LeishMANIAdb
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Guanine nucleotide-binding protein subunit beta-like protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Guanine nucleotide-binding protein subunit beta-like protein
Gene product:
WD domain - G-beta repeat - putative
Species:
Leishmania infantum
UniProt:
A4HY16_LEIIN
TriTrypDb:
LINF_180020100
Length:
910

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0005815 microtubule organizing center 2 1
GO:0005858 axonemal dynein complex 4 1
GO:0005875 microtubule associated complex 2 2
GO:0005929 cilium 4 2
GO:0030286 dynein complex 3 2
GO:0030990 intraciliary transport particle 2 1
GO:0032991 protein-containing complex 1 2
GO:0036064 ciliary basal body 3 1
GO:0042995 cell projection 2 2
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0110165 cellular anatomical entity 1 2
GO:0120025 plasma membrane bounded cell projection 3 2
GO:1902494 catalytic complex 2 2
GO:0005840 ribosome 5 1
GO:0005868 cytoplasmic dynein complex 4 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:1990904 ribonucleoprotein complex 2 1

Phosphorylation

Promastigote: 238

Expansion

Sequence features

A4HY16
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY16

Function

Biological processes
Term Name Level Count
GO:0003341 cilium movement 4 1
GO:0007017 microtubule-based process 2 2
GO:0007018 microtubule-based movement 3 2
GO:0009987 cellular process 1 2
GO:0006810 transport 3 1
GO:0010970 transport along microtubule 4 1
GO:0030705 cytoskeleton-dependent intracellular transport 4 1
GO:0031503 protein-containing complex localization 2 1
GO:0042073 intraciliary transport 3 1
GO:0046907 intracellular transport 3 1
GO:0051179 localization 1 1
GO:0051234 establishment of localization 2 1
GO:0051641 cellular localization 2 1
GO:0051649 establishment of localization in cell 3 1
GO:0099111 microtubule-based transport 4 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 2
GO:0005515 protein binding 2 2
GO:0045503 dynein light chain binding 3 2
GO:0045504 dynein heavy chain binding 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 141 145 PF00656 0.484
CLV_C14_Caspase3-7 227 231 PF00656 0.722
CLV_C14_Caspase3-7 313 317 PF00656 0.653
CLV_C14_Caspase3-7 380 384 PF00656 0.687
CLV_C14_Caspase3-7 693 697 PF00656 0.614
CLV_NRD_NRD_1 126 128 PF00675 0.607
CLV_NRD_NRD_1 129 131 PF00675 0.619
CLV_NRD_NRD_1 15 17 PF00675 0.479
CLV_NRD_NRD_1 182 184 PF00675 0.530
CLV_NRD_NRD_1 19 21 PF00675 0.470
CLV_NRD_NRD_1 194 196 PF00675 0.513
CLV_NRD_NRD_1 203 205 PF00675 0.502
CLV_NRD_NRD_1 207 209 PF00675 0.533
CLV_NRD_NRD_1 268 270 PF00675 0.444
