LeishMANIAdb
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Proline--tRNA ligase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Proline--tRNA ligase
Gene product:
prolyl-tRNA synthetase - putative
Species:
Leishmania infantum
UniProt:
A4HXZ5_LEIIN
TriTrypDb:
LINF_180017600 *
Length:
810

Annotations

Annotations by Jardim et al.

tRNA synthetase, prolyl-tRNA synthetase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 28
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 16
GO:0110165 cellular anatomical entity 1 16
GO:0017101 aminoacyl-tRNA synthetase multienzyme complex 3 2
GO:0032991 protein-containing complex 1 2
GO:0140535 intracellular protein-containing complex 2 2
GO:1902494 catalytic complex 2 2
GO:0016020 membrane 2 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4HXZ5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXZ5

PDB structure(s): 5xil_A

Function

Biological processes
Term Name Level Count
GO:0006082 organic acid metabolic process 3 16
GO:0006139 nucleobase-containing compound metabolic process 3 16
GO:0006399 tRNA metabolic process 7 16
GO:0006418 tRNA aminoacylation for protein translation 6 16
GO:0006433 prolyl-tRNA aminoacylation 7 16
GO:0006520 amino acid metabolic process 3 16
GO:0006725 cellular aromatic compound metabolic process 3 16
GO:0006807 nitrogen compound metabolic process 2 16
GO:0008152 metabolic process 1 16
GO:0009987 cellular process 1 16
GO:0016070 RNA metabolic process 5 16
GO:0019752 carboxylic acid metabolic process 5 16
GO:0034641 cellular nitrogen compound metabolic process 3 16
GO:0034660 ncRNA metabolic process 6 16
GO:0043038 amino acid activation 4 16
GO:0043039 tRNA aminoacylation 5 16
GO:0043170 macromolecule metabolic process 3 16
GO:0043436 oxoacid metabolic process 4 16
GO:0044237 cellular metabolic process 2 16
GO:0044238 primary metabolic process 2 16
GO:0044281 small molecule metabolic process 2 16
GO:0046483 heterocycle metabolic process 3 16
GO:0071704 organic substance metabolic process 2 16
GO:0090304 nucleic acid metabolic process 4 16
GO:1901360 organic cyclic compound metabolic process 3 16
GO:1901564 organonitrogen compound metabolic process 3 16
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 16
GO:0002161 aminoacyl-tRNA editing activity 5 15
GO:0003824 catalytic activity 1 16
GO:0004812 aminoacyl-tRNA ligase activity 4 16
GO:0004827 proline-tRNA ligase activity 5 16
GO:0005488 binding 1 16
GO:0005524 ATP binding 5 16
GO:0016787 hydrolase activity 2 15
GO:0016788 hydrolase activity, acting on ester bonds 3 15
GO:0016874 ligase activity 2 16
GO:0016875 ligase activity, forming carbon-oxygen bonds 3 16
GO:0017076 purine nucleotide binding 4 16
