Putative pumilio protein 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumilio protein 2 - putative

Species:

Leishmania infantum

UniProt:

A4HY12_LEIIN

TriTrypDb:

LINF_180019600

Length:

895

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HY12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY12

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	450	454	PF00656	0.412
CLV_C14_Caspase3-7	829	833	PF00656	0.688
CLV_NRD_NRD_1	105	107	PF00675	0.706
CLV_NRD_NRD_1	45	47	PF00675	0.674
CLV_NRD_NRD_1	521	523	PF00675	0.493
CLV_NRD_NRD_1	782	784	PF00675	0.800
CLV_PCSK_KEX2_1	104	106	PF00082	0.709
CLV_PCSK_KEX2_1	45	47	PF00082	0.674
CLV_PCSK_KEX2_1	782	784	PF00082	0.800
CLV_PCSK_SKI1_1	265	269	PF00082	0.451
CLV_PCSK_SKI1_1	442	446	PF00082	0.412
CLV_PCSK_SKI1_1	457	461	PF00082	0.252
CLV_PCSK_SKI1_1	518	522	PF00082	0.542
DEG_APCC_DBOX_1	517	525	PF00400	0.492
DOC_CKS1_1	422	427	PF01111	0.454
DOC_CKS1_1	682	687	PF01111	0.685
DOC_CKS1_1	756	761	PF01111	0.645
DOC_CKS1_1	762	767	PF01111	0.678
DOC_CKS1_1	770	775	PF01111	0.603
DOC_MAPK_gen_1	416	423	PF00069	0.412
DOC_PP1_RVXF_1	314	321	PF00149	0.412
DOC_PP2B_LxvP_1	409	412	PF13499	0.412
DOC_PP4_FxxP_1	739	742	PF00568	0.705
DOC_PP4_MxPP_1	98	101	PF00568	0.650
DOC_SPAK_OSR1_1	418	422	PF12202	0.412
DOC_USP7_MATH_1	120	124	PF00917	0.707
DOC_USP7_MATH_1	152	156	PF00917	0.526
DOC_USP7_MATH_1	551	555	PF00917	0.703
DOC_USP7_MATH_1	644	648	PF00917	0.719
DOC_USP7_MATH_1	850	854	PF00917	0.699
DOC_USP7_MATH_1	860	864	PF00917	0.744
DOC_USP7_UBL2_3	457	461	PF12436	0.362
DOC_WW_Pin1_4	421	426	PF00397	0.479
DOC_WW_Pin1_4	490	495	PF00397	0.362
DOC_WW_Pin1_4	681	686	PF00397	0.737
DOC_WW_Pin1_4	755	760	PF00397	0.746
DOC_WW_Pin1_4	761	766	PF00397	0.762
DOC_WW_Pin1_4	769	774	PF00397	0.640
DOC_WW_Pin1_4	785	790	PF00397	0.727
DOC_WW_Pin1_4	806	811	PF00397	0.720
LIG_14-3-3_CanoR_1	79	87	PF00244	0.678
LIG_APCC_ABBA_1	177	182	PF00400	0.494
LIG_APCC_ABBA_1	221	226	PF00400	0.412
LIG_BIR_II_1	1	5	PF00653	0.641
LIG_BRCT_BRCA1_1	811	815	PF00533	0.733
LIG_CtBP_PxDLS_1	412	416	PF00389	0.412
LIG_FHA_1	166	172	PF00498	0.643
LIG_FHA_1	272	278	PF00498	0.510
LIG_FHA_1	422	428	PF00498	0.487
LIG_FHA_1	531	537	PF00498	0.476
LIG_FHA_2	21	27	PF00498	0.660
LIG_FHA_2	444	450	PF00498	0.422
LIG_FHA_2	493	499	PF00498	0.412
LIG_FHA_2	859	865	PF00498	0.643
LIG_Integrin_isoDGR_2	589	591	PF01839	0.678
LIG_LIR_Apic_2	684	689	PF02991	0.681
LIG_LIR_Apic_2	738	742	PF02991	0.636
LIG_LIR_Apic_2	753	759	PF02991	0.575
LIG_LIR_Gen_1	187	197	PF02991	0.492
LIG_LIR_Gen_1	222	231	PF02991	0.362
LIG_LIR_Gen_1	81	89	PF02991	0.636
LIG_LIR_Nem_3	187	193	PF02991	0.489
LIG_LIR_Nem_3	222	227	PF02991	0.394
LIG_LIR_Nem_3	229	234	PF02991	0.409
LIG_LIR_Nem_3	236	242	PF02991	0.281
LIG_LIR_Nem_3	478	483	PF02991	0.524
LIG_LIR_Nem_3	728	733	PF02991	0.663
LIG_LIR_Nem_3	81	87	PF02991	0.631
LIG_PCNA_yPIPBox_3	241	253	PF02747	0.412
LIG_Pex14_2	184	188	PF04695	0.530
LIG_PTB_Apo_2	791	798	PF02174	0.712
LIG_PTB_Phospho_1	791	797	PF10480	0.711
LIG_Rb_pABgroove_1	242	250	PF01858	0.412
LIG_SH2_CRK	190	194	PF00017	0.490
LIG_SH2_CRK	682	686	PF00017	0.688
LIG_SH2_CRK	703	707	PF00017	0.607
LIG_SH2_CRK	756	760	PF00017	0.662
LIG_SH2_CRK	84	88	PF00017	0.632
LIG_SH2_GRB2like	480	483	PF00017	0.412
LIG_SH2_GRB2like	583	586	PF00017	0.684
LIG_SH2_GRB2like	792	795	PF00017	0.707
LIG_SH2_GRB2like	883	886	PF00017	0.597
LIG_SH2_SRC	792	795	PF00017	0.707
LIG_SH2_STAP1	480	484	PF00017	0.412
LIG_SH2_STAP1	752	756	PF00017	0.736
LIG_SH2_STAP1	80	84	PF00017	0.639
LIG_SH2_STAT3	242	245	PF00017	0.412
LIG_SH2_STAT3	284	287	PF00017	0.412
LIG_SH2_STAT3	402	405	PF00017	0.412
LIG_SH2_STAT3	483	486	PF00017	0.412
LIG_SH2_STAT3	715	718	PF00017	0.704
LIG_SH2_STAT3	721	724	PF00017	0.637
LIG_SH2_STAT3	883	886	PF00017	0.684
LIG_SH2_STAT5	180	183	PF00017	0.489
LIG_SH2_STAT5	242	245	PF00017	0.412
LIG_SH2_STAT5	402	405	PF00017	0.412
LIG_SH2_STAT5	471	474	PF00017	0.412
LIG_SH2_STAT5	483	486	PF00017	0.412
LIG_SH2_STAT5	583	586	PF00017	0.609
LIG_SH2_STAT5	721	724	PF00017	0.595
LIG_SH2_STAT5	792	795	PF00017	0.707
LIG_SH2_STAT5	80	83	PF00017	0.642
LIG_SH3_3	539	545	PF00018	0.665
LIG_SH3_3	655	661	PF00018	0.722
LIG_SH3_3	693	699	PF00018	0.684
LIG_SH3_3	739	745	PF00018	0.585
LIG_SH3_3	90	96	PF00018	0.662
LIG_SH3_5	186	190	PF00018	0.502
LIG_TRAF2_1	260	263	PF00917	0.504
LIG_TRAF2_1	447	450	PF00917	0.412
LIG_TRAF2_1	74	77	PF00917	0.749
LIG_TRAF2_1	889	892	PF00917	0.635
LIG_UBA3_1	269	276	PF00899	0.464
LIG_UBA3_1	309	316	PF00899	0.441
LIG_UBA3_1	455	461	PF00899	0.412
LIG_WRC_WIRS_1	181	186	PF05994	0.524
LIG_WRC_WIRS_1	197	202	PF05994	0.412
MOD_CDK_SPxxK_3	490	497	PF00069	0.362
MOD_CK1_1	128	134	PF00069	0.784
MOD_CK1_1	155	161	PF00069	0.532
MOD_CK1_1	285	291	PF00069	0.449
MOD_CK1_1	3	9	PF00069	0.610
MOD_CK1_1	601	607	PF00069	0.597
MOD_CK1_1	625	631	PF00069	0.632
MOD_CK1_1	763	769	PF00069	0.745
MOD_CK1_1	809	815	PF00069	0.747
MOD_CK1_1	853	859	PF00069	0.698
MOD_CK1_1	873	879	PF00069	0.618
MOD_CK2_1	443	449	PF00069	0.422
MOD_CK2_1	492	498	PF00069	0.412
MOD_CK2_1	540	546	PF00069	0.533
MOD_CK2_1	566	572	PF00069	0.595
MOD_GlcNHglycan	122	125	PF01048	0.806
MOD_GlcNHglycan	154	157	PF01048	0.494
MOD_GlcNHglycan	338	341	PF01048	0.478
MOD_GlcNHglycan	541	545	PF01048	0.647
MOD_GlcNHglycan	553	556	PF01048	0.606
MOD_GlcNHglycan	557	560	PF01048	0.572
MOD_GlcNHglycan	568	571	PF01048	0.588
MOD_GlcNHglycan	594	597	PF01048	0.722
MOD_GlcNHglycan	603	606	PF01048	0.710
MOD_GlcNHglycan	611	614	PF01048	0.659
MOD_GlcNHglycan	727	730	PF01048	0.696
MOD_GlcNHglycan	739	742	PF01048	0.657
MOD_GlcNHglycan	8	11	PF01048	0.615
MOD_GlcNHglycan	836	839	PF01048	0.673
MOD_GlcNHglycan	842	845	PF01048	0.785
MOD_GlcNHglycan	848	851	PF01048	0.681
MOD_GlcNHglycan	853	856	PF01048	0.603
MOD_GSK3_1	125	132	PF00069	0.773
MOD_GSK3_1	151	158	PF00069	0.548
MOD_GSK3_1	165	172	PF00069	0.554
MOD_GSK3_1	192	199	PF00069	0.500
MOD_GSK3_1	430	437	PF00069	0.412
MOD_GSK3_1	507	514	PF00069	0.512
MOD_GSK3_1	52	59	PF00069	0.674
MOD_GSK3_1	530	537	PF00069	0.571
MOD_GSK3_1	551	558	PF00069	0.694
MOD_GSK3_1	561	568	PF00069	0.670
MOD_GSK3_1	577	584	PF00069	0.560
MOD_GSK3_1	622	629	PF00069	0.675
MOD_GSK3_1	760	767	PF00069	0.742
MOD_GSK3_1	806	813	PF00069	0.758
MOD_GSK3_1	846	853	PF00069	0.675
MOD_GSK3_1	868	875	PF00069	0.716
MOD_N-GLC_1	3	8	PF02516	0.684
MOD_N-GLC_1	511	516	PF02516	0.519
MOD_N-GLC_1	551	556	PF02516	0.671
MOD_N-GLC_1	565	570	PF02516	0.676
MOD_N-GLC_1	601	606	PF02516	0.685
MOD_N-GLC_1	609	614	PF02516	0.655
MOD_N-GLC_1	625	630	PF02516	0.542
MOD_N-GLC_1	750	755	PF02516	0.681
MOD_N-GLC_1	810	815	PF02516	0.653
MOD_N-GLC_1	846	851	PF02516	0.620
MOD_N-GLC_1	858	863	PF02516	0.659
MOD_N-GLC_1	873	878	PF02516	0.568
MOD_NEK2_1	119	124	PF00069	0.754
MOD_NEK2_1	28	33	PF00069	0.682
MOD_NEK2_1	282	287	PF00069	0.412
MOD_NEK2_1	430	435	PF00069	0.496
MOD_NEK2_1	476	481	PF00069	0.474
MOD_NEK2_1	52	57	PF00069	0.680
MOD_NEK2_1	530	535	PF00069	0.458
MOD_NEK2_1	760	765	PF00069	0.728
MOD_NEK2_1	87	92	PF00069	0.654
MOD_NEK2_1	870	875	PF00069	0.624
MOD_NEK2_2	180	185	PF00069	0.508
MOD_NEK2_2	750	755	PF00069	0.681
MOD_NEK2_2	810	815	PF00069	0.653
MOD_PIKK_1	170	176	PF00454	0.539
MOD_PIKK_1	492	498	PF00454	0.412
MOD_PIKK_1	534	540	PF00454	0.476
MOD_PIKK_1	764	770	PF00454	0.684
MOD_PIKK_1	815	821	PF00454	0.670
MOD_PIKK_1	874	880	PF00454	0.585
MOD_PKA_2	142	148	PF00069	0.652
MOD_PKA_2	271	277	PF00069	0.509
MOD_PKA_2	561	567	PF00069	0.755
MOD_PKA_2	590	596	PF00069	0.606
MOD_PKA_2	78	84	PF00069	0.686
MOD_Plk_1	282	288	PF00069	0.412
MOD_Plk_1	392	398	PF00069	0.412
MOD_Plk_1	511	517	PF00069	0.512
MOD_Plk_1	750	756	PF00069	0.683
MOD_Plk_1	810	816	PF00069	0.673
MOD_Plk_1	831	837	PF00069	0.708
MOD_Plk_4	219	225	PF00069	0.362
MOD_Plk_4	511	517	PF00069	0.512
MOD_Plk_4	52	58	PF00069	0.747
MOD_Plk_4	530	536	PF00069	0.311
MOD_Plk_4	652	658	PF00069	0.730
MOD_Plk_4	810	816	PF00069	0.651
MOD_ProDKin_1	421	427	PF00069	0.473
MOD_ProDKin_1	490	496	PF00069	0.362
MOD_ProDKin_1	681	687	PF00069	0.738
MOD_ProDKin_1	755	761	PF00069	0.744
MOD_ProDKin_1	769	775	PF00069	0.641
MOD_ProDKin_1	785	791	PF00069	0.726
MOD_ProDKin_1	806	812	PF00069	0.720
MOD_SUMO_for_1	252	255	PF00179	0.485
MOD_SUMO_rev_2	257	267	PF00179	0.475
MOD_SUMO_rev_2	312	318	PF00179	0.362
MOD_SUMO_rev_2	453	462	PF00179	0.412
TRG_DiLeu_BaEn_3	450	456	PF01217	0.412
TRG_DiLeu_BaEn_4	229	235	PF01217	0.412
TRG_DiLeu_BaLyEn_6	209	214	PF01217	0.412
TRG_ENDOCYTIC_2	190	193	PF00928	0.482
TRG_ENDOCYTIC_2	673	676	PF00928	0.718
TRG_ENDOCYTIC_2	84	87	PF00928	0.629
TRG_ER_diArg_1	104	106	PF00400	0.709
TRG_ER_diArg_1	415	418	PF00400	0.412
TRG_ER_diArg_1	44	46	PF00400	0.659
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H745	Leishmania donovani	99%	100%
A4H9P5	Leishmania braziliensis	77%	95%
E9ARS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	98%
Q4QDP7	Leishmania major	94%	99%