Protein kintoun

Quick info Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein kintoun

Gene product:

pre-RNA processing PIH1/Nop17 - putative

Species:

Leishmania infantum

UniProt:

A4HXZ7_LEIIN

TriTrypDb:

LINF_180017900

Length:

767

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4HXZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXZ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.456
CLV_C14_Caspase3-7	376	380	PF00656	0.447
CLV_C14_Caspase3-7	487	491	PF00656	0.708
CLV_NRD_NRD_1	181	183	PF00675	0.292
CLV_NRD_NRD_1	264	266	PF00675	0.218
CLV_NRD_NRD_1	406	408	PF00675	0.277
CLV_NRD_NRD_1	480	482	PF00675	0.567
CLV_NRD_NRD_1	733	735	PF00675	0.453
CLV_NRD_NRD_1	76	78	PF00675	0.442
CLV_PCSK_KEX2_1	181	183	PF00082	0.292
CLV_PCSK_KEX2_1	264	266	PF00082	0.218
CLV_PCSK_KEX2_1	388	390	PF00082	0.197
CLV_PCSK_KEX2_1	406	408	PF00082	0.197
CLV_PCSK_KEX2_1	733	735	PF00082	0.457
CLV_PCSK_KEX2_1	752	754	PF00082	0.389
CLV_PCSK_KEX2_1	76	78	PF00082	0.442
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.267
CLV_PCSK_PC1ET2_1	752	754	PF00082	0.507
CLV_PCSK_PC7_1	384	390	PF00082	0.311
CLV_PCSK_SKI1_1	104	108	PF00082	0.460
CLV_PCSK_SKI1_1	136	140	PF00082	0.299
CLV_PCSK_SKI1_1	145	149	PF00082	0.287
CLV_PCSK_SKI1_1	157	161	PF00082	0.292
CLV_PCSK_SKI1_1	456	460	PF00082	0.226
CLV_PCSK_SKI1_1	761	765	PF00082	0.455
DEG_SCF_TRCP1_1	629	635	PF00400	0.607
DEG_SPOP_SBC_1	210	214	PF00917	0.525
DEG_SPOP_SBC_1	324	328	PF00917	0.663
DEG_SPOP_SBC_1	332	336	PF00917	0.710
DEG_SPOP_SBC_1	359	363	PF00917	0.623
DEG_SPOP_SBC_1	567	571	PF00917	0.551
DOC_CKS1_1	273	278	PF01111	0.418
DOC_CKS1_1	562	567	PF01111	0.698
DOC_CYCLIN_yCln2_LP_2	437	443	PF00134	0.451
DOC_MAPK_FxFP_2	100	103	PF00069	0.313
DOC_MAPK_gen_1	406	413	PF00069	0.490
DOC_MAPK_gen_1	750	758	PF00069	0.481
DOC_MAPK_MEF2A_6	406	415	PF00069	0.465
DOC_MAPK_MEF2A_6	432	441	PF00069	0.492
DOC_MAPK_MEF2A_6	456	465	PF00069	0.413
DOC_MAPK_NFAT4_5	456	464	PF00069	0.406
DOC_PP1_RVXF_1	219	226	PF00149	0.520
DOC_PP2B_LxvP_1	437	440	PF13499	0.467
DOC_PP4_FxxP_1	100	103	PF00568	0.313
DOC_USP7_MATH_1	138	142	PF00917	0.486
DOC_USP7_MATH_1	167	171	PF00917	0.511
DOC_USP7_MATH_1	18	22	PF00917	0.716
DOC_USP7_MATH_1	188	192	PF00917	0.538
DOC_USP7_MATH_1	193	197	PF00917	0.586
DOC_USP7_MATH_1	203	207	PF00917	0.578
DOC_USP7_MATH_1	208	212	PF00917	0.441
DOC_USP7_MATH_1	233	237	PF00917	0.401
DOC_USP7_MATH_1	304	308	PF00917	0.649
DOC_USP7_MATH_1	333	337	PF00917	0.706
DOC_USP7_MATH_1	352	356	PF00917	0.588
DOC_USP7_MATH_1	359	363	PF00917	0.560
DOC_USP7_MATH_1	503	507	PF00917	0.635
DOC_USP7_MATH_1	567	571	PF00917	0.666
DOC_USP7_MATH_1	616	620	PF00917	0.688
DOC_USP7_MATH_1	627	631	PF00917	0.658
DOC_USP7_MATH_1	647	651	PF00917	0.695
DOC_USP7_MATH_2	426	432	PF00917	0.456
DOC_USP7_UBL2_3	671	675	PF12436	0.553
DOC_USP7_UBL2_3	731	735	PF12436	0.537
DOC_WW_Pin1_4	189	194	PF00397	0.570
DOC_WW_Pin1_4	211	216	PF00397	0.350
DOC_WW_Pin1_4	272	277	PF00397	0.407
DOC_WW_Pin1_4	287	292	PF00397	0.471
DOC_WW_Pin1_4	319	324	PF00397	0.649
DOC_WW_Pin1_4	340	345	PF00397	0.569
DOC_WW_Pin1_4	355	360	PF00397	0.582
DOC_WW_Pin1_4	40	45	PF00397	0.462
DOC_WW_Pin1_4	413	418	PF00397	0.509
DOC_WW_Pin1_4	510	515	PF00397	0.663
DOC_WW_Pin1_4	516	521	PF00397	0.633
DOC_WW_Pin1_4	540	545	PF00397	0.669
DOC_WW_Pin1_4	549	554	PF00397	0.602
DOC_WW_Pin1_4	561	566	PF00397	0.641
LIG_14-3-3_CanoR_1	303	309	PF00244	0.448
LIG_14-3-3_CanoR_1	360	365	PF00244	0.550
LIG_14-3-3_CanoR_1	384	392	PF00244	0.500
LIG_14-3-3_CanoR_1	456	462	PF00244	0.451
LIG_14-3-3_CanoR_1	481	485	PF00244	0.610
LIG_APCC_ABBAyCdc20_2	55	61	PF00400	0.518
LIG_BIR_III_4	166	170	PF00653	0.456
LIG_BRCT_BRCA1_1	235	239	PF00533	0.406
LIG_BRCT_BRCA1_1	257	261	PF00533	0.467
LIG_BRCT_BRCA1_1	96	100	PF00533	0.377
LIG_CtBP_PxDLS_1	44	48	PF00389	0.455
LIG_deltaCOP1_diTrp_1	379	383	PF00928	0.406
LIG_EH1_1	581	589	PF00400	0.526
LIG_FHA_1	192	198	PF00498	0.531
LIG_FHA_1	227	233	PF00498	0.414
LIG_FHA_1	359	365	PF00498	0.540
LIG_FHA_1	458	464	PF00498	0.410
LIG_FHA_1	600	606	PF00498	0.568
LIG_FHA_1	650	656	PF00498	0.561
LIG_FHA_1	674	680	PF00498	0.579
LIG_FHA_2	156	162	PF00498	0.453
LIG_FHA_2	41	47	PF00498	0.447
LIG_FHA_2	440	446	PF00498	0.459
LIG_FHA_2	521	527	PF00498	0.559
LIG_FHA_2	546	552	PF00498	0.628
LIG_FHA_2	604	610	PF00498	0.551
LIG_FHA_2	659	665	PF00498	0.557
LIG_FHA_2	73	79	PF00498	0.435
LIG_LIR_Apic_2	170	175	PF02991	0.407
LIG_LIR_Apic_2	97	103	PF02991	0.340
LIG_LIR_Gen_1	236	247	PF02991	0.416
LIG_LIR_Gen_1	56	67	PF02991	0.406
LIG_LIR_Gen_1	95	106	PF02991	0.355
LIG_LIR_Nem_3	184	189	PF02991	0.484
LIG_LIR_Nem_3	236	242	PF02991	0.416
LIG_LIR_Nem_3	305	311	PF02991	0.669
LIG_LIR_Nem_3	401	405	PF02991	0.408
LIG_LIR_Nem_3	431	436	PF02991	0.513
LIG_LIR_Nem_3	56	62	PF02991	0.396
LIG_LIR_Nem_3	95	101	PF02991	0.373
LIG_PCNA_yPIPBox_3	581	595	PF02747	0.519
LIG_Pex14_2	96	100	PF04695	0.385
LIG_RPA_C_Fungi	593	605	PF08784	0.550
LIG_RPA_C_Fungi	708	720	PF08784	0.563
LIG_SH2_CRK	186	190	PF00017	0.518
LIG_SH2_SRC	186	189	PF00017	0.538
LIG_SH2_STAT3	82	85	PF00017	0.452
LIG_SH2_STAT5	367	370	PF00017	0.319
LIG_SH2_STAT5	762	765	PF00017	0.544
LIG_SH2_STAT5	82	85	PF00017	0.464
LIG_SH3_3	221	227	PF00018	0.266
LIG_SH3_3	293	299	PF00018	0.589
LIG_SH3_3	351	357	PF00018	0.617
LIG_SH3_3	387	393	PF00018	0.316
LIG_SH3_3	462	468	PF00018	0.256
LIG_SH3_3	505	511	PF00018	0.640
LIG_SH3_3	512	518	PF00018	0.613
LIG_SH3_3	554	560	PF00018	0.644
LIG_SUMO_SIM_anti_2	434	440	PF11976	0.406
LIG_SUMO_SIM_par_1	107	113	PF11976	0.338
LIG_SUMO_SIM_par_1	173	179	PF11976	0.262
LIG_SUMO_SIM_par_1	228	234	PF11976	0.352
LIG_SUMO_SIM_par_1	268	275	PF11976	0.381
LIG_SUMO_SIM_par_1	457	462	PF11976	0.344
LIG_TRAF2_1	43	46	PF00917	0.448
LIG_TRAF2_1	442	445	PF00917	0.321
LIG_TRAF2_1	657	660	PF00917	0.613
LIG_TRAF2_1	661	664	PF00917	0.631
LIG_TRAF2_1	712	715	PF00917	0.501
LIG_TRAF2_1	721	724	PF00917	0.450
LIG_WRC_WIRS_1	156	161	PF05994	0.294
LIG_WW_2	468	471	PF00397	0.585
MOD_CDC14_SPxK_1	552	555	PF00782	0.677
MOD_CDK_SPK_2	355	360	PF00069	0.607
MOD_CDK_SPxK_1	549	555	PF00069	0.624
MOD_CK1_1	132	138	PF00069	0.575
MOD_CK1_1	191	197	PF00069	0.547
MOD_CK1_1	206	212	PF00069	0.547
MOD_CK1_1	213	219	PF00069	0.366
MOD_CK1_1	269	275	PF00069	0.294
MOD_CK1_1	314	320	PF00069	0.603
MOD_CK1_1	326	332	PF00069	0.608
MOD_CK1_1	335	341	PF00069	0.681
MOD_CK1_1	355	361	PF00069	0.634
MOD_CK1_1	506	512	PF00069	0.720
MOD_CK1_1	543	549	PF00069	0.672
MOD_CK1_1	625	631	PF00069	0.735
MOD_CK1_1	632	638	PF00069	0.676
MOD_CK2_1	117	123	PF00069	0.513
MOD_CK2_1	155	161	PF00069	0.335
MOD_CK2_1	167	173	PF00069	0.351
MOD_CK2_1	40	46	PF00069	0.439
MOD_CK2_1	428	434	PF00069	0.407
MOD_CK2_1	439	445	PF00069	0.196
MOD_CK2_1	520	526	PF00069	0.628
MOD_CK2_1	545	551	PF00069	0.676
MOD_CK2_1	568	574	PF00069	0.651
MOD_CK2_1	627	633	PF00069	0.705
MOD_CK2_1	658	664	PF00069	0.568
MOD_CK2_1	72	78	PF00069	0.440
MOD_DYRK1A_RPxSP_1	549	553	PF00069	0.703
MOD_GlcNHglycan	119	122	PF01048	0.530
MOD_GlcNHglycan	130	134	PF01048	0.554
MOD_GlcNHglycan	14	17	PF01048	0.690
MOD_GlcNHglycan	141	144	PF01048	0.305
MOD_GlcNHglycan	208	211	PF01048	0.593
MOD_GlcNHglycan	21	24	PF01048	0.689
MOD_GlcNHglycan	252	255	PF01048	0.288
MOD_GlcNHglycan	27	30	PF01048	0.683
MOD_GlcNHglycan	318	321	PF01048	0.600
MOD_GlcNHglycan	328	331	PF01048	0.568
MOD_GlcNHglycan	335	338	PF01048	0.619
MOD_GlcNHglycan	354	357	PF01048	0.633
MOD_GlcNHglycan	475	478	PF01048	0.533
MOD_GlcNHglycan	570	573	PF01048	0.689
MOD_GlcNHglycan	617	621	PF01048	0.640
MOD_GlcNHglycan	624	627	PF01048	0.560
MOD_GlcNHglycan	629	632	PF01048	0.644
MOD_GlcNHglycan	633	637	PF01048	0.609
MOD_GlcNHglycan	649	652	PF01048	0.653
MOD_GSK3_1	134	141	PF00069	0.285
MOD_GSK3_1	157	164	PF00069	0.272
MOD_GSK3_1	189	196	PF00069	0.527
MOD_GSK3_1	206	213	PF00069	0.486
MOD_GSK3_1	265	272	PF00069	0.302
MOD_GSK3_1	277	284	PF00069	0.075
MOD_GSK3_1	319	326	PF00069	0.618
MOD_GSK3_1	331	338	PF00069	0.617
MOD_GSK3_1	355	362	PF00069	0.581
MOD_GSK3_1	367	374	PF00069	0.291
MOD_GSK3_1	424	431	PF00069	0.347
MOD_GSK3_1	497	504	PF00069	0.659
MOD_GSK3_1	506	513	PF00069	0.608
MOD_GSK3_1	516	523	PF00069	0.488
MOD_GSK3_1	545	552	PF00069	0.654
MOD_GSK3_1	599	606	PF00069	0.500
MOD_GSK3_1	625	632	PF00069	0.602
MOD_GSK3_1	752	759	PF00069	0.535
MOD_N-GLC_1	277	282	PF02516	0.259
MOD_N-GLC_1	6	11	PF02516	0.548
MOD_N-GLC_2	149	151	PF02516	0.259
MOD_NEK2_1	129	134	PF00069	0.594
MOD_NEK2_1	139	144	PF00069	0.383
MOD_NEK2_1	277	282	PF00069	0.377
MOD_NEK2_1	452	457	PF00069	0.355
MOD_NEK2_1	459	464	PF00069	0.328
MOD_NEK2_1	480	485	PF00069	0.570
MOD_NEK2_1	568	573	PF00069	0.507
MOD_PIKK_1	176	182	PF00454	0.344
MOD_PIKK_1	335	341	PF00454	0.683
MOD_PIKK_1	497	503	PF00454	0.729
MOD_PIKK_1	506	512	PF00454	0.698
MOD_PIKK_1	659	665	PF00454	0.677
MOD_PKA_1	752	758	PF00069	0.526
MOD_PKA_2	167	173	PF00069	0.379
MOD_PKA_2	234	240	PF00069	0.328
MOD_PKA_2	281	287	PF00069	0.381
MOD_PKA_2	302	308	PF00069	0.598
MOD_PKA_2	359	365	PF00069	0.548
MOD_PKA_2	371	377	PF00069	0.300
MOD_PKA_2	383	389	PF00069	0.362
MOD_PKA_2	480	486	PF00069	0.587
MOD_PKA_2	752	758	PF00069	0.474
MOD_PKB_1	10	18	PF00069	0.630
MOD_Plk_1	277	283	PF00069	0.259
MOD_Plk_1	94	100	PF00069	0.393
MOD_Plk_4	266	272	PF00069	0.406
MOD_ProDKin_1	189	195	PF00069	0.570
MOD_ProDKin_1	211	217	PF00069	0.350
MOD_ProDKin_1	272	278	PF00069	0.260
MOD_ProDKin_1	287	293	PF00069	0.470
MOD_ProDKin_1	319	325	PF00069	0.649
MOD_ProDKin_1	340	346	PF00069	0.571
MOD_ProDKin_1	355	361	PF00069	0.578
MOD_ProDKin_1	40	46	PF00069	0.457
MOD_ProDKin_1	413	419	PF00069	0.403
MOD_ProDKin_1	510	516	PF00069	0.665
MOD_ProDKin_1	540	546	PF00069	0.671
MOD_ProDKin_1	549	555	PF00069	0.604
MOD_ProDKin_1	561	567	PF00069	0.643
MOD_SUMO_rev_2	120	127	PF00179	0.545
TRG_DiLeu_BaEn_2	663	669	PF01217	0.680
TRG_DiLeu_BaEn_4	78	84	PF01217	0.449
TRG_ENDOCYTIC_2	186	189	PF00928	0.512
TRG_ENDOCYTIC_2	433	436	PF00928	0.401
TRG_ER_diArg_1	181	183	PF00400	0.379
TRG_ER_diArg_1	263	265	PF00400	0.275
TRG_ER_diArg_1	405	407	PF00400	0.357
TRG_ER_diArg_1	692	695	PF00400	0.453
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3H0	Leptomonas seymouri	52%	95%
A0A0S4JRA4	Bodo saltans	33%	100%
A0A1X0P812	Trypanosomatidae	35%	100%
A0A3Q8IB73	Leishmania donovani	98%	100%
A0A3R7N1E2	Trypanosoma rangeli	38%	100%
A4H9N3	Leishmania braziliensis	75%	98%
B1H1W9	Xenopus laevis	23%	97%
D0A5A8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ARR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
Q4QDR8	Leishmania major	90%	99%
Q8BPI1	Mus musculus	25%	94%
V5AZ63	Trypanosoma cruzi	38%	100%