Pyruvate metabolism, pyruvate dehydrogenase E1 component alpha subunit
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | yes | yes: 25 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 7 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | yes | yes: 14 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 11 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005737 | cytoplasm | 2 | 1 |
| GO:0110165 | cellular anatomical entity | 1 | 4 |
| GO:0043226 | organelle | 2 | 3 |
| GO:0043227 | membrane-bounded organelle | 3 | 3 |
| GO:0043229 | intracellular organelle | 3 | 3 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 3 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pescher et al. (upgregulation) | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
|
Lahav et al. - mRNA
- Protein
|
Related structures:
AlphaFold database: A4HY08
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006082 | organic acid metabolic process | 3 | 4 |
| GO:0006084 | acetyl-CoA metabolic process | 5 | 4 |
| GO:0006085 | acetyl-CoA biosynthetic process | 6 | 4 |
| GO:0006086 | acetyl-CoA biosynthetic process from pyruvate | 7 | 4 |
| GO:0006090 | pyruvate metabolic process | 7 | 4 |
| GO:0006139 | nucleobase-containing compound metabolic process | 3 | 4 |
| GO:0006163 | purine nucleotide metabolic process | 5 | 4 |
| GO:0006164 | purine nucleotide biosynthetic process | 6 | 4 |
| GO:0006637 | acyl-CoA metabolic process | 4 | 4 |
| GO:0006725 | cellular aromatic compound metabolic process | 3 | 4 |
| GO:0006753 | nucleoside phosphate metabolic process | 4 | 4 |
| GO:0006790 | sulfur compound metabolic process | 3 | 4 |
| GO:0006793 | phosphorus metabolic process | 3 | 4 |
| GO:0006796 | phosphate-containing compound metabolic process | 4 | 4 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 4 |
| GO:0008152 | metabolic process | 1 | 4 |
| GO:0009058 | biosynthetic process | 2 | 4 |
| GO:0009117 | nucleotide metabolic process | 5 | 4 |
| GO:0009150 | purine ribonucleotide metabolic process | 6 | 4 |
| GO:0009152 | purine ribonucleotide biosynthetic process | 7 | 4 |
| GO:0009165 | nucleotide biosynthetic process | 6 | 4 |
| GO:0009259 | ribonucleotide metabolic process | 5 | 4 |
| GO:0009260 | ribonucleotide biosynthetic process | 6 | 4 |
| GO:0009987 | cellular process | 1 | 4 |
| GO:0018130 | heterocycle biosynthetic process | 4 | 4 |
| GO:0019438 | aromatic compound biosynthetic process | 4 | 4 |
| GO:0019637 | organophosphate metabolic process | 3 | 4 |
| GO:0019693 | ribose phosphate metabolic process | 4 | 4 |
| GO:0019752 | carboxylic acid metabolic process | 5 | 4 |
| GO:0032787 | monocarboxylic acid metabolic process | 6 | 4 |
| GO:0033865 | nucleoside bisphosphate metabolic process | 5 | 4 |
| GO:0033866 | nucleoside bisphosphate biosynthetic process | 6 | 4 |
| GO:0033875 | ribonucleoside bisphosphate metabolic process | 6 | 4 |
| GO:0034030 | ribonucleoside bisphosphate biosynthetic process | 7 | 4 |
| GO:0034032 | purine nucleoside bisphosphate metabolic process | 5 | 4 |
| GO:0034033 | purine nucleoside bisphosphate biosynthetic process | 6 | 4 |
| GO:0034641 | cellular nitrogen compound metabolic process | 3 | 4 |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 4 | 4 |
| GO:0035383 | thioester metabolic process | 3 | 4 |
| GO:0035384 | thioester biosynthetic process | 4 | 4 |
| GO:0043436 | oxoacid metabolic process | 4 | 4 |
| GO:0043603 | amide metabolic process | 3 | 4 |
| GO:0043604 | amide biosynthetic process | 4 | 4 |
| GO:0044237 | cellular metabolic process | 2 | 4 |
| GO:0044238 | primary metabolic process | 2 | 4 |
| GO:0044249 | cellular biosynthetic process | 3 | 4 |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 4 | 4 |
| GO:0044272 | sulfur compound biosynthetic process | 4 | 4 |
| GO:0044281 | small molecule metabolic process | 2 | 4 |
| GO:0046390 | ribose phosphate biosynthetic process | 5 | 4 |
| GO:0046483 | heterocycle metabolic process | 3 | 4 |
| GO:0055086 | nucleobase-containing small molecule metabolic process | 3 | 4 |
| GO:0071616 | acyl-CoA biosynthetic process | 5 | 4 |
| GO:0071704 | organic substance metabolic process | 2 | 4 |
| GO:0072521 | purine-containing compound metabolic process | 4 | 4 |
| GO:0072522 | purine-containing compound biosynthetic process | 5 | 4 |
| GO:0090407 | organophosphate biosynthetic process | 4 | 4 |
| GO:1901135 | carbohydrate derivative metabolic process | 3 | 4 |
| GO:1901137 | carbohydrate derivative biosynthetic process | 4 | 4 |
| GO:1901293 | nucleoside phosphate biosynthetic process | 5 | 4 |
| GO:1901360 | organic cyclic compound metabolic process | 3 | 4 |
| GO:1901362 | organic cyclic compound biosynthetic process | 4 | 4 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 4 |
| GO:1901566 | organonitrogen compound biosynthetic process | 4 | 4 |
| GO:1901576 | organic substance biosynthetic process | 3 | 4 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 12 |
| GO:0004738 | pyruvate dehydrogenase activity | 4 | 10 |
| GO:0004739 | pyruvate dehydrogenase (acetyl-transferring) activity | 5 | 10 |
| GO:0016491 | oxidoreductase activity | 2 | 12 |
| GO:0016624 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor | 4 | 12 |
| GO:0016903 | oxidoreductase activity, acting on the aldehyde or oxo group of donors | 3 | 12 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 172 | 176 | PF00656 | 0.533 |
| CLV_C14_Caspase3-7 | 286 | 290 | PF00656 | 0.428 |
| CLV_NRD_NRD_1 | 235 | 237 | PF00675 | 0.239 |
| CLV_NRD_NRD_1 | 308 | 310 | PF00675 | 0.248 |
| CLV_NRD_NRD_1 | 58 | 60 | PF00675 | 0.224 |
| CLV_PCSK_FUR_1 | 56 | 60 | PF00082 | 0.228 |
| CLV_PCSK_KEX2_1 | 235 | 237 | PF00082 | 0.233 |
| CLV_PCSK_KEX2_1 | 58 | 60 | PF00082 | 0.224 |
| CLV_PCSK_SKI1_1 | 21 | 25 | PF00082 | 0.447 |
| CLV_PCSK_SKI1_1 | 3 | 7 | PF00082 | 0.575 |
| CLV_PCSK_SKI1_1 | 331 | 335 | PF00082 | 0.228 |
| DEG_Nend_Nbox_1 | 1 | 3 | PF02207 | 0.537 |
| DOC_CYCLIN_RxL_1 | 3 | 14 | PF00134 | 0.551 |
| DOC_MAPK_DCC_7 | 235 | 245 | PF00069 | 0.439 |
| DOC_MAPK_gen_1 | 48 | 55 | PF00069 | 0.309 |
| DOC_MAPK_gen_1 | 71 | 81 | PF00069 | 0.425 |
| DOC_MAPK_MEF2A_6 | 236 | 245 | PF00069 | 0.439 |
| DOC_MAPK_MEF2A_6 | 48 | 55 | PF00069 | 0.379 |
| DOC_MAPK_NFAT4_5 | 48 | 56 | PF00069 | 0.444 |
| DOC_PP2B_PxIxI_1 | 240 | 246 | PF00149 | 0.489 |
| DOC_PP4_FxxP_1 | 96 | 99 | PF00568 | 0.514 |
| DOC_USP7_MATH_1 | 157 | 161 | PF00917 | 0.506 |
| DOC_USP7_MATH_1 | 225 | 229 | PF00917 | 0.514 |
| DOC_USP7_UBL2_3 | 331 | 335 | PF12436 | 0.444 |
| DOC_WW_Pin1_4 | 173 | 178 | PF00397 | 0.533 |
| LIG_14-3-3_CanoR_1 | 293 | 301 | PF00244 | 0.445 |
| LIG_FHA_1 | 12 | 18 | PF00498 | 0.282 |
| LIG_FHA_1 | 315 | 321 | PF00498 | 0.533 |
| LIG_FHA_1 | 4 | 10 | PF00498 | 0.575 |
| LIG_FHA_2 | 292 | 298 | PF00498 | 0.453 |
| LIG_FHA_2 | 320 | 326 | PF00498 | 0.421 |
| LIG_FHA_2 | 348 | 354 | PF00498 | 0.529 |
| LIG_FHA_2 | 93 | 99 | PF00498 | 0.437 |
| LIG_Integrin_RGD_1 | 236 | 238 | PF01839 | 0.239 |
| LIG_LIR_Apic_2 | 373 | 378 | PF02991 | 0.490 |
| LIG_LIR_Apic_2 | 95 | 99 | PF02991 | 0.514 |
| LIG_LIR_Gen_1 | 118 | 125 | PF02991 | 0.430 |
| LIG_LIR_Gen_1 | 353 | 361 | PF02991 | 0.423 |
| LIG_LIR_Nem_3 | 353 | 359 | PF02991 | 0.399 |
| LIG_PCNA_PIPBox_1 | 349 | 358 | PF02747 | 0.563 |
| LIG_Pex14_2 | 121 | 125 | PF04695 | 0.428 |
| LIG_PTB_Apo_2 | 143 | 150 | PF02174 | 0.469 |
| LIG_PTB_Apo_2 | 212 | 219 | PF02174 | 0.514 |
| LIG_PTB_Phospho_1 | 143 | 149 | PF10480 | 0.489 |
| LIG_SH2_SRC | 239 | 242 | PF00017 | 0.428 |
| LIG_SH2_STAT3 | 80 | 83 | PF00017 | 0.439 |
| LIG_SH2_STAT5 | 110 | 113 | PF00017 | 0.469 |
| LIG_SH2_STAT5 | 239 | 242 | PF00017 | 0.428 |
| LIG_SH2_STAT5 | 360 | 363 | PF00017 | 0.461 |
| LIG_SH2_STAT5 | 80 | 83 | PF00017 | 0.439 |
| LIG_SH3_1 | 13 | 19 | PF00018 | 0.351 |
| LIG_SH3_2 | 16 | 21 | PF14604 | 0.400 |
| LIG_SH3_3 | 13 | 19 | PF00018 | 0.369 |
| LIG_SUMO_SIM_anti_2 | 50 | 55 | PF11976 | 0.394 |
| LIG_SUMO_SIM_par_1 | 249 | 255 | PF11976 | 0.428 |
| LIG_TRAF2_1 | 252 | 255 | PF00917 | 0.428 |
| LIG_WRC_WIRS_1 | 93 | 98 | PF05994 | 0.514 |
| MOD_CDK_SPK_2 | 173 | 178 | PF00069 | 0.533 |
| MOD_CK2_1 | 319 | 325 | PF00069 | 0.421 |
| MOD_GlcNHglycan | 222 | 225 | PF01048 | 0.333 |
| MOD_GlcNHglycan | 265 | 268 | PF01048 | 0.239 |
| MOD_GSK3_1 | 24 | 31 | PF00069 | 0.498 |
| MOD_GSK3_1 | 366 | 373 | PF00069 | 0.451 |
| MOD_NEK2_1 | 220 | 225 | PF00069 | 0.514 |
| MOD_NEK2_1 | 281 | 286 | PF00069 | 0.469 |
| MOD_NEK2_1 | 47 | 52 | PF00069 | 0.473 |
| MOD_NEK2_1 | 9 | 14 | PF00069 | 0.531 |
| MOD_NEK2_2 | 370 | 375 | PF00069 | 0.575 |
| MOD_PIKK_1 | 35 | 41 | PF00454 | 0.457 |
| MOD_PKA_2 | 225 | 231 | PF00069 | 0.469 |
| MOD_Plk_1 | 64 | 70 | PF00069 | 0.439 |
| MOD_Plk_4 | 180 | 186 | PF00069 | 0.453 |
| MOD_Plk_4 | 370 | 376 | PF00069 | 0.458 |
| MOD_ProDKin_1 | 173 | 179 | PF00069 | 0.533 |
| MOD_SUMO_for_1 | 301 | 304 | PF00179 | 0.501 |
| MOD_SUMO_for_1 | 333 | 336 | PF00179 | 0.431 |
| TRG_ENDOCYTIC_2 | 196 | 199 | PF00928 | 0.533 |
| TRG_ENDOCYTIC_2 | 278 | 281 | PF00928 | 0.428 |
| TRG_ER_diArg_1 | 234 | 236 | PF00400 | 0.439 |
| TRG_ER_diArg_1 | 55 | 58 | PF00400 | 0.426 |
| TRG_NES_CRM1_1 | 45 | 61 | PF08389 | 0.337 |
| TRG_NLS_Bipartite_1 | 58 | 75 | PF00514 | 0.428 |
| TRG_NLS_MonoExtN_4 | 69 | 75 | PF00514 | 0.428 |
| TRG_Pf-PMV_PEXEL_1 | 7 | 11 | PF00026 | 0.550 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1IKY9 | Leptomonas seymouri | 83% | 100% |
| A0A0N1P9U6 | Leptomonas seymouri | 24% | 80% |
| A0A0S4JJY6 | Bodo saltans | 68% | 100% |
| A0A1X0NHX6 | Trypanosomatidae | 24% | 91% |
| A0A1X0P7C8 | Trypanosomatidae | 77% | 100% |
| A0A3Q8IB83 | Leishmania donovani | 100% | 100% |
| A0A3R7KFA1 | Trypanosoma rangeli | 74% | 100% |
| A0A3S7WWV0 | Leishmania donovani | 26% | 79% |
| A0A422NSQ8 | Trypanosoma rangeli | 25% | 88% |
| A4H9P1 | Leishmania braziliensis | 93% | 100% |
| A4HC14 | Leishmania braziliensis | 24% | 100% |
| A4HZE0 | Leishmania infantum | 26% | 79% |
| A5A6H9 | Pan troglodytes | 27% | 85% |
| A5A6L0 | Pan troglodytes | 46% | 97% |
| A7MB35 | Bos taurus | 45% | 97% |
| D0A145 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 26% | 91% |
| D0A589 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 71% | 100% |
| E9ARS2 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 97% | 100% |
| E9AVC7 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 25% | 100% |
| G0SHF3 | Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) | 42% | 92% |
| O13366 | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) | 51% | 92% |
| O24457 | Arabidopsis thaliana | 35% | 88% |
| O31404 | Bacillus subtilis (strain 168) | 34% | 100% |
| O45924 | Caenorhabditis elegans | 26% | 88% |
| O66112 | Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) | 44% | 100% |
| P08559 | Homo sapiens | 46% | 97% |
| P09060 | Pseudomonas putida | 27% | 92% |
| P11178 | Bos taurus | 26% | 83% |
| P11960 | Rattus norvegicus | 25% | 86% |
| P12694 | Homo sapiens | 27% | 85% |
| P16387 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 51% | 90% |
| P21873 | Geobacillus stearothermophilus | 32% | 100% |
| P21881 | Bacillus subtilis (strain 168) | 32% | 100% |
| P26267 | Ascaris suum | 47% | 95% |
| P26268 | Ascaris suum | 47% | 97% |
| P26284 | Rattus norvegicus | 46% | 97% |
| P27745 | Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337) | 34% | 100% |
| P29803 | Homo sapiens | 49% | 97% |
| P29804 | Sus scrofa | 46% | 97% |
| P35485 | Acholeplasma laidlawii | 31% | 100% |
| P35486 | Mus musculus | 46% | 97% |
| P35487 | Mus musculus | 47% | 97% |
| P37940 | Bacillus subtilis (strain 168) | 27% | 100% |
| P47516 | Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) | 28% | 100% |
| P50136 | Mus musculus | 25% | 86% |
| P51267 | Porphyra purpurea | 36% | 100% |
| P52899 | Caenorhabditis elegans | 51% | 95% |
| P52900 | Sminthopsis macroura | 49% | 100% |
| P52901 | Arabidopsis thaliana | 48% | 97% |
| P52902 | Pisum sativum | 48% | 95% |
| P52903 | Solanum tuberosum | 47% | 97% |
| P60089 | Staphylococcus aureus (strain Mu50 / ATCC 700699) | 33% | 100% |
| P60090 | Staphylococcus aureus (strain MW2) | 33% | 100% |
| P75390 | Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) | 30% | 100% |
| P9WIS2 | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) | 26% | 100% |
| P9WIS3 | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | 26% | 100% |
| Q06437 | Rattus norvegicus | 48% | 97% |
| Q10489 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 48% | 92% |
| Q1RJX4 | Rickettsia bellii (strain RML369-C) | 44% | 100% |
| Q1XDM0 | Neopyropia yezoensis | 36% | 100% |
| Q4MTG0 | Bacillus cereus | 32% | 100% |
| Q4QC52 | Leishmania major | 24% | 100% |
| Q4QDQ1 | Leishmania major | 98% | 100% |
| Q4UKQ6 | Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) | 42% | 100% |
| Q54C70 | Dictyostelium discoideum | 50% | 100% |
| Q54M22 | Dictyostelium discoideum | 27% | 86% |
| Q5HGZ1 | Staphylococcus aureus (strain COL) | 33% | 100% |
| Q5HQ76 | Staphylococcus epidermidis (strain ATCC 35984 / RP62A) | 32% | 100% |
| Q5R490 | Pongo abelii | 46% | 97% |
| Q5SLR4 | Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) | 27% | 100% |
| Q654V6 | Oryza sativa subsp. japonica | 49% | 95% |
| Q68XA9 | Rickettsia typhi (strain ATCC VR-144 / Wilmington) | 42% | 100% |
| Q6GAC1 | Staphylococcus aureus (strain MSSA476) | 33% | 100% |
| Q6GHZ2 | Staphylococcus aureus (strain MRSA252) | 33% | 100% |
| Q6Z5N4 | Oryza sativa subsp. japonica | 49% | 97% |
| Q72GU1 | Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) | 27% | 100% |
| Q7XTJ3 | Oryza sativa subsp. japonica | 35% | 89% |
| Q820A6 | Staphylococcus aureus (strain N315) | 33% | 100% |
| Q84JL2 | Arabidopsis thaliana | 27% | 80% |
| Q8CPN3 | Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) | 32% | 100% |
| Q8H1Y0 | Arabidopsis thaliana | 48% | 96% |
| Q8HXW9 | Macaca fascicularis | 45% | 97% |
| Q8HXY4 | Macaca fascicularis | 27% | 85% |
| Q92IS3 | Rickettsia conorii (strain ATCC VR-613 / Malish 7) | 43% | 100% |
| Q9I1M2 | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 26% | 92% |
| Q9LPL5 | Arabidopsis thaliana | 28% | 80% |
| Q9R9N5 | Rhizobium meliloti (strain 1021) | 48% | 100% |
| Q9ZDR4 | Rickettsia prowazekii (strain Madrid E) | 42% | 100% |
| V5AZ52 | Trypanosoma cruzi | 74% | 100% |
| V5DIA0 | Trypanosoma cruzi | 25% | 88% |