CLV_NRD_NRD_1 353 355 PF00675 0.593
CLV_NRD_NRD_1 609 611 PF00675 0.497
CLV_NRD_NRD_1 64 66 PF00675 0.584
CLV_NRD_NRD_1 72 74 PF00675 0.501
CLV_NRD_NRD_1 729 731 PF00675 0.231
CLV_NRD_NRD_1 8 10 PF00675 0.519
CLV_NRD_NRD_1 844 846 PF00675 0.553
CLV_PCSK_KEX2_1 126 128 PF00082 0.625
CLV_PCSK_KEX2_1 14 16 PF00082 0.549
CLV_PCSK_KEX2_1 175 177 PF00082 0.487
CLV_PCSK_KEX2_1 184 186 PF00082 0.519
CLV_PCSK_KEX2_1 196 198 PF00082 0.550
CLV_PCSK_KEX2_1 203 205 PF00082 0.430
CLV_PCSK_KEX2_1 207 209 PF00082 0.513
CLV_PCSK_KEX2_1 268 270 PF00082 0.444
CLV_PCSK_KEX2_1 353 355 PF00082 0.593
CLV_PCSK_KEX2_1 635 637 PF00082 0.554
CLV_PCSK_KEX2_1 72 74 PF00082 0.532
CLV_PCSK_KEX2_1 729 731 PF00082 0.231
CLV_PCSK_KEX2_1 79 81 PF00082 0.563
CLV_PCSK_KEX2_1 8 10 PF00082 0.523
CLV_PCSK_KEX2_1 844 846 PF00082 0.553
CLV_PCSK_PC1ET2_1 14 16 PF00082 0.563
CLV_PCSK_PC1ET2_1 175 177 PF00082 0.465
CLV_PCSK_PC1ET2_1 184 186 PF00082 0.553
CLV_PCSK_PC1ET2_1 196 198 PF00082 0.506
CLV_PCSK_PC1ET2_1 635 637 PF00082 0.554
CLV_PCSK_PC1ET2_1 79 81 PF00082 0.539
CLV_PCSK_PC7_1 11 17 PF00082 0.581
CLV_PCSK_PC7_1 192 198 PF00082 0.457
CLV_PCSK_PC7_1 203 209 PF00082 0.451
CLV_PCSK_PC7_1 75 81 PF00082 0.603
CLV_PCSK_SKI1_1 175 179 PF00082 0.386
CLV_PCSK_SKI1_1 203 207 PF00082 0.571
CLV_PCSK_SKI1_1 234 238 PF00082 0.687
CLV_PCSK_SKI1_1 259 263 PF00082 0.344
CLV_PCSK_SKI1_1 347 351 PF00082 0.584
CLV_PCSK_SKI1_1 354 358 PF00082 0.592
CLV_PCSK_SKI1_1 401 405 PF00082 0.674
CLV_PCSK_SKI1_1 414 418 PF00082 0.449
CLV_PCSK_SKI1_1 573 577 PF00082 0.385
CLV_PCSK_SKI1_1 672 676 PF00082 0.422
DEG_APCC_DBOX_1 233 241 PF00400 0.583
DEG_SPOP_SBC_1 456 460 PF00917 0.494
DOC_MAPK_gen_1 467 477 PF00069 0.417
DOC_MAPK_MEF2A_6 470 479 PF00069 0.412
DOC_PP1_RVXF_1 267 274 PF00149 0.523
DOC_PP2B_LxvP_1 721 724 PF13499 0.443
DOC_PP4_FxxP_1 576 579 PF00568 0.342
DOC_USP7_MATH_1 104 108 PF00917 0.646
DOC_USP7_MATH_1 119 123 PF00917 0.626
DOC_USP7_MATH_1 34 38 PF00917 0.686
DOC_USP7_MATH_1 391 395 PF00917 0.736
DOC_USP7_MATH_1 456 460 PF00917 0.429
DOC_USP7_MATH_1 48 52 PF00917 0.752
DOC_USP7_MATH_1 55 59 PF00917 0.618
DOC_USP7_MATH_1 678 682 PF00917 0.605
DOC_USP7_MATH_1 683 687 PF00917 0.632
DOC_USP7_MATH_1 713 717 PF00917 0.497
DOC_USP7_MATH_1 737 741 PF00917 0.374
DOC_USP7_MATH_1 754 758 PF00917 0.509
DOC_USP7_MATH_2 638 644 PF00917 0.566
DOC_WW_Pin1_4 235 240 PF00397 0.664
DOC_WW_Pin1_4 35 40 PF00397 0.732
DOC_WW_Pin1_4 497 502 PF00397 0.441
DOC_WW_Pin1_4 517 522 PF00397 0.371
DOC_WW_Pin1_4 534 539 PF00397 0.365
DOC_WW_Pin1_4 642 647 PF00397 0.558
DOC_WW_Pin1_4 735 740 PF00397 0.557
DOC_WW_Pin1_4 798 803 PF00397 0.474
LIG_14-3-3_CanoR_1 167 177 PF00244 0.557
LIG_14-3-3_CanoR_1 263 271 PF00244 0.442
LIG_14-3-3_CanoR_1 523 531 PF00244 0.434
LIG_14-3-3_CanoR_1 563 571 PF00244 0.371
LIG_14-3-3_CanoR_1 849 855 PF00244 0.488
LIG_14-3-3_CanoR_1 899 909 PF00244 0.523
LIG_Actin_WH2_2 345 361 PF00022 0.540
LIG_Actin_WH2_2 883 901 PF00022 0.512
LIG_BIR_III_4 230 234 PF00653 0.593
LIG_BRCT_BRCA1_1 165 169 PF00533 0.554
LIG_Clathr_ClatBox_1 618 622 PF01394 0.300
LIG_eIF4E_1 668 674 PF01652 0.277
LIG_FHA_1 169 175 PF00498 0.543
LIG_FHA_1 402 408 PF00498 0.566
LIG_FHA_1 415 421 PF00498 0.382
LIG_FHA_1 589 595 PF00498 0.502
LIG_FHA_1 602 608 PF00498 0.539
LIG_FHA_1 715 721 PF00498 0.446
LIG_FHA_1 764 770 PF00498 0.412
LIG_FHA_1 789 795 PF00498 0.418
LIG_FHA_1 799 805 PF00498 0.420
LIG_FHA_2 239 245 PF00498 0.652
LIG_FHA_2 30 36 PF00498 0.571
LIG_FHA_2 317 323 PF00498 0.653
LIG_FHA_2 437 443 PF00498 0.726
LIG_FHA_2 517 523 PF00498 0.393
LIG_FHA_2 607 613 PF00498 0.576
LIG_FHA_2 66 72 PF00498 0.507
LIG_FHA_2 853 859 PF00498 0.433
LIG_FHA_2 861 867 PF00498 0.307
LIG_Integrin_isoDGR_2 360 362 PF01839 0.511
LIG_LIR_Gen_1 504 512 PF02991 0.320
LIG_LIR_Gen_1 612 621 PF02991 0.577
LIG_LIR_Gen_1 667 674 PF02991 0.276
LIG_LIR_Nem_3 287 292 PF02991 0.429
LIG_LIR_Nem_3 346 352 PF02991 0.587
LIG_LIR_Nem_3 504 509 PF02991 0.358
LIG_LIR_Nem_3 612 618 PF02991 0.616
LIG_LIR_Nem_3 667 671 PF02991 0.263
LIG_LIR_Nem_3 779 785 PF02991 0.368
LIG_NRBOX 506 512 PF00104 0.365
LIG_PCNA_yPIPBox_3 467 478 PF02747 0.453
LIG_PDZ_Wminus1_1 908 910 PF00595 0.380
LIG_REV1ctd_RIR_1 347 358 PF16727 0.589
LIG_SH2_NCK_1 753 757 PF00017 0.640
LIG_SH2_PTP2 668 671 PF00017 0.263
LIG_SH2_SRC 787 790 PF00017 0.357
LIG_SH2_STAP1 289 293 PF00017 0.406
LIG_SH2_STAP1 571 575 PF00017 0.470
LIG_SH2_STAP1 615 619 PF00017 0.474
LIG_SH2_STAT3 253 256 PF00017 0.430
LIG_SH2_STAT5 292 295 PF00017 0.424
LIG_SH2_STAT5 668 671 PF00017 0.263
LIG_SH2_STAT5 795 798 PF00017 0.390
LIG_SH3_3 303 309 PF00018 0.511
LIG_SH3_3 448 454 PF00018 0.533
LIG_SH3_3 478 484 PF00018 0.436
LIG_SH3_3 535 541 PF00018 0.331
LIG_SH3_3 764 770 PF00018 0.423
LIG_SUMO_SIM_anti_2 419 424 PF11976 0.430
LIG_SUMO_SIM_anti_2 504 511 PF11976 0.321
LIG_SUMO_SIM_anti_2 863 869 PF11976 0.352
LIG_SUMO_SIM_par_1 508 514 PF11976 0.427
LIG_SUMO_SIM_par_1 891 896 PF11976 0.344
LIG_TRAF2_1 122 125 PF00917 0.621
LIG_TRAF2_1 188 191 PF00917 0.466
LIG_TRAF2_1 309 312 PF00917 0.533
LIG_TRAF2_1 341 344 PF00917 0.590
LIG_TRAF2_1 68 71 PF00917 0.518
LIG_TRFH_1 661 665 PF08558 0.436
LIG_TYR_ITAM 612 632 PF00017 0.425
LIG_TYR_ITIM 773 778 PF00017 0.312
LIG_WRC_WIRS_1 503 508 PF05994 0.520
MOD_CDC14_SPxK_1 38 41 PF00782 0.622
MOD_CDC14_SPxK_1 537 540 PF00782 0.368
MOD_CDK_SPxK_1 35 41 PF00069 0.623
MOD_CDK_SPxK_1 517 523 PF00069 0.352
MOD_CDK_SPxK_1 534 540 PF00069 0.258
MOD_CK1_1 238 244 PF00069 0.616
MOD_CK1_1 37 43 PF00069 0.626
MOD_CK1_1 432 438 PF00069 0.720
MOD_CK1_1 44 50 PF00069 0.677
MOD_CK1_1 445 451 PF00069 0.672
MOD_CK1_1 459 465 PF00069 0.351
MOD_CK1_1 51 57 PF00069 0.595
MOD_CK1_1 527 533 PF00069 0.389
MOD_CK1_1 580 586 PF00069 0.376
MOD_CK1_1 606 612 PF00069 0.679
MOD_CK1_1 667 673 PF00069 0.541
MOD_CK1_1 714 720 PF00069 0.498
MOD_CK2_1 1 7 PF00069 0.508
MOD_CK2_1 119 125 PF00069 0.638
MOD_CK2_1 185 191 PF00069 0.545
MOD_CK2_1 29 35 PF00069 0.568
MOD_CK2_1 296 302 PF00069 0.555
MOD_CK2_1 316 322 PF00069 0.653
MOD_CK2_1 606 612 PF00069 0.629
MOD_CK2_1 65 71 PF00069 0.523
MOD_CK2_1 866 872 PF00069 0.517
MOD_CMANNOS 824 827 PF00535 0.296
MOD_Cter_Amidation 399 402 PF01082 0.523
MOD_GlcNHglycan 106 109 PF01048 0.741
MOD_GlcNHglycan 135 138 PF01048 0.519
MOD_GlcNHglycan 16 19 PF01048 0.609
MOD_GlcNHglycan 187 190 PF01048 0.603
MOD_GlcNHglycan 226 229 PF01048 0.702
MOD_GlcNHglycan 274 278 PF01048 0.557
MOD_GlcNHglycan 286 289 PF01048 0.581
MOD_GlcNHglycan 298 301 PF01048 0.476
MOD_GlcNHglycan 32 35 PF01048 0.705
MOD_GlcNHglycan 393 396 PF01048 0.654
MOD_GlcNHglycan 434 437 PF01048 0.709
MOD_GlcNHglycan 50 53 PF01048 0.628
MOD_GlcNHglycan 566 569 PF01048 0.537
MOD_GlcNHglycan 57 60 PF01048 0.689
MOD_GlcNHglycan 642 645 PF01048 0.654
MOD_GlcNHglycan 676 679 PF01048 0.595
MOD_GlcNHglycan 680 683 PF01048 0.597
MOD_GlcNHglycan 701 704 PF01048 0.608
MOD_GlcNHglycan 756 759 PF01048 0.652
MOD_GlcNHglycan 818 821 PF01048 0.353
MOD_GlcNHglycan 830 834 PF01048 0.343
MOD_GSK3_1 100 107 PF00069 0.555
MOD_GSK3_1 159 166 PF00069 0.558
MOD_GSK3_1 30 37 PF00069 0.700
MOD_GSK3_1 414 421 PF00069 0.549
MOD_GSK3_1 432 439 PF00069 0.602
MOD_GSK3_1 44 51 PF00069 0.623
MOD_GSK3_1 442 449 PF00069 0.690
MOD_GSK3_1 452 459 PF00069 0.463
MOD_GSK3_1 602 609 PF00069 0.544
MOD_GSK3_1 617 624 PF00069 0.256
MOD_GSK3_1 674 681 PF00069 0.495
MOD_GSK3_1 699 706 PF00069 0.603
MOD_GSK3_1 742 749 PF00069 0.561
MOD_GSK3_1 773 780 PF00069 0.298
MOD_GSK3_1 798 805 PF00069 0.400
MOD_GSK3_1 848 855 PF00069 0.403
MOD_GSK3_1 856 863 PF00069 0.311
MOD_N-GLC_1 429 434 PF02516 0.656
MOD_N-GLC_1 602 607 PF02516 0.616
MOD_N-GLC_2 552 554 PF02516 0.416
MOD_NEK2_1 273 278 PF00069 0.605
MOD_NEK2_1 296 301 PF00069 0.456
MOD_NEK2_1 416 421 PF00069 0.439
MOD_NEK2_1 457 462 PF00069 0.347
MOD_NEK2_1 511 516 PF00069 0.424
MOD_NEK2_1 564 569 PF00069 0.423
MOD_NEK2_1 621 626 PF00069 0.413
MOD_NEK2_1 850 855 PF00069 0.359
MOD_OFUCOSY 528 533 PF10250 0.387
MOD_PIKK_1 316 322 PF00454 0.653
MOD_PIKK_1 41 47 PF00454 0.636
MOD_PIKK_1 714 720 PF00454 0.476
MOD_PIKK_1 852 858 PF00454 0.398
MOD_PKA_1 14 20 PF00069 0.597
MOD_PKA_1 175 181 PF00069 0.449
MOD_PKA_1 27 33 PF00069 0.503
MOD_PKA_1 401 407 PF00069 0.439
MOD_PKA_1 65 71 PF00069 0.513
MOD_PKA_2 133 139 PF00069 0.693
MOD_PKA_2 14 20 PF00069 0.630
MOD_PKA_2 163 169 PF00069 0.512
MOD_PKA_2 175 181 PF00069 0.490
MOD_PKA_2 262 268 PF00069 0.433
MOD_PKA_2 466 472 PF00069 0.405
MOD_PKA_2 728 734 PF00069 0.512
MOD_PKA_2 848 854 PF00069 0.485
MOD_PKB_1 183 191 PF00069 0.516
MOD_Plk_1 429 435 PF00069 0.629
MOD_Plk_1 602 608 PF00069 0.575
MOD_Plk_2-3 442 448 PF00069 0.572
MOD_Plk_4 418 424 PF00069 0.467
MOD_Plk_4 429 435 PF00069 0.458
MOD_Plk_4 502 508 PF00069 0.373
MOD_Plk_4 664 670 PF00069 0.437
MOD_Plk_4 683 689 PF00069 0.543
MOD_Plk_4 737 743 PF00069 0.409
MOD_Plk_4 773 779 PF00069 0.431
MOD_ProDKin_1 235 241 PF00069 0.662
MOD_ProDKin_1 35 41 PF00069 0.735
MOD_ProDKin_1 497 503 PF00069 0.431
MOD_ProDKin_1 517 523 PF00069 0.368
MOD_ProDKin_1 534 540 PF00069 0.369
MOD_ProDKin_1 642 648 PF00069 0.555
MOD_ProDKin_1 735 741 PF00069 0.550
MOD_ProDKin_1 798 804 PF00069 0.467
MOD_SUMO_rev_2 179 186 PF00179 0.460
MOD_SUMO_rev_2 188 198 PF00179 0.514
MOD_SUMO_rev_2 23 30 PF00179 0.722
MOD_SUMO_rev_2 58 68 PF00179 0.730
MOD_SUMO_rev_2 71 81 PF00179 0.497
TRG_DiLeu_BaEn_1 201 206 PF01217 0.563
TRG_DiLeu_BaEn_1 429 434 PF01217 0.414
TRG_DiLeu_BaEn_4 201 207 PF01217 0.586
TRG_DiLeu_LyEn_5 201 206 PF01217 0.478
TRG_ENDOCYTIC_2 615 618 PF00928 0.477
TRG_ENDOCYTIC_2 629 632 PF00928 0.395
TRG_ENDOCYTIC_2 668 671 PF00928 0.484
TRG_ENDOCYTIC_2 775 778 PF00928 0.316
TRG_ER_diArg_1 183 186 PF00400 0.565
TRG_ER_diArg_1 203 205 PF00400 0.324
TRG_ER_diArg_1 206 208 PF00400 0.469
TRG_ER_diArg_1 267 269 PF00400 0.435
TRG_ER_diArg_1 326 329 PF00400 0.609
TRG_ER_diArg_1 352 354 PF00400 0.596
TRG_ER_diArg_1 470 473 PF00400 0.411
TRG_ER_diArg_1 72 75 PF00400 0.520
TRG_ER_diArg_1 728 730 PF00400 0.296
TRG_ER_diArg_1 8 11 PF00400 0.554
TRG_Pf-PMV_PEXEL_1 8 13 PF00026 0.586

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PED2 Leptomonas seymouri 57% 100%
A0A0S4JR75 Bodo saltans 33% 100%
A0A1X0P8I2 Trypanosomatidae 41% 100%
A0A3Q8ID60 Leishmania donovani 100% 100%
A0A3R7KCG9 Trypanosoma rangeli 40% 100%
A4H9P9 Leishmania braziliensis 76% 100%
E9ART0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 99%
Q4QDP3 Leishmania major 93% 100%
Q8C761 Mus musculus 23% 91%
Q8WVS4 Homo sapiens 23% 85%
V5BNK6 Trypanosoma cruzi 41% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS