Histone acetyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acetyltransferase (GNAT) family - putative

Species:

Leishmania infantum

UniProt:

A4HY02_LEIIN

TriTrypDb:

LINF_180018400

Length:

809

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7
GO:0000139	Golgi membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A4HY02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HY02

Function

Biological processes
Term	Name	Level	Count
GO:0007059	chromosome segregation	2	6
GO:0009987	cellular process	1	6
GO:0006473	protein acetylation	6	1
GO:0006474	N-terminal protein amino acid acetylation	5	1
GO:0006475	internal protein amino acid acetylation	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016570	histone modification	5	1
GO:0016573	histone acetylation	6	1
GO:0017196	N-terminal peptidyl-methionine acetylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0018206	peptidyl-methionine modification	6	1
GO:0018393	internal peptidyl-lysine acetylation	8	1
GO:0018394	peptidyl-lysine acetylation	7	1
GO:0019538	protein metabolic process	3	1
GO:0031365	N-terminal protein amino acid modification	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0043966	histone H3 acetylation	7	1
GO:0043967	histone H4 acetylation	7	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004596	peptide alpha-N-acetyltransferase activity	8	7
GO:0008080	N-acetyltransferase activity	6	7
GO:0016407	acetyltransferase activity	5	7
GO:0016410	N-acyltransferase activity	5	7
GO:0016740	transferase activity	2	7
GO:0016746	acyltransferase activity	3	7
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	7
GO:0034212	peptide N-acetyltransferase activity	7	7
GO:0004402	histone acetyltransferase activity	4	1
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	327	331	PF00656	0.652
CLV_C14_Caspase3-7	442	446	PF00656	0.630
CLV_C14_Caspase3-7	513	517	PF00656	0.523
CLV_C14_Caspase3-7	644	648	PF00656	0.609
CLV_C14_Caspase3-7	710	714	PF00656	0.677
CLV_NRD_NRD_1	128	130	PF00675	0.357
CLV_NRD_NRD_1	196	198	PF00675	0.316
CLV_NRD_NRD_1	405	407	PF00675	0.356
CLV_NRD_NRD_1	419	421	PF00675	0.357
CLV_NRD_NRD_1	518	520	PF00675	0.462
CLV_NRD_NRD_1	538	540	PF00675	0.371
CLV_NRD_NRD_1	542	544	PF00675	0.369
CLV_NRD_NRD_1	673	675	PF00675	0.464
CLV_NRD_NRD_1	758	760	PF00675	0.418
CLV_PCSK_FUR_1	671	675	PF00082	0.493
CLV_PCSK_KEX2_1	128	130	PF00082	0.357
CLV_PCSK_KEX2_1	196	198	PF00082	0.316
CLV_PCSK_KEX2_1	405	407	PF00082	0.411
CLV_PCSK_KEX2_1	419	421	PF00082	0.314
CLV_PCSK_KEX2_1	518	520	PF00082	0.462
CLV_PCSK_KEX2_1	538	540	PF00082	0.371
CLV_PCSK_KEX2_1	542	544	PF00082	0.369
CLV_PCSK_KEX2_1	671	673	PF00082	0.462
CLV_PCSK_KEX2_1	757	759	PF00082	0.418
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.411
CLV_PCSK_PC1ET2_1	419	421	PF00082	0.314
CLV_PCSK_PC7_1	538	544	PF00082	0.343
CLV_PCSK_SKI1_1	34	38	PF00082	0.367
CLV_PCSK_SKI1_1	384	388	PF00082	0.291
CLV_PCSK_SKI1_1	425	429	PF00082	0.348
CLV_PCSK_SKI1_1	577	581	PF00082	0.351
DEG_SPOP_SBC_1	144	148	PF00917	0.610
DEG_SPOP_SBC_1	159	163	PF00917	0.651
DEG_SPOP_SBC_1	176	180	PF00917	0.549
DEG_SPOP_SBC_1	261	265	PF00917	0.657
DOC_CDC14_PxL_1	486	494	PF14671	0.569
DOC_CKS1_1	705	710	PF01111	0.680
DOC_CYCLIN_RxL_1	44	55	PF00134	0.519
DOC_MAPK_gen_1	34	41	PF00069	0.559
DOC_MAPK_gen_1	405	411	PF00069	0.535
DOC_MAPK_gen_1	80	89	PF00069	0.608
DOC_MAPK_RevD_3	658	674	PF00069	0.647
DOC_PP1_RVXF_1	183	189	PF00149	0.544
DOC_PP1_RVXF_1	32	39	PF00149	0.566
DOC_PP1_RVXF_1	778	785	PF00149	0.530
DOC_PP2B_LxvP_1	459	462	PF13499	0.608
DOC_PP2B_LxvP_1	660	663	PF13499	0.649
DOC_SPAK_OSR1_1	543	547	PF12202	0.539
DOC_USP7_MATH_1	153	157	PF00917	0.741
DOC_USP7_MATH_1	159	163	PF00917	0.638
DOC_USP7_MATH_1	261	265	PF00917	0.651
DOC_USP7_MATH_1	312	316	PF00917	0.577
DOC_USP7_MATH_1	462	466	PF00917	0.661
DOC_USP7_MATH_1	468	472	PF00917	0.665
DOC_USP7_MATH_1	477	481	PF00917	0.562
DOC_USP7_MATH_1	608	612	PF00917	0.696
DOC_USP7_MATH_1	663	667	PF00917	0.707
DOC_USP7_MATH_1	712	716	PF00917	0.738
DOC_USP7_MATH_1	762	766	PF00917	0.669
DOC_WW_Pin1_4	104	109	PF00397	0.649
DOC_WW_Pin1_4	155	160	PF00397	0.754
DOC_WW_Pin1_4	247	252	PF00397	0.609
DOC_WW_Pin1_4	264	269	PF00397	0.658
DOC_WW_Pin1_4	53	58	PF00397	0.565
DOC_WW_Pin1_4	604	609	PF00397	0.600
DOC_WW_Pin1_4	674	679	PF00397	0.620
DOC_WW_Pin1_4	701	706	PF00397	0.791
DOC_WW_Pin1_4	717	722	PF00397	0.647
DOC_WW_Pin1_4	731	736	PF00397	0.613
DOC_WW_Pin1_4	82	87	PF00397	0.621
DOC_WW_Pin1_4	89	94	PF00397	0.615
LIG_14-3-3_CanoR_1	28	38	PF00244	0.576
LIG_14-3-3_CanoR_1	384	389	PF00244	0.491
LIG_14-3-3_CanoR_1	448	453	PF00244	0.611
LIG_14-3-3_CanoR_1	697	703	PF00244	0.614
LIG_14-3-3_CanoR_1	757	762	PF00244	0.674
LIG_14-3-3_CanoR_1	97	106	PF00244	0.606
LIG_BIR_III_2	204	208	PF00653	0.509
LIG_BRCT_BRCA1_1	478	482	PF00533	0.618
LIG_CaM_IQ_9	229	244	PF13499	0.508
LIG_deltaCOP1_diTrp_1	238	243	PF00928	0.551
LIG_eIF4E_1	403	409	PF01652	0.547
LIG_FHA_1	133	139	PF00498	0.651
LIG_FHA_1	150	156	PF00498	0.573
LIG_FHA_1	318	324	PF00498	0.718
LIG_FHA_1	333	339	PF00498	0.467
LIG_FHA_1	358	364	PF00498	0.487
LIG_FHA_1	372	378	PF00498	0.569
LIG_FHA_1	44	50	PF00498	0.511
LIG_FHA_1	647	653	PF00498	0.708
LIG_FHA_2	233	239	PF00498	0.535
LIG_FHA_2	437	443	PF00498	0.648
LIG_FHA_2	509	515	PF00498	0.647
LIG_FHA_2	528	534	PF00498	0.610
LIG_FHA_2	642	648	PF00498	0.610
LIG_FHA_2	65	71	PF00498	0.612
LIG_FHA_2	691	697	PF00498	0.659
LIG_FHA_2	708	714	PF00498	0.605
LIG_LIR_Apic_2	729	735	PF02991	0.613
LIG_LIR_Gen_1	213	223	PF02991	0.510
LIG_LIR_Gen_1	479	490	PF02991	0.633
LIG_LIR_Nem_3	125	130	PF02991	0.552
LIG_LIR_Nem_3	213	218	PF02991	0.478
LIG_LIR_Nem_3	37	41	PF02991	0.563
LIG_LIR_Nem_3	399	403	PF02991	0.539
LIG_LIR_Nem_3	479	485	PF02991	0.670
LIG_LIR_Nem_3	737	741	PF02991	0.559
LIG_LYPXL_yS_3	738	741	PF13949	0.560
LIG_NRBOX	407	413	PF00104	0.570
LIG_PCNA_yPIPBox_3	542	554	PF02747	0.523
LIG_Pex14_2	38	42	PF04695	0.559
LIG_Rb_LxCxE_1	768	781	PF01857	0.536
LIG_RPA_C_Fungi	344	356	PF08784	0.334
LIG_RPA_C_Fungi	566	578	PF08784	0.361
LIG_SH2_CRK	590	594	PF00017	0.407
LIG_SH2_CRK	800	804	PF00017	0.334
LIG_SH2_SRC	452	455	PF00017	0.499
LIG_SH2_STAP1	100	104	PF00017	0.489
LIG_SH2_STAP1	210	214	PF00017	0.381
LIG_SH2_STAP1	215	219	PF00017	0.320
LIG_SH2_STAP1	396	400	PF00017	0.437
LIG_SH2_STAP1	590	594	PF00017	0.382
LIG_SH2_STAT3	388	391	PF00017	0.334
LIG_SH2_STAT5	100	103	PF00017	0.488
LIG_SH2_STAT5	210	213	PF00017	0.371
LIG_SH2_STAT5	362	365	PF00017	0.288
LIG_SH2_STAT5	388	391	PF00017	0.298
LIG_SH2_STAT5	400	403	PF00017	0.452
LIG_SH2_STAT5	488	491	PF00017	0.436
LIG_SH2_STAT5	597	600	PF00017	0.416
LIG_SH3_3	133	139	PF00018	0.447
LIG_SH3_3	272	278	PF00018	0.516
LIG_SH3_3	365	371	PF00018	0.324
LIG_SH3_3	455	461	PF00018	0.539
LIG_SH3_3	672	678	PF00018	0.503
LIG_SH3_3	702	708	PF00018	0.557
LIG_SH3_3	90	96	PF00018	0.473
LIG_TRAF2_1	290	293	PF00917	0.440
LIG_TRAF2_1	302	305	PF00917	0.369
LIG_TRAF2_1	511	514	PF00917	0.391
LIG_TRAF2_1	530	533	PF00917	0.465
LIG_TRAF2_1	638	641	PF00917	0.562
LIG_TYR_ITIM	798	803	PF00017	0.334
LIG_WRC_WIRS_1	363	368	PF05994	0.290
MOD_CDC14_SPxK_1	677	680	PF00782	0.509
MOD_CDK_SPK_2	247	252	PF00069	0.499
MOD_CDK_SPK_2	731	736	PF00069	0.481
MOD_CDK_SPK_2	92	97	PF00069	0.465
MOD_CDK_SPxK_1	674	680	PF00069	0.514
MOD_CDK_SPxK_1	717	723	PF00069	0.571
MOD_CDK_SPxK_1	82	88	PF00069	0.520
MOD_CK1_1	120	126	PF00069	0.539
MOD_CK1_1	158	164	PF00069	0.546
MOD_CK1_1	19	25	PF00069	0.435
MOD_CK1_1	260	266	PF00069	0.571
MOD_CK1_1	267	273	PF00069	0.538
MOD_CK1_1	282	288	PF00069	0.557
MOD_CK1_1	326	332	PF00069	0.542
MOD_CK1_1	357	363	PF00069	0.334
MOD_CK1_1	469	475	PF00069	0.567
MOD_CK1_1	55	61	PF00069	0.459
MOD_CK1_1	604	610	PF00069	0.515
MOD_CK1_1	665	671	PF00069	0.581
MOD_CK1_1	701	707	PF00069	0.648
MOD_CK1_1	726	732	PF00069	0.541
MOD_CK1_1	734	740	PF00069	0.441
MOD_CK1_1	92	98	PF00069	0.490
MOD_CK2_1	164	170	PF00069	0.583
MOD_CK2_1	210	216	PF00069	0.401
MOD_CK2_1	232	238	PF00069	0.397
MOD_CK2_1	491	497	PF00069	0.406
MOD_CK2_1	508	514	PF00069	0.447
MOD_CK2_1	527	533	PF00069	0.489
MOD_CK2_1	762	768	PF00069	0.558
MOD_DYRK1A_RPxSP_1	674	678	PF00069	0.500
MOD_GlcNHglycan	166	169	PF01048	0.541
MOD_GlcNHglycan	259	262	PF01048	0.579
MOD_GlcNHglycan	269	272	PF01048	0.544
MOD_GlcNHglycan	330	333	PF01048	0.469
MOD_GlcNHglycan	431	434	PF01048	0.536
MOD_GlcNHglycan	464	467	PF01048	0.618
MOD_GlcNHglycan	602	606	PF01048	0.515
MOD_GlcNHglycan	610	613	PF01048	0.595
MOD_GlcNHglycan	623	626	PF01048	0.533
MOD_GlcNHglycan	700	703	PF01048	0.513
MOD_GlcNHglycan	713	717	PF01048	0.597
MOD_GlcNHglycan	764	767	PF01048	0.539
MOD_GlcNHglycan	77	80	PF01048	0.489
MOD_GSK3_1	113	120	PF00069	0.528
MOD_GSK3_1	140	147	PF00069	0.527
MOD_GSK3_1	149	156	PF00069	0.580
MOD_GSK3_1	15	22	PF00069	0.461
MOD_GSK3_1	160	167	PF00069	0.520
MOD_GSK3_1	176	183	PF00069	0.421
MOD_GSK3_1	243	250	PF00069	0.471
MOD_GSK3_1	253	260	PF00069	0.540
MOD_GSK3_1	262	269	PF00069	0.546
MOD_GSK3_1	313	320	PF00069	0.436
MOD_GSK3_1	328	335	PF00069	0.503
MOD_GSK3_1	444	451	PF00069	0.552
MOD_GSK3_1	462	469	PF00069	0.650
MOD_GSK3_1	60	67	PF00069	0.502
MOD_GSK3_1	604	611	PF00069	0.650
MOD_GSK3_1	613	620	PF00069	0.571
MOD_GSK3_1	646	653	PF00069	0.598
MOD_GSK3_1	98	105	PF00069	0.556
MOD_N-GLC_1	208	213	PF02516	0.303
MOD_NEK2_1	160	165	PF00069	0.557
MOD_NEK2_1	41	46	PF00069	0.395
MOD_NEK2_1	428	433	PF00069	0.601
MOD_NEK2_1	562	567	PF00069	0.509
MOD_NEK2_1	614	619	PF00069	0.630
MOD_NEK2_1	87	92	PF00069	0.522
MOD_NEK2_1	98	103	PF00069	0.506
MOD_NEK2_2	319	324	PF00069	0.545
MOD_NEK2_2	477	482	PF00069	0.516
MOD_PIKK_1	229	235	PF00454	0.348
MOD_PIKK_1	253	259	PF00454	0.569
MOD_PIKK_1	387	393	PF00454	0.334
MOD_PIKK_1	466	472	PF00454	0.633
MOD_PKA_1	34	40	PF00069	0.434
MOD_PKA_1	757	763	PF00069	0.564
MOD_PKA_2	15	21	PF00069	0.455
MOD_PKA_2	243	249	PF00069	0.458
MOD_PKA_2	323	329	PF00069	0.471
MOD_PKA_2	75	81	PF00069	0.512
MOD_PKA_2	757	763	PF00069	0.647
MOD_PKA_2	87	93	PF00069	0.499
MOD_Plk_1	282	288	PF00069	0.401
MOD_Plk_2-3	491	497	PF00069	0.406
MOD_Plk_2-3	527	533	PF00069	0.472
MOD_Plk_4	210	216	PF00069	0.401
MOD_Plk_4	296	302	PF00069	0.370
MOD_Plk_4	332	338	PF00069	0.460
MOD_Plk_4	34	40	PF00069	0.444
MOD_Plk_4	384	390	PF00069	0.315
MOD_Plk_4	477	483	PF00069	0.531
MOD_Plk_4	484	490	PF00069	0.348
MOD_Plk_4	491	497	PF00069	0.422
MOD_Plk_4	563	569	PF00069	0.319
MOD_Plk_4	728	734	PF00069	0.504
MOD_ProDKin_1	104	110	PF00069	0.556
MOD_ProDKin_1	155	161	PF00069	0.704
MOD_ProDKin_1	247	253	PF00069	0.507
MOD_ProDKin_1	264	270	PF00069	0.570
MOD_ProDKin_1	53	59	PF00069	0.447
MOD_ProDKin_1	604	610	PF00069	0.490
MOD_ProDKin_1	674	680	PF00069	0.514
MOD_ProDKin_1	701	707	PF00069	0.755
MOD_ProDKin_1	717	723	PF00069	0.552
MOD_ProDKin_1	731	737	PF00069	0.497
MOD_ProDKin_1	82	88	PF00069	0.520
MOD_ProDKin_1	89	95	PF00069	0.504
MOD_SUMO_rev_2	755	765	PF00179	0.524
TRG_DiLeu_BaEn_2	539	545	PF01217	0.442
TRG_DiLeu_BaLyEn_6	94	99	PF01217	0.464
TRG_ENDOCYTIC_2	215	218	PF00928	0.338
TRG_ENDOCYTIC_2	582	585	PF00928	0.375
TRG_ENDOCYTIC_2	590	593	PF00928	0.474
TRG_ENDOCYTIC_2	738	741	PF00928	0.431
TRG_ENDOCYTIC_2	800	803	PF00928	0.334
TRG_ER_diArg_1	127	129	PF00400	0.473
TRG_ER_diArg_1	184	187	PF00400	0.427
TRG_ER_diArg_1	195	197	PF00400	0.320
TRG_ER_diArg_1	502	505	PF00400	0.431
TRG_ER_diArg_1	518	520	PF00400	0.334
TRG_ER_diArg_1	537	539	PF00400	0.429
TRG_ER_diArg_1	542	544	PF00400	0.338
TRG_ER_diArg_1	670	673	PF00400	0.573
TRG_ER_diArg_1	756	759	PF00400	0.535
TRG_NLS_Bipartite_1	405	423	PF00514	0.395
TRG_NLS_MonoCore_2	417	422	PF00514	0.425
TRG_NLS_MonoExtN_4	418	423	PF00514	0.404
TRG_Pf-PMV_PEXEL_1	196	200	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4M7	Leptomonas seymouri	45%	98%
A0A3S7WV24	Leishmania donovani	100%	100%
A4H9N7	Leishmania braziliensis	70%	100%
E9ARR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
Q4QDQ8	Leishmania major	86%	99%