Complex1_LYR_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Complex 1 protein (LYR family)/Complex1 LYR-like - putative

Species:

Leishmania infantum

UniProt:

A4HXZ4_LEIIN

TriTrypDb:

LINF_180017500

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HXZ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HXZ4

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	4
GO:0016043	cellular component organization	3	4
GO:0022607	cellular component assembly	4	4
GO:0033108	mitochondrial respiratory chain complex assembly	6	4
GO:0034552	respiratory chain complex II assembly	6	4
GO:0034553	mitochondrial respiratory chain complex II assembly	7	4
GO:0043933	protein-containing complex organization	4	4
GO:0065003	protein-containing complex assembly	5	4
GO:0071840	cellular component organization or biogenesis	2	4

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	158	160	PF00675	0.650
CLV_NRD_NRD_1	190	192	PF00675	0.565
CLV_NRD_NRD_1	218	220	PF00675	0.431
CLV_NRD_NRD_1	236	238	PF00675	0.310
CLV_NRD_NRD_1	251	253	PF00675	0.310
CLV_NRD_NRD_1	46	48	PF00675	0.616
CLV_NRD_NRD_1	56	58	PF00675	0.564
CLV_PCSK_FUR_1	12	16	PF00082	0.646
CLV_PCSK_FUR_1	54	58	PF00082	0.562
CLV_PCSK_KEX2_1	14	16	PF00082	0.577
CLV_PCSK_KEX2_1	157	159	PF00082	0.665
CLV_PCSK_KEX2_1	190	192	PF00082	0.565
CLV_PCSK_KEX2_1	218	220	PF00082	0.431
CLV_PCSK_KEX2_1	251	253	PF00082	0.310
CLV_PCSK_KEX2_1	46	48	PF00082	0.616
CLV_PCSK_KEX2_1	56	58	PF00082	0.564
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.645
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.310
CLV_PCSK_SKI1_1	203	207	PF00082	0.310
CLV_PCSK_SKI1_1	238	242	PF00082	0.466
DEG_APCC_DBOX_1	202	210	PF00400	0.310
DEG_Nend_UBRbox_1	1	4	PF02207	0.543
DEG_SCF_FBW7_1	178	184	PF00400	0.628
DEG_SPOP_SBC_1	130	134	PF00917	0.600
DEG_SPOP_SBC_1	67	71	PF00917	0.581
DOC_CKS1_1	178	183	PF01111	0.570
DOC_MAPK_gen_1	32	40	PF00069	0.551
DOC_PP1_RVXF_1	240	246	PF00149	0.310
DOC_PP2B_LxvP_1	65	68	PF13499	0.614
DOC_USP7_MATH_1	117	121	PF00917	0.649
DOC_USP7_MATH_1	126	130	PF00917	0.548
DOC_USP7_MATH_1	137	141	PF00917	0.594
DOC_USP7_MATH_1	183	187	PF00917	0.608
DOC_USP7_MATH_1	189	193	PF00917	0.469
DOC_USP7_MATH_1	52	56	PF00917	0.563
DOC_USP7_MATH_1	68	72	PF00917	0.702
DOC_USP7_UBL2_3	14	18	PF12436	0.646
DOC_USP7_UBL2_3	238	242	PF12436	0.310
DOC_WW_Pin1_4	120	125	PF00397	0.572
DOC_WW_Pin1_4	133	138	PF00397	0.653
DOC_WW_Pin1_4	177	182	PF00397	0.701
DOC_WW_Pin1_4	185	190	PF00397	0.638
LIG_14-3-3_CanoR_1	128	137	PF00244	0.574
LIG_14-3-3_CanoR_1	218	222	PF00244	0.320
LIG_Actin_WH2_2	194	209	PF00022	0.322
LIG_APCC_ABBAyCdc20_2	47	53	PF00400	0.615
LIG_FHA_1	6	12	PF00498	0.503
LIG_FHA_1	73	79	PF00498	0.555
LIG_FHA_2	104	110	PF00498	0.562
LIG_FHA_2	143	149	PF00498	0.606
LIG_FHA_2	239	245	PF00498	0.258
LIG_GBD_Chelix_1	87	95	PF00786	0.619
LIG_PCNA_yPIPBox_3	190	202	PF02747	0.424
LIG_Pex14_1	245	249	PF04695	0.310
LIG_RPA_C_Fungi	214	226	PF08784	0.383
LIG_SH2_STAT3	224	227	PF00017	0.373
LIG_SH2_STAT3	229	232	PF00017	0.342
LIG_SH2_STAT3	39	42	PF00017	0.519
LIG_SH2_STAT5	150	153	PF00017	0.448
LIG_SH2_STAT5	224	227	PF00017	0.310
LIG_SH2_STAT5	39	42	PF00017	0.592
LIG_SH3_1	168	174	PF00018	0.588
LIG_SH3_3	168	174	PF00018	0.597
LIG_SH3_3	175	181	PF00018	0.529
LIG_SH3_3	35	41	PF00018	0.584
LIG_TRAF2_1	145	148	PF00917	0.627
MOD_CDC14_SPxK_1	188	191	PF00782	0.578
MOD_CDK_SPK_2	185	190	PF00069	0.612
MOD_CDK_SPxK_1	185	191	PF00069	0.728
MOD_CK1_1	120	126	PF00069	0.685
MOD_CK1_1	129	135	PF00069	0.554
MOD_CK1_1	261	267	PF00069	0.474
MOD_CK1_1	69	75	PF00069	0.631
MOD_CK1_1	86	92	PF00069	0.649
MOD_CK2_1	142	148	PF00069	0.625
MOD_CK2_1	238	244	PF00069	0.328
MOD_Cter_Amidation	249	252	PF01082	0.294
MOD_GlcNHglycan	139	142	PF01048	0.658
MOD_GlcNHglycan	185	188	PF01048	0.580
MOD_GlcNHglycan	191	194	PF01048	0.486
MOD_GlcNHglycan	221	224	PF01048	0.445
MOD_GSK3_1	126	133	PF00069	0.557
MOD_GSK3_1	142	149	PF00069	0.689
MOD_GSK3_1	173	180	PF00069	0.651
MOD_GSK3_1	181	188	PF00069	0.753
MOD_GSK3_1	197	204	PF00069	0.301
MOD_GSK3_1	68	75	PF00069	0.635
MOD_GSK3_1	82	89	PF00069	0.562
MOD_N-GLC_1	238	243	PF02516	0.468
MOD_NEK2_1	5	10	PF00069	0.559
MOD_PIKK_1	58	64	PF00454	0.611
MOD_PKA_2	189	195	PF00069	0.548
MOD_PKA_2	217	223	PF00069	0.320
MOD_Plk_1	146	152	PF00069	0.668
MOD_Plk_1	207	213	PF00069	0.389
MOD_Plk_4	146	152	PF00069	0.524
MOD_Plk_4	197	203	PF00069	0.310
MOD_ProDKin_1	120	126	PF00069	0.574
MOD_ProDKin_1	133	139	PF00069	0.656
MOD_ProDKin_1	177	183	PF00069	0.700
MOD_ProDKin_1	185	191	PF00069	0.629
TRG_ENDOCYTIC_2	202	205	PF00928	0.310
TRG_ER_diArg_1	156	159	PF00400	0.657
TRG_ER_diArg_1	189	191	PF00400	0.594
TRG_ER_diArg_1	45	47	PF00400	0.609
TRG_ER_diArg_1	54	57	PF00400	0.583
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.310

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8U5	Leptomonas seymouri	50%	98%
A0A3Q8IJR9	Leishmania donovani	99%	100%
A4H9N0	Leishmania braziliensis	67%	100%
E9ARQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QDS2	Leishmania major	89%	100%