GO:0030554 adenyl nucleotide binding 5 16
GO:0032553 ribonucleotide binding 3 16
GO:0032555 purine ribonucleotide binding 4 16
GO:0032559 adenyl ribonucleotide binding 5 16
GO:0035639 purine ribonucleoside triphosphate binding 4 16
GO:0036094 small molecule binding 2 16
GO:0043167 ion binding 2 16
GO:0043168 anion binding 3 16
GO:0052689 carboxylic ester hydrolase activity 4 15
GO:0097159 organic cyclic compound binding 2 16
GO:0097367 carbohydrate derivative binding 2 16
GO:0140098 catalytic activity, acting on RNA 3 16
GO:0140101 catalytic activity, acting on a tRNA 4 16
GO:0140640 catalytic activity, acting on a nucleic acid 2 16
GO:1901265 nucleoside phosphate binding 3 16
GO:1901363 heterocyclic compound binding 2 16

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 631 635 PF00656 0.410
CLV_NRD_NRD_1 495 497 PF00675 0.300
CLV_NRD_NRD_1 615 617 PF00675 0.204
CLV_NRD_NRD_1 726 728 PF00675 0.249
CLV_PCSK_KEX2_1 205 207 PF00082 0.249
CLV_PCSK_KEX2_1 306 308 PF00082 0.330
CLV_PCSK_KEX2_1 615 617 PF00082 0.250
CLV_PCSK_PC1ET2_1 205 207 PF00082 0.249
CLV_PCSK_PC1ET2_1 306 308 PF00082 0.330
CLV_PCSK_SKI1_1 100 104 PF00082 0.415
CLV_PCSK_SKI1_1 139 143 PF00082 0.224
CLV_PCSK_SKI1_1 206 210 PF00082 0.236
CLV_PCSK_SKI1_1 32 36 PF00082 0.429
CLV_PCSK_SKI1_1 452 456 PF00082 0.199
CLV_PCSK_SKI1_1 471 475 PF00082 0.199
CLV_PCSK_SKI1_1 798 802 PF00082 0.230
DEG_Nend_UBRbox_1 1 4 PF02207 0.451
DEG_SCF_FBW7_1 49 55 PF00400 0.419
DOC_CKS1_1 49 54 PF01111 0.423
DOC_CKS1_1 58 63 PF01111 0.410
DOC_CYCLIN_yCln2_LP_2 108 114 PF00134 0.307
DOC_CYCLIN_yCln2_LP_2 399 405 PF00134 0.237
DOC_MAPK_gen_1 205 212 PF00069 0.480
DOC_MAPK_gen_1 419 429 PF00069 0.399
DOC_MAPK_JIP1_4 206 212 PF00069 0.381
DOC_MAPK_MEF2A_6 205 212 PF00069 0.497
DOC_MAPK_MEF2A_6 422 431 PF00069 0.399
DOC_MAPK_MEF2A_6 565 573 PF00069 0.424
DOC_MAPK_MEF2A_6 648 656 PF00069 0.399
DOC_PP1_RVXF_1 171 178 PF00149 0.424
DOC_PP1_RVXF_1 251 258 PF00149 0.372
DOC_PP2B_LxvP_1 108 111 PF13499 0.429
DOC_PP2B_LxvP_1 488 491 PF13499 0.399
DOC_PP2B_LxvP_1 7 10 PF13499 0.485
DOC_PP2B_LxvP_1 775 778 PF13499 0.399
DOC_PP4_FxxP_1 442 445 PF00568 0.399
DOC_PP4_FxxP_1 543 546 PF00568 0.399
DOC_PP4_FxxP_1 779 782 PF00568 0.399
DOC_USP7_MATH_1 155 159 PF00917 0.466
DOC_USP7_MATH_1 662 666 PF00917 0.473
DOC_USP7_MATH_1 675 679 PF00917 0.500
DOC_USP7_MATH_1 750 754 PF00917 0.399
DOC_USP7_MATH_1 81 85 PF00917 0.508
DOC_USP7_MATH_1 86 90 PF00917 0.348
DOC_USP7_UBL2_3 164 168 PF12436 0.356
DOC_USP7_UBL2_3 243 247 PF12436 0.411
DOC_USP7_UBL2_3 794 798 PF12436 0.455
DOC_WW_Pin1_4 156 161 PF00397 0.363
DOC_WW_Pin1_4 192 197 PF00397 0.410
DOC_WW_Pin1_4 443 448 PF00397 0.410
DOC_WW_Pin1_4 45 50 PF00397 0.419
DOC_WW_Pin1_4 54 59 PF00397 0.533
DOC_WW_Pin1_4 60 65 PF00397 0.420
DOC_WW_Pin1_4 634 639 PF00397 0.399
DOC_WW_Pin1_4 682 687 PF00397 0.489
DOC_WW_Pin1_4 76 81 PF00397 0.428
LIG_14-3-3_CanoR_1 176 183 PF00244 0.448
LIG_14-3-3_CanoR_1 206 211 PF00244 0.416
LIG_14-3-3_CanoR_1 28 34 PF00244 0.452
LIG_14-3-3_CanoR_1 406 415 PF00244 0.399
LIG_14-3-3_CanoR_1 494 503 PF00244 0.470
LIG_14-3-3_CanoR_1 585 595 PF00244 0.275
LIG_14-3-3_CanoR_1 676 680 PF00244 0.415
LIG_14-3-3_CanoR_1 712 722 PF00244 0.440
LIG_Actin_WH2_2 162 178 PF00022 0.385
LIG_APCC_ABBA_1 571 576 PF00400 0.321
LIG_deltaCOP1_diTrp_1 453 463 PF00928 0.410
LIG_deltaCOP1_diTrp_1 717 721 PF00928 0.272
LIG_EH1_1 96 104 PF00400 0.209
LIG_FHA_1 136 142 PF00498 0.439
LIG_FHA_1 207 213 PF00498 0.471
LIG_FHA_1 218 224 PF00498 0.387
LIG_FHA_1 231 237 PF00498 0.431
LIG_FHA_1 33 39 PF00498 0.503
LIG_FHA_1 444 450 PF00498 0.428
LIG_FHA_1 507 513 PF00498 0.399
LIG_FHA_1 54 60 PF00498 0.426
LIG_FHA_1 562 568 PF00498 0.399
LIG_FHA_1 587 593 PF00498 0.376
LIG_FHA_1 708 714 PF00498 0.350
LIG_FHA_1 772 778 PF00498 0.442
LIG_FHA_1 799 805 PF00498 0.500
LIG_FHA_2 118 124 PF00498 0.410
LIG_FHA_2 157 163 PF00498 0.513
LIG_FHA_2 235 241 PF00498 0.439
LIG_FHA_2 318 324 PF00498 0.264
LIG_FHA_2 395 401 PF00498 0.403
LIG_FHA_2 496 502 PF00498 0.396
LIG_FHA_2 508 514 PF00498 0.405
LIG_FHA_2 600 606 PF00498 0.409
LIG_FHA_2 759 765 PF00498 0.431
LIG_LIR_Apic_2 441 445 PF02991 0.399
LIG_LIR_Apic_2 540 546 PF02991 0.446
LIG_LIR_Gen_1 195 203 PF02991 0.447
LIG_LIR_Gen_1 231 238 PF02991 0.527
LIG_LIR_Gen_1 312 322 PF02991 0.325
LIG_LIR_Gen_1 478 488 PF02991 0.410
LIG_LIR_Gen_1 716 725 PF02991 0.241
LIG_LIR_Gen_1 801 810 PF02991 0.467
LIG_LIR_Nem_3 195 200 PF02991 0.461
LIG_LIR_Nem_3 231 235 PF02991 0.527
LIG_LIR_Nem_3 237 241 PF02991 0.464
LIG_LIR_Nem_3 312 318 PF02991 0.331
LIG_LIR_Nem_3 326 330 PF02991 0.319
LIG_LIR_Nem_3 362 368 PF02991 0.338
LIG_LIR_Nem_3 411 417 PF02991 0.399
LIG_LIR_Nem_3 478 483 PF02991 0.410
LIG_LIR_Nem_3 716 721 PF02991 0.241
LIG_LIR_Nem_3 801 806 PF02991 0.467
LIG_Pex14_2 535 539 PF04695 0.399
LIG_SH2_CRK 232 236 PF00017 0.537
LIG_SH2_CRK 480 484 PF00017 0.399
LIG_SH2_NCK_1 480 484 PF00017 0.410
LIG_SH2_PTP2 315 318 PF00017 0.336
LIG_SH2_SRC 315 318 PF00017 0.336
LIG_SH2_STAP1 232 236 PF00017 0.388
LIG_SH2_STAP1 417 421 PF00017 0.399
LIG_SH2_STAP1 480 484 PF00017 0.401
LIG_SH2_STAP1 508 512 PF00017 0.399
LIG_SH2_STAT5 232 235 PF00017 0.381
LIG_SH2_STAT5 244 247 PF00017 0.283
LIG_SH2_STAT5 315 318 PF00017 0.292
LIG_SH2_STAT5 334 337 PF00017 0.284
LIG_SH2_STAT5 342 345 PF00017 0.287
LIG_SH2_STAT5 364 367 PF00017 0.320
LIG_SH2_STAT5 508 511 PF00017 0.424
LIG_SH3_2 61 66 PF14604 0.415
LIG_SH3_3 409 415 PF00018 0.410
LIG_SH3_3 46 52 PF00018 0.447
LIG_SH3_3 55 61 PF00018 0.459
LIG_SH3_3 578 584 PF00018 0.298
LIG_SH3_3 779 785 PF00018 0.404
LIG_SUMO_SIM_anti_2 122 129 PF11976 0.381
LIG_SUMO_SIM_anti_2 185 191 PF11976 0.478
LIG_SUMO_SIM_anti_2 472 478 PF11976 0.466
LIG_SUMO_SIM_anti_2 588 595 PF11976 0.377
LIG_SUMO_SIM_par_1 208 213 PF11976 0.504
LIG_SUMO_SIM_par_1 472 478 PF11976 0.466
LIG_TRAF2_1 120 123 PF00917 0.440
LIG_TRAF2_1 237 240 PF00917 0.363
LIG_TRAF2_1 602 605 PF00917 0.444
LIG_TRAF2_1 606 609 PF00917 0.439
LIG_TRAF2_1 749 752 PF00917 0.403
LIG_TYR_ITIM 325 330 PF00017 0.306
LIG_UBA3_1 199 205 PF00899 0.444
LIG_WRC_WIRS_1 235 240 PF05994 0.363
LIG_WRC_WIRS_1 512 517 PF05994 0.458
LIG_WW_3 582 586 PF00397 0.295
MOD_CDK_SPK_2 45 50 PF00069 0.419
MOD_CDK_SPxK_1 60 66 PF00069 0.414
MOD_CDK_SPxxK_3 443 450 PF00069 0.410
MOD_CDK_SPxxK_3 634 641 PF00069 0.399
MOD_CK1_1 15 21 PF00069 0.420
MOD_CK1_1 158 164 PF00069 0.466
MOD_CK1_1 22 28 PF00069 0.389
MOD_CK1_1 293 299 PF00069 0.563
MOD_CK1_1 30 36 PF00069 0.425
MOD_CK1_1 443 449 PF00069 0.410
MOD_CK1_1 48 54 PF00069 0.411
MOD_CK1_1 57 63 PF00069 0.438
MOD_CK2_1 117 123 PF00069 0.418
MOD_CK2_1 234 240 PF00069 0.450
MOD_CK2_1 317 323 PF00069 0.277
MOD_CK2_1 394 400 PF00069 0.408
MOD_CK2_1 479 485 PF00069 0.503
MOD_CK2_1 495 501 PF00069 0.330
MOD_CK2_1 507 513 PF00069 0.423
MOD_CK2_1 599 605 PF00069 0.399
MOD_CK2_1 746 752 PF00069 0.399
MOD_Cter_Amidation 494 497 PF01082 0.210
MOD_GlcNHglycan 260 263 PF01048 0.460
MOD_GlcNHglycan 292 295 PF01048 0.565
MOD_GlcNHglycan 311 314 PF01048 0.222
MOD_GlcNHglycan 329 333 PF01048 0.336
MOD_GlcNHglycan 672 675 PF01048 0.291
MOD_GlcNHglycan 68 71 PF01048 0.580
MOD_GlcNHglycan 748 751 PF01048 0.199
MOD_GSK3_1 15 22 PF00069 0.404
MOD_GSK3_1 151 158 PF00069 0.416
MOD_GSK3_1 212 219 PF00069 0.500
MOD_GSK3_1 23 30 PF00069 0.639
MOD_GSK3_1 230 237 PF00069 0.315
MOD_GSK3_1 44 51 PF00069 0.577
MOD_GSK3_1 507 514 PF00069 0.444
MOD_GSK3_1 53 60 PF00069 0.460
MOD_GSK3_1 556 563 PF00069 0.403
MOD_GSK3_1 596 603 PF00069 0.449
MOD_GSK3_1 62 69 PF00069 0.458
MOD_GSK3_1 72 79 PF00069 0.535
MOD_GSK3_1 746 753 PF00069 0.402
MOD_GSK3_1 794 801 PF00069 0.500
MOD_N-GLC_1 309 314 PF02516 0.383
MOD_N-GLC_1 634 639 PF02516 0.199
MOD_N-GLC_1 76 81 PF02516 0.586
MOD_NEK2_1 142 147 PF00069 0.420
MOD_NEK2_1 17 22 PF00069 0.395
MOD_NEK2_1 216 221 PF00069 0.388
MOD_NEK2_1 24 29 PF00069 0.396
MOD_NEK2_1 367 372 PF00069 0.405
MOD_NEK2_1 610 615 PF00069 0.527
MOD_NEK2_2 137 142 PF00069 0.381
MOD_NEK2_2 479 484 PF00069 0.428
MOD_PIKK_1 586 592 PF00454 0.433
MOD_PIKK_1 72 78 PF00454 0.534
MOD_PKA_1 746 752 PF00069 0.399
MOD_PKA_2 27 33 PF00069 0.654
MOD_PKA_2 405 411 PF00069 0.399
MOD_PKA_2 495 501 PF00069 0.500
MOD_PKA_2 670 676 PF00069 0.424
MOD_PKA_2 713 719 PF00069 0.453
MOD_Plk_1 212 218 PF00069 0.441
MOD_Plk_1 230 236 PF00069 0.404
MOD_Plk_1 309 315 PF00069 0.357
MOD_Plk_1 549 555 PF00069 0.455
MOD_Plk_1 662 668 PF00069 0.458
MOD_Plk_2-3 117 123 PF00069 0.424
MOD_Plk_4 137 143 PF00069 0.423
MOD_Plk_4 408 414 PF00069 0.410
MOD_Plk_4 479 485 PF00069 0.428
MOD_Plk_4 511 517 PF00069 0.441
MOD_Plk_4 549 555 PF00069 0.421
MOD_Plk_4 675 681 PF00069 0.425
MOD_Plk_4 799 805 PF00069 0.500
MOD_ProDKin_1 156 162 PF00069 0.363
MOD_ProDKin_1 192 198 PF00069 0.410
MOD_ProDKin_1 443 449 PF00069 0.410
MOD_ProDKin_1 45 51 PF00069 0.421
MOD_ProDKin_1 54 60 PF00069 0.529
MOD_ProDKin_1 634 640 PF00069 0.399
MOD_ProDKin_1 682 688 PF00069 0.488
MOD_ProDKin_1 76 82 PF00069 0.470
MOD_SUMO_for_1 305 308 PF00179 0.319
MOD_SUMO_for_1 464 467 PF00179 0.500
MOD_SUMO_rev_2 158 166 PF00179 0.466
MOD_SUMO_rev_2 293 301 PF00179 0.482
MOD_SUMO_rev_2 748 756 PF00179 0.387
MOD_SUMO_rev_2 92 102 PF00179 0.348
TRG_DiLeu_BaEn_1 123 128 PF01217 0.369
TRG_DiLeu_BaEn_1 98 103 PF01217 0.392
TRG_DiLeu_BaEn_2 716 722 PF01217 0.379
TRG_DiLeu_BaLyEn_6 2 7 PF01217 0.425
TRG_ENDOCYTIC_2 232 235 PF00928 0.510
TRG_ENDOCYTIC_2 252 255 PF00928 0.272
TRG_ENDOCYTIC_2 315 318 PF00928 0.276
TRG_ENDOCYTIC_2 327 330 PF00928 0.323
TRG_ENDOCYTIC_2 364 367 PF00928 0.320
TRG_ENDOCYTIC_2 480 483 PF00928 0.399
TRG_ENDOCYTIC_2 484 487 PF00928 0.399
TRG_ER_diArg_1 449 452 PF00400 0.399
TRG_ER_diArg_1 493 496 PF00400 0.452
TRG_ER_diArg_1 615 617 PF00400 0.470
TRG_ER_diArg_1 712 715 PF00400 0.407
TRG_Pf-PMV_PEXEL_1 615 620 PF00026 0.244
TRG_Pf-PMV_PEXEL_1 659 663 PF00026 0.306
TRG_PTS2 1 44 PF00400 0.386

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HY85 Leptomonas seymouri 84% 100%
A0A0S4JN58 Bodo saltans 58% 99%
A0A1X0P793 Trypanosomatidae 62% 100%
A0A3R7KPX0 Trypanosoma rangeli 65% 95%
A0A3S7WV15 Leishmania donovani 89% 100%
A0A3S7WV32 Leishmania donovani 100% 100%
A4H9N1 Leishmania braziliensis 89% 99%
A4HY00 Leishmania infantum 88% 100%
D0A5B2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 63% 100%
E9ARQ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
E9ARQ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 98%
O60155 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 45% 100%
P38708 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 48% 100%
Q4QDS0 Leishmania major 87% 100%
Q4QDS1 Leishmania major 96% 100%
Q8I5R7 Plasmodium falciparum (isolate 3D7) 39% 100%
Q9FYR6 Arabidopsis thaliana 37% 100%
V5AZ66 Trypanosoma cruzi 63% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS