Zinc finger (CCCH type) motif-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania infantum

UniProt:

A4HY05_LEIIN

TriTrypDb:

LINF_180018700

Length:

767

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HY05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY05

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.664
CLV_NRD_NRD_1	371	373	PF00675	0.686
CLV_NRD_NRD_1	440	442	PF00675	0.599
CLV_NRD_NRD_1	464	466	PF00675	0.579
CLV_PCSK_FUR_1	544	548	PF00082	0.555
CLV_PCSK_KEX2_1	371	373	PF00082	0.686
CLV_PCSK_KEX2_1	546	548	PF00082	0.583
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.583
CLV_PCSK_SKI1_1	292	296	PF00082	0.576
CLV_PCSK_SKI1_1	436	440	PF00082	0.545
CLV_PCSK_SKI1_1	6	10	PF00082	0.697
CLV_Separin_Metazoa	208	212	PF03568	0.551
DEG_Nend_Nbox_1	1	3	PF02207	0.647
DEG_SPOP_SBC_1	245	249	PF00917	0.712
DOC_ANK_TNKS_1	215	222	PF00023	0.549
DOC_CDC14_PxL_1	483	491	PF14671	0.558
DOC_CKS1_1	321	326	PF01111	0.723
DOC_CKS1_1	53	58	PF01111	0.677
DOC_CKS1_1	710	715	PF01111	0.736
DOC_CKS1_1	94	99	PF01111	0.666
DOC_CYCLIN_RxL_1	473	485	PF00134	0.530
DOC_MAPK_gen_1	465	474	PF00069	0.542
DOC_MAPK_MEF2A_6	427	434	PF00069	0.535
DOC_PP2B_LxvP_1	417	420	PF13499	0.549
DOC_PP2B_LxvP_1	724	727	PF13499	0.649
DOC_PP2B_PxIxI_1	44	50	PF00149	0.777
DOC_PP4_FxxP_1	170	173	PF00568	0.596
DOC_PP4_FxxP_1	303	306	PF00568	0.700
DOC_PP4_FxxP_1	651	654	PF00568	0.705
DOC_USP7_MATH_1	122	126	PF00917	0.685
DOC_USP7_MATH_1	134	138	PF00917	0.523
DOC_USP7_MATH_1	183	187	PF00917	0.662
DOC_USP7_MATH_1	198	202	PF00917	0.618
DOC_USP7_MATH_1	329	333	PF00917	0.692
DOC_USP7_MATH_1	356	360	PF00917	0.720
DOC_USP7_MATH_1	388	392	PF00917	0.571
DOC_USP7_MATH_1	477	481	PF00917	0.426
DOC_USP7_MATH_1	578	582	PF00917	0.667
DOC_USP7_MATH_1	67	71	PF00917	0.656
DOC_USP7_MATH_1	729	733	PF00917	0.718
DOC_USP7_MATH_1	89	93	PF00917	0.647
DOC_WW_Pin1_4	129	134	PF00397	0.723
DOC_WW_Pin1_4	155	160	PF00397	0.680
DOC_WW_Pin1_4	162	167	PF00397	0.583
DOC_WW_Pin1_4	169	174	PF00397	0.667
DOC_WW_Pin1_4	181	186	PF00397	0.610
DOC_WW_Pin1_4	239	244	PF00397	0.707
DOC_WW_Pin1_4	247	252	PF00397	0.622
DOC_WW_Pin1_4	258	263	PF00397	0.496
DOC_WW_Pin1_4	275	280	PF00397	0.521
DOC_WW_Pin1_4	302	307	PF00397	0.700
DOC_WW_Pin1_4	317	322	PF00397	0.586
DOC_WW_Pin1_4	352	357	PF00397	0.799
DOC_WW_Pin1_4	395	400	PF00397	0.680
DOC_WW_Pin1_4	41	46	PF00397	0.765
DOC_WW_Pin1_4	501	506	PF00397	0.562
DOC_WW_Pin1_4	52	57	PF00397	0.595
DOC_WW_Pin1_4	666	671	PF00397	0.707
DOC_WW_Pin1_4	675	680	PF00397	0.668
DOC_WW_Pin1_4	709	714	PF00397	0.734
DOC_WW_Pin1_4	742	747	PF00397	0.675
DOC_WW_Pin1_4	748	753	PF00397	0.617
DOC_WW_Pin1_4	93	98	PF00397	0.668
LIG_14-3-3_CanoR_1	113	117	PF00244	0.748
LIG_APCC_ABBAyCdc20_2	340	346	PF00400	0.595
LIG_BIR_III_4	293	297	PF00653	0.694
LIG_BRCT_BRCA1_1	125	129	PF00533	0.692
LIG_BRCT_BRCA1_1	131	135	PF00533	0.661
LIG_BRCT_BRCA1_1	151	155	PF00533	0.465
LIG_BRCT_BRCA1_1	266	270	PF00533	0.668
LIG_eIF4E_1	703	709	PF01652	0.757
LIG_FHA_1	159	165	PF00498	0.696
LIG_FHA_1	255	261	PF00498	0.664
LIG_FHA_1	263	269	PF00498	0.610
LIG_FHA_1	382	388	PF00498	0.564
LIG_FHA_1	525	531	PF00498	0.597
LIG_FHA_1	78	84	PF00498	0.706
LIG_FHA_2	593	599	PF00498	0.564
LIG_HP1_1	687	691	PF01393	0.744
LIG_Integrin_RGD_1	326	328	PF01839	0.608
LIG_LIR_Apic_2	302	306	PF02991	0.701
LIG_LIR_Apic_2	649	654	PF02991	0.709
LIG_LIR_Gen_1	410	421	PF02991	0.553
LIG_LIR_Gen_1	756	765	PF02991	0.641
LIG_LIR_Nem_3	410	416	PF02991	0.558
LIG_LIR_Nem_3	485	489	PF02991	0.571
LIG_LIR_Nem_3	756	760	PF02991	0.687
LIG_LYPXL_yS_3	486	489	PF13949	0.543
LIG_LYPXL_yS_3	661	664	PF13949	0.755
LIG_REV1ctd_RIR_1	61	70	PF16727	0.663
LIG_SH2_GRB2like	537	540	PF00017	0.551
LIG_SH2_PTP2	688	691	PF00017	0.751
LIG_SH2_SRC	703	706	PF00017	0.727
LIG_SH2_STAP1	409	413	PF00017	0.567
LIG_SH2_STAT5	537	540	PF00017	0.551
LIG_SH2_STAT5	688	691	PF00017	0.751
LIG_SH2_STAT5	703	706	PF00017	0.760
LIG_SH3_2	321	326	PF14604	0.690
LIG_SH3_3	176	182	PF00018	0.671
LIG_SH3_3	201	207	PF00018	0.768
LIG_SH3_3	219	225	PF00018	0.660
LIG_SH3_3	318	324	PF00018	0.805
LIG_SH3_3	484	490	PF00018	0.552
LIG_SH3_3	494	500	PF00018	0.437
LIG_SH3_3	50	56	PF00018	0.674
LIG_SH3_3	572	578	PF00018	0.566
LIG_SH3_3	620	626	PF00018	0.696
LIG_SH3_3	673	679	PF00018	0.783
LIG_SH3_3	707	713	PF00018	0.679
LIG_SH3_3	743	749	PF00018	0.729
LIG_SH3_3	91	97	PF00018	0.673
LIG_SUMO_SIM_anti_2	493	499	PF11976	0.580
LIG_SUMO_SIM_par_1	160	165	PF11976	0.668
LIG_SUMO_SIM_par_1	404	412	PF11976	0.428
LIG_TRFH_1	651	655	PF08558	0.639
MOD_CDK_SPK_2	317	322	PF00069	0.803
MOD_CDK_SPxK_1	320	326	PF00069	0.717
MOD_CDK_SPxxK_3	162	169	PF00069	0.657
MOD_CDK_SPxxK_3	93	100	PF00069	0.666
MOD_CK1_1	104	110	PF00069	0.721
MOD_CK1_1	112	118	PF00069	0.659
MOD_CK1_1	123	129	PF00069	0.508
MOD_CK1_1	150	156	PF00069	0.685
MOD_CK1_1	158	164	PF00069	0.633
MOD_CK1_1	16	22	PF00069	0.718
MOD_CK1_1	172	178	PF00069	0.605
MOD_CK1_1	231	237	PF00069	0.747
MOD_CK1_1	239	245	PF00069	0.631
MOD_CK1_1	258	264	PF00069	0.497
MOD_CK1_1	278	284	PF00069	0.596
MOD_CK1_1	320	326	PF00069	0.708
MOD_CK1_1	332	338	PF00069	0.767
MOD_CK1_1	378	384	PF00069	0.690
MOD_CK1_1	397	403	PF00069	0.639
MOD_CK1_1	43	49	PF00069	0.765
MOD_CK1_1	468	474	PF00069	0.580
MOD_CK1_1	583	589	PF00069	0.624
MOD_CK1_1	668	674	PF00069	0.738
MOD_CK1_1	70	76	PF00069	0.742
MOD_CK1_1	732	738	PF00069	0.677
MOD_CK1_1	756	762	PF00069	0.723
MOD_CK2_1	302	308	PF00069	0.717
MOD_CK2_1	398	404	PF00069	0.661
MOD_CK2_1	408	414	PF00069	0.458
MOD_CK2_1	501	507	PF00069	0.585
MOD_Cter_Amidation	544	547	PF01082	0.564
MOD_DYRK1A_RPxSP_1	181	185	PF00069	0.579
MOD_GlcNHglycan	103	106	PF01048	0.546
MOD_GlcNHglycan	116	119	PF01048	0.613
MOD_GlcNHglycan	122	125	PF01048	0.586
MOD_GlcNHglycan	136	139	PF01048	0.568
MOD_GlcNHglycan	16	19	PF01048	0.695
MOD_GlcNHglycan	174	177	PF01048	0.627
MOD_GlcNHglycan	185	188	PF01048	0.673
MOD_GlcNHglycan	238	241	PF01048	0.734
MOD_GlcNHglycan	262	265	PF01048	0.651
MOD_GlcNHglycan	284	287	PF01048	0.734
MOD_GlcNHglycan	30	33	PF01048	0.614
MOD_GlcNHglycan	334	337	PF01048	0.780
MOD_GlcNHglycan	35	38	PF01048	0.538
MOD_GlcNHglycan	375	378	PF01048	0.691
MOD_GlcNHglycan	582	585	PF01048	0.670
MOD_GlcNHglycan	589	592	PF01048	0.668
MOD_GlcNHglycan	603	606	PF01048	0.545
MOD_GlcNHglycan	616	619	PF01048	0.583
MOD_GlcNHglycan	630	633	PF01048	0.591
MOD_GlcNHglycan	693	696	PF01048	0.727
MOD_GlcNHglycan	731	734	PF01048	0.675
MOD_GlcNHglycan	738	741	PF01048	0.747
MOD_GlcNHglycan	77	80	PF01048	0.675
MOD_GlcNHglycan	85	88	PF01048	0.634
MOD_GlcNHglycan	91	94	PF01048	0.590
MOD_GSK3_1	112	119	PF00069	0.756
MOD_GSK3_1	147	154	PF00069	0.736
MOD_GSK3_1	158	165	PF00069	0.611
MOD_GSK3_1	171	178	PF00069	0.627
MOD_GSK3_1	228	235	PF00069	0.747
MOD_GSK3_1	254	261	PF00069	0.582
MOD_GSK3_1	274	281	PF00069	0.600
MOD_GSK3_1	295	302	PF00069	0.707
MOD_GSK3_1	352	359	PF00069	0.737
MOD_GSK3_1	394	401	PF00069	0.719
MOD_GSK3_1	404	411	PF00069	0.442
MOD_GSK3_1	41	48	PF00069	0.730
MOD_GSK3_1	415	422	PF00069	0.425
MOD_GSK3_1	51	58	PF00069	0.607
MOD_GSK3_1	514	521	PF00069	0.567
MOD_GSK3_1	524	531	PF00069	0.459
MOD_GSK3_1	583	590	PF00069	0.655
MOD_GSK3_1	66	73	PF00069	0.578
MOD_GSK3_1	664	671	PF00069	0.713
MOD_GSK3_1	704	711	PF00069	0.668
MOD_GSK3_1	725	732	PF00069	0.694
MOD_GSK3_1	89	96	PF00069	0.699
MOD_GSK3_1	9	16	PF00069	0.744
MOD_N-GLC_1	150	155	PF02516	0.783
MOD_N-GLC_1	255	260	PF02516	0.695
MOD_N-GLC_1	274	279	PF02516	0.558
MOD_N-GLC_1	356	361	PF02516	0.651
MOD_N-GLC_1	378	383	PF02516	0.668
MOD_N-GLC_1	664	669	PF02516	0.569
MOD_N-GLC_1	729	734	PF02516	0.662
MOD_NEK2_1	1	6	PF00069	0.641
MOD_NEK2_1	116	121	PF00069	0.741
MOD_NEK2_1	244	249	PF00069	0.713
MOD_NEK2_1	28	33	PF00069	0.739
MOD_NEK2_1	295	300	PF00069	0.742
MOD_NEK2_1	432	437	PF00069	0.621
MOD_NEK2_1	550	555	PF00069	0.393
MOD_NEK2_1	663	668	PF00069	0.569
MOD_NEK2_1	691	696	PF00069	0.722
MOD_NEK2_1	716	721	PF00069	0.710
MOD_NEK2_1	736	741	PF00069	0.499
MOD_NEK2_1	75	80	PF00069	0.731
MOD_NEK2_1	753	758	PF00069	0.735
MOD_OFUCOSY	253	259	PF10250	0.638
MOD_PIKK_1	398	404	PF00454	0.628
MOD_PIKK_1	419	425	PF00454	0.582
MOD_PKA_1	465	471	PF00069	0.559
MOD_PKA_2	112	118	PF00069	0.796
MOD_PKA_2	210	216	PF00069	0.592
MOD_PKA_2	468	474	PF00069	0.582
MOD_PKA_2	517	523	PF00069	0.576
MOD_Plk_1	150	156	PF00069	0.701
MOD_Plk_1	255	261	PF00069	0.664
MOD_Plk_1	378	384	PF00069	0.657
MOD_Plk_1	493	499	PF00069	0.533
MOD_Plk_2-3	404	410	PF00069	0.512
MOD_Plk_4	264	270	PF00069	0.711
MOD_Plk_4	299	305	PF00069	0.769
MOD_Plk_4	404	410	PF00069	0.603
MOD_Plk_4	412	418	PF00069	0.456
MOD_Plk_4	493	499	PF00069	0.546
MOD_Plk_4	646	652	PF00069	0.715
MOD_Plk_4	699	705	PF00069	0.783
MOD_ProDKin_1	129	135	PF00069	0.722
MOD_ProDKin_1	155	161	PF00069	0.681
MOD_ProDKin_1	162	168	PF00069	0.581
MOD_ProDKin_1	169	175	PF00069	0.667
MOD_ProDKin_1	181	187	PF00069	0.609
MOD_ProDKin_1	239	245	PF00069	0.706
MOD_ProDKin_1	247	253	PF00069	0.621
MOD_ProDKin_1	258	264	PF00069	0.494
MOD_ProDKin_1	275	281	PF00069	0.524
MOD_ProDKin_1	302	308	PF00069	0.700
MOD_ProDKin_1	317	323	PF00069	0.585
MOD_ProDKin_1	352	358	PF00069	0.799
MOD_ProDKin_1	395	401	PF00069	0.677
MOD_ProDKin_1	41	47	PF00069	0.769
MOD_ProDKin_1	501	507	PF00069	0.560
MOD_ProDKin_1	52	58	PF00069	0.594
MOD_ProDKin_1	666	672	PF00069	0.707
MOD_ProDKin_1	675	681	PF00069	0.664
MOD_ProDKin_1	709	715	PF00069	0.736
MOD_ProDKin_1	742	748	PF00069	0.675
MOD_ProDKin_1	93	99	PF00069	0.668
MOD_SUMO_rev_2	557	567	PF00179	0.616
TRG_DiLeu_BaLyEn_6	659	664	PF01217	0.751
TRG_ENDOCYTIC_2	486	489	PF00928	0.576
TRG_ENDOCYTIC_2	661	664	PF00928	0.755
TRG_ENDOCYTIC_2	688	691	PF00928	0.751
TRG_Pf-PMV_PEXEL_1	216	220	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID50	Leishmania donovani	100%	100%
A4H9L3	Leishmania braziliensis	64%	100%
E9ARR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QDQ5	Leishmania major	92%	100%