LeishMANIAdb
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Ethanolamine-phosphate cytidylyltransferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Ethanolamine-phosphate cytidylyltransferase
Gene product:
cholinephosphate cytidylyltransferase A - putative
Species:
Leishmania infantum
UniProt:
A4HY04_LEIIN
TriTrypDb:
LINF_180018600
Length:
589

Annotations

Annotations by Jardim et al.

Phospholipid biosynthesis, cholinephosphate cytidylyltransferase A

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 12
GO:0110165 cellular anatomical entity 1 12
GO:0005737 cytoplasm 2 1
GO:0005829 cytosol 2 1

Expansion

Sequence features

A4HY04
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY04

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 12
GO:0006644 phospholipid metabolic process 4 12
GO:0006646 phosphatidylethanolamine biosynthetic process 6 12
GO:0006650 glycerophospholipid metabolic process 5 12
GO:0006793 phosphorus metabolic process 3 12
GO:0006796 phosphate-containing compound metabolic process 4 12
GO:0008152 metabolic process 1 12
GO:0008610 lipid biosynthetic process 4 12
GO:0008654 phospholipid biosynthetic process 5 12
GO:0009058 biosynthetic process 2 12
GO:0009987 cellular process 1 12
GO:0019637 organophosphate metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044249 cellular biosynthetic process 3 12
GO:0044255 cellular lipid metabolic process 3 12
GO:0045017 glycerolipid biosynthetic process 4 12
GO:0046337 phosphatidylethanolamine metabolic process 6 12
GO:0046474 glycerophospholipid biosynthetic process 5 12
GO:0046486 glycerolipid metabolic process 4 12
GO:0071704 organic substance metabolic process 2 12
GO:0090407 organophosphate biosynthetic process 4 12
GO:1901576 organic substance biosynthetic process 3 12
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004306 ethanolamine-phosphate cytidylyltransferase activity 6 12
GO:0016740 transferase activity 2 12
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 12
GO:0016779 nucleotidyltransferase activity 4 12
GO:0016780 phosphotransferase activity, for other substituted phosphate groups 4 12
GO:0070567 cytidylyltransferase activity 5 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 584 588 PF00656 0.713
CLV_NRD_NRD_1 199 201 PF00675 0.346
CLV_NRD_NRD_1 388 390 PF00675 0.308
CLV_NRD_NRD_1 542 544 PF00675 0.353
CLV_NRD_NRD_1 577 579 PF00675 0.491
CLV_PCSK_KEX2_1 199 201 PF00082 0.330
CLV_PCSK_KEX2_1 388 390 PF00082 0.309
CLV_PCSK_KEX2_1 479 481 PF00082 0.266
CLV_PCSK_KEX2_1 542 544 PF00082 0.353
CLV_PCSK_PC1ET2_1 479 481 PF00082 0.276
CLV_PCSK_SKI1_1 134 138 PF00082 0.541
CLV_PCSK_SKI1_1 202 206 PF00082 0.327
CLV_PCSK_SKI1_1 303 307 PF00082 0.570
CLV_PCSK_SKI1_1 436 440 PF00082 0.306
DEG_APCC_DBOX_1 302 310 PF00400 0.409
DEG_SCF_FBW7_1 550 557 PF00400 0.634
DOC_CKS1_1 431 436 PF01111 0.626
DOC_CKS1_1 530 535 PF01111 0.562
DOC_CKS1_1 551 556 PF01111 0.642
DOC_MAPK_gen_1 332 342 PF00069 0.540
DOC_MAPK_gen_1 388 396 PF00069 0.554
DOC_MAPK_HePTP_8 236 248 PF00069 0.337
DOC_MAPK_MEF2A_6 220 227 PF00069 0.449
DOC_MAPK_MEF2A_6 239 248 PF00069 0.337
DOC_MAPK_MEF2A_6 303 310 PF00069 0.391
DOC_MAPK_MEF2A_6 338 345 PF00069 0.486
DOC_MAPK_MEF2A_6 36 45 PF00069 0.605
DOC_MAPK_MEF2A_6 460 469 PF00069 0.537
DOC_MAPK_MEF2A_6 517 525 PF00069 0.459
DOC_MAPK_NFAT4_5 220 228 PF00069 0.449
DOC_MAPK_NFAT4_5 338 346 PF00069 0.484
DOC_MAPK_RevD_3 373 389 PF00069 0.372
DOC_PP1_RVXF_1 27 34 PF00149 0.636
DOC_PP1_SILK_1 544 549 PF00149 0.521
DOC_PP2B_LxvP_1 156 159 PF13499 0.505
DOC_PP2B_LxvP_1 427 430 PF13499 0.533
DOC_PP2B_LxvP_1 53 56 PF13499 0.606
DOC_USP7_MATH_1 146 150 PF00917 0.464
DOC_USP7_MATH_1 568 572 PF00917 0.684
DOC_USP7_UBL2_3 265 269 PF12436 0.657
DOC_USP7_UBL2_3 334 338 PF12436 0.555
DOC_WW_Pin1_4 430 435 PF00397 0.624
DOC_WW_Pin1_4 503 508 PF00397 0.476
DOC_WW_Pin1_4 529 534 PF00397 0.562
DOC_WW_Pin1_4 550 555 PF00397 0.626
LIG_14-3-3_CanoR_1 171 181 PF00244 0.356
LIG_14-3-3_CanoR_1 199 207 PF00244 0.532
LIG_14-3-3_CanoR_1 213 219 PF00244 0.479
LIG_14-3-3_CanoR_1 29 34 PF00244 0.561
LIG_14-3-3_CanoR_1 44 53 PF00244 0.609
LIG_14-3-3_CanoR_1 566 573 PF00244 0.617
LIG_14-3-3_CanoR_1 578 585 PF00244 0.545
LIG_Actin_WH2_2 91 106 PF00022 0.707
LIG_BIR_II_1 1 5 PF00653 0.649
LIG_BRCT_BRCA1_1 7 11 PF00533 0.552
LIG_Clathr_ClatBox_1 375 379 PF01394 0.344
LIG_EH1_1 285 293 PF00400 0.449
LIG_EH1_1 414 422 PF00400 0.520
LIG_eIF4E_1 337 343 PF01652 0.581
LIG_eIF4E_1 415 421 PF01652 0.547
LIG_FHA_1 159 165 PF00498 0.491
LIG_FHA_1 173 179 PF00498 0.242
LIG_FHA_1 26 32 PF00498 0.601
LIG_FHA_1 317 323 PF00498 0.395
LIG_FHA_1 45 51 PF00498 0.535
LIG_FHA_1 551 557 PF00498 0.555
LIG_FHA_2 10 16 PF00498 0.537
LIG_FHA_2 224 230 PF00498 0.363
LIG_FHA_2 483 489 PF00498 0.473
LIG_FHA_2 530 536 PF00498 0.541
LIG_FHA_2 582 588 PF00498 0.679
LIG_IRF3_LxIS_1 181 187 PF10401 0.451
LIG_LIR_Apic_2 477 481 PF02991 0.562
LIG_LIR_Apic_2 528 533 PF02991 0.477
LIG_LIR_Apic_2 535 541 PF02991 0.534
LIG_LIR_Gen_1 160 167 PF02991 0.513
LIG_LIR_Gen_1 209 219 PF02991 0.481
LIG_LIR_Gen_1 283 294 PF02991 0.358
LIG_LIR_Gen_1 324 333 PF02991 0.365
LIG_LIR_Gen_1 359 367 PF02991 0.353
LIG_LIR_LC3C_4 319 322 PF02991 0.449
LIG_LIR_Nem_3 160 166 PF02991 0.497
LIG_LIR_Nem_3 209 214 PF02991 0.486
LIG_LIR_Nem_3 238 244 PF02991 0.288
LIG_LIR_Nem_3 283 289 PF02991 0.357
LIG_LIR_Nem_3 324 328 PF02991 0.403
LIG_LIR_Nem_3 35 41 PF02991 0.561
LIG_LIR_Nem_3 359 364 PF02991 0.397
LIG_LIR_Nem_3 534 540 PF02991 0.537
LIG_LIR_Nem_3 76 80 PF02991 0.589
LIG_NRBOX 178 184 PF00104 0.363
LIG_NRBOX 286 292 PF00104 0.475
LIG_NRBOX 398 404 PF00104 0.630
LIG_NRBOX 60 66 PF00104 0.592
LIG_PDZ_Class_3 584 589 PF00595 0.674
LIG_Pex14_2 38 42 PF04695 0.567
LIG_PTB_Apo_2 267 274 PF02174 0.653
LIG_PTB_Apo_2 72 79 PF02174 0.639
LIG_PTB_Phospho_1 267 273 PF10480 0.651
LIG_PTB_Phospho_1 72 78 PF10480 0.631
LIG_SH2_CRK 317 321 PF00017 0.343
LIG_SH2_CRK 337 341 PF00017 0.587
LIG_SH2_CRK 361 365 PF00017 0.324
LIG_SH2_CRK 478 482 PF00017 0.562
LIG_SH2_CRK 530 534 PF00017 0.501
LIG_SH2_CRK 538 542 PF00017 0.499
LIG_SH2_CRK 71 75 PF00017 0.526
LIG_SH2_GRB2like 518 521 PF00017 0.562
LIG_SH2_NCK_1 530 534 PF00017 0.476
LIG_SH2_SRC 415 418 PF00017 0.533
LIG_SH2_STAP1 425 429 PF00017 0.528
LIG_SH2_STAT5 163 166 PF00017 0.500
LIG_SH2_STAT5 241 244 PF00017 0.363
LIG_SH2_STAT5 273 276 PF00017 0.578
LIG_SH2_STAT5 277 280 PF00017 0.555
LIG_SH2_STAT5 354 357 PF00017 0.574
LIG_SH2_STAT5 381 384 PF00017 0.555
LIG_SH2_STAT5 415 418 PF00017 0.506
LIG_SH2_STAT5 498 501 PF00017 0.562
LIG_SH3_1 548 554 PF00018 0.625
LIG_SH3_3 501 507 PF00018 0.501
LIG_SH3_3 548 554 PF00018 0.637
LIG_SH3_5 159 163 PF00018 0.520
LIG_SUMO_SIM_anti_2 177 183 PF11976 0.453
LIG_SUMO_SIM_anti_2 285 291 PF11976 0.420
LIG_SUMO_SIM_anti_2 327 332 PF11976 0.451
LIG_SUMO_SIM_anti_2 362 369 PF11976 0.364
LIG_SUMO_SIM_par_1 181 187 PF11976 0.362
LIG_SUMO_SIM_par_1 247 253 PF11976 0.449
LIG_SUMO_SIM_par_1 318 324 PF11976 0.364
LIG_SUMO_SIM_par_1 374 379 PF11976 0.384
LIG_SUMO_SIM_par_1 419 424 PF11976 0.512
LIG_TRAF2_1 12 15 PF00917 0.648
LIG_TRAF2_1 485 488 PF00917 0.469
LIG_TRFH_1 353 357 PF08558 0.413
LIG_TYR_ITIM 315 320 PF00017 0.475
LIG_TYR_ITIM 516 521 PF00017 0.562
LIG_UBA3_1 305 312 PF00899 0.431
LIG_UBA3_1 330 338 PF00899 0.551
LIG_WRC_WIRS_1 322 327 PF05994 0.344
MOD_CDK_SPxK_1 430 436 PF00069 0.626
MOD_CK1_1 149 155 PF00069 0.398
MOD_CK1_1 203 209 PF00069 0.551
MOD_CK1_1 282 288 PF00069 0.328
MOD_CK1_1 32 38 PF00069 0.557
MOD_CK1_1 359 365 PF00069 0.283
MOD_CK1_1 506 512 PF00069 0.487
MOD_CK1_1 569 575 PF00069 0.640
MOD_CK2_1 223 229 PF00069 0.363
MOD_CK2_1 482 488 PF00069 0.458
MOD_CK2_1 9 15 PF00069 0.546
MOD_GlcNHglycan 122 125 PF01048 0.562
MOD_GlcNHglycan 148 151 PF01048 0.464
MOD_GlcNHglycan 202 205 PF01048 0.328
MOD_GSK3_1 145 152 PF00069 0.470
MOD_GSK3_1 209 216 PF00069 0.533
MOD_GSK3_1 21 28 PF00069 0.581
MOD_GSK3_1 405 412 PF00069 0.522
MOD_GSK3_1 44 51 PF00069 0.578
MOD_GSK3_1 5 12 PF00069 0.568
MOD_GSK3_1 529 536 PF00069 0.562
MOD_GSK3_1 546 553 PF00069 0.410
MOD_GSK3_1 556 563 PF00069 0.542
MOD_GSK3_1 577 584 PF00069 0.660
MOD_N-GLC_1 258 263 PF02516 0.407
MOD_NEK2_1 184 189 PF00069 0.393
MOD_NEK2_1 223 228 PF00069 0.324
MOD_NEK2_1 423 428 PF00069 0.514
MOD_NEK2_1 5 10 PF00069 0.637
MOD_NEK2_1 64 69 PF00069 0.518
MOD_NEK2_1 73 78 PF00069 0.517
MOD_PIKK_1 356 362 PF00454 0.450
MOD_PKA_2 279 285 PF00069 0.476
MOD_PKA_2 43 49 PF00069 0.578
MOD_PKA_2 577 583 PF00069 0.674
MOD_PKB_1 200 208 PF00069 0.599
MOD_PKB_1 564 572 PF00069 0.589
MOD_Plk_1 113 119 PF00069 0.770
MOD_Plk_1 169 175 PF00069 0.414
MOD_Plk_1 282 288 PF00069 0.343
MOD_Plk_1 421 427 PF00069 0.517
MOD_Plk_1 5 11 PF00069 0.570
MOD_Plk_1 569 575 PF00069 0.687
MOD_Plk_2-3 581 587 PF00069 0.680
MOD_Plk_4 113 119 PF00069 0.770
MOD_Plk_4 174 180 PF00069 0.320
MOD_Plk_4 223 229 PF00069 0.339
MOD_Plk_4 250 256 PF00069 0.344
MOD_Plk_4 282 288 PF00069 0.348
MOD_Plk_4 29 35 PF00069 0.563
MOD_Plk_4 316 322 PF00069 0.351
MOD_Plk_4 359 365 PF00069 0.291
MOD_Plk_4 398 404 PF00069 0.525
MOD_Plk_4 409 415 PF00069 0.508
MOD_Plk_4 5 11 PF00069 0.570
MOD_Plk_4 533 539 PF00069 0.565
MOD_Plk_4 556 562 PF00069 0.534
MOD_Plk_4 73 79 PF00069 0.620
MOD_ProDKin_1 430 436 PF00069 0.627
MOD_ProDKin_1 503 509 PF00069 0.476
MOD_ProDKin_1 529 535 PF00069 0.562
MOD_ProDKin_1 550 556 PF00069 0.623
MOD_SUMO_rev_2 571 580 PF00179 0.693
TRG_DiLeu_BaEn_1 14 19 PF01217 0.640
TRG_DiLeu_BaEn_1 283 288 PF01217 0.363
TRG_DiLeu_BaLyEn_6 461 466 PF01217 0.476
TRG_ENDOCYTIC_2 163 166 PF00928 0.481
TRG_ENDOCYTIC_2 241 244 PF00928 0.344
TRG_ENDOCYTIC_2 317 320 PF00928 0.364
TRG_ENDOCYTIC_2 337 340 PF00928 0.622
TRG_ENDOCYTIC_2 361 364 PF00928 0.313
TRG_ENDOCYTIC_2 518 521 PF00928 0.558
TRG_ENDOCYTIC_2 537 540 PF00928 0.428
TRG_ENDOCYTIC_2 71 74 PF00928 0.509
TRG_ENDOCYTIC_2 77 80 PF00928 0.566
TRG_ER_diArg_1 199 202 PF00400 0.548
TRG_ER_diArg_1 388 390 PF00400 0.509
TRG_ER_diArg_1 541 543 PF00400 0.539

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I259 Leptomonas seymouri 78% 100%
A0A0S4JNN5 Bodo saltans 47% 100%
A0A1X0P717 Trypanosomatidae 62% 100%
A0A3Q8IA23 Leishmania donovani 100% 100%
A0A422P0J5 Trypanosoma rangeli 61% 100%
A4H9L4 Leishmania braziliensis 92% 99%
D0A5A2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 57% 100%
E9ARR7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4QDQ6 Leishmania major 96% 100%
V5BEI8 Trypanosoma cruzi 59% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS