNA_PIPBox_1	493	502	PF02747	0.438
LIG_Pex14_2	288	292	PF04695	0.414
LIG_REV1ctd_RIR_1	238	247	PF16727	0.408
LIG_SH2_CRK	413	417	PF00017	0.650
LIG_SH2_STAP1	6	10	PF00017	0.582
LIG_SH2_STAT5	234	237	PF00017	0.577
LIG_SH2_STAT5	283	286	PF00017	0.491
LIG_SH2_STAT5	90	93	PF00017	0.232
LIG_SH3_2	27	32	PF14604	0.629
LIG_SH3_3	166	172	PF00018	0.385
LIG_SH3_3	24	30	PF00018	0.625
LIG_SH3_3	302	308	PF00018	0.408
LIG_SH3_3	417	423	PF00018	0.499
LIG_SH3_3	499	505	PF00018	0.466
LIG_SUMO_SIM_anti_2	463	471	PF11976	0.450
LIG_SUMO_SIM_par_1	192	199	PF11976	0.414
LIG_SUMO_SIM_par_1	300	306	PF11976	0.487
LIG_SUMO_SIM_par_1	307	312	PF11976	0.484
LIG_SUMO_SIM_par_1	316	323	PF11976	0.452
LIG_SUMO_SIM_par_1	463	471	PF11976	0.450
LIG_TRAF2_1	369	372	PF00917	0.495
LIG_TRAF2_1	63	66	PF00917	0.491
LIG_WRC_WIRS_1	289	294	PF05994	0.414
LIG_WRC_WIRS_1	496	501	PF05994	0.440
LIG_WW_3	391	395	PF00397	0.510
LIG_WW_3	501	505	PF00397	0.473
MOD_CDK_SPxK_1	23	29	PF00069	0.617
MOD_CK1_1	250	256	PF00069	0.433
MOD_CK1_1	35	41	PF00069	0.581
MOD_CK1_1	350	356	PF00069	0.487
MOD_CK2_1	18	24	PF00069	0.616
MOD_CK2_1	186	192	PF00069	0.408
MOD_CK2_1	334	340	PF00069	0.474
MOD_CK2_1	366	372	PF00069	0.485
MOD_CK2_1	60	66	PF00069	0.491
MOD_GlcNHglycan	179	182	PF01048	0.281
MOD_GlcNHglycan	336	339	PF01048	0.302
MOD_GlcNHglycan	342	345	PF01048	0.328
MOD_GlcNHglycan	436	439	PF01048	0.282
MOD_GSK3_1	146	153	PF00069	0.532
MOD_GSK3_1	203	210	PF00069	0.550
MOD_GSK3_1	228	235	PF00069	0.408
MOD_GSK3_1	320	327	PF00069	0.408
MOD_GSK3_1	35	42	PF00069	0.577
MOD_GSK3_1	350	357	PF00069	0.463
MOD_GSK3_1	421	428	PF00069	0.577
MOD_GSK3_1	46	53	PF00069	0.707
MOD_GSK3_1	478	485	PF00069	0.435
MOD_GSK3_1	507	514	PF00069	0.515
MOD_GSK3_1	56	63	PF00069	0.544
MOD_N-GLC_1	127	132	PF02516	0.223
MOD_NEK2_1	146	151	PF00069	0.540
MOD_NEK2_1	241	246	PF00069	0.427
MOD_NEK2_1	288	293	PF00069	0.481
MOD_NEK2_1	303	308	PF00069	0.389
MOD_NEK2_1	376	381	PF00069	0.452
MOD_NEK2_1	441	446	PF00069	0.452
MOD_NEK2_2	133	138	PF00069	0.344
MOD_NEK2_2	152	157	PF00069	0.372
MOD_NEK2_2	236	241	PF00069	0.408
MOD_PK_1	32	38	PF00069	0.597
MOD_PK_1	478	484	PF00069	0.437
MOD_PKA_1	32	38	PF00069	0.597
MOD_PKA_2	157	163	PF00069	0.441
MOD_PKA_2	32	38	PF00069	0.597
MOD_PKA_2	434	440	PF00069	0.508
MOD_PKA_2	46	52	PF00069	0.594
MOD_Plk_1	127	133	PF00069	0.223
MOD_Plk_1	186	192	PF00069	0.408
MOD_Plk_2-3	18	24	PF00069	0.616
MOD_Plk_4	152	158	PF00069	0.443
MOD_Plk_4	236	242	PF00069	0.561
MOD_Plk_4	32	38	PF00069	0.597
MOD_Plk_4	376	382	PF00069	0.595
MOD_Plk_4	396	402	PF00069	0.527
MOD_Plk_4	428	434	PF00069	0.454
MOD_Plk_4	495	501	PF00069	0.439
MOD_Plk_4	83	89	PF00069	0.532
MOD_ProDKin_1	23	29	PF00069	0.633
MOD_ProDKin_1	81	87	PF00069	0.408
MOD_SUMO_rev_2	371	379	PF00179	0.451
MOD_SUMO_rev_2	501	510	PF00179	0.482
MOD_SUMO_rev_2	78	85	PF00179	0.384
MOD_SUMO_rev_2	9	17	PF00179	0.625
TRG_DiLeu_BaEn_1	66	71	PF01217	0.489
TRG_DiLeu_BaEn_4	371	377	PF01217	0.490
TRG_ENDOCYTIC_2	134	137	PF00928	0.587
TRG_ENDOCYTIC_2	289	292	PF00928	0.548
TRG_ENDOCYTIC_2	413	416	PF00928	0.478
TRG_ER_diArg_1	262	264	PF00400	0.392
TRG_ER_diArg_1	511	513	PF00400	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IUN3	Bodo saltans	72%	69%
A0RA13	Bacillus thuringiensis (strain Al Hakam)	25%	74%
A4H9S2	Leishmania braziliensis	90%	100%
A7FFQ9	Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)	26%	75%
A7GLG4	Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)	25%	74%
A7ZJ80	Escherichia coli O139:H28 (strain E24377A / ETEC)	26%	75%
A8GB61	Serratia proteamaculans (strain 568)	26%	75%
A9VFM1	Bacillus mycoides (strain KBAB4)	25%	74%
B0R9M0	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	21%	71%
B1IY32	Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks)	26%	75%
B1JR96	Yersinia pseudotuberculosis serotype O:3 (strain YPIII)	26%	75%
B1LLE1	Escherichia coli (strain SMS-3-5 / SECEC)	26%	75%
B1X6M8	Escherichia coli (strain K12 / DH10B)	26%	75%
B2TMJ2	Clostridium botulinum (strain Eklund 17B / Type B)	24%	75%
B2TTJ7	Shigella boydii serotype 18 (strain CDC 3083-94 / BS512)	27%	75%
B2V2P3	Clostridium botulinum (strain Alaska E43 / Type E3)	24%	75%
B5XZE9	Klebsiella pneumoniae (strain 342)	25%	75%
B5YQN9	Escherichia coli O157:H7 (strain EC4115 / EHEC)	26%	75%
B6HYQ5	Escherichia coli (strain SE11)	26%	75%
B7HDF9	Bacillus cereus (strain B4264)	25%	74%
B7HWG1	Bacillus cereus (strain AH187)	25%	74%
B7II09	Bacillus cereus (strain G9842)	26%	74%
B7JRB8	Bacillus cereus (strain AH820)	24%	74%
B7LAA4	Escherichia coli (strain 55989 / EAEC)	26%	75%
B7LKR7	Escherichia fergusonii (strain ATCC 35469 / DSM 13698 / CCUG 18766 / IAM 14443 / JCM 21226 / LMG 7866 / NBRC 102419 / NCTC 12128 / CDC 0568-73)	26%	75%
B7M5L3	Escherichia coli O8 (strain IAI1)	26%	75%
B7N9U0	Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC)	27%	75%
B7NMQ0	Escherichia coli O7:K1 (strain IAI39 / ExPEC)	27%	75%
C1EYK0	Bacillus cereus (strain 03BB102)	25%	74%
C3LF99	Bacillus anthracis (strain CDC 684 / NRRL 3495)	25%	74%
C4LDL7	Tolumonas auensis (strain DSM 9187 / TA4)	25%	75%
C4ZWH3	Escherichia coli (strain K12 / MC4100 / BW2952)	26%	75%
O30085	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	23%	74%
P03960	Escherichia coli (strain K12)	26%	75%
P32113	Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R)	22%	71%
P35597	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	24%	66%
P57699	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	21%	71%
P57700	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	22%	77%
P59219	Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)	25%	74%
Q0TRT3	Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)	22%	75%
Q324L0	Shigella boydii serotype 4 (strain Sb227)	27%	75%
Q3Z4A6	Shigella sonnei (strain Ss046)	27%	75%
Q63FR0	Bacillus cereus (strain ZK / E33L)	25%	74%
Q667S4	Yersinia pseudotuberculosis serotype I (strain IP32953)	26%	75%
Q6HN78	Bacillus thuringiensis subsp. konkukian (strain 97-27)	24%	74%
Q72TM6	Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)	24%	74%
Q7N6W6	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	24%	75%
Q81HQ0	Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711)	25%	74%
Q8PCM1	Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)	24%	75%
Q8X9F9	Escherichia coli O157:H7	26%	75%
Q926K7	Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)	24%	75%
Q93MV5	Myxococcus xanthus	24%	75%
Q9CCL1	Mycobacterium leprae (strain TN)	21%	71%
Q9RZP0	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	24%	76%
Q9ZL53	Helicobacter pylori (strain J99 / ATCC 700824)	21%	75%